Comparing Divalproex Sodium vs Lithium
| Divalproex sodium | Lithium |
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| Divalproex sodium | Lithium |
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Prescription only
Divalproex may be used for the treatment of absence or partial seizures, as a preventive treatment for migraines, and to treat mania associated with bipolar disorder. Divalproex may adversely and... View more |
Prescription only
Lithium may be used to treat manic episodes associated with bipolar disorder; however, there is a fine line between too much and too little, and ongoing monitoring is needed to prevent lithium... View more |
Related suggestions Borderline Personality Disorder
Cyclothymic Disorder
Popular comparisons
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| More about Divalproex sodium | More about Lithium | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Divalproex sodium has an average rating of 6.6 out of 10 from a total of 504 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 24% reported a negative effect. |
Lithium has an average rating of 7.3 out of 10 from a total of 485 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 20% reported a negative effect. |
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| Drug Class | |||||||||||||||||
| Side Effects | |||||||||||||||||
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See also: divalproex sodium side effects in more detail. |
See also: lithium side effects in more detail. |
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| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all divalproex sodium prices |
View all lithium prices |
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| Dosage Forms Available | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Depakote, Depakote ER, Depakote Sprinkles | Lithium Carbonate ER, Lithobid | ||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
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16 hours |
29 hours |
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| CSA Schedule ** View glossary of terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category D
Positive evidence of risk
When Treating Epilepsy And Manic Episodes Associated With Bipolar Disorder
Category X
Not for use in pregnancy
When Treating Migraine See the full pregnancy warnings document. |
Category D
Positive evidence of risk
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 409 drugs are known to interact with divalproex sodium:
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A total of 719 drugs are known to interact with lithium:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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March 10, 1983 |
April 06, 1970 |
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| WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
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N/A |
N/A |
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| Related Treatment Guide | |||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.