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Tirzepatide User Reviews & Ratings (Page 3)

Brand names: Mounjaro, Zepbound

Tirzepatide has an average rating of 8.6 out of 10 from a total of 1,040 reviews on Drugs.com. 81% of reviewers reported a positive experience, while 7% reported a negative experience.

Reviews for Tirzepatide

  • fatfa...
  • Taken for 1 to 6 months
  • April 13, 2023

Mounjaro (tirzepatide) for Weight Loss (Obesity/Overweight) "I started taking this medication for weight loss. My first round of the 4 injections was 2.5 mg, and it had no negative side effects at all. I just had no appetite. I lost 10 lbs within that 4 weeks. I then moved up to the 0.5 mg. The day after taking the first injection, nausea hit like a train. I never threw up but was just nauseous. I called my doctor, and she prescribed medication for the nausea which helped immensely. By the time I took my second injection, the nausea had gone away, and I had lost another 5 lbs. I still have so much more to go and I'm very optimistic. I literally have had no appetite; nothing sounds good or tastes good. I do drink as much water as I can throughout the day. I've had no problems with constipation but as a precaution, I take a couple of stool softeners once a week and I'm good to go. I used to have a sweet tooth, but not now. Great benefits, has tolerable side effects, and is very easy to use."

10 / 10
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  • Reepy
  • Taken for 1 to 6 months
  • March 15, 2024

Zepbound (tirzepatide) for Weight Loss (Obesity/Overweight) "Was on Wegovy 2 months (PsA weight loss need) - horrible. Lost 18 pounds but got depression, which is odd for me as I have never had it. Once off it, about 3 weeks, I was fine. Decided to give ZepBound a try, a friend had great success with Monjouro (diabetic); when this came out, I was approved. Having a friend with experience really helped to get me through the first 3 weeks. They were rough. But I knew to stay away from meats for 5 days after shot and ANYTHING with fat or oil - it will not digest. 2 days after the shot are the hardest as far as digestion; eat very small, eat early or reflux will occur. My 'go to' is a cup of mac & cheese, half a bagel (plain) or berries (apples indigestible). No variety for me on this. Menthol cough drop a lifesaver - soothes my stomach. Sugars OK. Diarrhea from some foods, turned to some constipation after 2 months. Lost 27 pounds in 3 months, the fatigue is my worst side effect. Find your digestible foods, stick with them, exclusively."

8 / 10
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  • Conce...
  • Taken for less than 1 month
  • October 2, 2022

Mounjaro (tirzepatide) for Diabetes, Type 2 "Started taking 2.5 last Thursday. Day 1, no side effects, day 2, mild nausea, day 3, everything broke loose! Dizzy spells, clammy sweats, severe abdominal pains, and bloating. Ended up in ER and blood pressure was so high I was at stroke level! Readings were 220/123, 187/113, 197/116, 178/112! No issues before medication! Beware, this medication is so new there is no telling how many other side effects it can have! I pray this mess gets out of my system soon!"

1 / 10
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Frequently asked questions

  • APB
  • Taken for 6 months to 1 year
  • March 10, 2023

Mounjaro (tirzepatide) for Weight Loss (Obesity/Overweight) "Good results. Immediate appetite suppression starting with the lowest dose. More importantly, my food cravings went away. It takes a couple of weeks, at most, to get through the psychological part of less appetite/less food. You get full quickly, and yet you feel like you still want to eat because your mind is telling you, 'how can you be full already, you've only had 4 bites?' It only takes one or two times of being nauseated or vomiting to remember to eat less. I have lost 48 lbs in exactly 7 months, and my hypertension is gone."

9 / 10
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  • Melani
  • Taken for less than 1 month
  • March 6, 2024

Zepbound (tirzepatide) for Weight Loss (Obesity/Overweight) "I just had my 2nd shot of Zepbound and the side effects so far are that I burp a lot (lol) & feel a little tired, but nothing major at all. I can’t eat much at all, maybe a few bites, and it takes me forever to get those few bites down; then I’m full for a few hours. I have been keeping a complete diary of this. So determined. Hope this helps."

10 / 10
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Are you taking this medicine?

  • My st...
  • Taken for 1 to 6 months
  • February 13, 2023

Mounjaro (tirzepatide) for Diabetes, Type 2 "Started 10/26. Weight 245, female. 2.5 1x, 5, 1x, 10mg, last 2 months. Current 214. Zero exercise unfortunately. I have read so many reviews and I am baffled at all these bad side effects, since mine were so minor (except constipation and tiredness day after injection). Learned early, no sugar, breads, or pasta/potato. I take no other meds, do a strict low carb and fast. I have a protein shake at noon, a meat and a LC veg for dinner (small portion always), then freeze a protein shake for two hours and it makes ice creamish. Delish! That’s all I eat daily. Hunger is now fully controllable! My A1C started at 6.7, BUT I was on low carb for 6 weeks prior to blood work so likely much higher in general. Last week's blood test showed A1C at 5.0. My ALT SGPT (liver) was high last test, and normal range this time. What did go up were my top 4 CBC numbers. Overall, this is a game changer. So grateful. I truly believe eating right is the key when on this med. Hope this helps someone."

9 / 10
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  • Dot
  • Taken for 6 months to 1 year
  • June 29, 2023

Mounjaro (tirzepatide) for Weight Loss (Obesity/Overweight) "I am currently taking Mounjaro. I was weighing 263 lbs in November 2023, and I have lost 93 lbs. I am at 170 now. I went from size 18 and 20 to size 12. I was on Ozempic and could not take that; it made me so sick. I have no problems with Mounjaro other than sulfur burps and a lot of gas. I have to make myself eat, and when I do, I only eat a bite of food. I am on the 7.5 dosage now, and I am so lucky that my insurance covers it, and my cost is $25.00."

10 / 10
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More FAQ

  • ROZIE
  • Taken for 1 to 6 months
  • June 14, 2024

Mounjaro (tirzepatide) for Weight Loss (Obesity/Overweight) "I have been in Mounjaro for 7 weeks now & have lost 1 & half stone. I was Always tired and feet and back were killing me due to me being overweight. Since taking this drug I have only experienced feeling cold & the odd headache here and there. The positive side to taking Mounjaro is I no longer have menopausal hot sweats at night & can jog up my stairs without breathlessness, constant food cravings gone & feel genuinely happier. I drink plenty of water as recommended as this seems to help with weight loss. Overall Mounjaro has changed my life for the better."

10 / 10
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  • CPA
  • Taken for 1 to 6 months
  • July 17, 2024

Mounjaro (tirzepatide) for Diabetes, Type 2 "I started the medication in November of last year. I started with 5 mg and incrementally increased the dosage up to 15mg. The small hypodermic needle made it easy to inject. At 10 mg, I reached a plateau with the weight loss. I eventually went up to 15 mg and stayed on that dose for 2 months. The primary reason for taking it was for type 2 Diabetes and I benefited from weight loss as I was also overweight. As of today, I have lost 35 lbs but stopped the Monjaro about a month ago. My appetite seem to slowly get back to normal which is not a good thing. I also did intermittent fasting so that helped a lot with the cravings, etc. I also get some bouts of constipation but my diet made up for that. My urine smelled different. I pray there was no effects on my kidneys. My blood sugars are normal. My A1C is 5.2 so I chose to stop the medication and continue the weight loss journey naturally."

7 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • January 3, 2024

Mounjaro (tirzepatide) for Weight Loss (Obesity/Overweight) "I'm a 53-year-old male and my weight has gone up slowly with each passing year, so the ladies at my doctor's office were telling me how they all were losing weight by taking the Mounjaro shots. I was a little bit worried at first because of the thought of having to give myself a shot. I barely felt it, so I started out on the 2.5 shots, and the only side effect I got was the burping sulfur taste. This is the absolute best thing I could have done; it's lowered my blood pressure, and I'm off the meds for that. I sleep better and feel healthier, the only bad thing is my clothes don't fit. I'm feeling better about myself. I'm now on the 10mgs, but each month I went up to a stronger dose, but I'm going to stay with the 10s as a maintenance shot. I don't feel hungry at all; I have no cravings, I have to make myself eat, and when I do eat, it's just a little bit at a time. You don't want to overeat on this or you will be sorry. I highly recommend it. A big thanks to the makers of Mounjaro. I've lost 40 pounds in 4 months."

10 / 10
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  • Susan
  • Taken for 1 to 6 months
  • March 26, 2024

Zepbound (tirzepatide) for Weight Loss (Obesity/Overweight) "I've been on Zepbound for about 3 months. I'm 5'3' and started at 167. So far I have lost 12 lbs. trying to maintain a 1,200 calorie diet. The main thing is to watch what you eat and quit when you are full. The only side effects I've seen are fatigue and constipation. The shots don't bother me at all and no nausea, thank goodness. The only thing I'm really worried about is gaining it back when I stop. Good luck to all!"

10 / 10
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  • krp
  • Taken for 1 to 6 months
  • October 6, 2022

Mounjaro (tirzepatide) "Started taking specifically for weight loss. Starting weight on Aug 1 was 192 lbs and did the 2.5mg for a month. Weight on Aug 30 was 176 lbs! Only side effect was the WORST dry mouth - whoa! Not expecting that but it went away. It completely took away constant thoughts of eating and cravings. Weight loss was effortless. Started 5mg - 2nd week had a lot more nausea - felt like pregnancy nausea. If I was busy, I wouldn't think about it but if I thought about eating or smelled food - no thank you! It was the most intense the day after I did my shot and for the next 2 days or so. Weight after 2 months - 162.6 lbs! I'm on week 7 of 5mg and the nausea is basically gone. Weight hasn't changed for the last week."

10 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • February 26, 2024

Zepbound (tirzepatide) for Weight Loss (Obesity/Overweight) "I have been taking Zepbound for seven and a half weeks now. I have lost 20 lbs! I am happy about that. I love how it takes that constant hunger I felt and cravings for junk are gone - that’s a miracle in itself. I did have some side effects of bloating, nausea, and sulfur burps and gas, but they do seem to taper off as your body adjusts to the dose. I am now up to a 5 mg dose but have opted to stay here for now because the nausea was increasing. I have no hunger at all. I will try it another month at 5 mg and if no relief in the nausea, I will ask to go back to the 2.5 dose. I continue to lose 2-3 pounds a week and it is adding up."

10 / 10
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  • Mike
  • Taken for 1 to 6 months
  • March 5, 2024

Zepbound (tirzepatide) for Weight Loss (Obesity/Overweight) "Been on Zepbound 7 weeks now. Lost about 22 lbs so far with no exercise. This stuff is amazing at curbing your appetite. But beware, stick to healthy foods and minimal portions because the nausea is otherworldly. I ate too much too late in the day yesterday. I had to leave work early today for the second time since being on this med. Light-headed, profuse sweating, chills, diarrhea almost non-stop and even puking. This med is a miracle, but you cannot mess around. Take it seriously. Cut back portions, minimal dairy, low sugar and don't eat too late. I'm excited to see how far I can go on this med. So thankful I have access."

10 / 10
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  • Mark
  • Taken for 1 to 6 months
  • June 29, 2024

Zepbound (tirzepatide) for Weight Loss (Obesity/Overweight) "Update on my review from May 25, 2024. I have now been on Zepbound for 16 weeks. Current dosage 10 mg. In these 16 weeks, I have lost 40 pounds, from 204 lb to 164 lb, and my waist size has gone from 40 inches to 36 inches. For context, I am 5'10' tall. Even more incredibly, my blood pressure has decreased from 195/90 to an average of 116/60 as of today. I have more energy and am running regularly 5 days per week. I am also sleeping better, which I think comes from a lessening of sleep apnea symptoms. The only remarkable side effect has been occasional constipation, which is relieved by Miralax. With not only weight loss but improvement in other health measures, I consider my Zepbound treatment to be quite successful!"

10 / 10
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  • ali
  • Taken for 1 to 6 months
  • April 29, 2024

Zepbound (tirzepatide) for Weight Loss (Obesity/Overweight) "Started at the end of Jan 24. 4 weeks at 2.5mg, 8 weeks at 5mg due to lack of supply. I've had to seek alternatives due to the shortage of this drug, but it is worth it. I've lost 30 pounds in 14 weeks and moved up to 7.5mg on my last dose. The food noise is gone. The alcohol noise is gone. Other than some nausea and fatigue on shot day, side effects have been mild and easily manageable. I wish I'd have been able to start this long ago and gotten my life back. 30 pounds to go and I have no doubt I will be successful."

10 / 10
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  • Mike...
  • Taken for 1 to 6 months
  • January 15, 2024

Zepbound (tirzepatide) for Weight Loss (Obesity/Overweight) "I’m an 6’4, 275 male, 62 years old - no diabetes or health issues, on no other meds. Obtained prescription via Dr and took first 2.5mg injection on Dec. 24. Lost 10 pounds with the first 3 shots, then Dr said I could go to 5mg (saved the last 2.5mg pen for future use) because weight loss had stopped. After starting mg, lost 2 pounds in 2 days - so combined weight loss using 2.5/5mg is now at 12 pounds in e weeks! No significant/terrible side effects except some constipation, intermittent fatigue, and minor chills at times (not a lot - could just be the cold weather). Ive yo-yoed up and down with weight for years. Because of my size, I can eat a lot of food - but this drug has significantly reduced my appetite and I have more energy overall. I can’t wait to see the results in a few more months. Zepbound has so far been perfect for me. I don’t mind the $550 price (with the Lilly savings card - has been hard to get CVS to make it work but that’s another story/nightmare)."

10 / 10
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  • chris...
  • Taken for 1 to 2 years
  • September 15, 2023

Mounjaro (tirzepatide) for Weight Loss (Obesity/Overweight) "This medication has given me my life back. I have been on the diet and workout train for the last 24 years, but nothing worked to lose a significant amount of weight. I did take one medication that worked temporarily years ago but left me feeling like trash, and once I was finished, the weight came back and then some. I have lost 90 lbs on Mounjaro over the last 14 months. Yes, my eating did improve because it quieted the food noise. I no longer starve myself throughout the day and then binge. Mounjaro has truly changed my life. I was giving up hope and falling into depression because nothing worked, and I didn't want to risk my life with surgery. Thank you to the makers of this medication. You have no idea how you are changing people with weight loss struggles. It's so much bigger than stop eating and working out more. I wish people would understand, and I wish insurance would approve this for weight loss. So many people are struggling. I never got real sick, sometimes a little nausea the day after."

10 / 10
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  • Candy
  • Taken for 1 to 6 months
  • April 18, 2024

Zepbound (tirzepatide) for Weight Loss (Obesity/Overweight) "I am in my 50s and I stayed on the 2.5 for 2 months and just began the 5 mg today. I had gastric sleeve exactly a year before covid, lucky me, huh? Working from home, no gym, already had depression, joint, and severe back issues. It all did not mix with slowing down and sitting down. I gained half of the weight I lost, and the high cholesterol returned. I started Zepbound on Feb 17, 2024, and lost 18 lbs by my first check-up on April 1. Very fast. My cholesterol dropped significantly. I do not have high blood pressure, but it was down too. All blood work is great. The only side effect is constipation that I fixed with Miralax. There are no food cravings or noise in my head. I get full very fast, although I have to remind myself to eat. I have dry mouth; I bought sugar-free popsicles to deal with that. I have been sleeping better, although I stay up late due to the energy it gives me."

10 / 10
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  • baechr
  • Taken for 1 to 6 months
  • March 18, 2024

Zepbound (tirzepatide) for Weight Loss (Obesity/Overweight) "Absolutely life-changing. For the first time in my life, I'm satisfied by reasonable portions. I'm not always thinking about the next thing that I'll be eating. I'm able to feel and respond to my actual hunger cues without my scarcity brain taking over. Even if I wasn't losing weight, the relief of food obsession and binge eating disorder would be worth it. Four weeks in, down 13 lbs and very satisfied. Only side effect has been feeling cold and some mild constipation."

10 / 10
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  • Jean
  • Taken for 6 months to 1 year
  • June 25, 2023

Mounjaro (tirzepatide) for Weight Loss (Obesity/Overweight) "I have never had anything like this in my life! I was always small and IBW until I went through menopause. Afterwards, I gained weight regardless of what I did. Nothing I tried, and no program I did helped. Once I reached a size 22 on my 5'4 frame and weighed almost 230 lb, I decided to do something else. By this time, I had also become "pre-diabetic" and was insulin resistant. I have been on Mounjario for 7 months and am now a size 8, down 65 pounds. My blood sugars are perfect, and I feel like my old self again! The journey has been effortless, and I enjoy the foods I like, but my body metabolizes it better. I have now switched to Wegovy since insurance only covers Mounjaro if you are a diabetic. I would stay on it forever, but cannot continue to pay almost $1100.00/month for it."

10 / 10
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  • Chris
  • Taken for less than 1 month
  • June 29, 2022

Mounjaro (tirzepatide) "Started with 2.5, been on it nearly three weeks, anticipated side effects but other than mild constipation, I experienced none. My appetite was nonexistent, had to remember to eat. Night eating gone, overeating gone, strong cravings gone. Injection easy peasy. Coupon only way I could afford this med (25/mo versus over 1k/mo). No feeling weird like stimulants, just pretty normal. I'm pairing with intermittent fasting per my GP and trying to incorporate intuitive eating as much as possible. I am not counting calories or weighing myself but I am likely down 5-10# in 2 weeks combo of water weight and loss. Bloat gone, body feels good, excited to see if this keeps working this well."

10 / 10
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  • Happy...
  • Taken for 1 to 6 months
  • September 25, 2022

Mounjaro (tirzepatide) "I started Mounjaro on July 1, 2022. I just turned 74 and was at the end of my rope with my obesity. I immediately developed a sour stomach/nausea and heartburn. But the wonderful side effect of having no appetite and not obsessing about food EVERY WAKING MOMENT was worth it. I still enjoy food, just eat less than half what I used to and no snacking. I lost 30 pounds in 2 months. I take one more injection (totally painless and easy to give) of 7.5 mg and then move up to 10 mg. My worst problem is terrible constipation. I’m working on it by using Colace, etc. but haven’t solved it completely. Since I’m on Medicare, I am paying THOUSANDS of dollars for this drug. So my savings account is decreasing but so is my weight. If I can afford it, I hope to stay on Mounjaro for one year. I still go to Weight Watchers and live by their eating plan which is very healthy."

10 / 10
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  • disap...
  • Taken for 1 to 6 months
  • April 1, 2024

Zepbound (tirzepatide) for Weight Loss (Obesity/Overweight) "After so many people I knew were doing so well on these injections, I started Zepbound 6 weeks ago. I was fine for 24 hours, then the side effects kicked in. I don't recall ever feeling this sick. Sulfur burps, churning stomach, started vomiting and diarrhea for 3 full days. I was sick for days after the first shot. I had no hunger while so very sick. Week 2 and 3 had no problems and the food cravings were gone. I was prepared to be very successful on this medication. Week 4 sulfur burps came back again, 24 hours after my injection. The same reactions returned but less violent; I was sick for 24 hours. Maybe a fluke? Week 5 and 24 hours in, same sulfur burps started it again: diarrhea, stomach spasms, and vomiting. Nope, off the Zepbound. I would rather stay fat than make myself sick with every dose. I never got beyond 2.5. I know this has been wonderful for some people; it's just not for me."

8 / 10
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  • Gabsdad
  • Taken for 6 months to 1 year
  • June 7, 2024

Mounjaro (tirzepatide) for Weight Loss (Obesity/Overweight) "210 to 165 in three months. Started on 2.5ml and increased to 5.0ml after the first month. I went back to 2.5ml after the third month. I have been experiencing low blood pressure symptoms now at six months. My doctors are trying to balance my other medications which may be causing this."

10 / 10
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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.