Contrave Alternatives Compared
| Contrave (bupropion / naltrexone) | Semaglutide | Zepbound (tirzepatide) |
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| Contrave (bupropion / naltrexone) | Semaglutide | Zepbound (tirzepatide) |
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Prescription only
Prescribed for Weight Loss (Obesity/Overweight). Contrave may also be used for purposes not listed in this medication guide. |
Prescription only
Semaglutide lowers blood sugar levels by mimicking the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the liver. It is taken... View more |
Prescription only
Prescribed for Weight Loss (Obesity/Overweight), Obstructive Sleep Apnea/Hypopnea Syndrome. Zepbound may also be used for purposes not listed in this medication guide. |
Related suggestions Weight Loss (Obesity/Overweight)
Popular comparisons
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| More about Contrave (bupropion / naltrexone) | More about Semaglutide | More about Zepbound (tirzepatide) | ||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||
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Contrave has an average rating of 6.6 out of 10 from a total of 1986 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 25% reported a negative effect. |
Semaglutide has an average rating of 6.9 out of 10 from a total of 2403 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 21% reported a negative effect. |
Zepbound has an average rating of 9.1 out of 10 from a total of 190 ratings on Drugs.com. 89% of reviewers reported a positive effect, while 1% reported a negative effect. |
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| Side Effects | ||||||||||||||||||
| Generic Availability | ||||||||||||||||||
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N/A |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||
View all Contrave prices |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Zepbound prices |
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| Dosage Forms Available | ||||||||||||||||||
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N/A |
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| Brand Names | ||||||||||||||||||
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N/A |
Ozempic, Rybelsus, Wegovy | Other tirzepatide brands include: Mounjaro | ||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||
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21 hours |
168 hours |
120 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||
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A total of 751 drugs are known to interact with Contrave:
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A total of 267 drugs are known to interact with Semaglutide:
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A total of 412 drugs are known to interact with Zepbound:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||
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| Disease Interactions | ||||||||||||||||||
| First Approval Date | ||||||||||||||||||
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September 10, 2014 |
December 05, 2017 |
N/A |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||
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| Related Treatment Guide | ||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.