Skyrizi User Reviews & Ratings

• Anonymous
• Taken for 1 to 2 years
• December 1, 2022

For Crohn's Disease "I'm in a clinical trial taking Skyrizi to treat my Crohn's disease symptoms. I've been injecting the medicine every 8 weeks for at least the last two years and I'm happy to report I've been in remission and symptom-free. The downside: it has wreaked havoc on my immune system and I get sick with everything to the extreme now. My body cannot fight off anything I'm exposed to. I've also gained a major amount of weight: 30 pounds in one year! My doctor says it's normal because I'm not in malabsorption anymore, but it's as if my metabolism has slowed versus absorbing. I don't eat any more than usual, yet keep gaining weight."

• Anonymous
• Taken for less than 1 month
• November 9, 2020

For Plaque Psoriasis "In October 2020, I took my first starter dose of Skyrizi. Within one week, I noticed my skin stopped flaking and started clearing up. After four weeks, my skin is almost cleared up. My body was 80% covered with plaque psoriasis. In November 2020, I will be taking my first full dose. I am very happy with the results. The only side effect I have noticed is urinating more than normal."

• Waf...
• Taken for 1 to 2 years
• December 27, 2024

For Psoriatic Arthritis "I've been on Skyrizi for 1 year now. Psoriasis flaking on the skin disappeared within a week of my first loading dose. PSA was my main issue, afflicting my hands/fingers and right knee. Joint stiffness and pain is about 90% gone. Most days, I don't think about joint pain. As the next injection date draws near, I notice swelling and joint pain start to creep back into my life, but nowhere near the intensity it was to begin with before my Skyrizi journey. I take 1 injection every 12 weeks, and it is very easy to administer on my own. I don't know what I'd do without it, it has helped me live my life."

• mmi...
• Taken for 1 to 2 years
• September 8, 2021

For Plaque Psoriasis "Been taking Skyrizi for more than a year now after failing on several other biologics, systemics for plaque psoriasis. Also went onto this medication with high blood pressure and heart issues and long COVID symptoms. It cleared me within 4 weeks, and I would say has the least amount of side effects out of any other biologic systemic I have taken. It also seems to control other miscellaneous inflammation, and I have not become immune to it quickly, unlike other medications. Not a single lesion has returned, I am 100% clear from having 20% severe coverage prior. I did get pneumonia recently, unfortunately for the 4th time, but antibiotics cleared it within a week. You do need to watch for infections, if you are not getting better on your own, see a doctor. This will happen on any biologic or systemic as it's my 4th time going through that. After what I have experienced, Skyrizi's benefits outweigh the risks, and in my opinion, would be the least risky internal treatment for psoriasis."

• MJP...
• Taken for 1 to 6 months
• November 29, 2022

For Plaque Psoriasis "I've just had my 3rd dose of Skyrizi, and I couldn't be happier. I've had psoriasis for over 60 years, and I figured it was about time for me to get a break. My plaques were mostly mild until I turned about 55. Then they just started appearing everywhere, to the point where all I was thinking about was how to get rid of them. I'm a very healthy person -- I exercise daily, don't drink alcohol, don't smoke, and I'm not on any medications at all. But no matter what, the plaques just kept coming. I resisted medication for years because I just don't like taking drugs. But I finally caved and started Skyrizi. For me, the really noticeable effects started with the second shot. For the first time since I was 3 years old, my scalp is totally clear of plaques. My elbows, knees, and torso are totally clear. I have a random spot here and there, but that's it. Skyrizi has been great for my psoriasis, but also great for my mental health -- I no longer worry about plaques all over my body."

• mgc...
• Taken for 1 to 2 years
• September 15, 2023

For Crohn's Disease "This drug has been an absolute miracle and should be the first-line treatment for many Crohn's patients to speak to their doctor about. After 13+ years of different medications, this is the only one that has given both symptom relief and also a 90% improvement in inflammation/lab markers. Honestly, it delivers what the commercials promise. However, it is very expensive and critical to have good insurance. The on-body injector is the easiest and most pain-free injection method I have had. It took about 6 months to really see marked results in labs. In my journey, I've tried Humira (became ineffective), all the pill/foam/suppository options (zero improvement), Entyvio (worked some but the infusion center schedule was difficult with my work travel), lastly Stelara and Cimzia, which caused neurological issues including a tonic-clonic meltdown with Cimzia specifically. I cannot think of any side effects to date other than no longer looking for a bathroom constantly. Nothing is truly everything."

• J J...
• Taken for 1 to 6 months
• February 11, 2022

For Plaque Psoriasis "I have plaque psoriasis, and I have tried the pills, but nothing has worked like Skyrizi. I have only had my second dose. My scalp and skin look great, the redness and flakes. Not a lot of side effects. I even had Covid just before my second dose. Everything went well. I am so glad my doctor started me on this medicine."

• NEK...
• Taken for 1 to 6 months
• August 19, 2024

For Psoriatic Arthritis "I have PsA and psoriasis, HLA-B27+ with elevated monocytes 900+. The 1st week after taking your first dose, you’ll feel like crap since your immune system gets all scrambled, but after that, you will find significant joint improvement and experience less fatigue. Also got a headache, felt mildly nauseous, and had slight constipation. Your intestines have to adjust, almost all PsA patients have some hidden intestinal inflammation as this disease is systemic (impacts the entire body). It feels like a disease flare-up + sinus infection at the same time, lol. The headaches were tension/sinus type. Your joints will hurt more the 1st week. It’s normal, stick with it. I was able to shower and wash my entire body standing up for the first time in 10 years tonight. Usually, I can only wash 50% before my back gets too stiff, my feet begin to burn/throb, and my muscles in my upper body give out due to muscle and systemic fatigue. I’m 36F, btw."

• Gre...
• Taken for 1 to 6 months
• November 21, 2022

For Plaque Psoriasis "WOW!!! I have been suffering from psoriasis ever since my first Moderna COVID jab in May 2021. I broke out head to toe in red, itchy circles, and my scalp was the WORST! My scalp was shedding dandruff everywhere. I saw four different dermatologists, and I got many topical treatments, and I tried every OTC and holistic treatment, but within four days of my first dose of Skyrizi in August 2022, my psoriasis cleared up - 100%. ONE HUNDRED PERCENT. Zero side effects. I’m on my third dose, and I’m still 100% clear and I have zero side effects. I am so over the moon happy with this medication. I can finally sleep well at night because I’m not itching. I can finally wear black again. I got my life back. It took a lot of effort on my part to get a dermatologist to finally prescribe me it, but it’s soooooo worth it!"

• Bil...
• Taken for 1 to 6 months
• December 29, 2023

For Crohn's Disease "I have had the two infusion doses. No side effects except my anemia is worse. Which may not be related. It is almost like I don't have Crohn's anymore. I was doing well with Inflectra but developed antibodies to it."

• Rob...
• Taken for 6 months to 1 year
• April 2, 2023

For Psoriatic Arthritis "The effects of the medication were slow-acting, but I was told this. After four shots, I have a 90% reduction in psoriasis and a 100% reduction in dactylitis. Joint stiffness starts to come back a few weeks prior to the next dosage, but I have been taking the medication for just less than a year. Overall, I am happy with the results."

• Pat...
• March 15, 2025

For Psoriatic Arthritis "I changed from Otezla to Skyrizi without problems. I didn’t realize the Otezla had been giving me diarrhea, I thought it was from lack of bowel movement, but once on the Skyrizi, my weight has jumped 20+ pounds, and no more diarrhea. My arthritis has been under control, and no psoriasis on skin in the usual places."

• Amy...
• Taken for 6 months to 1 year
• March 8, 2024

For Psoriatic Arthritis "After 2 years of trying six different biologics, my rheumatologist and I finally found one that has helped my severe PsA - Skyrizi. I use the prefilled syringes and it is so easy to dose. After two starter doses, I only have to inject once every three months! Pretty amazing! Although my symptoms are not gone, my joints feel so much better. I would say they have improved by 75%. I have only had one side effect that I get sometimes - cold sores on my lips. I use Aqaphor once or twice a day, which helps a lot. Thank goodness I have an aggressive and very positive rheumatologist. His work and this drug have made a huge improvement to my quality of life."

• R B...
• Taken for 1 to 2 years
• June 25, 2021

For Psoriasis "I have been on Skyrizi for over a year and a half now. My psoriasis cleared up soon after the initial doses. My skin has been clear and smooth. I had no bad reactions to this drug, and it has been a Godsend. Would highly recommend. I get mine from AbbVie at no cost."

• Pac...
• Taken for 2 to 5 years
• August 4, 2023

For Plaque Psoriasis "In two months, the plaques were no longer spreading and stopped itching. After 6 months, they were fading, and after 2 years, I have perhaps 1 dime-sized eruption every few months. I can wear shorts again!"

• Cla...
• Taken for 1 to 6 months
• May 2, 2022

For Psoriasis "I had a really bad stomach pain followed by a crazy itching all over my body. I’ve taken two doses of Skyrizi, and I had the same reaction twice, a month apart. How can I get rid of these symptoms? I’m so scared that it will happen again. I’m never taking Skyrizi again!"

• Gle...
• Taken for 1 to 6 months
• April 8, 2024

For Crohn's Disease "Previously on Entiviyo until efficacy declined and symptoms came back. Skyrizi chosen due to past history with CNS lymphoma. Symptoms disappeared after initial dosing of Skyrizi. Just had my second 8-week interval self-dosing and still no Crohn’s symptoms. I have had a bout of pneumonia (not new for me) while on Skyrizi. My immunoglobulin G was just tested and is slightly below acceptable range. Self-dosing is easy to do and have had no problems."

• Bil...
• Taken for 1 to 6 months
• December 29, 2023

For Crohn's Disease "I have had the two infusion doses. No side effects except my anemia is worse. Which may not be related. It is almost like I don't have Crohn's anymore. I was doing well with Inflectra but developed antibodies to it."

• ASG...
• Taken for 1 to 6 months
• September 5, 2024

For Plaque Psoriasis "At the age of 70 years old, I developed psoriasis. A few months later, I was in full-blown plaque psoriasis everywhere on my body. I had an emergency visit from my skin doctor. She recommended I try Skyrizi. By the second dose, almost all my plaque psoriasis had disappeared. I cannot express how happy I am. I highly recommend it to anyone who may be suffering from plaque psoriasis. It has also helped a lot with my joint pain."

• Fer...
• Taken for 6 months to 1 year
• October 16, 2023

For Plaque Psoriasis "Overall, I have had a rather good experience with Skyrizi. Unfortunately, I have experienced a lot of itching, not of a dangerous nature, but the psoriasis, for which I take the medication, has been pretty much cured. I have, however, had a raving appetite on this and I have also begun to suffer hair loss (hair is coming out in handfuls and has gone VERY thin). On the whole though, my experience has been okay."

• Pap...
• Taken for 1 to 2 years
• August 21, 2021

For Plaque Psoriasis "Worked great, but I had to stop taking due to upper respiratory infections. Before taking this, I never got an upper infection. My first injection, I wound up in the hospital with sepsis, double pneumonia incubated 3 days. I tried taking for a year but had to stop. Worked great."

• Gut...
• Taken for 1 to 6 months
• March 19, 2025

For Crohn's Disease "100% not saying this will happen to you, but I do want to report what happened with my wife. She has taken many biologics over the years from Remicade to Entyvio and beyond, and this is the first time this has ever happened to us. We began the treatment in November 2024, and as of today, March 2025, all of my wife's hair has fallen out. Now she is not like the poor cancer chemo patients who go completely bald, but she has just stubble now, and we have had to purchase a wig for her. It seemed to be working basically just... okay, but the hair loss is just too much for us, and we are jumping ship at this point. She had the best response to this, 'If it is doing this to me outside, I can't imagine what it is doing to me inside!' She is spot on. I hope you have better results, and I hope that the drug company does not force this to be removed, there are also several reports of this on Reddit as well. Good luck and keep fighting the good fight."

• Ke ...
• Taken for 1 to 6 months
• November 27, 2022

For Plaque Psoriasis "To get started, I spent $3,300 to begin my initial dose of Skyrizi. After which, I used Abbie Assistance for my following two doses (every 2 months). So far, it's controlling my plaque psoriasis quite well, but why is it $21,000 for its retail cost (per injection)? It's quite ridiculous! We find it excessively expensive, and I'm a 100% disabled veteran. The VA will only pay for a medicated tape, which is useless in trying to control plaque psoriasis all over the body!"

• mmi...
• Taken for 1 to 2 years
• March 18, 2022

For Psoriasis "Went into Skyrizi failing every other biologic system you could think of before it, trying to treat plaque psoriasis and arthritis for 12 years. Although it cannot treat the PSA for more than a month per loading dose, Skyrizi not only cleared my skin quicker than the competitors, it also didn't have a severe effect on my existing health conditions, unlike the rest. In fact, I noticed some of those other conditions improve temporarily. I have also been able to enjoy a flexible diet and other bad habits without a single lesion or breakout since starting it. I cannot break the effectiveness of this biologic no matter what I eat or drink. I would say, based on my experience, it is the least risky and most effective thus far and has taught us the IL-23 pathway is critical to treating many other autoimmune diseases."

• ric...
• Taken for 1 to 2 years
• April 30, 2024

For Psoriatic Arthritis "Have been treating with several drugs over the past 8 years. First with no side effects for me. Pain & swelling returns 4 to 5 weeks prior to next injection, 10 days later I'm great again. Believe injections should be sooner as 3 months is a long time for any med to last. First one I can tolerate without rashes, medical side effects. Will keep taking it..."