Contrave Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Contrave (bupropion / naltrexone)	Mounjaro (tirzepatide)	Phentermine	Enter another drug to compare

Contrave (bupropion / naltrexone)

Mounjaro (tirzepatide)

Phentermine

Prescription only

Prescribed for Weight Loss (Obesity/Overweight). Contrave may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Weight Loss (Obesity/Overweight), Type 2 Diabetes. Mounjaro may also be used for purposes not listed in this medication guide.

Prescription only

Phentermine may be used short-term as an aid to weight loss; however, it can be addictive and tolerance may develop to its weight-losing effects, rendering it less effective with time. Prescribed for... View more

More about Contrave (bupropion / naltrexone)

More about Mounjaro (tirzepatide)

More about Phentermine

Ratings & Reviews

Contrave has an average rating of 6.6 out of 10 from a total of 1987 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 25% reported a negative effect.

Mounjaro has an average rating of 8.6 out of 10 from a total of 1255 ratings on Drugs.com. 80% of reviewers reported a positive effect, while 6% reported a negative effect.

Phentermine has an average rating of 8.7 out of 10 from a total of 3015 ratings on Drugs.com. 84% of reviewers reported a positive effect, while 5% reported a negative effect.

View all 1987 reviews

View all 1255 reviews

View all 3015 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Nausea (31.5%)
Headaches (17.3%)
Constipation (12.0%)
Dizziness (10.5%)
Dry mouth (9.0%)
Tiredness (5.8%)
Anxiety (5.1%)

View all Contrave side effects

Nausea (15.8%)
Constipation (10.6%)
Diarrhea (7.6%)
Loss of appetite (4.5%)
Upset stomach (4.3%)
Vomiting (4.2%)
Burping (4.1%)

View all Mounjaro side effects

Dry mouth (26.3%)
Insomnia (9.6%)
Headaches (6.7%)
Anxiety (6.0%)
Constipation (4.4%)
Heart palpitations (4.3%)
Loss of appetite (2.9%)

View all Phentermine side effects

Drug Class

Anorexiants

GLP-1 Agonists (Incretin Mimetics)

Generic Availability

No lower cost generic approved

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	120 tablet, extended release
Strength	90 mg-8 mg
Per unit^*	$5.52
Cost^*	$661.96

View all Contrave prices

Quantity	2 mL
Strength	2.5 mg/0.5 mL
Per unit^*	$568.27
Cost^*	$1,136.53

View all Mounjaro prices

Quantity	7 tablet
Strength	37.5 mg
Per unit^*	$1.78
Cost^*	$12.49

View all Phentermine prices

Get free Discount Card

Dosage Forms

Oral tablet, extended release

Subcutaneous solution

Oral capsule
Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

21 hours

120 hours

20 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Some potential for abuse

Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.

Pregnancy Category

Category X Not for use in pregnancy

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Category X Not for use in pregnancy

See the full pregnancy warnings document.

Drug Interactions

A total of 756 drugs are known to interact with Contrave:

218 major drug interactions (950 brand and generic names)
533 moderate drug interactions (2434 brand and generic names)
5 minor drug interactions (16 brand and generic names)

A total of 414 drugs are known to interact with Mounjaro:

15 major drug interactions (34 brand and generic names)
398 moderate drug interactions (2269 brand and generic names)
1 minor drug interactions (10 brand and generic names)

A total of 196 drugs are known to interact with Phentermine:

43 major drug interactions (185 brand and generic names)
151 moderate drug interactions (741 brand and generic names)
2 minor drug interactions (5 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more

Tirzepatide may affect the absorption of other medications that you take by mouth. In some cases... View more
Talk to your doctor before using alcohol together with tirzepatide. Alcohol may affect blood... View more

Using phentermine with alcohol can increase the risk of cardiovascular side effects such as... View more

Disease Interactions

First Approval Date

September 10, 2014

N/A

August 14, 1973

WADA Class View classifications

N/A

S6 - Stimulants

More Information

Patient Resources

Contrave uses

Mounjaro uses

Phentermine uses

Professional Resources

Prescribing information

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Contrave Alternatives Compared

Further information

Compare Drugs