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Contrave Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Contrave Wegovy Mounjaro
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Contrave (bupropion / naltrexone) Wegovy (semaglutide) Mounjaro (tirzepatide)
Prescription only

Prescribed for Weight Loss (Obesity/Overweight). Contrave may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Weight Loss (Obesity/Overweight), Cardiovascular Risk Reduction. Wegovy may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Weight Loss (Obesity/Overweight), Diabetes - Type 2. Mounjaro may also be used for purposes not listed in this medication guide.

More about Contrave (bupropion / naltrexone) More about Wegovy (semaglutide) More about Mounjaro (tirzepatide)
Ratings & Reviews

Contrave has an average rating of 6.6 out of 10 from a total of 1982 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 25% reported a negative effect.

Wegovy has an average rating of 7.4 out of 10 from a total of 403 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 18% reported a negative effect.

Mounjaro has an average rating of 8.6 out of 10 from a total of 1059 ratings on Drugs.com. 80% of reviewers reported a positive effect, while 6% reported a negative effect.

View all 1982 reviews

View all 403 reviews

View all 1059 reviews

Drug Class
Side Effects

Contrave side effects

Wegovy side effects

Mounjaro side effects
Generic Availability

No lower cost generic approved

No lower cost generic approved

No lower cost generic approved
Pricing and Coupons * Prices are without insurance
Quantity 120 tablet, extended release
Dosage 90 mg-8 mg
Per Unit* $5.57
Cost* $667.84

View all Contrave prices

Quantity 2 mL
Dosage 0.25 mg/0.5 mL (0.25 mg dose)
Per Unit* $715.01
Cost* $1,430.01

View all Wegovy prices

Quantity 2 mL
Dosage 2.5 mg/0.5 mL
Per Unit* $567.62
Cost* $1,135.24

View all Mounjaro prices

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Dosage Forms Available
  • Oral tablet, extended release
  • Subcutaneous solution
  • Subcutaneous solution
Brand Names

N/A

 Other semaglutide brands include: Ozempic, Rybelsus Other tirzepatide brands include: Zepbound
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

21 hours

168 hours

120 hours
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
X
Category X Not for use in pregnancy

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.
Drug Interactions

A total of 749 drugs are known to interact with Contrave:

  • 216 major drug interactions (942 brand and generic names)
  • 528 moderate drug interactions (2413 brand and generic names)
  • 5 minor drug interactions (16 brand and generic names)

A total of 266 drugs are known to interact with Wegovy:

  • 15 major drug interactions (34 brand and generic names)
  • 250 moderate drug interactions (1429 brand and generic names)
  • 1 minor drug interactions (10 brand and generic names)

A total of 411 drugs are known to interact with Mounjaro:

  • 15 major drug interactions (34 brand and generic names)
  • 395 moderate drug interactions (2259 brand and generic names)
  • 1 minor drug interactions (10 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more
  • Semaglutide may affect the absorption of other medications that you take by mouth. In some cases... View more
  • Talk to your doctor before using alcohol together with semaglutide. Alcohol may affect blood... View more
  • Tirzepatide may affect the absorption of other medications that you take by mouth. In some cases... View more
  • Talk to your doctor before using alcohol together with tirzepatide. Alcohol may affect blood... View more
Disease Interactions
First Approval Date

September 10, 2014

N/A

N/A
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources
Professional Resources
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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