Trulicity and Gas: What Users Say

• Mar...
• Taken for 1 to 6 months
• August 27, 2020

For Type 2 Diabetes "On metformin 1000mg then 500mg for approx a month - gassy, slightly nauseated, and constantly feeling the need to be in the bathroom. Switched to Trulicity, on it now for the third month. So much better, back to feeling my regular self, and losing weight. I have mastered my cravings for sugar. A1C went from 10 to 6.2."

• Mom...
• Taken for 1 to 6 months
• June 24, 2020

For Type 2 Diabetes "I have been taking Trulicity for 7 weeks now. I have had horrible burps, gas, and extremely bad diarrhea. I don't know if I would recommend this drug to anyone. I can't even take a walk without worrying if I am going to have an accident."

• Net...
• Taken for 1 to 6 months
• February 10, 2021

For Type 2 Diabetes "Nurse practitioner started me on Trulicity 1.5 in September 2020 due to elevating A1C, up to 8.5. Started out good but pretty bad heartburn even taking Famotidine, 20 mg daily. Recheck December 2020, A1C down to 6.5. Stopped Famotidine and started Omeprazole, 40 mg daily which stopped the heartburn but now with bloating, burping, gas and constipation. Have stopped the Omeprazole and bloating is better and heartburn back, using antacids. On Metformin, 1,000 mg twice daily for years. Good news other than the lower A1C is that I have lost almost 30 lbs. Have feeling of being unwell. Usually feel much worse after eating. At first, my appetite was decreased but now I stay hungry all the time and crave sweets. Going back to see my NP this week and stopping Trulicity unless she can change things around because I sure don't like the way I feel, not worth it. Taking fiber for constipation. Trulicity helped my diabetes but hurt my quality of life."

• Ric...
• Taken for less than 1 month
• February 13, 2020

For Type 2 Diabetes "Dr. prescribed in the fall. Reading these reviews I was TERRIFIED. Dr. insisted that he had never had a patient with such experiences. Spoke with a friend who was on it. He reported a little nausea the first couple of weeks but it subsided. So far, I have experienced NO side effects other than a little gas. Very tolerable. Looking forward to seeing my labs next month."

• Mis...
• Taken for 1 to 6 months
• December 24, 2018

For Type 2 Diabetes "Started taking Trulicity 11/2018. Began with 0.75 ml for two weeks. Slight side effects of a little gas and nausea. Nothing else. Bumped up to 1.5 ml and the gas and nausea got a bit worse but went away quickly. Anything greasy results in mild diarrhea so I’ve eliminated all greasy foods from my diet. If you pay attention to what you eat, you can eliminate the side effects. Please be aware you definitely can’t eat the same amount of food as you did prior to taking this medication. I have lost 17 lbs in 6 weeks. It’s a great drug. You just have to pay close attention to what and how much you eat."

• Emi...
• February 12, 2020

For Type 2 Diabetes "I was on Trulicity for 6 months. The first 5 months, my symptoms were mild enough that I could manage them. Around 5 months in, I started getting extremely bloated, gassy, sulfur burps, extreme fatigue, diarrhea, nausea, vomiting, and headaches. I would get sick 2-3 days after my injection. Since stopping Trulicity, I've still periodically gotten sick (extreme bloating, gas, sulfur burps, diarrhea, vomiting, extreme fatigue). I've had my low-functioning gallbladder removed, and I've had an EGD done... and I'm still sick. Nobody can seem to diagnose or fix the digestive issues Trulicity has caused me. I've been off of Trulicity for 10 months. I'm at my wits' end. I wish these awful effects would go away for good."

• Anonymous
• Taken for 1 to 6 months
• April 5, 2019

For Type 2 Diabetes "Trulicity almost killed me with gassy diarrhea. I was on it for about 4 months. It is a very violent drug. I've been off of it for 3 weeks and still have bad symptoms. Lost around 25 lb from pooping liquid, and I thought I was going to blow up from the gas. While going through this, I have heard of similar symptoms from other friends."

• Bre...
• Taken for less than 1 month
• January 17, 2021

For Cardiovascular Risk Reduction "My doctor injected me with a Trulicity pen on Friday in her office. As time has gone on, now Sunday, I'm so sick. I have severe abdominal pain, an extremely sick feeling, threw up once, have diarrhea, terrible sulfur burps, and gas. No appetite, which I suppose is a good thing to a point, but I'm scared to eat due to the nauseating feeling. Overall, I just don't feel good. I cannot wait for it to wear off. I will never take this medication again, these side effects are not worth it."

• Zoe...
• Taken for less than 1 month
• November 2, 2020

For Cardiovascular Risk Reduction "I was prescribed this for weight loss, and it has been the worst thing ever. Bedridden and unable to work for 6 days now. Vomiting and diarrhea the whole day. Complete loss of control of my bowels. Unable to care for my kids. BP dropped to 74/48 at one stage, been to ED yesterday for IV fluids, but today it's worse than ever! Severe gastric upset, gas, pain, weakness, fatigue. Constant nausea that Maxolon and Ondansetron doesn't touch! I feel so awful! Don't risk this! I have heard of many now who have had these severe symptoms. I have not been this sick in 15 years! Diarrhea every 15-30 mins, using nappy rash cream on my bum now. Nightmare!"

• Dap...
• Taken for 1 to 6 months
• September 12, 2019

For Type 2 Diabetes "It's been almost 4 weeks now since I've been on the Trulicity 0.75 mg weekly. I did experience some mild nausea and a few headaches, but overall, my experience has been great. My appetite has decreased a lot. I was advised to stay on the 1000 mg of metformin at bedtime by my endocrinologist, which balanced out the constipation and diarrhea. I am, however, gassy... lol... but I can deal with that. I have experienced some weight loss, but I don't know how much. I see it in my clothing, and I feel much lighter. I also have increased energy."

• Ste...
• Taken for less than 1 month
• July 18, 2019

For Type 2 Diabetes "Lucky for us in the UK, meds are all free on the NHS. So, I have now been on Trulicity for 3 weeks. 1st week, awful nausea with tummy ache. Appetite non-existent. 2nd week, similar, but noticed nausea reduced, in fact, it comes and goes in bouts. Not too much bloating, but gassy at times. Bloods down dramatically to 5.5-6.5. Reduced Gliclazide from 2 per day down to half a tablet per day. 3rd week, feeling much better with side effects reduced further again. Weight loss over 3 weeks, average 10 pounds, so very happy. Intend to stay on this for the long term, with exercise, my weight will come off quickly. Very happy with Trulicity, and if you are lucky like me, stay on it. Sorry for all of you who couldn't stick with it."

• Maw...
• Taken for less than 1 month
• June 2, 2020

For Type 2 Diabetes "Started Trulicity 5 days ago on Thursday afternoon. Horrible night. Horrible indigestion, bloating, nausea, gas, feeling so bad and weak all over. Wanted this medicine out of my body. Late Monday afternoon, began to feel better. Today, Tuesday, still feel better with just some belching. Have to eat little at a time and eat ginger cookies for some leftover nausea after eating. Sugar levels have been lower. Now trying to decide if the same thing will happen with the second dose on Thursday and if I want to do another injection."

• goo...
• Taken for less than 1 month
• September 13, 2019

For Type 2 Diabetes "I was given the Trulicity injection because my A1C (sugar levels) was at 8.5%. I decided to take it on a Friday because I knew there might be some side effects. Well, let me tell you. This stuff knocked me hard for the first week. I felt like my entire gastro system was not functioning. My stomach didn't digest normally, I felt sick all the time. The 2nd day I had a lot of gas coming from both ends. I was embarrassed at how much. I felt like I wasn't urinating very much, my bowel movements were almost nonexistent. I had stomach pains that lasted at least 5 days. After 7 days, I am just now starting to feel better. No drug should EVER make you feel the way I felt. Please think twice before taking this drug, it was TOXIC!!! Medication is supposed to make you feel better, not worse. I have serious intestinal and stomach issues, so if you do as well, I would stay clear of this drug. It puts your stomach into a gastroparesis state, AKA slow stomach. NOT a good thing to suffer from."

• Wil...
• Taken for 1 to 6 months
• September 11, 2020

For Type 2 Diabetes "I have had type 2 diabetes for 16 years. Controlled well on a low-carb, high-fat eating plan (LCHF) diet. Got too difficult and gradually went back to a normal diet, but still low carbs. HBA1c was rising, so Dr. suggested Trulicity. I've had 5 injections and will see Dr. on Monday, this week. I've had enough, my levels have gone up even when combined with Metformin. I am getting side effects of feeling nauseous for about three days after the injection, burping, wind, constipated, no appetite. All thought of food makes me feel sick, the only good point is I lost 3 kgs. I can't continue, it's not suitable for me. If my readings had come down, maybe... a big maybe I'd continue. I've tried for just about 6 weeks, but I feel shaky, sick, constipated, it's not worth it for me."

• Net...
• Taken for less than 1 month
• January 25, 2019

For Type 2 Diabetes "Had 1 dose. The first day was good. But by Thursday, I was burping that gas smell. Had gas-like pain on the right side of the body, diarrhea, loose stool, the worst. Couldn't sleep, now at the ER because I feel horrible. Haven't eaten much of anything. Won't be taking this again, hate the side effects early on."

• Hop...
• Taken for less than 1 month
• February 21, 2020

For Type 2 Diabetes "Just started Trulicity 3 days ago. The next day I started with gas pains, burping, and nausea. Today I have been drinking peppermint tea, and it has helped. The doc warned me about the side effects and said they would go away in a few weeks. My A1C was 11 consistently this past year. I needed to try something different. I am going to do my best to stick with it. If I can reach my goal weight and goal A1C, then it will be worth it. Hopefully."

• SR1...
• Taken for less than 1 month
• December 4, 2018

For Type 2 Diabetes "OMG! My doc gave me a two-week sample of Trulicity. The injection was easy but, boom, side effects right away! Absolutely no appetite, no energy, gas, and loss of concentration. It is a shame because it has lowered my morning numbers into the 'normal' range. About the third day in, I woke at 3 a.m. violently ill! I will not be taking this medication again and suggest no one ever take it!"

• Jea...
• July 27, 2017

For Type 2 Diabetes "I just took my first dose Sunday night. I woke up in the middle of the night last night (2nd night in) with extreme acid reflux, very bad stomach bloating, very bad gas, both belching and flatulence, which tastes like nothing I can even describe and smells just as bad. Has anyone ever encountered this before with this medicine?"

• Jea...
• July 27, 2017

For Type 2 Diabetes "I just took my first dose Sunday night. I woke up in the middle of the night last night (2nd night in) with extreme acid reflux, very bad stomach bloating, very bad gas, both belching and flatulence, which tastes like nothing I can even describe and smells just as bad. Has anyone ever encountered this before with this medicine?"

• Boo...
• Taken for 1 to 6 months
• February 18, 2017

For Type 2 Diabetes "I have been taking the 1.5 dose now for about a month, it has really gotten my diabetes under control. Yes, I had a little stomach issues (mostly gassy) in the first week or so I used it, but it cleared up. I inject it into my stomach, but I alternate sides every week, so I am not injecting it in the same place all the time. I think this helps. I have experienced a bit of weight loss, about 2 pounds in a month, which is not terrible. But looking at all the other comments in here, I guess it affects people in different ways. My experience has really not been bad at all. I hate giving myself injections, but it far outweighs the high sugar readings. You're supposed to be between 70 and 99, I was 481. I am now down around the 100 mark."

• JRa...
• Taken for 6 months to 1 year
• December 14, 2018

For Type 2 Diabetes "I have been on a controlled double-blind study for some six months now, not knowing for certain that of two possibilities, I am taking a high dose (1.5) or a lower one (0.75). Because of the sometimes severe side effects, I have to conclude it is the higher dose. I have lost a good deal of weight, and my A1C has dropped from 7.5 or so to 6.7. That's the good news. The bad news is that, like so many other people, I have had really unpleasant side effects, and these seem to be getting worse over time. They include constipation, diarrhea, stomach cramps, awful-tasting belches frequently with a burning acidic taste as well, bad gas, and a more or less constant low-grade nausea malaise."

• MGF...
• Taken for 1 to 6 months
• August 20, 2020

For Type 2 Diabetes "I have been taking Trulicity for 14 weeks. My A1C was 7.5 and, 12 weeks in, dropped to 6.5. The doctor was happy with that, but the first 12 weeks felt weak, tired, gassy, etc., most of which I have read in this thread from others. For years, I drank a good amount of milk and used 1/2 and 1/2 in coffee every week. I also ate my fair share of ice cream... (I know/I know) So now, for two weeks, I have been off all of that, including cheese, and have become very mindful of not drinking or eating dairy as much as possible. Have had zero side effects from Trulicity over the past two weeks. We'll see how it goes, but maybe the two go hand in hand, at least for me."

• Ink...
• Taken for 1 to 6 months
• April 11, 2021

For Type 2 Diabetes "Taking the lowest dose of Trulicity. Awful stomach issues... gas, bloating, bad taste from burping. I am also very tired, can't do my normal 2 hours a day walking. Been on this for 4 weeks. Told my doctor, and she said to inject every other week. So what will that do? And so low a dosage, then what's the point? Will that reduce anything? She never told me the side effects and instead just that you can lose weight. What's up with this medicine? Lost 13 pounds in 4 weeks from not being able to eat. And this is a good drug?? Let's rethink this."

• Deb...
• Taken for 6 months to 1 year
• October 24, 2017

For Type 2 Diabetes "It's been 4 months since my last post as I wanted to give it a few months to see how this was going to work. So, I have been on Trulicity for six months now with Metformin. When I hit the five-month period, the diarrhea, gas, and sulfur belching finally subsided. I no longer have any of those side effects. However, I still haven't lost any weight at all, but I think that was because when I first started Trulicity, I was taking it with Glimepiride, and that one has a side effect of weight gain, so I think the two meds were fighting each other, lol. I have been back on the Metformin with Trulicity for about a week now, so we will see what this does. I was diagnosed with stage 3 chronic kidney disease (CKD 3), so I am watching my diet closely."

• Veg...
• December 6, 2018

For Type 2 Diabetes "12/06/2018 I took my shot on Saturday, Nov 3rd. By Monday, I was bloated, gassy, had severe diarrhea, stomach cramps, and vomiting. I was in the emergency room twice for dehydration in a 2-week time span. I really wanted it to work, but it was not worth the side effects. I have never been so sick in my life. After 28 days of diarrhea and severe stomach cramps, I had to start probiotics as this drug killed all my good bacteria in my gut. It has been about 33 days since I stopped, and I'm still sick. The probiotics have stopped the diarrhea, however, my bowel movements are not back to normal, and I'm still very gassy. Never again will I take this drug, just not worth the side effects, and I don't even know if I will ever be back to normal again. I hope it did NOT do long-term damage to my entire gastrointestinal system."