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Saxenda and Sick: What Users Say

Sick: mentioned by 59 users (4.1%)

Based on user experiences from 1,448 Saxenda reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

nausea 38.2%
constipation 12.8%
headaches 10.8%
tiredness 8.1%
vomiting 7.7%
diarrhea 7.5%
fatigue 6.8%
heartburn 4.4%
loss of appetite 4.1%
sick 4.1%

Reviews for Saxenda

Commonly mentioned side effects
  • Joh...
  • Taken for 6 months to 1 year
  • September 14, 2019

For Weight Loss (Obesity/Overweight) "Worked wonders for me. I could barely make it through the first six weeks. The sickness and nausea along with other painful side effects... but into my seventh week, which put me into my second week at a 3.0 dose, I started to feel normal again. I am into my eighth month, and I have lost 65 pounds along with Saxenda, eating right, and taking the stairs... if you are having a rough go of this, please stick it out. I am living proof this works!"

10 / 10
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211 Report
  • Sta...
  • Taken for 1 to 6 months
  • June 28, 2019

For Weight Loss (Obesity/Overweight) "I am a Latina female who is 5'4" and about to turn 39. I started taking Saxenda on May 13th at 332.6 lbs. I was really ill and started a low-calorie diet and tried to get at least a small walk in daily. I have lost almost 40 lbs already, which is just so crazy! When I first began taking the medication, I had headaches and I did feel sick and nauseated for the first few days. I almost wanted to quit, but I told myself this was very important to me, and I worked through it. Every time I upped my dosage, I had a day or two where I felt a bit queasy, but it passed quickly. I no longer feel sick from the medication, and I find it helps me to feel very full very quickly, and that it is almost like gastric bypass in a needle. I also no longer crave sugar, which is a huge deal for me. I think it is amazing, and I would recommend it to anyone considering gastric bypass. They should definitely try this first!"

8 / 10
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128 Report
  • moo...
  • Taken for less than 1 month
  • March 23, 2021

For Weight Loss (Obesity/Overweight) "I have just moved on to my 3rd week and just upped my dose to the 1.8 mg. The side effects have been quite severe for me. I am feeling very dizzy when I stand up, lethargic, and feeling very sick. I have no appetite at all, so I have been forcing myself to eat. I have lost 3 kg - 6.61 pounds in just over 2 weeks. I'm not going to lie, it's not making me feel good at all. But I know it will all be worth it in the end. Working full-time probably isn't the best thing, I think it would be much easier to do this if I was at home all the time. I'm hoping the side effects will subside soon, and I can go about my day normally."

7 / 10
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48 Report

Frequently asked questions

  • Exo...
  • March 11, 2021

For Weight Loss (Obesity/Overweight) "Works great, I lost 8.4 lbs in the 1st week, but at a cost. Never so sick in my life! Threw up everything but my spleen! Started out with the belching. Sounded like an old drunk. Then the bloat began. My stomach looked and felt like I swallowed a hot air balloon. Next, the diarrhea, nothing but pure liquid. At this point, I was a little concerned about becoming dehydrated. Finally, the vomiting, the violent, whatever you ate was coming out of your nose kind of vomiting. I was like, 'There is no way a medicine could make a person feel this bad!' But it can, and did! However, I still feel this could be a good weight loss solution, especially since I have high BP, and this doesn't have stimulants and is 'safer.' Reading over other reviews, some people are having great luck with it. My doctor called me in Zofran, and I'm only going to do 0.3 every other day to see if my body adjusts. If I don't see an improvement in 2 weeks, I will just accept this is not a medication for me and go another route."

6 / 10
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46 Report
  • She...
  • Taken for 1 to 6 months
  • February 5, 2020

For Weight Loss (Obesity/Overweight) "I have been on Saxenda since December 9, 2019. I have upped my dose according to my doctor. I have now lost 17 lb. I am now on full dose since the beginning of January. It's only now that I am suffering really badly with sickness and diarrhea. I am waiting to hear from my doctor to decide a way forward. I really don’t want to stop taking it as I feel it generally works for me and my lifestyle."

8 / 10
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43 Report

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  • Jen...
  • October 22, 2019

For Weight Loss (Obesity/Overweight) "Just started taking Saxenda on Sunday, October 14. My start weight was 112.2 kgs (247 pounds). I weighed myself on Sunday, October 20, and the scales really shocked me, it said I was 108.4 kgs (239 pounds). I have been overweight and dieting all my life. I was recently diagnosed with PCOS. Losing weight has been very hard. I track my steps and calories, I have been reducing the size of my meals. I had half a tuna sandwich and had to stop eating. The drug works on suppressing appetite, but the side effects are also very high for me. I have had diarrhea, constipation, lack of energy, headaches, feeling sick, and vomiting. I have dry mouth and am taking Hydralyte to compensate for the lack of fluids I can keep in my system. I am in two minds about this drug, I don't know if I am going to continue it after I finish the 5 pens in my first box. The drug costs so much, $389 Australian, and can't claim anything back on my private health."

6 / 10
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41 Report
  • Win...
  • Taken for 1 to 6 months
  • February 22, 2017

For Weight Loss (Obesity/Overweight) "I wrote a review previously after a few days of taking Saxenda. I am now on my 4th week (2.4 mg), and so far, I have lost 18 lbs! I am so happy. This is based on minimal exercise and just eating healthily. As many people have said, it does curb your appetite. I could normally eat a full plate, but now my body lets me know when I am 'full,' and I can literally not eat more than half a plate. Any more than that, and I will start to feel sick. I also stay away from fatty foods; again, trying to eat this will also make me feel sick afterward, so I have been on grilled salmon and vegetables most nights for dinner. I get incredibly thirsty, so I have a liter water bottle with me everywhere I go. This also helps me feel less hungry."

9 / 10
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More FAQ

  • Rob...
  • Taken for less than 1 month
  • March 8, 2017

For Weight Loss (Obesity/Overweight) "I started on Saxenda on February 14, 2017. My weight was 295 lbs, I am 6'3" tall and 55 years of age. Today it is March 8, 2017. When I began using this product, I experienced some sickness, itching, and I was very tired, however, the appetite suppression effect was immediate. As such, I modified my diet to include more healthy and 'weight loss friendly' foods. I also upped my doses every 4 days instead of every week as recommended. I am very pleased to announce today that all of the symptoms except the itching have resolved themselves. I have been on a full 3.0 dose since March 2nd. At this time, I am 281.2 lbs, which is down about 14 pounds. My goal is a 50-pound weight reduction, and I feel that, with Saxenda, this is a very realistic goal."

10 / 10
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42 Report
  • Syr...
  • May 25, 2021

For Weight Loss (Obesity/Overweight) "I am currently on week 3 of taking Saxenda. The first night was horrible. My advice is to eat very small meals the first day of taking this medication. I ate a very normal portion meal and was extremely sick my first night. After that, I was weak the next day (lack of sleep from the night before). That was the only issue I've had so far. I eat very small meals and have posted 10 pounds in two weeks. Overall, I do feel a bit tired from the medication, and I got my period 6 days early (coincidence? Maybe). Satisfied so far. Will give an update after my six-week supply runs out."

8 / 10
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20 Report
  • P H...
  • February 8, 2017

For Weight Loss (Obesity/Overweight) "I've been on Saxenda since January 10th. I went to my follow-up Dr. visit and down 11 pounds, no exercise. Along with a 1500 calorie diet, she did encourage me to start exercising. I have noticed if I even attempt to eat the wrong foods, I get sick. This medicine REALLY WORKS!!"

10 / 10
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35 Report
  • Ste...
  • Taken for 6 months to 1 year
  • March 10, 2018

For Weight Loss (Obesity/Overweight) "Titration period is going to suck for some people! You may be really sick like I was. Go slow, not everyone can bump up every week. If you eat bad, you will pay for it and be extremely sick the next day. I’m 6 months in and have lost 50 lbs. I don’t get sick anymore unless I eat bad, and then your body warns you with egg burps that all hell is about to break loose. If you can power through the titration period, it’s worth it and will get better! I’m down 50 lbs."

10 / 10
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25 Report
  • Hal...
  • September 9, 2016

For Weight Loss (Obesity/Overweight) "Been on Saxenda for 6 weeks and have lost 19 pounds. I was sick for the first 2 weeks, guess my body was getting used to it. Now I'm fine. I love it. I have tried so many other things. This is the best."

9 / 10
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29 Report
  • gir...
  • Taken for 1 to 6 months
  • November 1, 2019

For Weight Loss (Obesity/Overweight) "The first week I took Saxenda, I felt so weak and sick, but lost 4 kilos. The second week, I felt better and lost 3 kilos. Then it just stopped working. I was back to hungry all the time and stopped losing weight. Stayed on it for 2 months nearly and still nothing. Can't afford to keep paying $400. If it was a fair price, I would have continued it."

5 / 10
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22 Report
  • Ins...
  • March 22, 2016

For Weight Loss (Obesity/Overweight) "Started on Feb 11, 16. Now at 3.0 max lost 12 lbs so far. Same thing, never hungry but still have dry mouth. Still feel a little sick after shot but not too bad. Heartburn can be bad at times, but starting using an acid-reducing product. One pill works well, maybe 12 hrs, not so for Tums or Rolaids, have to take too many, plus makes me sick. Taking shot after breakfast, good time for me. My work plan pays 80%, which is great. I will continue till I lose 50. First time in my life I don't think about food, so it's worth it... Stay positive, everyone."

10 / 10
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28 Report
  • Lau...
  • Taken for less than 1 month
  • October 19, 2019

For Weight Loss (Obesity/Overweight) "So I first took Saxenda in January, then I stopped sleeping and couldn't eat. I did lose weight, though, but the sickness was awful, and I stopped due to the inconvenience of constant bleeding as if I was on a constant period. I was so weak, then, a few weeks after, I was rushed into the hospital with abdo pain, it was pancreas and gallstones. Grrr, anyway, I started back on Saxenda 3 days ago. I inject at night, no bleeding, no sickness, and just a bit of migraine. Ohh, and acne, never in my life have I had bad skin - well, now I do. Apart from that, side effects are all good here ... however, I'm still so hungry, it doesn't seem to have curbed my appetite this time around, so I'm thinking of upping the dose earlier than prescribed. I guess I will update on weight loss in a few weeks."

5 / 10
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22 Report
  • Not...
  • August 10, 2019

For Weight Loss (Obesity/Overweight) "Having been sold it by a company that glamorizes it with celebrities like Kerry Katona, feeling a little overweight with a BMI of 27. I was prescribed this for 5 pens that worked out to £650. The side effects were really bad headaches, feeling sick, but I still managed to eat. I did more exercise and did not lose a pound. The nurse told me to stay on it, so I did for 6 months until I realized I was depressed and now owing £2000 to my bank! I was feeling worse than I ever did. Didn’t want to go to work, but I was still encouraged to stay on it as it had to work. I ended up really down, was a risk to myself, and so was told not to take Saxenda as it was a new drug and not enough was known about it. There had been 5 others via yellow card who had suicidal thoughts and a list of depression. When my mental health searched the makers Novo, it states people with a history of depression or suicidal thoughts should not take this."

1 / 10
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23 Report
  • suz...
  • Taken for less than 1 month
  • May 25, 2022

For Weight Loss (Obesity/Overweight) "On week 3, I lost about one stone. Took about a week to get used to it. During week one, I felt sickly, had some lightheadedness, constipation, but it passed after about a week. Now on a 1.8 dose, and all is well. My appetite has decreased massively, and sometimes I have to remember to eat. I won't deny the first week was a little ropey, but my advice would be to stick with it as it does improve. For me, this is a wonder drug! I have battled all my life with weight, and this has had such a positive impact on my mental health and my overall well-being. Amazing!"

10 / 10
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11 Report
  • Sma...
  • October 10, 2016

For Weight Loss (Obesity/Overweight) "I began this medication 6 weeks ago. I read reviews first and thought, wow, this might work. Over the last 10 years, I have lost 135 lbs through diet and exercise. I am recovering from an injury and can't workout with the intensity I had, so I began this drug. I didn't notice any side effects or loss of appetite. The next week, I increased the dosage with no results either. From reading reviews, I thought, what's wrong with me that it doesn't work? I increased the dosage the third week only to feel sick, and thought, I don't want to feel this way. I rarely put reviews up, but I want people to know it's not just them, it didn't work for others as well."

2 / 10
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25 Report
  • Mrs...
  • Taken for less than 1 month
  • November 18, 2018

For Weight Loss (Obesity/Overweight) "I started using Saxenda on 31st October to help aid weight loss. I was extremely worried about all the side effects, but I have lost 11 lbs since. Yesterday, I increased my dosage to 1.8, and today I have suffered massively with feeling sick and having pains in my stomach. I am going to reduce my dosage back to 1.2 and continue until I feel it is no longer working. So far, I'm really happy with the results!"

7 / 10
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18 Report
  • GGa...
  • Taken for less than 1 month
  • December 12, 2020

For Weight Loss (Obesity/Overweight) "First time taking Saxenda, no problems. Increased dosage as stated, lost 8 lbs in a month. Two years later, got a new Saxenda pen, have been violently sick, felt ill, and extremely tired every day. Now I am covered in a rash, even on my eyelids, short of breath, pale, sickly, burning sensation. I took it for 2 weeks, stopped 2 days ago, and feel like death. No clear help anywhere on what to do, how long it takes to get out of your system. There's a COVID epidemic, can't get into doctors. Feel really silly I didn't click on straight away that the pen was making me sick, I thought I had food poisoning. Then I took a COVID test and got a negative result, thank God. But that's how ill I've been, I actually thought I had COVID."

1 / 10
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26 Report
  • GGa...
  • Taken for less than 1 month
  • December 12, 2020

For Weight Loss (Obesity/Overweight) "First time taking Saxenda, no problems. Increased dosage as stated, lost 8 lbs in a month. Two years later, got a new Saxenda pen, have been violently sick, felt ill, and extremely tired every day. Now I am covered in a rash, even on my eyelids, short of breath, pale, sickly, burning sensation. I took it for 2 weeks, stopped 2 days ago, and feel like death. No clear help anywhere on what to do, how long it takes to get out of your system. There's a COVID epidemic, can't get into doctors. Feel really silly I didn't click on straight away that the pen was making me sick, I thought I had food poisoning. Then I took a COVID test and got a negative result, thank God. But that's how ill I've been, I actually thought I had COVID."

1 / 10
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26 Report
  • GGa...
  • Taken for less than 1 month
  • December 12, 2020

For Weight Loss (Obesity/Overweight) "First time taking Saxenda, no problems. Increased dosage as stated, lost 8 lbs in a month. Two years later, got a new Saxenda pen, have been violently sick, felt ill, and extremely tired every day. Now I am covered in a rash, even on my eyelids, short of breath, pale, sickly, burning sensation. I took it for 2 weeks, stopped 2 days ago, and feel like death. No clear help anywhere on what to do, how long it takes to get out of your system. There's a COVID epidemic, can't get into doctors. Feel really silly I didn't click on straight away that the pen was making me sick, I thought I had food poisoning. Then I took a COVID test and got a negative result, thank God. But that's how ill I've been, I actually thought I had COVID."

1 / 10
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26 Report
  • Sad...
  • Taken for 1 to 2 years
  • June 24, 2022

For Weight Loss (Obesity/Overweight) "Saxenda made me sick the entire time I used it, and I lost about 20 lbs (I am active and work out 4-5 times a week and eat a healthy diet) initially. After I stopped taking it, the weight came back and more. No matter what I do, exercise and monitor diet, I cannot lose weight as I have many times in my life. Somehow, I feel Saxenda altered my metabolism irrevocably. I DO NOT SUGGEST ever using this drug."

1 / 10
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16 Report
  • ILo...
  • February 8, 2017

For Weight Loss (Obesity/Overweight) "I started with this drug on Tuesday, not too bad when taken at bedtime, however, I wanted my injection time to be first thing in the morning as this is much easier for me time-wise. Today was the second injection-oh my heavens, can we say morning sickness?! That is exactly what it feels like. I have virtually no appetite. I tried to eat a little something (I had been on Dr's orders to fast for blood work), so let me tell you how that went-it didn't. I could not get past the taste of food in my mouth, I was physically ill. I stopped at SBUX and bought a hot tea-oh heaven! I was able to soothe my stomach and feel a little bit better. I have to muster through work regardless of how I feel. I am hoping for results-not a miracle. Here we go!"

8 / 10
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20 Report
  • Tur...
  • Taken for 1 to 6 months
  • November 6, 2017

For Weight Loss (Obesity/Overweight) "6 weeks in and I've seen some great results! Started on 86 kgs, now down to 79.9 kgs. Here are some great pointers for people to use. 1. An eating plan is very important. 2. Regular exercise that keeps your heart pumping at least 3 times a week. 3. Don't inject more than 1.2 ml, otherwise, it makes you hurl, literally, and you won't be able to keep food down. 4. Have one day off a week with no injection. 5. Have your cheat meal the day you don't inject, otherwise, it makes you feel sick."

9 / 10
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19 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.