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Mounjaro

Pronunciation: mown-JAHR-OH
Generic name: tirzepatide
Dosage form: single-dose pen (2.5 mg/0.5 mL, 5 mg/0.5 mL, 7.5 mg/0.5 mL, 10 mg/0.5 mL, 12.5 mg/0.5 mL, 15 mg/0.5 mL), single-dose vial (2.5 mg/0.5 mL, 5 mg/0.5 mL, 7.5 mg/0.5 mL, 10 mg/0.5 mL, 12.5 mg/0.5 mL, 15 mg/0.5 mL)
Drug class: GLP-1 Agonists (Incretin Mimetics)

Medically reviewed by Carmen Pope, BPharm. Last updated on Sep 1, 2025.

What is Mounjaro?

Mounjaro is used for type 2 diabetes to help lower blood sugar levels. Mounjaro has also been shown to help with weight loss and maintain the lost weight in clinical trials when combined with diet and exercise. It is a once-weekly injection that can be self-administered and should be used alongside dietary changes and exercise.

Mounjaro works by activating two gut hormone receptors, GIP and GLP-1, to manage blood sugar. This stimulates insulin release when glucose is high, reduces liver glucagon production, slows stomach emptying to control post-meal sugar spikes, and increases fullness to reduce appetite and food intake. 

Mounjaro's dual mechanism of action makes it significantly more effective than semaglutide for weight loss, which only activates GLP-1 receptors, as demonstrated in the head-to-head Surmount-5 clinical trial (NCT05822830), which reported an overall 47% greater weight loss with tirzepatide (Mounjaro, Zepbound) compared to semaglutide.

Mounjaro (tirzepatide) received FDA approval on May 13, 2022. There is no Mounjaro generic. The 2 different brands of tirzepatide (Mounjaro and Zepbound) are made by Eli Lilly and Company but are FDA-approved for different conditions.

What is the cost of Mounjaro?

The cost for prescription drugs varies depending on your insurance plan and which pharmacy you use. Refer to the Mounjaro price guide page for more cost information.

You may also be eligible for other savings. See "What is the Mounjaro Coupon or Savings Card?"

Mounjaro Side Effects

Common Mounjaro Side Effects: What to Expect

The most common side effects of Mounjaro (tirzepatide) affect the digestive system and typically occur during the first few weeks of treatment.

Gastrointestinal Side Effects:

Important: These Mounjaro side effects are usually mild to moderate and tend to improve over time as your body adjusts to the medication. Side effects typically peak during weeks 1 to 2 and gradually improve from week 3 or 4. Most patients experience reduced side effects after 4-8 weeks of treatment.

Serious Mounjaro Side Effects and Black Box Warning

FDA Black Box Warning: Thyroid Cancer Risk

Possible thyroid tumors, including cancer. In animal studies, Mounjaro and similar GLP-1 medications caused thyroid tumors, including thyroid cancer. The human risk is unknown. Symptoms of thyroid cancer to watch for:

Contraindications: Do not use Mounjaro if you or your family have a history of:

Pancreatitis (Pancreas Inflammation)

Mounjaro may increase the risk of acute pancreatitis, a serious condition requiring immediate medical attention.

Symptoms requiring emergency care:

Action: Stop Mounjaro immediately and seek emergency medical care.

Hypoglycemia (Low Blood Sugar)

You may have a higher risk for low blood sugar levels if you use Mounjaro in addition to other medicines that can also lower blood sugar, such as insulin, sulfonylureas (glipizide, glyburide, glimepiride), or other diabetes medications. Symptoms of low blood sugar levels are:

Serious Allergic Reactions (Anaphylaxis)

Mounjaro may cause an allergic reaction in some people. Stop using Mounjaro and get medical help right away if you have any symptoms of a serious allergic reaction, such as:

Kidney Problems and Dehydration

Certain people have a higher risk of kidney problems when taking Mounjaro. If you have existing kidney disease, are elderly, or take ACE inhibitors or diuretics, severe diarrhea and vomiting from Mounjaro can lead to dangerous dehydration that may worsen kidney function or cause new kidney problems.

Prevention:

Gastroparesis (Delayed Gastric Emptying)

Slower than normal gastric emptying and severe, persistent stomach problems have been reported with Mounjaro. Symptoms may include feeling full quickly when eating, persistent nausea and vomiting, and abdominal bloating and pain. Tell your healthcare provider if you have stomach problems that are severe or do not go away.

NAION (Vision Problems)

Recent safety update: Studies have linked GLP-1 drugs like Mounjaro to a rare vision-threatening condition called non-arteritic anterior ischemic optic neuropathy (NAION).

Symptoms to report immediately:

Mounjaro has also been associated with diabetic retinopathy complications in people with a history of diabetic retinopathy.

Gallbladder Problems

Gallbladder issues have occurred in some people who use Mounjaro. Tell your healthcare provider right away if you get symptoms of gallbladder problems, which may include:

Surgical Complications

Important: Mounjaro slows gastric emptying, increasing the risk of aspiration during surgery or procedures requiring anesthesia.

Action required: Inform all healthcare providers about Mounjaro use before any surgical procedures.

Other Warnings

Talk to your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Mounjaro. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Who Should Not Take Mounjaro?

Absolute Contraindications:

Use with Caution:

Pregnancy

Tell your healthcare provider if you are pregnant, you become pregnant, or plan to become pregnant while using this medicine. It is not known if this medicine will harm your unborn baby.

This medicine can make birth control pills less effective. Ask your doctor about other birth control options such as an injection, implant, skin patch, vaginal ring, condom, diaphragm, cervical cap, or contraceptive sponge. If you take birth control pills, you may need to use additional birth control methods for 4 weeks after starting this medicine, and for 4 weeks each time the dose is increased.

Breastfeeding

Tell your healthcare provider if you are breastfeeding or plan to breastfeed while using this medicine. It is not known whether this tirzepatide passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby while using this medicine.

How should I use Mounjaro?

You should read the Instructions for Use carefully and ask your pharmacist or doctor to explain any part you do not understand. It is important to use this medicine exactly as directed. Do not take more or less of it or more often than your doctor prescribes.

Mounjaro is a pre-filled pen injected under the skin (subcutaneously).

Your healthcare provider will usually start you on a low dose, which will be gradually increased, but not more than once every 4 weeks.

You may change the day of the week you use this medicine as long as there are at least three days between doses.

You may give insulin in the same area as this medicine, but they should not be given right next to each other. Do not mix insulin and Mounjaro in the same injection.

Mounjaro controls type 2 diabetes but does not cure it. It may take four weeks or longer before you see the full benefit of this medicine. Continue to take this medicine even if you feel well. Do not stop taking this medicine without talking to your doctor.

For more detailed instructions with diagrams on how to use this medicine, click here: Instructions for Mounjaro.

Dosing Information

Dose of Mounjaro for Type 2 Diabetes (Adult):

Comments: The 2.5 mg dosage is for starting treatment and is not intended for glycemic control.

The day of weekly administration can be changed, if necessary, as long as the time between the 2 doses is at least 3 days (72 hours).

What strengths are Mounjaro pens?

Mounjaro is available as a single-dose autoinjector pen or vial in the following strengths:

In the past, there have been issues with Mounjaro availability due to increased demand, leading to drug shortages for some strengths. This is now resolved.

What should I do if I miss a dose?

Take the missed dose as soon as you remember it within 4 days after the missed dose.

However, if more than 4 days have passed, skip the missed dose and continue your regular dosing schedule. Do not inject two doses within 3 days of each other.

What should I do in case of an overdose?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at Poison Help If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

What other drugs affect Mounjaro?

Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

Birth control pills may not work as well while receiving Mounjaro. Your doctor may suggest you use another form of birth control for 4 weeks after starting this medicine and for 4 weeks after each dose change.

Taking other medicines to treat diabetes like insulin, sulfonylureas, or other GLP-1 agonists such as Ozempic (see Mounjaro vs Ozempic) with this treatment may increase your risk of low blood sugar levels. Talk to your doctor and pharmacist about low blood sugar and how to manage it.

This medicine delays gastric emptying and has the potential to change the absorption of other medicines that are taken orally.

This list is not complete. Many other drugs may interact with this medicine, including prescription and over-the-counter medicines, vitamins, and herbal products. To check for interactions with this medicine click the link below.

How do I store Mounjaro?

Store your Mounjaro pens in the refrigerator between 36⁰F to 46⁰F (2⁰C to 8⁰C) in their original carton to protect them from light.

If needed, or while traveling, each single-dose Mounjaro pen can be stored at room temperature up to 86⁰F (30⁰C) for up to 21 days.

Ingredients

Active ingredient: tirzepatide

Inactive ingredients: sodium chloride, sodium phosphate dibasic heptahydrate, and water for injection. Hydrochloric acid solution and/or sodium hydroxide solution may have been added to adjust the pH.

Manufacturer

Mounjaro is made by Eli Lilly and Company, commonly known as Lilly. They are an American pharmaceutical company based in Indianapolis that was founded in 1876. 

Frequently Asked Questions About Mounjaro Side Effects

How long do Mounjaro side effects last?

Most common side effects (nausea, diarrhea) typically improve within 4-8 weeks as your body adjusts to the medication.

Can I prevent Mounjaro side effects?

While not entirely preventable, taking with food, starting with lower doses, and following dietary recommendations can minimize side effects.

How can I manage common Mounjaro side effects?

For nausea and vomiting:

For diarrhea:

For decreased appetite:

Are Mounjaro side effects dangerous?

Most side effects are mild and temporary. However, serious side effects like pancreatitis and thyroid tumors require immediate medical attention.

Should I stop Mounjaro if I have side effects?

Don't stop without consulting your doctor. Many side effects improve with time or dose adjustments.

Popular FAQ

What is the natural Mounjaro recipe for weight loss?

The “natural Mounjaro recipe” has exploded in popularity as a viral wellness drink, with social media users touting its potential for weight loss and metabolic health. While the name is inspired by the prescription medication Mounjaro (tirzepatide), it’s important to clarify that this homemade drink is not a substitute for any pharmaceutical therapy. Instead, it reflects a growing interest in natural, do-it-yourself solutions for weight management and overall wellness.

Continue reading
Mounjaro vs Ozempic: Which is right for you?

Mounjaro and Ozempic are prescription medicines used alongside diet and exercise to help control blood sugar (glucose) levels in adults with type 2 diabetes. Ozempic is also approved to lower the risk of a major cardiovascular event (like a heart attack or stroke) in patients with type 2 diabetes, as well as to reduce the risk of worsening kidney disease and heart-related death in patients with type 2 diabetes. Mounjaro has not yet received these indications, although studies are ongoing.

In a large, 2024 retrospective study in adults with overweight or obesity and treated for type 2 diabetes, Mounjaro led to at least a 5% weight loss within one year in 81.8% of adults compared to 66.5% of those using Ozempic. Continue reading

Zepbound vs. Mounjaro: Comparison Guide for Weight Loss and Diabetes Treatment

Zepbound and Mounjaro contain the same active ingredient (tirzepatide) and both are made by Eli Lilly and Company, but they have different FDA approved uses and insurance coverage. Zepbound is approved for chronic weight management and obstructive sleep apnea (OSA) and Mounjaro is approved for type 2 diabetes.

Continue reading
Why am I not losing weight on Mounjaro?

It takes time, about 8 to 12 weeks to see a 6% to 8% weight loss in adults using Mounjaro. Other reasons include the need to follow a reduced calorie diet and exercise program, your dose may need to be increased, or side effects may affect your treatment. Continue reading

Ozempic Mounjaro Wegovy & Zepbound: Weight Loss Compared

Ozempic, Mounjaro, Wegovy and Zepbound can all lead to long-term weight loss, but only Wegovy and Zepbound are approved by the FDA for this use. In studies, Zepbound has led to a 21% weight loss in adults using the highest dose, while Wegovy has led to about a 15% weight loss.

Continue reading
Do Ozempic, Wegovy, Mounjaro & Zepbound cause hair loss?

There’s no evidence that hair loss is a direct side effect of Ozempic, Wegovy, Mounjaro or Zepbound. Hair loss is more likely due to the stress of rapid weight loss on your body, which can lead to temporary shedding of hair over several months, a condition known as telogen effluvium.

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Which GLP-1 drug is best for weight loss?

The most effective GLP-1 drug for weight loss currently (as of mid-2025) is tirzepatide, marketed under the names Zepbound (for weight loss) and Mounjaro (for diabetes).

Continue reading
Can you switch between Ozempic and Mounjaro?

Yes, you can switch between Ozempic and Mounjaro under the supervision of a healthcare professional. There is no one way to switch that is recommended for everyone. Your healthcare provider will consider the reason you are stopping, how long you have been taking your current medication, and the date of your last dose when deciding the best way to switch between these medications. Continue reading

How long does it take for Mounjaro to start working?

Mounjaro (generic name: tirzepatide) will start to lower your blood sugar levels right away but it can take 8 to 12 weeks to reach your target A1C goal. When compared to some other diabetes treatments, studies have shown that it can take 8 weeks to reach an A1C target of ≤7% and 12 weeks to reach an A1C ≤6.5% with Mounjaro. Significant weight loss can occur as early as 28-weeks. Continue reading

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.