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NP Thyroid and Brain Fog: What Users Say

Brain fog: mentioned by 30 users (12.1%)

Based on user experiences from 247 NP Thyroid reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

anxiety 14.2%
tiredness 12.6%
brain fog 12.1%
fatigue 11.7%
headaches 11.7%
weight gain 9.7%
depression 8.9%
heart palpitations 8.1%
joint pain 8.1%
hair loss 7.7%

Reviews for NP Thyroid

Commonly mentioned side effects
  • Ama...
  • Taken for less than 1 month
  • November 17, 2020

For Underactive Thyroid "DO NOT TAKE THIS. I was on Nature-Throid with no problems for about a year before being switched to this garbage due to recall. I took NP Thyroid for about a week and ended up in the back of an ambulance this morning because my husband thought I was having a heart attack. I am a 30-year-old female athlete with no underlying health conditions other than an underactive thyroid. The past week on it has been a blur. Brain fog, irritability, heart palpitations, achy body and joints, breathlessness, migraines, nausea, dizziness, extreme fatigue, and anxiety. I don't know what's in this stuff, but it needs to be pulled. There is something very wrong with NP Thyroid. Stay far away from this stuff."

1 / 10
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  • Eli...
  • Taken for 6 months to 1 year
  • November 6, 2019

For Underactive Thyroid "Do not take this medicine! Started in July. He gave me samples first. Those were good. Did blood work again, doubled dosage and got script in August. My hair dried out and started falling out. Then insomnia, anxiety, panic attacks, depression, crying for no reason, menstrual cycle irregular, throat burning, stomach hurt, headaches, very greasy, complete brain fog, itchy with bumps, could barely talk, bad back shoulder and neck pain. Barely functioning day to day, I felt empty inside, like I was losing it. I couldn't talk right. I was waking up at 12 am wide awake, couldn't relax, completely amped and exhausted at the same time. I didn't understand what was happening. I stopped taking it. Every day my brain got clearer and felt more like me, my personality came back. I have always been healthy and didn't look at the side effects. I feel stupid for not, lesson learned. This isn't ok! I'm so glad I found this site and it all makes sense now. Please report this! I am!"

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  • Den...
  • February 12, 2020

For Underactive Thyroid "I’ve been on NP for 4 months. I haven’t been feeling well and have a splitting headache, so I googled side effects. I don’t know what made me think it could be thyroid medicine. For some reason, it just popped into my head. I have very bad headaches daily, bloated stomach, constipation, I’m very cold all the time, foggy, and just out of it. I’m so tired and have a 'I don’t care' attitude. I used to take levo and didn’t have any of these problems. My numbers aren’t changing, so the doctor keeps increasing the dosage. Now at 120 mg, I have such blurry vision, which is sometimes double vision. Heart palpitations. Chest pain. Joint pain. I can’t sleep. I'm glad I came here to read, I thought I must have a terrible disease. Seeing doctor in a few days."

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Frequently asked questions

  • Anonymous
  • October 28, 2019

For Underactive Thyroid "I have been taking NP Thyroid for about one year now since NatureThroid became unavailable in 0.5 grain. It's been okay but the last two months I have begun feeling horrible. I have no energy, feel very tired, digestive problems, bloated painful stomach, headaches, brain fog, leg cramps, anxiety/panic attacks, depressed, complete loss of libido, fat gain around the middle, and more. In early September, I noticed my NP Thyroid refill smelled horrible. I contacted my pharmacist and he told me batches vary - it's normal. So I continued to take it, feeling worse over time. I stopped taking it for 3 days as a trial this week and felt somewhat better. I since found a few websites and blogs that discuss the issues. I am not alone. Will contact Naturopath tomorrow to see what my options are. I too, like others, feel poisoned. It seems like my reaction is more than just hypothyroid symptoms. I did not feel this badly before starting thyroid hormones."

2 / 10
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  • aka...
  • Taken for less than 1 month
  • May 20, 2021

For Underactive Thyroid "Last week, my pharmacy gave me NP Thyroid instead of regularly prescribed Armour Thyroid. At first, I noticed the strong smell and taste of mildew/cat wee. I checked the label on my prescription and noticed it wasn’t Armour. A week into taking this, I noticed my body aching and heart palpitations. Then my heart started pounding, and I got all jittery. My hands and knees were shaking, and I felt weak with a headache and brain fog. I called my pharmacist, and after talking to them, they exchanged that medication for my regular Armour. After looking into this medication, I found out it has been recalled multiple times, and my symptoms were identical to other multiple people's reviews. Please do not take this medicine. It is terrible."

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  • Bow...
  • Taken for 6 months to 1 year
  • October 26, 2019

For Thyroid Cancer "When I found NP Thyroid 11 months ago, I got my life back. I struggled for a year on different medications after a total thyroidectomy for cancer, but now Acella changed all that. That's over now. They changed the supplier for the active ingredient, claiming it worked exactly the same. It does not. I am having memory problems, brain fog, heart palpitations, headache, and a burning throat. There is something wrong with these pills. No more NP Thyroid for me."

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  • Del...
  • Taken for 10 years or more
  • September 16, 2019

For Hypothyroidism, After Thyroid Removal "I have been on thyroid for 15 years. 8 years before thyroid removal, 7 years after. I started with Synthroid at the beginning, I felt 'normal.' Then it was difficult to get Synthroid, and I switched to Nature Thyroid. Was on that for a very long time, made me feel better, no headaches, didn’t fluctuate in weight. Then the money-hungry pharmaceutical companies decided that we didn’t pay enough for our working thyroid medicine and didn’t make enough. So, I switched to NP. Now I am back to being fatigued all the time, migraines again, weight gain, brain fog, cramps in my legs, the list goes on. When are these pharmaceuticals going to be accountable for screwing with the well-being of hundreds of thousands of people?"

3 / 10
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  • Lym...
  • Taken for less than 1 month
  • October 20, 2020

For Underactive Thyroid "Started taking NP Thyroid about 3 weeks ago. I was taking WP Thyroid due to recall, no longer available. I have chronic Lyme and co-infections. I've been feeling a lot better lately. About 2 weeks ago, I started feeling very anxious, heart palpitations, extreme fatigue, severely depressed, brain fog, muscle pain/aches, and the list is endless. I really thought it was one of my co-infections coming back. Paid $580 to get tested for it, and I was negative. Couldn't figure out what was causing all of this until I Googled NP Thyroid, it smells like cat pee. I will no longer be taking it. I don't know what to change it to, I see my doc on Monday, I hope to get it sorted. Please don't touch this stuff."

1 / 10
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  • Mom...
  • January 27, 2019

For Underactive Thyroid "Was doing well on Naturethroid, up until they seemed to change the formula. So switched to NP. Fatigue okay, but brain fog much worse, painful joints, stiffness in muscles, and leg pain that feels similar to restless legs. The worst symptom though is headaches-constant. Am now experimenting with altering my dose (again!), but I’ll have to swap to Armour, I think. I’m in the U.K. Getting hold of NDT is like finding a unicorn. I despair. I wish Naturethroid had never changed. I know they deny a reformulation, but it worked like a dream for me before their manufacturing issues, and I felt well. Now I’m back in the hypo pit, and it’s dreadful."

3 / 10
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  • Roz...
  • Taken for 1 to 6 months
  • April 22, 2023

For Underactive Thyroid "I am suffering from incredible brain fog, dizziness, and confusion that are so severe that I have nearly fallen off the steps three times. I also experience other symptoms that other women have written about, such as difficulty breathing, constant nose dripping, sneezing, and fluctuating body temperature. Additionally, I sweat profusely while sleeping and have the worst body odor. For me, it took some time to build up in my system. Initially, I felt slightly better, but it quickly became horrendous. I am grateful to have found this website. Like many others on Nature-Throid, I have not been on any medication for a couple of years. I used to think that the medication had a strange taste, but I assumed that it was normal."

1 / 10
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  • Ame...
  • December 4, 2018

For Hypothyroidism, After Thyroid Removal "Like most with the WP/Naturethroid shortage, was switched to this drug back in 2017. On it 4 months; 120 mg/2 grains in the am, and 30 mg/a half grain in the afternoon. Managed to get back on Naturethroid right when it became available again in early 2018, not the greatest as they reformulated it and my levels were low, but at least no side effects. When my prescription for it ran out recently, I had no insurance to see my doctor again yet, and so had no choice but to take something I already had on hand. This time, after 6 hours of taking the first dose of NP, I experienced the most profound sadness/deep depression, complete with crying spells. It lasted for hours; I was in bed crying my eyes out for no apparent reason. Not like me! And that’s not all. Headache, dizziness, anxiety, heart pounding, feeling like I was going to pass out, diarrhea, vision problems, confusion/disorientation/brain fog, no appetite, “wired but tired” feeling, shortness of breath...what a list, good grief!"

2 / 10
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  • Anonymous
  • Taken for 6 months to 1 year
  • February 19, 2021

For Underactive Thyroid "I have been on Nature Throid for years and have felt great. My doctor switched me to NP after Nature Throid was recalled. I felt okay at first, and now symptoms are popping up: sore arms, depression, constipation, brain fog, weight gain, puffy skin, and fatigue. This medicine isn't consistent, and not to mention, it smells and tastes like pee. Stop recalling medicine that works for people for pharmaceutical benefit. It's wrong. This stuff is junk."

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  • Anonymous
  • October 25, 2021

For Underactive Thyroid "I was on Armour Thyroid for many years. Pharmacy recommended NP because of the price difference, so switched me to NP, and I noticed extreme flu-like symptoms, headaches, hair loss, insomnia, swelling (even facial swelling), all-over body pain, and constant exhaustion. I asked to be switched back to Armour after a month of misery on NP, and to please make note on my account to NEVER give me NP again because of the terrible reactions. After new blood work, I unknowingly was given NP again and took it without realizing that it wasn’t Armour. My life became a living nightmare! The anxiety attacks have been awful. My nails break easily, hair falls out in alarming amounts, continuous dull headaches accompanied by brain fog that has been very concerning. The feeling of exhaustion is unbelievable, and I cannot sleep. Joint pain, miserable indigestion and reflux, profuse sweating, inflammation, and muscle aches. My energy is ZERO, and the crying makes me feel crazy! NP Thyroid is HORRIBLE!!"

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  • Anonymous
  • August 16, 2018

For Hypothyroidism, After Thyroid Removal "I never write reviews, but want to share my experience with NP Thyroid by Acella. I have many of the same problems listed here already. I have taken thyroid replacement for 20 years. I had been on Armour for years; my dosage is closely monitored as my blood levels fluctuate a lot. My doctor switched my dosage, and the pharmacy filled it with the generic NP Thyroid instead of Armour. We have new health insurance. I decided to try it; maybe it would help keep my levels more steady. Three weeks in, and this is the worst I have ever felt mentally. I have never been so depressed in my life. I have dealt with anxiety, but this is different: hopeless, weepy, with a dark depression. I have gained over 10 pounds, and all I want to do is sleep. The confusion and brain fog are almost scary; I can't remember or figure out simple things I do every day. Maybe if I could give it more time, my body would 'adjust,' but I had to call my doctor to go back to Armour. There is no way I could take the NP another day."

1 / 10
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  • JFe...
  • Taken for 1 to 6 months
  • February 22, 2021

For Underactive Thyroid "Please be careful with this medication. I am barely putting it all together this morning. I was on NatureThroid for a while. I lost weight but was jittery. So my doc changed me to NP Thyroid. For 3 months, I noticed I was starting to gain weight and became extremely tired in the afternoon but thought nothing of it. Then I had my prescription refilled on 1/27, and on 1/31 everything came crashing down. I woke to my body buzzing like slight electrocution. My anxiety went through the roof, ringing in my ears (like loud buzzing), inability to focus, complete insomnia. I would wake at 12:45 every night extremely hot like a hot flash and couldn't go back to sleep (thyroid regulates body temperature). I was a zombie! I took myself off this stuff and am recovering SLOWLY because it screwed with my adrenals too. Thyroid and adrenals are linked. Awaiting blood test results to see where to go next."

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  • Sic...
  • Taken for less than 1 month
  • April 30, 2019

For Hashimoto's disease "I was on Armour Thyroid as was doing okay. Not great, but certainly better than when I was on Synthroid. Then my pharmacy changed my prescription to NP Thyroid from ACE without telling me, and I have been horribly sick to my stomach, headaches, exhausted, confused, and foggy-brained. No medicine is worth this."

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  • Cha...
  • Taken for 1 to 2 years
  • September 13, 2019

For Hashimoto's disease "Loved NP Thyroid but then started feeling really ill. Migraines, fatigue, nausea, joint pain, brain fog, etc. This was my lifesaver and now just horrible. My doctor switched me to medication from a compounding pharmacy. So disappointed in Acella Pharmaceuticals for changing what was a wonderful product."

1 / 10
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  • Jul...
  • Taken for 6 months to 1 year
  • November 21, 2021

For Underactive Thyroid "I started taking NP Thyroid in April of 2021, so a little over 7 months. I have gotten married and all in this time being on the new med. I literally felt like I was dying with the amount of panic and anxiety attacks I was having, not feeling myself, brain fog, feeling doomed, exhausted, overwhelmed, and overall just off. Instead of checking on the thyroid medication, because I have taken a few different kinds since I was 11 years old when I was originally diagnosed (I’m 35 now) and never having any side effects, I completely regret it. I literally thought I was losing my mind. The waves of emotions along with the ups and downs were just brutal. I had complete loss of my sex drive along with any feelings at all. I thought that it was stress from work and my wedding, thought I had a mental breakdown. I went as far as to see a therapist and then a psychiatrist, trying multiple medications to fix this. I stopped taking the NP Thyroid and the rest a few days ago, feeling better and better every day!"

1 / 10
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  • Don...
  • Taken for 2 to 5 years
  • December 5, 2021

For Hashimoto's disease "Switched from other brand after moving to a naturopath Dr. to help with my Hashimoto's. I really would not recommend Thyroid NP. For the last 2 years, I’ve had stomach burning, enough to make me think it was an ulcer, and loss of eyebrows and hair on my head, absolutely zero energy, leg aches, weight gain, and a massively foggy brain as of lately… I’ve been off for 3 days, and I can already feel the difference. Leaving my naturopath and heading back to my regular Dr. for Synthroid. I didn’t connect the dots until recently. And this stuff is not regulated well, it had 3 recalls in the last year… that’s not good."

3 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • August 5, 2018

For Hashimoto's disease "This medication may as well be a placebo. I only took it because of the NatureThroid shortage, and I’ve been miserable the whole 90 days. No energy, brain fog, and raging insomnia (hence this review at 4:58 AM, after finally falling asleep at 1 AM), and now screwed-up menstrual cycles to add to the joy."

3 / 10
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  • Dal...
  • Taken for 1 to 6 months
  • October 14, 2021

For Underactive Thyroid "Do not take this medicine! I have been on it for a month. My head is all foggy, and it popped in my head today to check the side effects of this drug. I can't walk straight, my head feels like I have some sort of sinus infection. I wake up several times a night. It is like I am drunk! Thank God I checked the side effects. I am stopping this medication immediately. Beware!!"

1 / 10
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  • Pun...
  • March 15, 2019

For Hypothyroidism, After Thyroid Removal "TSH went up from 1.3 to 12.8 while taking NP Thyroid. It did nothing for me but cause terrible brain fog, joint pain, stomach issues, etc. Going back to Levothyroxine and going to add a small amount of T3."

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  • Coo...
  • Taken for 1 to 6 months
  • June 17, 2018

For Hashimoto's disease "I was humming along great on Naturethroid until I couldn’t get it. Compounded worked great until I had a reaction to a batch. Now I’m on NP Thyroid and did fine at first but now have no energy and brain fog. Also, skin breakouts and lower immunity. Can’t wait to get back to Naturethroid."

4 / 10
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  • EBa...
  • December 29, 2020

For Underactive Thyroid "Armour Thyroid for many years with no issues. Armour became difficult to get, and a couple of years ago my doc switched me to Nature Throid. I had no issues. About a year ago, my prescription was filled with NP Thyroid. Since then, I've had horrible body aches, brain fog, depression, and bad anxiety. I literally thought I was going crazy! I've always been happy and outgoing. After many, many days of researching, I found comments and reviews that stated people on NP Thyroid feeling the same way I was. I've now been off all thyroid medication for over a month, and while tired, constipated, and other normal hypothyroid symptoms, I feel better. No longer crazy, anxious, and depressed. My body hurts some, but nothing like when taking this stuff. My doctor has now prescribed Nature Throid again, and I will start it tomorrow. I'm looking forward to getting my life back, laughing again, and being able to think and function. Stay away from NP Thyroid!!!!"

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  • Lan...
  • Taken for less than 1 month
  • March 10, 2021

For Underactive Thyroid "I could only last 10 days on NP Thyroid. I became so much more exhausted I couldn’t get myself out of bed. Increased brain fog. Increased headaches. Increased depression. Increased water retention. Stomach became bloated and developed constipation. I’ve been off of it for 5 days and still feeling off. I’m very sensitive to drugs, but this has never happened to me with other thyroid medications."

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.