Mounjaro and Headaches: What Users Say

• Pam...
• Taken for 1 to 6 months
• April 11, 2023

For Weight Loss (Obesity/Overweight) "This medication was a life changer for me. I’m a 49-year-old female. I never had a problem with my weight until after the age of 45. Then during Covid, I gained 30 pounds and got up to 189. I was exercising regularly and trying to eat healthy, but could not lose any weight. I started Mounjaro and lost 12 pounds the first month. I had very little side effects. The only thing I experienced was fatigue, a slight headache, and I felt very cold. Once I became used to the medication, after a couple of months, those side effects diminished. I’ve been on the medication for 6 months and have lost a total of 56 pounds. I’m now at 133 pounds. My goal weight is 130. I feel better than I did when I was in my 20s and 30s. This medication was life-changing for me. It not only helped me to lose weight, but it also lowered my A1C, lowered my triglycerides, and blood pressure."

• TGM...
• Taken for 1 to 6 months
• January 1, 2023

"Was prescribed 2.5, 8 weeks ago, for weight loss. Had never heard of this drug. No issue giving the injection. I was excited to be taking this after research. Have lost a total of 43 lbs and dropped several sizes. This drug has been a miracle for me. I’ve struggled with weight for my entire life and have gained/lost 80+ many times. Never have I had anything to take away my desire to eat like this. Food tastes totally different. Even morning coffee doesn’t taste good anymore. I am thrilled with the results. Sometimes I do have a slight headache and constipation was terrible the 1st week but subsided. In 3 days, I start on the 5 dosage. For me, a slight headache is worth the weight I’ve lost and the lack of hip pain now that I’ve lost the weight. I’ve gone from a size 24 to a 16. I am a 60-year-old female, 5’2”, current weight 198 - want to lose another 35-40 and will be content for my age. I feel happy and healthy! I take a multivitamin every day. Had lab work on 12/06/22 - perfect!"

• Fem...
• Taken for less than 1 month
• September 1, 2022

"Lost 5 lbs in one week. First 2 days after injection, I am spacey & can't think clearly; just feel a little odd mentally. Also, EXTREMELY tired/run-down feeling. Otherwise, mild headache & constipation the rest of the week. Overall, would say it's worth it as I no longer binge or even eat much. Never in my life did I think I could stop obsessing over food and dieting. Maybe one day this drug could be reverse-engineered for anorexia or bulimia. Definitely took care of that awful desire and craving to eat all day and night."

• Nop...
• Taken for less than 1 month
• September 15, 2022

For Type 2 Diabetes "Holy side effects. First, if you eat when you take it, it just sits in your stomach and you’ll be burping it for 12 hours. The headache is insane. Starts immediately. Then you are hit with 3 days of nausea, fatigue, and just overall fatigue. Just when you start to feel better, cue the insane heartburn! It took me 5 days to feel normal again. I’ll pass on this even though I lost 5 pounds the first week."

• ROZ...
• Taken for 1 to 6 months
• June 14, 2024

For Weight Loss (Obesity/Overweight) "I have been on Mounjaro for 7 weeks now and have lost 1 and a half stone. I was always tired, and my feet and back were killing me due to being overweight. Since taking this drug, I have only experienced feeling cold and the odd headache here and there. The positive side to taking Mounjaro is I no longer have menopausal hot sweats at night and can jog up my stairs without breathlessness, constant food cravings are gone, and I feel genuinely happier. I drink plenty of water as recommended, as this seems to help with weight loss. Overall, Mounjaro has changed my life for the better."

• SIM...
• Taken for less than 1 month
• June 12, 2023

For Weight Loss (Obesity/Overweight) "I have been on Mounjaro for 3 weeks (2.5 mg injection), and it has helped me tremendously. I started out at 333 lbs. Now I weigh 319 lbs. I feel full for longer. Just feel tired a lot, but I take vitamins and something for energy, so that has helped. I take stool softeners so I won't get constipated. I had a slight headache for a couple of days when I first started, but not bad. I don't crave snacks, caffeine, or sweets like I used to on a daily basis. If I even overeat a little, I feel miserable, so I have to watch that. Managing your portions is very important. I'm doing better with that now. It doesn't take much for me to eat and drink to be satisfied. My BP has been good. My doctor said I may be able to get off BP meds soon. I am so grateful for this new med. Can't wait to move up to the next dosage."

• MJC...
• Taken for 6 months to 1 year
• March 4, 2023

For Weight Loss (Obesity/Overweight) "Been on Mounjaro since 9/11/22. Today is 3/4/23. I have lost close to 60 lbs and went from a pant size 46 down to 40. My wife says I “lost my tire” looking at me from behind. Started at 2.5 dose. Was dizzy and unsteady in the early days. Headache and nausea till my body acclimated. Switched my shot day to Friday night so if I’m not feeling great, it’s the weekend and not impacting work. Worked up to 5.0 then 7.5. Did each for 8 weeks instead of 4 to level off the side effects. Wanted to stay at that level, but no one can get it. Took my first 10.0 shot last night. So far so good. All my levels are great. Sulfur burps if I overeat. Am also doing Herbalife shakes 2 times a day and having a sensible dinner. I still snack after dinner, but nothing crazy. Exercise 5/6 times per week. I think 7.5 should be my maintenance dose, but again, no one can get it. Will trade the mild side effects for being able to fit into my clothes."

• Eli...
• Taken for 1 to 6 months
• January 3, 2023

For Type 2 Diabetes "I have been on Mounjaro for 9 weeks. I had to jump from 5 to 10 mg last week due to shortage issues. I am having several problems with severe bloating, constipation, headache, and stomach pain. I have severe gas that keeps me up most of the night and can be a sign of impending intermittent diarrhea at times. I am always full and started pushing myself to eat as I can go all day with nothing. Now I have small welts and itching at injection sites. Total weight loss: “0.” My blood sugar is higher, especially in the morning. This drug is horrible, and I won’t put my body through it anymore. I can lose weight easier and healthier than this since it ruined my Thanksgiving, Christmas, and New Year’s Eve. I was so excited to try it and had hope. I’m thankful for all those who are benefiting from it. Good luck to all. It just wasn’t for me."

• Lin...
• Taken for 1 to 6 months
• November 10, 2024

For Type 2 Diabetes "I’ve been taking 2.5 ml for 4 weeks and had few side effects apart from zero appetite, a little nausea, and a migraine (think the migraine was due to not eating). Now, week 5, increased to 5 ml and a different story: quite a lot of nausea, diarrhea, headache, and tiredness. Also again, total lack of appetite. Fortunately, these side effects more or less calmed down 2 or 3 days after taking the dose. I’m hoping it’s a temporary thing when you take a new dose - I can live with that."

• Isa...
• Taken for less than 1 month
• September 21, 2022

"Took my first dose of 2.5 on 09/20, tried it on my stomach. Injection was not bad; I did start with a massive headache last night. My stats: 43 yo, female, 254 lb, 5'5" and goal is to lose 100 lbs; although for now, I will be happy to lose 25 to end the year."

• Duc...
• Taken for 1 to 6 months
• October 16, 2022

For Type 2 Diabetes "I was using Ozempic, but Dr. switched to Mounjaro. It has been terrible! I lost a lot of weight on Ozempic but gained some back since being on Mounjaro. Also, my blood sugar rose 10-15 points since switching! I have had numerous side effects, mainly headaches and constipation. When giving it, it always seems to leak back out of my skin, and I've tried stomach, arms, thighs- all the same! I am not happy."

• BMC...
• Taken for less than 1 month
• October 3, 2022

For Type 2 Diabetes "I'm only on my second week, but I've lost 7 pounds so far. It forces me to eat because if I don't, I feel sick, but when I eat, I get full super fast. So it's like it's forcing me to do good and not starve myself. I really like that. The first week I had slight nausea here and there and a couple of headaches. Also, a little indigestion. I do feel pretty tired. I've been eating a low-carb diet. I'm going to incorporate exercise at the end of this week. I can only imagine how much I have the potential to lose once I start exercising if I've lost 7 just by eating better. Overall, I am satisfied with this drug. I'm on the low dose right now."

• jef...
• Taken for 1 to 6 months
• February 21, 2025

For Type 2 Diabetes "The first week I didn't see much. The second week, blood sugar was a little better. I didn't take it the second or third due to acute leg and feet swelling, which has never been a problem. Took many tests for artery blockage, every test my doctor could come up with. The swelling left as quick as it appeared. I got started back on Mounjaro, it started working with remarkable performance, with blood sugar at around 6.7 from the high 11s, but having a very upset stomach. Following week, very sick at stomach, headaches, I felt a lot worse. I may have caught a flu that has been going around. I normally do not have the flu. I don't know if it was the Mounjaro or flu, the symptoms were the same and did not have a fever. I am due to take the Mounjaro injection tomorrow. Haven't decided what to do yet."

• Kni...
• Taken for 1 to 6 months
• January 23, 2023

"50-year-old male, 6'1'. Had gastric sleeve surgery in June of 2019. By March of 2020, I had gone from my all-time high of 341 lbs down to 238 lbs. Went back up to 274 lbs by August of '22. I went on Mounjaro to lose weight. I have increased dosage from 2.5 mg to 5 mg to 7.5 mg to currently now 10 mg. Results: I have gone from 274 lbs to 227 lbs (as of yesterday). So, almost 50 lbs in just under 6 months. Ease of use: 1x a week epi-pen-like injection. Comes with 1-month supply (4 pens). Keep refrigerated. Pain from injection: non-existent. The first time I used the pen, I thought I did it wrong as I felt no pain. Side effects: none. The most I can say is that I only have to do a number two only 1 to 2 times a week now. Not constipated, just don't have the food in me where I need to go. I've read some people's experiences regarding side effects, headaches, rashes, etc... and fortunately I have had none."

• Suf...
• Taken for 1 to 6 months
• December 31, 2022

For Type 2 Diabetes "My dose at 2.5 mg was tolerable. Minimal side effects. 5 mg more side effects with nausea, sour stomach, gas. 7.5 mg has been a disaster. Heartburn. Headaches, lethargy, tiredness, no appetite, and need to force food on myself. Low blood sugar on CGM Libre2. I can't eat enough to get myself back to 90. I keep pegging 70 because I can't eat and am sick to my stomach all the time. My sleep is interrupted, and I must lie down constantly. I feel like I want to sleep all the time. Weight has dropped from 250 to 233 lbs, but if I can't get out of bed, what's the point? I will talk to my doc about going back to 2.5 mg for the A1C control, but this drug needs work."

• bel...
• Taken for 6 months to 1 year
• May 11, 2023

For Type 2 Diabetes "A little bit of back story for the full benefit of transparency… I am a type 2 diabetic on an insulin pump, taking 2 Synjardy every morning in addition to my once-a-week injection. I was completely insulin resistant. Since starting the Mounjaro in September 2022 on the lowest dose, I have worked my way up to 10 mg. Now, a supply shortage kept me from getting my one-month supply twice in the last 7 months. When starting again, it did give me nausea and headaches, my doctor prescribed Zofran, and I took ibuprofen. When I started, I weighed 330 pounds and am currently down to 289 as of yesterday. The biggest benefit to me is that my pump has had to work less because the Mounjaro keeps my blood sugar steady at about 90. I am hoping as I continue to lose weight, I need less and less insulin, that is the doctor's goal. So while yes, there are side effects initially, they did not hang around for me, and if you can push through them, they do subside. I am 48 years old and have been diabetic since I was 23."

• Ala...
• Taken for 1 to 6 months
• August 19, 2023

For Type 2 Diabetes "I started with 2 1/2, went up to five, and then now I am at 10. I lost a few pounds a week, although my appetite is much less than usual. The side effects have been very minimal, mostly headache, sore throat, and hoarseness seems to linger, never really goes. Constipation can be an issue at times, that only for myself, but other people I know on the same drug. My PA is working very closely with her and paying attention to absolutely everything closely. I feel that it’s a safe drug so far if you have a doctor or PA that is on board with you and to a full degree of attention. My hope is that once my A1c is in order, I will be able to discontinue the drug completely, although some studies recommend that not to be probable, again, working closely with my doctor and care team. Thank you for your time."

• A1w...
• Taken for 6 months to 1 year
• October 14, 2024

For Type 2 Diabetes "I went vegan in 1/23. I previously removed or reduced sugar, gluten, and carbs. Over 9 months, my glucose level fell slightly, and I lost 20 lbs. I had no progress for 4 months. In Jan. of 24, I started Mounjaro. Today, my A1c is 5.1, and I lost another 44 lbs. I've had minor nausea as I started 10 and get a headache for a day or two after I inject. I've experienced a great deal of hair loss even though I try to maintain 90 mg protein daily. Contraindications say a small percentage of users have this side effect and usually not to such a high degree. I believe everyone prescribed this drug could decrease many side effects with minimal nutritional counseling. I'm happy that I've gotten my A1c in line, and additional weight loss was a great side effect for me. I'm concerned about what happens when I stop using it because the effect of not feeling hungry and food not tasting great seems to be the biggest help for me. I feel great and have more energy. I eat very thoughtfully. Wish I could have done this years ago."

• Hon...
• Taken for 1 to 6 months
• October 6, 2022

"I have been taking Mounjaro for 7 weeks. 4 weeks of that I was on the 2.5 mg dose and lost 15 lbs by the 4th week. The last 3 weeks I've been on the 5 mg and I've lost ZERO lbs. Seems kind of useless to take when you have all the side effects (constipation, diarrhea, bloating, gas, nausea, headache, severe fatigue) for 3 weeks straight with no weight loss. I am considering going off this medication, I think it was all just hype. I've also stopped having periods. 40 years old, SW 199, CW 185, GW 140. Also following website food/calories recommendations. I have no other disease, just obesity."

• RBj...
• Taken for 1 to 6 months
• August 29, 2023

For Weight Loss (Obesity/Overweight) "I started using Mounjaro in March 2023, with a 2.5 mg dose, for weight loss. I shifted to 5 mg after 2 weeks; I stayed with each dose for around 2-3 months. I lost 10 kg by August (6 mo.). I had a freeze in weight loss for 5 weeks, then I lost 1.8 kg in 2 weeks when I took 10 mg. In terms of side effects, I experienced them during the first weeks of every upgrade in dose; like nausea and sometimes vomiting, headache, stomach pain, constipation and diarrhea, laziness, body ache, mood change; the worst was with 10 mg. As I have urticaria, I experienced an allergy at the needle site after week 10, which resolved in 3 days every time. This week I have pelvic, vaginal, and lower abdominal pain similar to period pain, although I have been menopausal for 4 years! I am happy about the results with minimal side effects."

• Rwi...
• Taken for 1 to 6 months
• March 19, 2023

For Type 2 Diabetes "My A1C and glucose levels are great. I am not on insulin. Side effects are rotten. Nausea, GERD, constipation/diarrhea, headache, stomach pain, decreased appetite every shot lessens over the week. Had this with Ozempic and Trulicity too, but not as severe. I have seen no weight loss benefit despite a decent diet and moderate exercise 3-5 times per week. Other side effects I’m not sure are related: feeling of lump in throat, slight face rash, occasional blurred vision, tingling in hands."

• Rev...
• December 29, 2022

For Type 2 Diabetes "I was prescribed this medication after having an ESG procedure to help with weight loss and in hopes of reversing Type 2. I also have PCOS and a family history of Type 2. After being on this medication, I am down at least 10 lbs (don’t remember my weight when I started), and my blood glucose is not in the diabetic range. My A1C was 5.9, down from 7.9, and I expect that to be lower on my next labs. I do have some side effects, the most prominent is constipation. Miralax helps. I used to get a headache after injection, but I take ibuprofen beforehand, and that helps. I also inject my thigh, not my stomach, and I do it before bed. I have to remember to eat and drink water. I would recommend this medication. I hope I’ve lost enough weight to get off and stay off. So far, so good."

• HMP...
• Taken for 1 to 6 months
• October 23, 2024

For Weight Loss (Obesity/Overweight) "Lost 30 lbs. (12%) in about 20 weeks. Had a few mild headaches in the first week or two, but they subsided. In the last week, headaches have gotten more severe. Almost like a migraine. Taking Advil to control. Checking with provider on next step. Do I stop, change dosage, timing?"

• Slo...
• Taken for less than 1 month
• May 17, 2023

For Weight Loss (Obesity/Overweight) "Female, 52 years, beginning weight 177 lbs, 5'7. I took my fourth injection of 2.5 mg this morning. I've been eating about 500 calories/day. The first week I lost 2 lbs and I walked 3 miles 2 days and lifted weights 1 day. The second week back to 177 lbs, including 2 days in the gym. In the third week, I traveled and did not exercise or weigh myself. I ate out for Mother's Day and for a friend's baby shower. When I returned, I was 175 lbs. In 3 weeks, I've lost a total of 4 lbs. Side effects for me have been a little more tired-duh-less energy going in. This doesn't seem worth the cost. We meet with the doctor tomorrow about upping it to 5 mg. My husband has been diligent about walking 5-7 miles per day also on 2.5 mg, 500 calories/day, and has lost about 8 lbs. (He has more to lose than me). His side effects were little nausea the first week, a slight decrease in focus and energy, some mild headaches, and diarrhea. Says pooping is faster."

• Luc...
• Taken for 1 to 6 months
• July 11, 2024

For Weight Loss (Obesity/Overweight) "Love this medication and have lost 10kg in 6 weeks with a good diet and exercise. However, the side effects can be pretty intense. 2.5mg - sulfur burps, lethargy, flatulence, weight loss, decreased appetite, nausea. 5mg - sulfur burps, flatulence, abdominal distension, nausea, weight loss, chills, fever, headaches."