Caplyta User Reviews & Ratings

• Sar...
• Taken for 1 to 6 months
• June 17, 2022

For Bipolar Disorder "Amazing so far. I have been on it for six weeks and after getting past the first three days taking it- which gave me awful headaches, nausea, dry mouth, and fatigue - I started to feel something in me change. After three weeks I can say I noticed that the typical bad, ruminating thoughts of despair and general negativity were decreasing. And now at six weeks I can honestly say I have days where I catch myself and think, “Wow— I haven’t thought anything bad today”. I have never had a med this effective, and have a very sensitive/resistant system that has made med therapy a chore because nothing ever seems to work, or I end up having bad side effects. For the first time in 25+ years I feel hopeful; I am finding real joy in things, laughing genuinely, and I am able to be more compassionate and realistic with the pressures I put on myself. It’s improving my outlook on life and in turn improving my relationships. This is a miracle med for me."

• Cap...
• Taken for less than 1 month
• February 18, 2022

For Schizophrenia "I have had a very positive experience with Caplyta so far. I have been on several antipsychotics that worked but had side effects that were not tolerable. On the first day of taking this, I had dry mouth and a headache. Since then, I have not had a single side effect. After a week on it, I feel great. I haven't gained weight on it which is a good sign. I have more motivation and am sleeping normally after having those problems on Vraylar. My mood is also not flat like it was on the other medications that I had been on previously. I am not normally the person to write reviews but I saw all of the bad reviews and thought that maybe by sharing my experience it would help others. Maybe many people don't write reviews unless they have a bad experience? I am not sure but my experience on it has been very good. Would recommend to anyone who couldn't tolerate the side effects of other antipsychotics."

• Fee...
• Taken for 1 to 6 months
• September 6, 2020

For Schizophrenia "This medicine Caplyta has been a lifesaver for my bipolar! I've experienced sleepiness and dry mouth in the beginning, but those have gone away in the 5 weeks I've been on this medicine. My bipolar is completely under control and the severe depression is gone. I feel motivated, happy and able to participate in life. I'm so happy to have found this medicine. I finally feel 'normal'."

• Val...
• Taken for 1 to 6 months
• October 26, 2023

For Bipolar Disorder "Caplyta has changed my life. For many years, I took other antipsychotics and also tried lithium. They left me with tremors, gaining 75 pounds, suicidally depressed. I have bipolar type 1, sensory integration disorder, ADD, agoraphobia, OCD, and anxiety. On all previous mood stabilizers and antipsychotics, I had a flat mood, no real happiness. But still crushing bouts of depression. Also, I have never been able to keep my house clean. I often hoard. I have issues with keeping up my hygiene. I was full of self-doubts and paralyzed with fear. Just generally waiting to die. I have been tweaking the Caplyta, 42mg, with my other meds - Trintellix 20mg, buspirone 30mg, Rexulti 4mg, and clonazepam 2mg for sleep or as needed. I started taking Caplyta in late May. I felt it really kicked in September. My house is immaculate. I bathe every day. My intrusive thoughts/voices have significantly decreased. I rarely feel suicidal. I can leave my house alone. I have lost weight. I feel amazing!"

• Hap...
• Taken for 2 to 5 years
• December 13, 2021

For Schizophrenia "I would often complain to my psychiatrist about how many meds I was taking for my schizoaffective bipolar. He'd always assure me that brains and meds are like locks and keys; sometimes you only need one key to open the lock, and other times you need multiple keys at once. I'm a multiple keys type of girl. I've been on a myriad of psych meds, but slowly found out that I needed several at once to keep things steady, but I still felt 'crazy'. I was angry, extremely paranoid, sleepy, hallucinating constantly, and I felt so unsafe in the world, like everyone was out to get me. I read about a new med coming out and begged my psychiatrist to let me take it. 'Okay, we'll see how it works for you,' he said. It was slow at first, or so I thought. I didn't realize the small changes that were happening. I became less angry, less paranoid. I stopped hallucinating. But most of all, I started to feel happy. I never realized life could be so peaceful."

• Esb...
• Taken for 1 to 6 months
• March 24, 2023

For Bipolar Disorder "Caplyta is a game changer! For me, my bipolar depression is mostly compounded by my ADHD, creating extremely low energy and so much restlessness. Because all other antipsychotics block the D1 dopamine receptor, they never help me beyond pulling me out of an acute hypomanic or mixed episode. Caplyta is a D1 and D2 agonist (promoter)! It has been remarkable for keeping me level and helping with my depression without causing any weight gain whatsoever. Two months on it, and I’ve lost everything I gained and more from when I was on Abilify. Caplyta is my savior. It’s my miracle all-in-one. Please try it, and give it a few weeks."

• Anonymous
• Taken for 1 to 6 months
• February 23, 2022

For Bipolar Disorder "Caplyta is my fifth trial antipsychotic, and the first one that has produced no side effects. I have noticed a substantial shift in my depression and mood. It has not completely alleviated all of my symptoms, but it is definitely helping. I take it in combination with Lamictal 300 and Divalproex 250."

• Anonymous
• Taken for less than 1 month
• April 16, 2022

For Bipolar Disorder "Here is a weird one. I've been on Caplyta for a week as of today. And I seem to embarrassingly lost bladder control. Yesterday I had 3 accidents and today I have had 3 as well! It hits out of nowhere that I have to go, and if I don't get to a toilet within a minute, I just go uncontrollably on myself. I can't stop it. I'm 32, haven't had a child in nearly 10 years. I don't know what could be causing this other than I've been on a new medicine. I'm so embarrassed. I'm a school bus driver, it happened today at the end of my route before I could make it back to the bus yard, and I soaked myself and the seat of the bus. I was so embarrassed on the walk to my car! Has anyone else had this happen?"

• Mau...
• Taken for 1 to 6 months
• August 7, 2024

For Bipolar Disorder "This drug has changed my life after failing 14 antidepressants (major classes and atypicals). I have suffered from treatment-resistant bipolar II depression since puberty and was stunned to see that this was only the second drug approved for bipolar II depression next to Seroquel, which turned me into a zombie. Being an antipsychotic, it starts working in days, not weeks or months. I’ve used it for two months. First, I noticed social withdrawal disappear as I became more friendly and outgoing, then noticed the negative thought spirals and intrusive thoughts disappear. Verbal intelligence and executive function seem better. Things like dating, job interviews, and social events became easier. I don’t worry as much about finances or my future or past. The main side effect is morning grogginess. But it gets better. One very important detail: this drug is metabolized by the P450 complex. Do NOT mix with any cannabis products including CBD as you’ll get VERY sick."

• Bee...
• Taken for 1 to 6 months
• May 23, 2022

For Bipolar Disorder "My God, this medication has changed my life. I am able to separate my emotions from my logic. I'm not depressed or angry anymore. Is this what life is like for 'normal people'? I feel like I have hope in my life which I really haven't had before. I have bipolar 2 as well as C-PTSD. I take this alongside Lamictal, Celexa, and Prazosin (for PTSD nightmares). Whoever made this drug is a lifesaver. I've had side effects of dry mouth and felt an improvement within 2 weeks."

• RL8...
• Taken for less than 1 month
• June 10, 2022

For Bipolar Disorder "I’m very early into taking this medication. About six days to be exact. I have BP1 disorder, generalized anxiety, and panic disorder. I have been on several different medications over the years. Currently, I take 450mg ER Lithium once in the AM and twice at night. Lamictal (brand name) 100mg once daily and 1mg Xanax 4x daily as needed. Speaking with my psychiatrist about my irritability and flat mood, we decided to give Caplyta a try. I was skeptical because of how new it is, not to mention seemingly bad reviews. That being said, the first night was a bit hairy. I would get unbelievably cold like I was in Antarctica with no clothes on. Then I would be burning up. A brutal headache ensued late and into the next day. I was considering not taking it the next day, but I decided to stick with it. I’m glad I did. The side effects were drastically less the next day and more or less gone completely, and I noticed a difference for sure (i.e., more engaged, better mood)"

• apa...
• Taken for 1 to 6 months
• March 10, 2023

For Bipolar Disorder "I've been on Caplyta going on 4 months now. My depression has never been worse, I now have high blood pressure, dystonia, heartbeat irregularities, SEVERE constipation, severe anxiety, and broken sleep, about 10 hours a day. I've never felt this horrible on an antipsychotic med in my life before, and I've been on most of them. I can't get out of bed to shower, do chores, do any self-care, cooking, clean, etc. These drugs' side effects are worse than any drug I've taken for my BP2 depression. I've almost landed in the ER for heart palpitations and high blood pressure and resting heart rate in the high 80s to low 90s. The amount of apathy I have is unlike anything I've experienced. It may work well for schizophrenia, but for my BP2, it is the worst drug I've ever taken in over 32 years. I would never recommend this drug to anyone for BP2 depression."

• Bub...
• Taken for 1 to 6 months
• November 10, 2021

For Schizophrenia "Absolutely GODSEND!!! I have been on every drug for my schizophrenia up to clozapine, and nothing worked without making me an emotionless drooling void. I have been on Caplyta for about three months, and my quality of life has improved exponentially. My schizo was so bad, I had, by and large, stopped all hygiene, never left the house, and was consumed by paranoia and voices that no one but me could hear. I am now extremely hygienic, I have set routines and schedules again, I am able to go out in public, I converse with complete strangers every day, and I am so optimistic and happy again. I am on no antidepressants anymore, my anxiety is much lessened, and am happy again."

• Ray...
• Taken for 1 to 6 months
• March 11, 2022

For Bipolar Disorder "Caplyta made my depression worse. It was like I was in a black hole for a month. It got rid of my mania for sure. But the crushing depression made it a really bad choice for me. I will never take this again."

• Bes...
• Taken for 1 to 2 years
• April 3, 2025

For Bipolar Disorder "I have tried several other medications over the last decade. This one is the best experience yet. 42 mg capsules once per day. Nearly no side effects. Some dizziness if I get up too quickly. Depression is 95% gone. Mild mood swings. Mania is present at times but very mild and manageable. I am not currently on any other psych meds."

• Man...
• Taken for 1 to 6 months
• August 28, 2023

For Bipolar Disorder "I would ignore these negative reviews. They seem to be people who only stayed on the drug for a couple of days. I have bipolar depression. Eleven months ago, I was hit with the worst depression of my life. I couldn't get off my bed or off the couch. I slept a ton. My house was trashed for months. My doctor wanted me to try Caplyta. Now. The first day I took it, it was horrifying. I took it at night and woke up in the middle of the night with the worst throbbing headache I have ever had. ER worthy. I rushed to take an 800mg ibuprofen, and that only cut the pain down in half. A few hours after I went to bed after being awoken by a headache, I woke up in the AM. I felt completely drunk. I couldn't walk straight, bumping into walls, etc. I will tell you, after the first day of taking this med, the next day I had no symptoms. No headache, I did feel a little wobbly, but not as bad as the first day. On the third day, no side effects. The third day is when my depression completely vanished. Amazing."

• Bab...
• Taken for 1 to 6 months
• February 12, 2022

For Bipolar Disorder "I’ve been taking Caplyta for almost a month for bipolar depression. I immediately felt better emotionally but have developed a perpetual need to yawn/take a deep breath and a tightness across my upper abdomen. I’ve also noticed tension in the front of my neck and chest. It is not ideal and I am constantly debating these pros and cons. I have more mental clarity than I have had in years, but I am aggravated by yawning or semi-nauseous."

• PAP...
• Taken for 1 to 6 months
• January 23, 2025

For Bipolar Disorder "Really relieved my depression. I was ready to give up and didn’t think I would be able to stay alive much longer. Caplyta changed my life. It is the first antidepressant that worked, and I have tried many. It does make me sedated and sleepy, but the effects only last about two hours. I usually take it before bed, so by morning I am fine. Initially, I had terrible dry mouth, and my nose would plug up, but after about 45 days, those symptoms went away. I hope this medicine is always available. It is very expensive, but fortunately, my insurance covers most of it. I slowly went from 10 to 20 to 40 mgs."

• del...
• Taken for less than 1 month
• November 2, 2020

For Schizophrenia "I'm on Caplyta for schizoaffective, alongside lithium. It has helped me so much! I was struggling with a lot of intrusive non-realities and visuals, delusions relating to fears and paranoias, disconnection, overwhelming conversations in my head, and severe mood swings, which had been affecting me for years. It has gone a long, long way in helping these issues. My first week was a bit rough but not overwhelming. The first dose left me extremely drowsy, so I decided to take it in the evenings before bed. In the subsequent days, I did feel a bit of dread as it set in. Six days in, I felt like I was able to move it to the mornings and my body was getting used to it. Even before then, it helped me with my symptoms a lot. I really have to take it with food. I've had to eat fuller breakfasts since getting on it, or else the drowsiness comes back, but it's easily preventable. This medication has really changed my life, and I'd encourage anyone trying it to wait a week unless the side effects are too severe."

• Fuh...
• Taken for less than 1 month
• March 17, 2022

For Bipolar Disorder "I started this med a couple of days ago. I feel okay. Extreme dry mouth. I literally woke up in the night to chug milk, water, and OJ. That being said, I usually can only sleep 90 minutes each time I fall asleep through the night. I’ve been sleeping 3-5 hours each time the last couple of nights, and for the first time in years, I'm feeling like I’ve had some rest when I awake. For years, crawling out of bed in the morning, I felt like I had the crap beaten out of me. The only side effect I’m worried about is the weight gain. But I will continue to work with my doctor to see if we can make a go of this. I’ve tried many meds over the years. This is the only one I have hope for, as the others made me crazier, made me want to gamble, and one had me so zombified that I was going to Jack in the Box every night for like 200 mini churros."

• Sur...
• Taken for 1 to 6 months
• September 28, 2020

For Schizophrenia "I have Schizophrenia. After four years and as many different prescriptions, a 30+ lb weight gain, and blood glucose & cholesterol levels off the charts, my doctor prescribed the new drug, Caplyta. It's been five weeks and I've lost 2 lb. In addition, my sleep, sex drive, and well-being are feeling restored to a level I’d nearly forgotten and haven't been at since my mid-20s. Looking forward to the follow-up blood work in two months."

• eja...
• Taken for 1 to 6 months
• June 17, 2022

For Bipolar Disorder "Doctor started me on this new medicine as an adjunct to the other medications I take. It took around 2 weeks to notice any real effects from this drug. Caplyta certainly did lift my mood, but I did have to come off of this drug due to the side effects. This is a relatively new drug, and I don’t think many of the side effects are documented well. I stopped because Caplyta made me lose control of my bladder, and it made me feel like I had to go to the bathroom all the time. This was to the point where I got tested for a UTI (negative). I also got shooting pains in my rib cage near my upper chest. I’m not saying it’s a bad drug, just feel it out and listen to your body."

• 233...
• Taken for less than 1 month
• December 18, 2024

For Bipolar Disorder "I have never reviewed a drug before. I have chronic pain and have always also just had the anxiety/depression diagnosis. Now I’m seeing a new psychiatrist, and he said I’m not depressed, I’m bipolar. This was said one week ago for the first time, and I am 41. He wanted me to stop taking the Wellbutrin and the Cymbalta (which weren’t doing anything but I was trying to stay the course) and try Caplyta. Since about April, I have been in bed, and it was getting worse in the last month or so that my exhaustion was so severe that I would do one thing, like grocery shopping, and I was done. The first day on Caplyta, I was woozy, I felt unsteady on my feet, afraid to drive. By Sunday, no side effects whatsoever, and I spent time with friends, went out to lunch, and took the kids clothes shopping. Monday, all day Christmas shopping and wrapping. Today, I went to a friend’s all morning, saved my daughter on stage. I have actually never felt this good and happy. I didn’t know it was possible."

• Anonymous
• Taken for less than 1 month
• June 24, 2020

For Schizophrenia "I've had very few side effects so far. This med, Caplyta, doesn't make me feel like a zombie like the other meds, and I can think more clearly. The only side effects I've experienced are mild nausea and internal restlessness. I'll have to see how the next upcoming doses go."

• jsn...
• Taken for 6 months to 1 year
• September 24, 2022

For Bipolar Disorder "FYI, there is a lot of you out there expecting Caplyta to start working to relieve your symptoms on day one when the pharma corpos clearly state on their websites that Caplyta begins to work after two weeks but doesn't reach full strength until after six weeks of taking Caplyta. Side effects may start up any day, even on day one, and they can really suck, so call your doctor rather than wait and see if it all fixes itself. I'm on Caplyta, which worked well for me, it changed my life and even saved it as I almost committed suicide before I was stopped by my wife, who talked me out of it. I decided to give meds a try as a last resort. One last try. The Caplyta, lithium, and Lamictal greatly improved my bipolar symptoms as the weeks went by, and eventually, they vanished along with my suicidal urges. My marriage was saved as all of the chaos I caused during my episodes were now just memories of a previous life 1.5 years ago."