Orlistat Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Orlistat	Wegovy (semaglutide)	Mounjaro (tirzepatide)	Enter another drug to compare

Orlistat

Wegovy (semaglutide)

Mounjaro (tirzepatide)

Prescription and OTC

Prescribed for Weight Loss (Obesity/Overweight), Nonalcoholic Steatohepatitis. Orlistat may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Weight Loss (Obesity/Overweight), Cardiovascular Risk Reduction. Wegovy may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Weight Loss (Obesity/Overweight), Type 2 Diabetes. Mounjaro may also be used for purposes not listed in this medication guide.

More about Orlistat

More about Wegovy (semaglutide)

More about Mounjaro (tirzepatide)

Ratings & Reviews

Orlistat has an average rating of 7.4 out of 10 from a total of 400 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 17% reported a negative effect.

Wegovy has an average rating of 7.6 out of 10 from a total of 483 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 15% reported a negative effect.

Mounjaro has an average rating of 8.5 out of 10 from a total of 1285 ratings on Drugs.com. 79% of reviewers reported a positive effect, while 6% reported a negative effect.

View all 400 reviews

View all 483 reviews

View all 1285 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Diarrhea (11.0%)
Gas (5.0%)
Upset stomach (5.0%)
Constipation (3.3%)
Bloating (1.8%)
Oily skin (1.5%)
Cramps (1.3%)

View all Orlistat side effects

Nausea (32.3%)
Constipation (14.3%)
Vomiting (10.6%)
Diarrhea (9.7%)
Tiredness (6.6%)
Headaches (6.2%)
Heartburn (6.2%)

View all Wegovy side effects

Nausea (16.5%)
Constipation (11.4%)
Diarrhea (7.9%)
Upset stomach (4.7%)
Loss of appetite (4.5%)
Vomiting (4.4%)
Burping (4.2%)

View all Mounjaro side effects

Drug Class

Peripherally acting antiobesity agents

GLP-1 Agonists (Incretin Mimetics)

GLP-1 Agonists (Incretin Mimetics)

Generic Availability

Lower cost generic

No lower cost generic approved

Pricing and Coupons * Prices are without insurance

Quantity	90 capsule
Strength	120 mg
Per unit^*	$6.18
Cost^*	$556.41

View all Orlistat prices

Quantity	2 mL
Strength	0.25 mg/0.5 mL (0.25 mg dose)
Per unit^*	$725.05
Cost^*	$1,450.10

View all Wegovy prices

Quantity	2 mL
Strength	2.5 mg/0.5 mL
Per unit^*	$581.34
Cost^*	$1,162.67

View all Mounjaro prices

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Dosage Forms

Oral capsule

Subcutaneous solution

Subcutaneous solution

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

13.5 hours

168 hours

120 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category X Not for use in pregnancy

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Drug Interactions

A total of 145 drugs are known to interact with Orlistat:

9 major drug interactions (20 brand and generic names)
136 moderate drug interactions (2104 brand and generic names)

A total of 273 drugs are known to interact with Wegovy:

15 major drug interactions (34 brand and generic names)
257 moderate drug interactions (1451 brand and generic names)
1 minor drug interactions (10 brand and generic names)

A total of 414 drugs are known to interact with Mounjaro:

15 major drug interactions (34 brand and generic names)
398 moderate drug interactions (2271 brand and generic names)
1 minor drug interactions (10 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Food may affect the absorption of semaglutide when taken orally. It is recommended that oral... View more
Talk to your doctor before using alcohol together with semaglutide. Alcohol may affect blood... View more

Tirzepatide may affect the absorption of other medications that you take by mouth. In some cases... View more
Talk to your doctor before using alcohol together with tirzepatide. Alcohol may affect blood... View more

Disease Interactions

First Approval Date

April 23, 1999

N/A

WADA Class View classifications

N/A

More Information

Patient Resources

Orlistat uses

Wegovy uses

Mounjaro uses

Professional Resources

Prescribing information

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Orlistat Alternatives Compared

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