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Divalproex sodium Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Divalproex sodium Caplyta (lumateperone) Lybalvi (olanzapine / samidorphan)
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Divalproex sodium Caplyta (lumateperone) Lybalvi (olanzapine / samidorphan)
Prescription only

Divalproex may be used for the treatment of absence or partial seizures, as a preventive treatment for migraines, and to treat mania associated with bipolar disorder. Divalproex may adversely and... View more

Prescription only

Caplyta is an atypical antipsychotic that is used to treat adults with schizophrenia or depression associated with bipolar disorder. Sleepiness is the most common side effect and it should not be... View more

Prescription only

Prescribed for Bipolar Disorder, Schizophrenia. Lybalvi may also be used for purposes not listed in this medication guide.

More about Divalproex sodium More about Caplyta (lumateperone) More about Lybalvi (olanzapine / samidorphan)
Ratings & Reviews

Divalproex sodium has an average rating of 6.6 out of 10 from a total of 509 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 24% reported a negative effect.

Caplyta has an average rating of 6.6 out of 10 from a total of 183 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 29% reported a negative effect.

Lybalvi has an average rating of 8.0 out of 10 from a total of 16 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 7% reported a negative effect.

View all 509 reviews

View all 183 reviews

View all 16 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Divalproex sodium side effects

View all Caplyta side effects

View all Lybalvi side effects
Drug Class
Generic Availability

Lower cost generic

No lower cost generic approved

No lower cost generic approved
Pricing and Coupons * Prices are without insurance
Quantity 80 each
Strength 500 mg
Per unit* $1.28
Cost* $102.16

View all Divalproex sodium prices

Quantity 30 each
Strength 42 mg
Per unit* $59.81
Cost* $1,794.43

View all Caplyta prices

Quantity 30 tablet
Strength 15 mg-10 mg
Per unit* $57.63
Cost* $1,728.91

View all Lybalvi prices

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Dosage Forms
  • Oral delayed release capsule
  • Oral delayed release tablet
  • Oral tablet, extended release
  • Oral capsule
  • Oral tablet
Brand Names
Depakote, Depakote ER, Depakote Sprinkles

N/A

N/A
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

16 hours

18 hours

54 hours (empirically)
CSA Schedule 1 View glossary of CSA terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
D
Category D Positive evidence of risk

When Treating Epilepsy And Manic Episodes Associated With Bipolar Disorder

X
Category X Not for use in pregnancy

When Treating Migraine

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.
Drug Interactions

A total of 410 drugs are known to interact with Divalproex sodium:

  • 24 major drug interactions (68 brand and generic names)
  • 363 moderate drug interactions (2276 brand and generic names)
  • 23 minor drug interactions (203 brand and generic names)

A total of 602 drugs are known to interact with Caplyta:

  • 167 major drug interactions (620 brand and generic names)
  • 434 moderate drug interactions (1716 brand and generic names)
  • 1 minor drug interactions (3 brand and generic names)

A total of 699 drugs are known to interact with Lybalvi:

  • 66 major drug interactions (350 brand and generic names)
  • 625 moderate drug interactions (2352 brand and generic names)
  • 8 minor drug interactions (24 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Alcohol can increase the nervous system side effects of divalproex sodium such as dizziness... View more
  • Grapefruit and grapefruit juice may increase the blood levels of lumateperone. In some cases, this... View more
  • Using lumateperone together with alcohol may increase side effects such as dizziness, drowsiness... View more
  • Alcohol can increase the nervous system side effects of OLANZapine such as dizziness, drowsiness... View more
Disease Interactions
First Approval Date

March 10, 1983

December 20, 2019

May 28, 2021
WADA Class View classifications

N/A

N/A

N/A
More Information
Patient Resources
Professional Resources
Related Treatment Guide

1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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