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Quetiapine Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Quetiapine Caplyta (lumateperone) Lybalvi (olanzapine / samidorphan)
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Quetiapine Caplyta (lumateperone) Lybalvi (olanzapine / samidorphan)
Prescription only

Quetiapine is an antipsychotic that calms and sedates, helping to relieve psychotic thoughts and manic and depressive behavior. Sedation, low blood pressure, and weight gain are common side effects... View more

Prescription only

Caplyta is an atypical antipsychotic that is used to treat adults with schizophrenia or depression associated with bipolar disorder. Sleepiness is the most common side effect and it should not be... View more

Prescription only

Prescribed for Bipolar Disorder, Schizophrenia. Lybalvi may also be used for purposes not listed in this medication guide.

More about Quetiapine More about Caplyta (lumateperone) More about Lybalvi (olanzapine / samidorphan)
Ratings & Reviews

Quetiapine has an average rating of 7.2 out of 10 from a total of 2250 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 18% reported a negative effect.

Caplyta has an average rating of 6.6 out of 10 from a total of 184 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 29% reported a negative effect.

Lybalvi has an average rating of 8.1 out of 10 from a total of 16 ratings on Drugs.com. 75% of reviewers reported a positive effect, while 6% reported a negative effect.

View all 2250 reviews

View all 184 reviews

View all 16 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Quetiapine side effects

View all Caplyta side effects

View all Lybalvi side effects
Drug Class
Generic Availability

Lower cost generic

No lower cost generic approved

No lower cost generic approved
Pricing and Coupons * Prices are without insurance
Quantity 50 each
Strength 25 mg
Per unit* $1.34
Cost* $66.94

View all Quetiapine prices

Quantity 30 each
Strength 42 mg
Per unit* $61.18
Cost* $1,835.40

View all Caplyta prices

Quantity 30 tablet
Strength 5 mg-10 mg
Per unit* $58.95
Cost* $1,768.40

View all Lybalvi prices

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Dosage Forms
  • Oral tablet
  • Oral tablet, extended release
  • Oral capsule
  • Oral tablet
Brand Names
Seroquel, Seroquel XR

N/A

N/A
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

6 hours

18 hours

54 hours (empirically)
CSA Schedule 1 View glossary of CSA terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.
Drug Interactions

A total of 745 drugs are known to interact with Quetiapine:

  • 147 major drug interactions (502 brand and generic names)
  • 593 moderate drug interactions (2331 brand and generic names)
  • 5 minor drug interactions (21 brand and generic names)

A total of 604 drugs are known to interact with Caplyta:

  • 167 major drug interactions (620 brand and generic names)
  • 435 moderate drug interactions (1719 brand and generic names)
  • 2 minor drug interactions (5 brand and generic names)

A total of 700 drugs are known to interact with Lybalvi:

  • 66 major drug interactions (350 brand and generic names)
  • 626 moderate drug interactions (2356 brand and generic names)
  • 8 minor drug interactions (24 brand and generic names)
Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
  • Grapefruit and grapefruit juice may increase the blood levels of lumateperone. In some cases, this... View more
  • Using lumateperone together with alcohol may increase side effects such as dizziness, drowsiness... View more
  • Alcohol can increase the nervous system side effects of OLANZapine such as dizziness, drowsiness... View more
Disease Interactions
First Approval Date

September 26, 1997

December 20, 2019

May 28, 2021
WADA Class View classifications

N/A

N/A

N/A
More Information
Patient Resources
Professional Resources
Related Treatment Guide

1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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