Bupropion / naltrexone Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Bupropion / naltrexone	Wegovy (semaglutide)	Mounjaro (tirzepatide)	Enter another drug to compare

Bupropion / naltrexone

Wegovy (semaglutide)

Mounjaro (tirzepatide)

Prescription only

Prescribed for Weight Loss (Obesity/Overweight). Bupropion / naltrexone may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Weight Loss (Obesity/Overweight), Cardiovascular Risk Reduction. Wegovy may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Weight Loss (Obesity/Overweight), Type 2 Diabetes. Mounjaro may also be used for purposes not listed in this medication guide.

More about Bupropion / naltrexone

More about Wegovy (semaglutide)

More about Mounjaro (tirzepatide)

Ratings & Reviews

Bupropion / naltrexone has an average rating of 6.6 out of 10 from a total of 2069 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 25% reported a negative effect.

Wegovy has an average rating of 7.6 out of 10 from a total of 483 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 15% reported a negative effect.

Mounjaro has an average rating of 8.5 out of 10 from a total of 1285 ratings on Drugs.com. 79% of reviewers reported a positive effect, while 6% reported a negative effect.

View all 2069 reviews

View all 483 reviews

View all 1285 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Nausea (32.4%)
Headaches (17.5%)
Constipation (11.9%)
Dizziness (11.2%)
Dry mouth (8.9%)
Tiredness (5.8%)
Anxiety (5.3%)

View all Bupropion / naltrexone side effects

Nausea (32.3%)
Constipation (14.3%)
Vomiting (10.6%)
Diarrhea (9.7%)
Tiredness (6.6%)
Headaches (6.2%)
Heartburn (6.2%)

View all Wegovy side effects

Nausea (16.5%)
Constipation (11.4%)
Diarrhea (7.9%)
Upset stomach (4.7%)
Loss of appetite (4.5%)
Vomiting (4.4%)
Burping (4.2%)

View all Mounjaro side effects

Drug Class

Anorexiants

GLP-1 Agonists (Incretin Mimetics)

GLP-1 Agonists (Incretin Mimetics)

Generic Availability

N/A

No lower cost generic approved

Pricing and Coupons * Prices are without insurance

We could not find an exact match for this medicine. Try searching the Price Guide directly.

Quantity	2 mL
Strength	0.25 mg/0.5 mL (0.25 mg dose)
Per unit^*	$725.05
Cost^*	$1,450.10

View all Wegovy prices

Quantity	2 mL
Strength	2.5 mg/0.5 mL
Per unit^*	$581.34
Cost^*	$1,162.67

View all Mounjaro prices

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Dosage Forms

N/A

Subcutaneous solution

Subcutaneous solution

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

21 hours

168 hours

120 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category X Not for use in pregnancy

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Drug Interactions

A total of 758 drugs are known to interact with Bupropion / naltrexone:

219 major drug interactions (953 brand and generic names)
534 moderate drug interactions (2437 brand and generic names)
5 minor drug interactions (16 brand and generic names)

A total of 273 drugs are known to interact with Wegovy:

15 major drug interactions (34 brand and generic names)
257 moderate drug interactions (1451 brand and generic names)
1 minor drug interactions (10 brand and generic names)

A total of 414 drugs are known to interact with Mounjaro:

15 major drug interactions (34 brand and generic names)
398 moderate drug interactions (2271 brand and generic names)
1 minor drug interactions (10 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more

Food may affect the absorption of semaglutide when taken orally. It is recommended that oral... View more
Talk to your doctor before using alcohol together with semaglutide. Alcohol may affect blood... View more

Tirzepatide may affect the absorption of other medications that you take by mouth. In some cases... View more
Talk to your doctor before using alcohol together with tirzepatide. Alcohol may affect blood... View more

Disease Interactions

First Approval Date

September 10, 2014

N/A

WADA Class View classifications

N/A

More Information

Patient Resources

Wegovy uses

Mounjaro uses

Professional Resources

Prescribing information

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Bupropion / naltrexone Alternatives Compared

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