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Methotrexate User Reviews & Ratings (Page 2)

Brand names: Otrexup, Methotrexate LPF Sodium, Trexall, Rasuvo, Xatmep, Jylamvo

Methotrexate has an average rating of 6.5 out of 10 from a total of 335 reviews on Drugs.com. 52% of reviewers reported a positive experience, while 24% reported a negative experience.

Reviews for Methotrexate

Commonly mentioned side effects
  • Pip...
  • January 16, 2013

For Psoriasis "I have been on methotrexate for 2 1/2 years. I cleared up within 2 months and have stayed cleared up! Knowing you can only have so many grams in a certain amount of time makes me sad because soon I will have to stop taking it and switch to something different. I am 39 and have had psoriasis since I was 21. I can wear shorts and a t-shirt and feel normal. Methotrexate has given me my freedom back and I have had no side effects. If you have psoriasis, you should give it a try. For me, it's been so worth it."

10 / 10
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  • TPC...
  • Taken for 1 to 6 months
  • October 18, 2015

For Psoriasis "I was diagnosed with severe advanced plaque psoriasis in Dec 2014. I was 60% covered when I first went to my dermatologist. By the end of Mar 2015, after trying one ointment after another, I was 95% covered, in pain (felt like 3rd-degree sunburn), the itching was like a million fire ant bites 24/7. I couldn't lay down or sleep. The doctor started me on Methotrexate in May. Within 6 weeks, I was totally clear and still am (10/18/15). I take 2-2.5mg tablets Mon AM & again Mon PM then 1 Tues AM for a total of 12.5 mg a weekly. I also take 1-1mg Folic Acid every day. I go in for follow-ups and blood work every 3 months but I'm fine now... thanks to Methotrexate."

10 / 10
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  • mam...
  • Taken for 1 to 6 months
  • February 27, 2019

For Rheumatoid Arthritis "I was on 12.5 mg of methotrexate per week for 6 weeks. I gradually got more tired and had more brain fog as each week went by. My hair was falling out at an alarming rate. By week 6, I was having heart palpitations. My joints felt good, but everything else not so much. I stopped using it, and after 3 days, I felt much better."

2 / 10
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89 Report

Frequently asked questions

  • Dpa...
  • Taken for 1 to 6 months
  • July 1, 2014

For Rheumatoid Arthritis "I have been on methotrexate for two months now and have slowly increased my dose to 17.5 mg/week. I started on a daily dose of folic acid but switched to a weekly dose of Leucovorin due to dizziness a couple of days after my methotrexate dose. My pain and inflammation are gone and I feel so much better. I am once again able to do the things I love and have no side effects. I'm RF negative, but my rheumatologist chose to treat me quickly and aggressively based on symptoms and a high CCP. I'm thankful she did. I hope methotrexate will be a long-term solution to treat my rheumatoid arthritis."

10 / 10
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  • Ann...
  • Taken for 1 to 6 months
  • July 31, 2015

For Rheumatoid Arthritis "When all other meds/combo of meds failed my rheumy put me on MTX (8 tabs @ 2.5 mg once a week). I still take 4 mg prednisone twice a day, 400 mg of Plaquenil at night, and folic acid every morning. It's been a long road and a lot of ups and downs but I have seen the most progress since MTX was added to my combo of meds. I still have some pain but the stiffness (which used to last most of the day) and the swelling have improved. I am always nauseous and feel lethargic the first 24-48 hours after the MTX dose but 1-2 days of that is better than the alternative. I've always been extremely active so it has been rough struggling to do simple things."

10 / 10
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  • Sav...
  • Taken for 1 to 2 years
  • December 22, 2019

For Rheumatoid Arthritis "When I was first diagnosed with RA six years ago, this methotrexate was the first medication that I was prescribed. I was just in so much pain at that time and being newly diagnosed, I just wanted to feel like myself again. But... over the course of the first three months, I gained just under 15 pounds. (And to make it worse, I was so bloated, even though I was barely eating). Then... worse yet, about nine months into my treatment, my long hair began to fall out (not in large clumps), but I started noticing my hair was all over everything. Okay, so now I have joint pain, I cannot fit into my clothes, and my hair is falling out. I was taking this medication for 14 months before I was changed, and throughout that time I am unable to say it really did anything to help me - although my doctor said it did stop “the flare-up”. Please note: even though I am no longer on this medication, I did not actually notice this helping with my joints, and I do still have flare-ups occasionally."

5 / 10
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  • Aig...
  • Taken for 6 months to 1 year
  • August 12, 2016

For Psoriasis "At age 66, after a very stressful phase of work over 7 months, I developed psoriasis very suddenly. With no previous skin problems & no family history of psoriasis either, I conclude that the stress was the trigger. I had the psoriasis all over but the worst was on my scalp - it felt like an iron band pressing in around my head. The dermatologist prescribed a whole range of creams and ointments over a year. Nothing worked. Finally in Nov. 2015 I was prescribed methotrexate + 1 folic acid tablet weekly. I was told it would take up to 3 months to kick in & it did, but in Aug. '16 I am virtually clear with no side effects. The dosage has increased to 15 mg weekly & all my blood tests are normal. But will I have to stay on methotrexate for life?"

9 / 10
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More FAQ

  • Ccd...
  • August 29, 2018

For Rheumatoid Arthritis "Please don't take this medicine. My mother had taken this once a week for 12 years. It did help her RA, but not greatly. Then she died suddenly. An autopsy confirmed this medicine destroyed all her blood cells."

1 / 10
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  • Goo...
  • Taken for 1 to 6 months
  • November 2, 2018

For Rheumatoid Arthritis "I have been on methotrexate for 6 weeks and have had no side effects. Has greatly reduced my RA symptoms along with 5mg daily dose of prednisone. I can walk again and no pain in hands. It’s worked well for me."

9 / 10
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  • Big...
  • Taken for 1 to 6 months
  • November 7, 2012

For Rheumatoid Arthritis "After many years of joint pain, finally found a physician who looked at x-rays, labs, family history, my entire medical history, and determined that I indeed had Rheumatoid Arthritis. I have noticed a significant change after being put on Methotrexate, Prednisone, Folic Acid, and Tramadol. However, now that winter is here, joints are worse and I am now on the highest dose of Methotrexate (20mg) a week but I'm able to get out and do more with less pain than before."

8 / 10
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  • All...
  • May 7, 2016

For Psoriasis "I was diagnosed with psoriasis at the age of 14. My life was hell by the time I was 18. It covered pretty much everywhere the sun didn't shine. I tried everything topical, UV light and sunbathing, different diets - you name it, I tried it. In my 30s, I accepted that the only way I was ever going to have relief was by sunbathing once every three or so months until I was so burnt it forced the psoriasis to slow down. I met a random stranger who saw my psoriasis and mentioned methotrexate. He told me his story, so I gave it a try. I hope the people who are complaining after six or even seven weeks stay the course. It took me four months to see results. I am 40 now and have been 95% clear for the past eight years. 12mg once a week."

9 / 10
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  • pet...
  • January 12, 2011

For Rheumatoid Arthritis "This medicine is wonderful. Without it, I could not move my fingers, wrists, knees, and ankles. I feel normal, and people cannot believe that I have RA. The only downside is my skin on my arms is thinned and very easy to bruise, bleed, and mark. But this is a small price to pay for a normal lifestyle and to be able to work."

10 / 10
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  • Dor...
  • Taken for less than 1 month
  • October 4, 2014

For Rheumatoid Arthritis "Just taken my third dose of methotrexate this week (upped to 20mg after 2 weeks on 10mg)... take folic acid 5mg 3x a week. So far, side effects have been manageable. Not sure if it's the medication or the steroid injections, but I am starting to feel like my old self again. No swelling and little pain now, so I am now able to do the things I used to take for granted again. Feel hopeful about this medicine."

8 / 10
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  • Mis...
  • July 19, 2015

For Rheumatoid Arthritis "I got my RA seven years ago and have taken MTX since then. For me, it has worked great. I had no weird side effects either. I took 8 tablets a week for seven years, but now I'm down to 6 tablets... and it works great too. I am Swedish, and our MTX looks a bit different."

10 / 10
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  • Pea...
  • October 23, 2016

For Rheumatoid Arthritis "I was started on Plaquenil when diagnosed with RA about two years ago at the end of summer. I told the doctor there was no way I would take MTX. By the following late spring, I had what took me a while to realize was a major flare-up. I already had one pointer finger that couldn't bend, and now the other one was stuck in the out position. I couldn't make fists. So, I started on MTX once a week, along with 1 mg of folic acid per day. After about two months, I began to see improvements. After a longer time, my doctor said I was in remission. I take both Plaquenil and MTX, with few side effects. On my MTX day, and the day after, I'm sometimes low energy, and often slightly queasy. Not enough to keep me from eating entirely."

10 / 10
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  • Anonymous
  • October 19, 2012

Methotrexate for Rheumatoid Arthritis "Took methotrexate for 6 months after diagnosis for Rheumatoid arthritis, seemed to work fairly well for the pain/stiffness, but I had terrible side effects including nausea, fatigue, mood swings - almost couldn't get to work, coming up stairs felt like my feet weighed 500 pounds each - almost could not function at all. Now going to try an injectable form to see if that will not cause the side effects - hopeful."

2 / 10
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  • Anonymous
  • October 13, 2011

For Rheumatoid Arthritis "I'm 30 years old and have been on 20mg of methotrexate for 2 years now. While I have experienced some side effects (mainly abdominal pain), I would not and will not stop taking it. So far for me, the benefits have far outweighed any costs of being on methotrexate. The disease activity has dropped, and I have far less swelling in my wrists, fingers, and shoulders and have been able to get back into bowling leagues which I love."

9 / 10
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126 Report
  • Lar...
  • May 14, 2016

For Rheumatoid Arthritis "I had taken methotrexate for 21 years through the VA, plus Enbrel, Humira, folic acid, and more. Well, this is a warning. I now have NASH, which is a disease caused by the medications, leading to cirrhosis of the liver. It is incurable. Just change foods. Pray it doesn't get worse."

10 / 10
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  • Mrs...
  • Taken for 1 to 6 months
  • June 9, 2014

For Psoriasis "I have suffered with psoriasis since I was 19 years old, now in my 40s, I have tried everything on the market. I have been on methotrexate since New Year's Day, and I am so happy to say that it has nearly all gone. I can holiday with all my friends and don't feel embarrassed. I am so happy. I would recommend it. It's a slow process, but five months in and pretty much clear. No side effects, just tired on the day of medication, but that's not an issue."

9 / 10
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  • flu...
  • Taken for 6 months to 1 year
  • April 5, 2013

For Psoriasis "I've had severe psoriasis, which covered me head to toe since I was 5. I'm now 30. Tried every trick in the book from lotions and potions, light therapy, & homeopathic remedies. I put off taking methotrexate for fear of becoming a glow-in-the-dark alien with the side effects! Finally gave in last year and so glad I did. It cleared within 3 weeks. I'm now on 15mg a week and only have slight patches of psoriasis dotted about. Had a few bad headaches now and then but nothing extreme. A little wobbly on the blood tests but nothing life-threatening just yet. Much better quality of life at the moment, and much less hoovering, haha."

9 / 10
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114 Report
  • Nig...
  • Taken for 10 years or more
  • February 8, 2016

For Rheumatoid Arthritis "I am 62, and was diagnosed with RA about 10 years ago. I have been through a battery of drugs to suppress my immune system, ending up on subcutaneous methotrexate 10mg. I originally had a 'bad day' the day after my injections, however, it seems to be getting to be a bad couple of days lately. Intense pressure headache (I'm also a migraine sufferer), nausea, confusion, tiredness, and now really troubled sleep, nightmares, and some visual disruption (almost hallucinations), feelings of panic, unease, and claustrophobia. I know the alternatives, stop and face RA full on, but I would rather get 3/4 good days than be on the road to being completely disabled."

7 / 10
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  • Nak...
  • July 1, 2013

For Rheumatoid Arthritis "I have taken methotrexate for 17 years and am now on 20mg per week. I have also been on Rituximab infusions for the past 3 years, and together, the two medicines work very well. I am mostly pain-free, except for mornings."

8 / 10
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114 Report
  • ACS...
  • July 5, 2014

For Rheumatoid Arthritis "I have been on methotrexate for almost a year. I am up to 20 mg a week. I take folic acid and leucovorin calcium 12 hours after the methotrexate. I was taking Enbrel but now take Xeljanz. Before the biologics, the methotrexate wasn't working very well. I take prednisone too. I am only 36 but at least I can function better than I did. I still flare about twice a month. I suffer side effects from methotrexate. My hair has severely thinned out and I get very tired after taking it. It looks like I'll be on it for a long time though. Hopefully it gets better. I would really like my hair to come back."

6 / 10
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107 Report
  • Uk ...
  • Taken for 1 to 6 months
  • August 15, 2012

For Rheumatoid Arthritis "I have only been taking this medicine for a short while and the benefits are good so far. I am still able to keep working as a paramedic, which is physically demanding. Without my 20mg, I slowly turn into a statue."

8 / 10
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  • sca...
  • Taken for less than 1 month
  • December 30, 2013

For Psoriasis "I have had psoriasis on my scalp since I was a baby with 'Cradle Cap.' It was left untreated until I was about 21. I have tried every cream and t-gel out there. Nothing cleared it up fully. Since I turned 24, the condition has spread to other parts of my body, usually parts that don't get much light. Psoriasis is terrible and affects everyone so differently. This condition has kept me from getting close to people and even kept me from going to hairdressers. Finally, I decided to start this medicine. I'm currently on my fourth week of 15mg oral methotrexate. I have noticed a huge decrease in itching, and my patches seem to be not as scaly. I really hope this works, so far so good."

9 / 10
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102 Report

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