Trulicity and Loss Of Appetite: What Users Say

• Jan...
• September 19, 2020

For Type 2 Diabetes "When I first started Trulicity, I thought it was the end of me. Between the diarrhea, vomiting, headaches, stomach pain, and loss of appetite, I could barely leave my bed. My physician said it would take time to improve, at least 4 to 6 weeks. He moved my dose to 0.75 mg, with no metformin. This drug changed my life."

• NCW...
• Taken for 6 months to 1 year
• August 20, 2017

For Type 2 Diabetes "I have lost 60 lbs taking 1 injection each week for the last 9 months. My A1C is best since 2012. It has helped decrease my appetite immensely and is the main reason for the weight loss. Once I started seeing some results, it was easy to moderate intake and start to make better food & beverage choices. It has been a life-changer for me. I am hoping to drop another 20 lbs by Nov 1. I was 365 lbs in 2009 and now 242 lbs. Good luck to all!"

• eva...
• Taken for 1 to 6 months
• August 29, 2018

For Type 2 Diabetes "I was waiting a long time (a year) until I started using Trulicity pen. Why? I was scared after reading many reviews about side effects. But when metformin was not effective and I had constant UTIs which meant antibiotics, I didn't have a choice. I wish I had started it earlier. I have no side effects! The shot is not painful and easy to do, no diarrhea, no mood changes, no vomiting, no stomach pain, no gases. Yes, I have a little less appetite, especially in the morning, a little fewer visits to the bathroom for number twos (but I have at least one movement), a little nausea sometimes but nothing bothersome, not even noticeable. Each person reacts differently, usually bad reviews are from people with a strong negative reaction to the medication. That's why I am writing this review. Maybe somebody who really needs this medication will not be scared to try it as I was. I gave fewer stars because the lowest dose didn't lower my morning sugar level. Maybe more side effects will come with a higher dose, which I need to try."

• com...
• Taken for 1 to 2 years
• November 6, 2020

For Type 2 Diabetes "Started the Trulicity medication over 2 years ago. Have had no appetite since. Now I have lost 105 lbs and look like a stick man. I kept telling Dr., but he was not worried, saying A1C looked great. I feel horrible all the time. My family is very worried about me. My Dr. has left the practice, and my new one is very concerned that it has gone this far. This drug is really hard on my body. I feel weak all the time, headaches, no appetite. I can eat half of a burger and feel sick and unable to eat any more. I have an appointment with my new Dr. in a week. I hope he has an alternative, as there will be nothing left of me within a couple more months. Do not take this drug. Oh my, I wish my other Dr. would have listened to me before I got this bad. Went from 315 lbs to 187 lbs now. Enough is enough."

• Ste...
• Taken for 1 to 6 months
• May 17, 2021

For Type 2 Diabetes "I've been on Trulicity since January of this year, having one dose once a week. It still makes me feel nauseous. My side effects are I can't eat, bloating, diarrhea, painful pain in the lower abdomen. I've mentioned all this to my doctor, and she keeps saying my body just needs to get used to it. Don't think it will ever get used to this."

• Bre...
• Taken for less than 1 month
• January 17, 2021

For Cardiovascular Risk Reduction "My doctor injected me with a Trulicity pen on Friday in her office. As time has gone on, now Sunday, I'm so sick. I have severe abdominal pain, an extremely sick feeling, threw up once, have diarrhea, terrible sulfur burps, and gas. No appetite, which I suppose is a good thing to a point, but I'm scared to eat due to the nauseating feeling. Overall, I just don't feel good. I cannot wait for it to wear off. I will never take this medication again, these side effects are not worth it."

• Ern...
• July 28, 2019

For Type 2 Diabetes "Been on Januvia for the last 8 yrs. With a strict diet and a less active life, I've been keeping A1 between 7-9. Still not so good for the no carbs diets. In June 19, started with Trulicity. 1st week was like a zombie: gas in stomach, fatigue, no appetite, pain in bladder, also pancreas, inflated abdomen. 2nd week - little better. Most of the side effects disappeared, but still some discomfort. Week 5, almost all gone. Feel in good shape, no discomfort at all. Sugar went down and stabilized at 110-130 fasting. Never went above 170. But keep in mind! You need to eat as much as possible right: no carbs (potatoes, bread, rice, etc.), more green vegetables, no alcohol at all, no sweets, no sparkling. Few fruits - 1 apple/day, apricot (2-3 pcs), nuts, low-fat meat (fish, beef, chicken), corn flour meal, salads. There is no way to stay on type 2 too long and eat everything and look for a miracle medication that will fix all problems. Will stay on Trulicity a few more months to see if it's worth it. So far, it does."

• Lyd...
• Taken for 1 to 2 years
• March 23, 2019

For Type 2 Diabetes "I've been taking this drug for over a year now. While it has decreased my A1C to normal, I have experienced nausea the entire time. Diarrhea the entire time, loss of appetite to the point of forgetting to eat, and recently have started to have severe upper stomach pain, especially after I eat. Doesn't matter what I eat or how little or how much. The pain radiates to my back. Been doing a little research, and I firmly believe this drug has caused me to have pancreatitis. All this time, I thought it was normal side effects, but at some point during the past year, I've developed another medical issue because of this drug. I am stopping usage today. I can barely eat anything. I wake up in the middle of the night in pain, and it is starting to negatively affect my day-to-day life. Be careful with this drug and pay attention to your symptoms."

• Kim...
• Taken for 1 to 2 years
• September 13, 2019

For Type 2 Diabetes "I have spent the last week in a living nightmare - like I've never known. Trulicity 1.5 has been working for 2 years with little or no side effects. A1C dropped from 9.5 and stayed at 5.7. Good and steady. Right? It has curbed my appetite, I lost about 25 lbs, but need to lose more. I wasn't eating much, but hit a plateau. So, my doc talked me into increasing to 1.5. One shot. That was Friday night. No appetite since then. When I say no appetite, let me be clear. The thought of food makes me want to puke. I have not eaten anything solid in almost a week... oh, and starting Monday night, the worst searing pain in my abdomen I have ever experienced. Diarrhea, pain... no food... oh wait, I get it. This higher dosage will make me never eat again. That is the goal. Gotcha. Glucose between 72 and 94... so there is that."

• gri...
• Taken for 1 to 6 months
• October 20, 2016

For Type 2 Diabetes "I take my 6th dose of 0.75 mg Trulicity tomorrow (10/21/16), and I feel great! The first few doses came with some nausea and a little cramping, but I was expecting it. Now I don't have cramping or nausea, but I notice that my appetite is almost non-existent for the first day or two, so I just remind myself to eat small, healthy meals to keep me from feeling bad. I have lost a total of 18 lbs since starting Trulicity 5 weeks ago, and I went from my blood sugar averaging 200-300 to having blood sugar levels that range from 80-150. I have more energy, and I don't feel like I am in a fog all of the time. It has really made a difference for me so far."

• Ruz...
• Taken for 1 to 6 months
• December 21, 2019

For Type 2 Diabetes "I am into my 2nd month of taking this medicine as recommended by my Diabetes Educator Nurse, as I was finding it hard to lower my blood sugars to an acceptable level. I was on (and still am as well) Jardiamet 1000/12.5 twice a day. I went straight on to the 1.5 dose. My blood sugar readings have improved, and my loss of appetite has meant I am losing weight. My side effect seems to be, especially the first couple of days each week, a real loss of energy. I get very tired after doing any physical work and need a good old 'lie down!' I was not like this before and feel like I am getting old before my time!"

• Sav...
• May 21, 2023

For Type 2 Diabetes "My husband was in a bad car accident, and the pain and stress caused his blood sugar to be very high. After 3 months, he was prescribed Trulicity to get it to come down. Well, he had stomach pains, nausea, vomiting, and decreased appetite, and he lost 30 pounds in 2 months. He was NOT OBESE! Now he is weak and still can’t eat, even after quitting it 3 weeks ago."

• Spr...
• April 30, 2020

For Type 2 Diabetes "This is my 2nd month on Trulicity. First month, I had the 1.75 and had too many side effects: nausea, stomach pain, loss of appetite, and some ankle swelling. Called doctor, and he reduced dosage to the .75, and so far, so good. I can’t take this med with Metformin, though, because I get a worse effect when I take both together."

• Wil...
• Taken for 1 to 6 months
• September 11, 2020

For Type 2 Diabetes "I have had type 2 diabetes for 16 years. Controlled well on a low-carb, high-fat eating plan (LCHF) diet. Got too difficult and gradually went back to a normal diet, but still low carbs. HBA1c was rising, so Dr. suggested Trulicity. I've had 5 injections and will see Dr. on Monday, this week. I've had enough, my levels have gone up even when combined with Metformin. I am getting side effects of feeling nauseous for about three days after the injection, burping, wind, constipated, no appetite. All thought of food makes me feel sick, the only good point is I lost 3 kgs. I can't continue, it's not suitable for me. If my readings had come down, maybe... a big maybe I'd continue. I've tried for just about 6 weeks, but I feel shaky, sick, constipated, it's not worth it for me."

• Jay...
• July 11, 2018

For Type 2 Diabetes "My A1C numbers have NEVER been good. I would try so hard to eat right through the day, at night, I would be so hungry that a 4th meal would only do-plus being an emotional eater did not help. I started taking Trulicity about 8 months ago, A1C 8.3, 176 pounds. The best and only side effect was loss of appetite and loss of the emotional urges to eat. 3 months ago, A1C was 7.3, lost 22 pounds, ate healthy. Just had more blood work. A1C 5.5, morning glucose reading is 90, have lost 13 more pounds, slowly and healthfully, and feel great! I see the endocrinologist tomorrow and worry he will take me off Trulicity. Hope he decides to lower insulin, Levemir, and at the very least just lower the dose of Trulicity to see if I can maintain great numbers and weight loss! Trulicity seems to be my lifesaver! With the weight loss and great numbers, my new hobby is ME! Plus, I feel so good I am trying to just ease through stress because I can’t control anyone else...and just want to live."

• Mit...
• December 15, 2016

For Type 2 Diabetes "I have been using Trulicity 1.5 for almost one year (started February?). Super easy, nearly painless injections 1x week. Sometimes stomach hurts or a tad bit of decreased appetite. However, nothing serious, nothing at all like the horrid Bydureon. That was THE most awful injections I have ever done and refuse to ever use that again! Trulicity, along with a small amount of Levemir and Metformin, have my blood sugars where they should be. My biggest complaint is the cost. OMG!! The drug manufacturers are gouging us all!!"

• SR1...
• Taken for less than 1 month
• December 4, 2018

For Type 2 Diabetes "OMG! My doc gave me a two-week sample of Trulicity. The injection was easy but, boom, side effects right away! Absolutely no appetite, no energy, gas, and loss of concentration. It is a shame because it has lowered my morning numbers into the 'normal' range. About the third day in, I woke at 3 a.m. violently ill! I will not be taking this medication again and suggest no one ever take it!"

• Kat...
• October 13, 2016

For Type 2 Diabetes "I took my first dose of Trulicity yesterday. Never used any diabetes drugs before. There is definitely a decreased appetite. But to keep sugar levels steady, you have to eat a little a few times a day. I would say every 2 hours. Nuts are a good idea, small apple pieces, cut-up chicken, yogurt, nothing heavy. People have diarrhea because you should not have fatty and fried food at all. The only side effect that I have is a sudden feeling that I am going to pass out, following a panic attack. I guess my body is adjusting. I'll give it a try for a month. I appreciate everyone's input, it's so helpful."

• Liv...
• Taken for 1 to 6 months
• March 22, 2016

For Type 2 Diabetes "I started taking Trulicity roughly 6 weeks ago. At that time, my A1C was 14.6 due to falling into a deep depression, and I had stopped caring about my health. Needless to say, my endocrinologist started me on the lower dose (0.75) of Trulicity for 6 weeks, and my A1C dropped to 10.3. I'm not where I need to be yet, but we've upped the dose to 1.5, and I can't wait for my 3-month follow-up to see what my A1C reads then! My insurance does cover this medication, but it's over $100 monthly. My doctor does give me samples that Trulicity gives her. At first, when taking this medication, I wouldn't want to eat much for about 3-4 days after my injection. I still notice decreased appetite on those days, but I don't feel so sick anymore."

• Ang...
• Taken for 2 to 5 years
• August 30, 2019

For Type 2 Diabetes "The day after taking Trulicity, I’m pretty dizzy and lightheaded, so I take it when my weekend starts to not interfere with work. I’ve noticed extreme diarrhea while taking it if I eat spicy food, specifically anything with chili powder or chili flakes. Sulfur burps on any soda except Diet Coke. This I can live with, though, as it seems miraculous on my blood sugar levels. 8.1 to 6.3 now. The max dose of Metformin couldn’t do that. And it’s so easy to take. One injection a week! Weight loss and loss of appetite are normal, but I could stand to eat less. Will use forever if it keeps sugars as it is."

• pra...
• Taken for 1 to 6 months
• November 28, 2019

For Type 2 Diabetes "I continue from my previous review on October 7, 2019. So, 4 doses of 0.75 and 6 doses of 1.5 from 14 OCT. My A1C comes down from 9.5 to 6.6 (was on Janumet 50/1000 twice a day + 60 mg gliclazide) - changed to Trulicity + 2000 metformin + 60 gliclazide. After this result, the doctor has put me off gliclazide. Now only Trulicity 0.75 weekly + metformin 1000 twice a day, which is good. The side effects are extreme fatigue on days 3 and 4, lack of appetite, and diarrhea once in a while. I hope going back to 0.75 should get rid of these side effects. Diet is very important, I have recorded the diet that works for me in the previous posts. Stay healthy!"

• Dia...
• Taken for 1 to 6 months
• January 30, 2017

For Type 2 Diabetes "I have had no problems with Trulicity other than weight loss. I have been taking the injectable 0.75 for 8 weeks now with absolutely no problems. I'm not sure of my A1C as they are doing it February 10th. I have found I have absolutely no appetite and have to force myself to eat or even remember to eat, as I always seem to have that 'full' feeling. The doctor also has me on the once-a-day dose of Januvia and glipizide. I'll update on my A1C when it's checked again. Thank goodness for my insurance paying anything that has to do with diabetes, as between Trulicity and Januvia, it would break the bank!"

• Don...
• Taken for 1 to 6 months
• October 9, 2019

For Type 2 Diabetes "Review 2, week 10. I did ride it out, and the nausea and lack of appetite did subside at around week 4. However, week 8/9 it came back. Not sure why. Wasn’t as bad as the first 3 weeks. I’m due for a review at the doc's end of the month, so will see how it’s helped my A1c. Weight loss has been amazing. Just don’t think it’s the healthiest way to lose weight, due to not being able to eat."

• One...
• Taken for less than 1 month
• December 30, 2015

For Type 2 Diabetes "Today I started week 3, and here are the 3 biggest side effects I have been experiencing: 1. Nausea - Comes out of nowhere. It's comparable to a mid-level sea sickness-type feeling. At times I feel like I need to vomit; however, I came very close once and got past it. 2. Loss of appetite - I'm never hungry. Although I have to eat, I have made better choices when I do. My cravings for anything sweet have diminished altogether. 3. Heartburn - Just like the nausea; it comes out of nowhere and I want to drink a gallon of Pepto to help, which I did try once and I couldn't. Overall, like with any medication, there are going to be side effects. Some more severe than others, but try it and see how it might work for you. Best of luck!!"

• Mic...
• Taken for 1 to 6 months
• June 24, 2016

For Type 2 Diabetes "Week 6 update... The first 5 shots (5 weeks), lowest dose of 0.75. I had the usual nausea for a day or two after each shot and loss of appetite... no big deal, as it felt good to NOT be hungry and craving the carbs! Week 6 was this past Sunday. No nausea, but started with the sulfur burps and diarrhea Thursday night. Might not be connected, seeing it is week 6 and NOT week 1 or 2? I am down around 11 - 12 pounds since starting 6 weeks ago. Levels have been running NO higher than 126... UNHEARD of for me :) Also take Metformin XR x2 pills daily. I am soooo anxious to get my A1c level checked in a couple of months :)"