Clozaril Alternatives Compared
| Clozaril (clozapine) | Rexulti (brexpiprazole) | Lybalvi (olanzapine / samidorphan) |
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| Clozaril (clozapine) | Rexulti (brexpiprazole) | Lybalvi (olanzapine / samidorphan) |
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Prescription only
Prescribed for Schizophrenia. Clozaril may also be used for purposes not listed in this medication guide. |
Prescription only
Rexulti is an atypical antipsychotic that may be used to treat adults with schizophrenia or depression, or used to relieve agitation associated with dementia in Alzheimer's disease. Most people... View more |
Prescription only
Prescribed for Bipolar Disorder, Schizophrenia. Lybalvi may also be used for purposes not listed in this medication guide. |
Related suggestions Schizophrenia
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| More about Clozaril (clozapine) | More about Rexulti (brexpiprazole) | More about Lybalvi (olanzapine / samidorphan) | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Clozaril has an average rating of 7.8 out of 10 from a total of 15 ratings on Drugs.com. 77% of reviewers reported a positive effect, while 15% reported a negative effect. |
Rexulti has an average rating of 6.6 out of 10 from a total of 486 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 25% reported a negative effect. |
Lybalvi has an average rating of 8.0 out of 10 from a total of 16 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 7% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||||||||||
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View all Clozaril side effects |
View all Rexulti side effects |
View all Lybalvi side effects |
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| Generic Availability | ||||||||||||||||||||||||||
| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Clozaril prices |
View all Rexulti prices |
View all Lybalvi prices |
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| Dosage Forms | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Other clozapine brands include: Clopine, Clozapine Synthon, Denzapine, Versacloz |
N/A |
N/A |
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||||||||||
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10.3 hours |
91 hours |
54 hours (empirically) |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 941 drugs are known to interact with Clozaril:
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A total of 596 drugs are known to interact with Rexulti:
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A total of 699 drugs are known to interact with Lybalvi:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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| First Approval Date | ||||||||||||||||||||||||||
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September 26, 1989 |
July 10, 2015 |
May 28, 2021 |
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| WADA Class View classifications | ||||||||||||||||||||||||||
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N/A |
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N/A |
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| Related Treatment Guide | ||||||||||||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.