Trulicity and Diarrhea: What Users Say

• tae...
• May 20, 2021

For Type 2 Diabetes "I’ve been on Trulicity for 4 months now, and I’m telling you, it is horrible. I have gastroparesis and had my gallbladder out 6 years ago, so of course, all these gastric side effects hit me hard! Last week, I started with the violent diarrhea and vomiting to the point I went to the ER! Of course, my doctor didn’t know why I was so sick! Well, my A1C went from 11 to 9 with this med, and most of the time, it would linger at 230 BS all day, then spike on me at night. So, it wasn’t getting my numbers low enough anyway. The belching was so nasty, it also made me puke. I’m done with this drug. I’m going to cut carbs, sugar, and walk every day instead. I’m sick of being sick!"

• pra...
• Taken for less than 1 month
• September 24, 2019

For Type 2 Diabetes "3rd Week on Trulicity 0.75 (read my review below for 1st week). I did not have major side effects except headache for 1st week. The second week, day 2 after the shot was miserable. I had diarrhea continuously from 6 pm to 9 pm - luckily I was home by then and could not even digest water. I went to bed. Day 3 and after was uneventful. I have seen a pattern that diet matters. Assuming you take your shot on Monday: Day 2 and 3 Diet (Tue & Wed): No heavy carbs/sugary foods, eat a lot of veggies (avoid cauliflower, broccoli, legumes), apple, pear is fine. Full-fat yogurt (no sweetened). Drink plenty of water (no soda or sparkling water), but don't overdo it. Keep the dinner light. Day 4 - Thu: Add bread or rice for lunch (80 gms). Pasta is also fine. Mozzarella cheese (or any fresh cheese - 100 gm) for dinner with vegetables. Day 5 - Friday: Same as day 4. Day 6 and 7 (Sat & Sun): Get back to your normal diet. Day 1 (shot is due): Follow Day 2 diet. I will keep posting the updates."

• Jan...
• September 19, 2020

For Type 2 Diabetes "When I first started Trulicity, I thought it was the end of me. Between the diarrhea, vomiting, headaches, stomach pain, and loss of appetite, I could barely leave my bed. My physician said it would take time to improve, at least 4 to 6 weeks. He moved my dose to 0.75 mg, with no metformin. This drug changed my life."

• Mom...
• Taken for 1 to 6 months
• June 24, 2020

For Type 2 Diabetes "I have been taking Trulicity for 7 weeks now. I have had horrible burps, gas, and extremely bad diarrhea. I don't know if I would recommend this drug to anyone. I can't even take a walk without worrying if I am going to have an accident."

• Cab...
• Taken for less than 1 month
• February 28, 2020

For Type 2 Diabetes "I took this drug for the 1st time on Monday. By Thursday I was having extreme vomiting and diarrhea, reflux and burps that smelled and tasted like poop. No way I will be taking this again. Calling the Dr. Asap."

• Pin...
• Taken for 1 to 6 months
• July 22, 2019

For Type 2 Diabetes "Wanted to share my review of Trulicity because my experience has been a positive one. I was so afraid to take this after all the bad reviews. I know that everyone's experience on a med is different, but I'm glad that I gave this a try. It's been 4 weeks now, and I have experienced little to no side effects. A bit of dizziness the first week was about all. After 1 month on Trulicity, my A1C has gone from 8.3 to 6.6. I had previously tried both Metformin and Metformin XR and could not tolerate the constant nausea and diarrhea. So far this med has worked well for me, I'm down 8 lbs after one month, and have more focus and energy. I'll continue on with the med, and will update if anything changes."

• Luc...
• Taken for less than 1 month
• October 19, 2019

For Type 2 Diabetes "If you want to feel like walking death, this monstrosity of a 'medication' is for you! I have taken 1 dose of Trulicity, 2 days ago...never again. Sitting on the toilet with explosive diarrhea & projectile vomiting into the tub all night long, my body is killing me, my head is pounding, I'm beyond bloated, the sulfur burps are ridiculous & I feel like I'm getting stabbed in the stomach. It is the same exact thing I went through with Ozempic...don't ever take that stuff either."

• Mam...
• Taken for 1 to 6 months
• June 7, 2020

For Type 2 Diabetes "Trulicity was okay for the first few weeks with just some slight diarrhea and belching. Now I have been taking it for 3 months, and I just don't know if I can take it anymore. I have severe diarrhea and vomiting for 2 days after my injection, as well as weakness and dizziness. I just got my next 3-month supply and honestly can't afford to waste it, but I don't think I can handle this much longer."

• Emi...
• February 12, 2020

For Type 2 Diabetes "I was on Trulicity for 6 months. The first 5 months, my symptoms were mild enough that I could manage them. Around 5 months in, I started getting extremely bloated, gassy, sulfur burps, extreme fatigue, diarrhea, nausea, vomiting, and headaches. I would get sick 2-3 days after my injection. Since stopping Trulicity, I've still periodically gotten sick (extreme bloating, gas, sulfur burps, diarrhea, vomiting, extreme fatigue). I've had my low-functioning gallbladder removed, and I've had an EGD done... and I'm still sick. Nobody can seem to diagnose or fix the digestive issues Trulicity has caused me. I've been off of Trulicity for 10 months. I'm at my wits' end. I wish these awful effects would go away for good."

• Mis...
• Taken for 1 to 6 months
• December 24, 2018

For Type 2 Diabetes "Started taking Trulicity 11/2018. Began with 0.75 ml for two weeks. Slight side effects of a little gas and nausea. Nothing else. Bumped up to 1.5 ml and the gas and nausea got a bit worse but went away quickly. Anything greasy results in mild diarrhea so I’ve eliminated all greasy foods from my diet. If you pay attention to what you eat, you can eliminate the side effects. Please be aware you definitely can’t eat the same amount of food as you did prior to taking this medication. I have lost 17 lbs in 6 weeks. It’s a great drug. You just have to pay close attention to what and how much you eat."

• Kar...
• April 30, 2020

For Type 2 Diabetes "I have been on this medication for about six weeks. I just took my seventh-week shot two days ago, and I feel like I am dying. I am nauseated, dizzy, weak, extreme diarrhea, and I have burning and numbness in my legs and feet. I was initially taking Victoza, which I did very well on, but I lost my insurance and could not afford the hopper tags. So my doctor tried me on Trulicity and I honestly feel so bad. I have a month's worth of shots left, but I am trying my best to get this medication out of my system. Talking to my doctor about something new. Praying for us all."

• Zoe...
• Taken for less than 1 month
• November 2, 2020

For Cardiovascular Risk Reduction "I was prescribed this for weight loss, and it has been the worst thing ever. Bedridden and unable to work for 6 days now. Vomiting and diarrhea the whole day. Complete loss of control of my bowels. Unable to care for my kids. BP dropped to 74/48 at one stage, been to ED yesterday for IV fluids, but today it's worse than ever! Severe gastric upset, gas, pain, weakness, fatigue. Constant nausea that Maxolon and Ondansetron doesn't touch! I feel so awful! Don't risk this! I have heard of many now who have had these severe symptoms. I have not been this sick in 15 years! Diarrhea every 15-30 mins, using nappy rash cream on my bum now. Nightmare!"

• Anonymous
• February 20, 2020

For Type 2 Diabetes "Injected myself for the first time on a Friday night. Feeling very pleased as my levels dropped to 7s. Sunday arvo out and about with hubby. Started getting bad stomach pains. Just before getting into the car, I started projectile vomiting. It wouldn’t stop. Very embarrassed as this was on the footpath and road, and people could see. Pain still very intense in my abdomen. Got home and still projectile vomiting. Doctor prescribed me medicine to stop the vomiting. That worked, but the pain in my abdomen just intensified more. Had foul sulfur burping as well. Later that night was fully constipated, but did finally manage to go. Thought yay finally no more pain. Wrong! 5 minutes later explosive diarrhea nonstop. I’m still in intense pain, still got diarrhea, haven’t been to work all week. Never ever have I felt such intense pain. Doctors daily and still no relief. WORST medication ever! Stay well away from this torture drug!"

• Ste...
• Taken for 1 to 6 months
• May 17, 2021

For Type 2 Diabetes "I've been on Trulicity since January of this year, having one dose once a week. It still makes me feel nauseous. My side effects are I can't eat, bloating, diarrhea, painful pain in the lower abdomen. I've mentioned all this to my doctor, and she keeps saying my body just needs to get used to it. Don't think it will ever get used to this."

• Bre...
• Taken for less than 1 month
• January 17, 2021

For Cardiovascular Risk Reduction "My doctor injected me with a Trulicity pen on Friday in her office. As time has gone on, now Sunday, I'm so sick. I have severe abdominal pain, an extremely sick feeling, threw up once, have diarrhea, terrible sulfur burps, and gas. No appetite, which I suppose is a good thing to a point, but I'm scared to eat due to the nauseating feeling. Overall, I just don't feel good. I cannot wait for it to wear off. I will never take this medication again, these side effects are not worth it."

• bes...
• November 3, 2015

For Type 2 Diabetes "I started Trulicity about a year ago because the medication I was on kept crystallizing and was hard to inject. I have lost weight, about 22 pounds, over the course of a year. The biggest things to get used to were the nausea and the diarrhea, but after giving 4 weeks to adjust to the medication, my blood sugar does not spike like it used to, and I felt better. I don't have my usual cravings for anything bad for me, but I do have an appetite. I tell anyone who needs to lose a few pounds and lower blood sugar to stick with it. It will get better. I can't complain about the medication. All anti-diabetic agents cause stomach issues. Hang in there."

• Poc...
• Taken for 1 to 6 months
• December 21, 2019

For Type 2 Diabetes "Diabetes for 8 years, taking 2000 mg Metformin. Dr. added 0.75 mg Trulicity per week. No real change in BSL (blood sugar levels) - still staying in the 180-225 range in fasting levels in the morning. Not really exercising. No big side effects either. On the day she changed me to 1.25 mg pen, I got a refill on my 0.75 mg pens plus the 1.25 mg pens a day or 2 later. So using the 0.75 mg pens 2x week - this has made the weight drop off and the appetite go down. I've lost 22 lbs in 3 months, which is a good rate and so encouraging to stay at it. No real bad side effects that would make me want to get off Trulicity. Diarrhea seems to come with eating fats. Maybe the 2x week is better for me. I'm only paying about $30 per 4 pen box on my insurance, so it is affordable. Just wonder if I ever had to stop using Trulicity - would the weight and appetite come back."

• Ell...
• Taken for less than 1 month
• April 3, 2020

For Type 2 Diabetes "This is the worst medicine ever, and I’ve taken quite a few. I had to take Trulicity because my insurance won’t cover Victoza without a fight, and this is the second time I’m given low-rated/poorly tolerated medication for this reason. Thanks, Tricare. That same night, I had awful stomach cramping and diarrhea. Then the stomach pain was a little less severe but more persistent. I also suffered fatigue, constipation, bloating, sulfur burps, heartburn, nausea, dizziness, poor sleep, nightmares in addition to the stomach pain. Once it was so bad, it woke me up! I had constipation switched with diarrhea and heartburn for almost 2 weeks, and I stopped the medicine already. It stays in your system for DAYS and still messes with you. It’s awful."

• Gen...
• Taken for 1 to 2 years
• November 22, 2019

For Type 2 Diabetes "Been on Trulicity for a year now and have lost 35 lbs. A1C is right where it needs to be. I used to take Metformin, and it was a nightmare with having to deal with diarrhea, extreme stomach nausea, and just anytime that I was out and about with errands or out to eat and having to worry or stress if I was going to have to rush getting to a restroom. Trulicity does have its side effects of fatigue here and there. It also suppresses appetite, which is a good thing. Stools are much better other than a spell of diarrhea once in a while, but nothing compared to Metformin. Trulicity is also easier to deal with-just one shot once a week compared to Metformin, where I was pilled to death at 500 mg, 2 in the morning and 2 in the evening, Monday through Sunday, 365 days a year."

• Kik...
• Taken for 1 to 6 months
• January 4, 2020

For Type 2 Diabetes "For the love of anything, don't take this if you can avoid it. I've taken Trulicity for 3.5 months now, hoping my body will somehow tolerate it. Not the case. I've lost over 40 lbs. I feel like I have food poisoning every day. Bloated. Diarrhea, constipation, horrid nausea. Now I am starting to vomit. Losing weight is good, but not like this."

• Nan...
• November 12, 2019

For Type 2 Diabetes "I've been a diabetic for 23 years, and for the last 4 years, I've been all over the charts with my A1C. Dr. prescribed Trulicity last week, I should have read the reviews on this site first. I've been sick the last 4 days! I swear I felt it in my lungs the minute it was injected, then the nausea started. I've been in bed the better part of the last 4 days, but between the cramping, dizziness, diarrhea, headaches, and high blood pressure readings, I've decided it's not working for me. It's not worth the misery. I wanted to give it a chance, but I can't live like this any longer. Any food I put in my stomach feels like a sharp pain, it feels like my insides are turned inside out! I'm 58, and I've quit! Life's too short."

• Pre...
• Taken for 1 to 6 months
• December 28, 2018

For Type 2 Diabetes "The first dose I did okay with, but each dose after it seems to make me sicker. I usually start feeling bad within 24 hours of taking the shot. It started out as just a stomach ache. Last month, I got so sick. I thought I had food poisoning or the flu. It started with burping up a rotten egg taste. My body felt like I was on fire. I was so weak all I could do was lay my head on the trash can and wait to vomit. Then the diarrhea and stomach cramps came. I spent 4 days throwing up and running to the bathroom. I took my shot yesterday and today, the same exact thing happened. I'm so sick. Burping started around 2 pm, by 5 pm, I knew I was going to vomit. By 6 pm, I was vomiting, and I continue to throw up, and the diarrhea has now come as well. I haven't gotten violently ill every time I take the shot, but after two times, I won't be taking it again. I've never felt so sick in my life. My numbers didn't go down enough to make me want to continue on this medicine."

• Lyd...
• Taken for 1 to 2 years
• March 23, 2019

For Type 2 Diabetes "I've been taking this drug for over a year now. While it has decreased my A1C to normal, I have experienced nausea the entire time. Diarrhea the entire time, loss of appetite to the point of forgetting to eat, and recently have started to have severe upper stomach pain, especially after I eat. Doesn't matter what I eat or how little or how much. The pain radiates to my back. Been doing a little research, and I firmly believe this drug has caused me to have pancreatitis. All this time, I thought it was normal side effects, but at some point during the past year, I've developed another medical issue because of this drug. I am stopping usage today. I can barely eat anything. I wake up in the middle of the night in pain, and it is starting to negatively affect my day-to-day life. Be careful with this drug and pay attention to your symptoms."

• Dap...
• Taken for 1 to 6 months
• September 12, 2019

For Type 2 Diabetes "It's been almost 4 weeks now since I've been on the Trulicity 0.75 mg weekly. I did experience some mild nausea and a few headaches, but overall, my experience has been great. My appetite has decreased a lot. I was advised to stay on the 1000 mg of metformin at bedtime by my endocrinologist, which balanced out the constipation and diarrhea. I am, however, gassy... lol... but I can deal with that. I have experienced some weight loss, but I don't know how much. I see it in my clothing, and I feel much lighter. I also have increased energy."

• Kat...
• January 26, 2020

For Type 2 Diabetes "On Trulicity for 2 months. Suddenly, uncontrollable, explosive, painful diarrhea 10 to 12 times a day. Unable to eat much and lost 40 lbs in 8 weeks. I now have decreased kidney function. I suffered for 8 weeks, four trips to doctors, 2 trips to the hospital. Finally, I requested a colonoscopy, that should tell you how desperate I was. Biopsies were taken during the colonoscopy. Results returned inflammatory bowel disease. Treatment now is 4 months on steroids. So now I get to go through the side effects of the steroids. I was also informed by my specialist that this disease could return at any time. Causes of the disease included drug-induced. The diarrhea, along with the abdominal pain, was nearly unbearable. Beware that this drug can cause life-threatening health problems. Please save yourself. I absolutely would not recommend this drug."