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Lybalvi User Reviews & Ratings

Lybalvi has an average rating of 8.1 out of 10 from a total of 16 reviews on Drugs.com. 75% of reviewers reported a positive experience, while 6% reported a negative experience.

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Reviews for Lybalvi

  • Vio...
  • Taken for less than 1 month
  • April 30, 2022

For Bipolar Disorder "Lybalvi has reworked olanzapine into a masterpiece. The buzz is that when sandimorphan is approved as a standalone med, it will treat personality disorders and addictions. For my bipolar 2 disorder, it has shaved off my nervous edge. I like myself more. It offers the mania-busting calm of olanzapine but makes me feel like I belong in this world. My doctor has once again improved my life immeasurably by knowing what to prescribe."

10 / 10
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  • Bay...
  • Taken for 1 to 6 months
  • April 29, 2024

For Bipolar Disorder "I was on the lowest dose of Lybalvi and was switched to it from Olanzapine, because I was told that Lybalvi had the Olanzapine with the Sanadorphin to combat weight gain. While the Lybalvi did help to stabilize my mood and helped with my motivation, I did feel tired and had trouble waking up. Not only that, but I got to my heaviest weight ever because I always felt hungry. People claim this medication is the best, but I will never forget how its side effects ruined my confidence."

7 / 10
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9 Report
  • Mir...
  • Taken for 1 to 6 months
  • August 24, 2023

For Bipolar Disorder "I like this medication. I was not sure I wanted to take it because Zyprexa caused serious weight gain. I gained about 13-15 lbs in a month, and that’s my only complaint. My irritability is much better. I have lost my libido, completely disinterested, and that would be why I stop this medication. Samidorphan is related to Naltrexone, by the way, so if you take medication for pain management or enjoy drinking alcohol, you may want to take another medication as it acts like an antagonist to the opioid receptors."

8 / 10
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9 Report

Frequently asked questions

  • Roc...
  • Taken for 6 months to 1 year
  • December 11, 2023

"I've had some constipation and dry mouth, but no other serious side effects so far. I have lost 25 pounds in about 6 months. I have noticed some restlessness and anxiety, but my doctor is treating that along with insomnia with a different medication. Lybalvi has been great, helping manage my bipolar symptoms since coming off of lithium after being diagnosed with CKD. I am on a 20mg/10mg dose and feeling stable."

8 / 10
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6 Report
  • OKe...
  • Taken for 6 months to 1 year
  • November 12, 2023

"Not good for sleep. I suffered a traumatic brain injury 30 years ago and have a lot of problems with sleep. This drug seems to worsen my insomnia. I'm very active and have a difficult time stopping. I have had no hallucinations and voices in my head have stopped. I really miss sleep. The stopping of hallucinations and voices in my head is why I stay on the medication. If you need to be rested because of your daily activities, I would not recommend."

8 / 10
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4 Report

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  • src...
  • Taken for 6 months to 1 year
  • October 1, 2024

For Bipolar Disorder "I was on Lybalvi 10/10 for nine months. I gained a bunch of weight. I followed the same diet I’ve been on for 32 years (Weight Watchers) and exercised 90 minutes per day. I didn’t find Lybalvi to be much better than Olanzapine."

3 / 10
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  • Den...
  • Taken for 1 to 6 months
  • September 7, 2024

For Bipolar Disorder "I was on Zyprexa for 10 years, and it has given me an amazing life. I can't express my gratitude for this drug enough. Words can't express it. But I gained 50 pounds. I almost didn't care because I have a great life because of it. My psychiatrist got me Lybalvi, and in 2 months I have lost 21 pounds, and I'm still losing. It's amazing. I feel stable and well, just as I did on Zyprexa, except I have more clarity on Lybalvi. It's as if the little bit of fog I had has lifted. When it comes to eating, Lybalvi gives me the power to choose healthy foods because my feeling of hunger is taken away. My dose is 20/10, meaning Zyprexa 20mg and the other drug (the weight loss drug) is the 10."

10 / 10
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  • pik...
  • Taken for 1 to 6 months
  • July 8, 2024

For Bipolar Disorder "I've been taking this medication for over 2 months. It helps me sleep, and it controls my suicidal ideations. It has done wonders for my mental health. I am on 20 mg of this drug. I have gained weight from the generic form of Zyprexa. My doctor told me that this drug should not cause any weight gain. I have not lost nor gained any weight since starting this drug. I hope to lose the weight that I gained from the generic form. I am happy with this drug."

8 / 10
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2 Report
  • Sta...
  • Taken for 1 to 6 months
  • December 16, 2024

For Bipolar Disorder "It saved me on one level, I was hearing voices and beginning to get suicidal because of it. But right now, I have so many side effects. I've taken a number of different medications over the years and generally, I tolerate them well, but lots of digestive issues, nerve reactivity, and weight gain."

5 / 10
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  • APS...
  • Taken for 2 to 5 years
  • July 10, 2024

For Bipolar Disorder "I have had a good experience. I still have bipolar symptoms and supplement the Lybalvi with 10 mg of generic olanzapine. It has controlled the mania well. The depression is more difficult to manage. I started taking it in early July of 2022. I had been on Zyprexa for about 10 years and gained a lot of weight. I have lost 110 pounds since I began taking Lybalvi."

10 / 10
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  • SYo...
  • Taken for 6 months to 1 year
  • June 6, 2024

For Bipolar Disorder "My experience was great at first, it helped to get my mixed episodes under control with very little manic episodes. I loved taking it, but have since stopped due to the fact it raised my blood sugar levels and caused my PCP to believe I had type 2 diabetes. It doesn't run in my family and since I stopped taking it (sadly) my levels have returned to normal. I was on 5/10mg of Lybalvi, but after about 6 months I had to stop it. Kudos to those who can, cause it is very helpful in managing symptoms."

8 / 10
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  • Ang...
  • Taken for 1 to 6 months
  • November 12, 2024

For Bipolar Disorder "My doctors have diagnosed me with several things over the years, usually bipolar or schizoaffective, but sometimes they add autism and ADHD or both. Anyway, one major issue I've had is meltdowns, these were especially bad as a child, and they came back after traumatic experiences (PTSD maybe, they often add borderline too to my alphabet soup). Basically, I couldn't control my emotions very well. Anyway, many atypical antipsychotics have been tried on me. Recently, I was given Lybalvi... I can't believe the difference!!!! I mean, I still have emotions, thank goodness, but they aren't overwhelming me anymore!!! I can feel sad without feeling like I'll lose control now! If this continues, I feel like I'll soon have my life back. I'm serious, is it the added medication that makes this med stand out from other atypicals I have tried? The major side effect I've had is dry mouth."

10 / 10
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  • gro...
  • Taken for 1 to 6 months
  • December 5, 2024

For Bipolar Disorder "I've been taking the 10-10 mg for about 3+ months for bipolar type 1 disorder, aka manic depression. I tried over 9+ different antipsychotics for bipolar type 1 for the past 21 years. This is so far the best, with the least side effects for me. I noticed weight gain of about 10-15 pounds, which is bad, but at least not unlike Seroquel, which made me gain 85 lbs. It also, I think, helps me sleep and wake up refreshed the next day. I never felt more normal and had no mood swings."

9 / 10
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  • Cur...
  • Taken for 1 to 6 months
  • September 28, 2023

For Schizophrenia "I'm in the second month of taking the drug. I was on Zyprexa alone for five years. This stuff has a punch. Don't drive cars. Hopefully I can get over the sedation in another couple weeks."

6 / 10
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14 Report
  • Ron...
  • Taken for 1 to 6 months
  • December 5, 2023

For Schizophrenia "Been on it for 5 months now, was on Seroquel but it stopped working. Great medication, it works wonders."

9 / 10
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10 Report
  • lyn...
  • Taken for 1 to 2 years
  • November 16, 2023

For Bipolar Disorder "Help me focus much better. No more hallucinations. Function and mood every day more calmly. My eating is less than before."

10 / 10
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7 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.