Skip to main content

Saxenda and Headaches: What Users Say

Headaches: mentioned by 156 users (10.8%)

Based on user experiences from 1,448 Saxenda reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

nausea 38.2%
constipation 12.8%
headaches 10.8%
tiredness 8.1%
vomiting 7.7%
diarrhea 7.5%
fatigue 6.8%
heartburn 4.4%
loss of appetite 4.1%
sick 4.1%

Reviews for Saxenda

Commonly mentioned side effects
  • Lau...
  • January 15, 2021

For Weight Loss (Obesity/Overweight) "I started Saxenda 2 months ago. I can’t get over the headaches and nausea I get when I take it! I lost 38 pounds but feel awful. I wonder if all this misery is worth it. I will post again when I increase my dose."

1 / 10
Was this helpful?YesNo
302 Report
  • Nin...
  • Taken for less than 1 month
  • August 22, 2020

For Weight Loss (Obesity/Overweight) "On Saxenda for 5 days, still on 0.6mg dose. First day was horrible with side effect symptoms of nausea and stomach pain, but other than the first day and occasional headaches and low energy, I am fine. I am 5'7" and 190 lb, after five days I have lost 10.5 lb. I was a dieter for my life and my thyroid is underactive, hardly lose weight on a 1200-calorie diet. Now I cannot consume more than 400 calories a day."

10 / 10
Was this helpful?YesNo
237 Report
  • Cra...
  • Taken for less than 1 month
  • September 19, 2019

For Weight Loss (Obesity/Overweight) "I’ve been on this for two weeks and lost 2.6kg. Currently on 1.2ml. My advice: keep your fluids up. I got super dehydrated, headache etc. I’ve been drinking mineral water which has fixed it. Also, in relation to feeling tired and sluggish, I would recommend that you need to eat quality food/smoothies. Because all my cravings and appetite have disappeared, I can’t eat rubbish because I get full, and then don’t eat anything good. Then I feel sluggish. I hope this helps some of you. Good luck with your journeys and keep going! Remember, courage is not finding the strength to go on, it’s going on when you no longer have the strength."

8 / 10
Was this helpful?YesNo
169 Report

Frequently asked questions

  • Mel...
  • Taken for 1 to 6 months
  • October 4, 2020

For Weight Loss (Obesity/Overweight) "I’ve been using this for 3 months now, and I’ve lost 16kgs so far. Sometimes it fluctuates, but generally, I’ll lose weight quite rapidly. Every time I changed the dosage, I’d have headaches all day. I do have some weeks of bad constipation, thus not losing any weight over that time, but I take medication for that. Overall, I’m happy with the results. Change of diet is definitely key. As I’m in lockdown, our gyms are closed, so I haven’t been able to do much exercise at all."

10 / 10
Was this helpful?YesNo
129 Report
  • Anonymous
  • Taken for 1 to 6 months
  • February 12, 2020

For Weight Loss (Obesity/Overweight) "I’ve been on Saxenda since 3rd January. I’ve lost 9.5 kilos thus far! It hasn’t been easy, but so worth it. My advice is take it before bed for fewer side effects, always have pain relievers for the headaches and nausea tablets for the nausea. As it costs money, I’ve made a massive effort to eat super healthy, sometimes having to force myself as I just didn’t feel like eating. I’ve also logged into MyFitnessPal every single day. So, I’m definitely putting in the effort to get the best results from the medication."

9 / 10
Was this helpful?YesNo
134 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
  • Sta...
  • Taken for 1 to 6 months
  • June 28, 2019

For Weight Loss (Obesity/Overweight) "I am a Latina female who is 5'4" and about to turn 39. I started taking Saxenda on May 13th at 332.6 lbs. I was really ill and started a low-calorie diet and tried to get at least a small walk in daily. I have lost almost 40 lbs already, which is just so crazy! When I first began taking the medication, I had headaches and I did feel sick and nauseated for the first few days. I almost wanted to quit, but I told myself this was very important to me, and I worked through it. Every time I upped my dosage, I had a day or two where I felt a bit queasy, but it passed quickly. I no longer feel sick from the medication, and I find it helps me to feel very full very quickly, and that it is almost like gastric bypass in a needle. I also no longer crave sugar, which is a huge deal for me. I think it is amazing, and I would recommend it to anyone considering gastric bypass. They should definitely try this first!"

8 / 10
Was this helpful?YesNo
128 Report
  • DJa...
  • Taken for less than 1 month
  • March 1, 2021

For Weight Loss (Obesity/Overweight) "I started Saxenda 2/24/21 and so far on 3/1/21, I have lost 6.2 pounds. The only side effects that I have had are headaches and fatigue. It’s not horrible for me, and I’m able to continue. I’m still on the 0.6 dosage and look forward to losing an additional 29 pounds. Good luck to everyone ❤️"

10 / 10
Was this helpful?YesNo
96 Report

More FAQ

  • Jen...
  • Taken for 2 to 5 years
  • September 1, 2018

For Weight Loss (Obesity/Overweight) "I started taking Saxenda two years ago. I was at my wit's end. I was 37 and weighed 235 lb, which was the most I’d ever weighed. I’ve struggled with weight loss my whole life. Saxenda takes some getting used to. Make sure you titrate up to the recommended dose or you will feel very ill. Headaches, vomiting, fatigue. I am sensitive to medication side effects. I fought through that, and after about 3 months, the side effects went away as long as I took it at the same time every day. I dropped 20 lbs immediately, then it slowed. I was 207 lb for a whole year and was ready to quit, when I dropped another quick 20. I am now 160 lbs (just dropped 5 lbs last week) and, literally, none of my clothes fit me (even my 'skinny' clothes). I work out sporadically and I eat what I want, just much less of it. I don’t feel hungry anymore. I stop eating after about eating 1/2 of my food, and I feel stuffed. I never thought I’d find something that worked so effectively for me."

9 / 10
Was this helpful?YesNo
123 Report
  • Pat...
  • June 5, 2021

For Weight Loss (Obesity/Overweight) "I have been on Saxenda for 1 week now and just increased my dose to 1.2 today. From the first day I experienced a suppressed appetite, which was great. When I started last week, I was 120 kg, and today I weighed in at 118 kg. I am happy that it is heading in the right direction. At day 5 of injections, I became very ill with reflux, vomiting, headache, burping, no energy, bloating, and abdominal pain... a horrible feeling. Because of this, I have not exercised at all. Today on day 8, I feel a little better, but the bloating still remains and is uncomfortable. I will stick with it because I do have high hopes for this medication. In Australia, I’m paying around $380 plus needles (100 for $19). It is suppressing my hunger and cravings, my body wants fruit and veg, anything else feels wrong and does not satisfy. Stay hydrated. I'm off to the chemist to hopefully find some relief for my bloated tummy... it’s like I’m 7 months pregnant!! Hope to follow up with some good news next week!!"

8 / 10
Was this helpful?YesNo
79 Report
  • MaG...
  • Taken for less than 1 month
  • October 26, 2019

For Weight Loss (Obesity/Overweight) "This drug has been a 10 for me in terms of rapid weight loss in the short time I've been on it. I have zero cravings for sugar anymore (I used to eat 3-4 chocolate bars a day). Now I can sit beside a cake & not even want a little bite. Saxenda has decreased my appetite so much that I have to choose healthy foods because I eat so little that I want my body to have healthy fuel. I sometimes have to even force myself to eat because I'm not hungry. I am now eating to live, not living to eat!!! Unlike other reviews, I find myself very alert & energetic on Saxenda, or maybe I'm just motivated because I see results! BUT for side effects I give it a 3 rating. My only complaint is headaches. All the time, every day. But for me, the positives outweigh the headaches!"

9 / 10
Was this helpful?YesNo
94 Report
  • Las...
  • May 23, 2017

For Weight Loss (Obesity/Overweight) "Started on 0.6 mg Saxenda on May 8th, weighing 342 lbs. After 7 days, I upped the dosage to 0.9 mg for 5 days, then to 1.2 mg. I have had no side effects from the medication aside from a very slight headache the first few days, could be unrelated since it's allergy season right now. Today is May 23rd, and I've lost 15 lbs. I am using this drug along with a low-carb diet. My constant hunger was gone starting with the first injection. Is this how normal people feel? I don't wake up hungry, I don't go through my day always feeling hungry, I don't go to bed hungry. It's so liberating to be able to focus on other things instead of constantly being consumed by hunger."

10 / 10
Was this helpful?YesNo
110 Report
  • Bos...
  • July 24, 2019

For Weight Loss (Obesity/Overweight) "I started on 22/07/19 with a 0.6 dose, however, I accidentally doubled up on the following day. Day 1, I ate like a horse. Day 2, I wanted nothing to do with food, which was odd as food is my go-to for comfort and enjoyment. I also found through my lack of desire to eat that food was a time filler for me, something to fill boredom. It came to dinner and the food smelt delicious, and because of my history, I thought I would be able to override the medication and eat as normal, however, the desire was not completely there. If I am being honest, the habit was there, but because the desire was not, it took very little willpower to overcome the eating for the sake of eating (I feel that is very important). The side effects: I feel very vague, headaches, nausea, neck hurts a lot, and lots of cramps, but nothing unbearable. I know it's only day 4, but I am very optimistic, and it is definitely working, my eating is 95% less, which is extraordinary."

8 / 10
Was this helpful?YesNo
71 Report
  • Hap...
  • February 17, 2021

For Weight Loss (Obesity/Overweight) "On Sept 1, 2020, I was 210 lbs and 5.1 ft tall. The start was terrible. Got all the side effects: headaches, dizzy, nausea, heartburn, no energy, irritable, and bad stomach pains. But I stuck it out. The smaller doses didn’t stop my cravings; I was still hungry, so I ate small healthy snacks and smaller meals. As doses increased, side effects got worse, and constipation set in. I’ve been losing approx 5 lbs per month, but I’m okay with my slow progress. Side effects got better except for heartburn and constipation. I was diagnosed with type 2 diabetes and was given 1 year to turn it around. As of last week, I am no longer diabetic. Today is Feb. 16, 2021, and I am currently 180 lbs. I’ve lost 2 clothing sizes. I give myself small goals to keep myself motivated. There are days I don’t want to even look at food and some days that I still get cravings. But I’m good with only having a small portion to settle my cravings. I walk and climb an average of 3 times per week for 40 min."

8 / 10
Was this helpful?YesNo
51 Report
  • Lan...
  • Taken for less than 1 month
  • March 29, 2019

For Weight Loss (Obesity/Overweight) "I started Saxenda on 3/22/19. I am 5'3", 44 years old, and my starting weight was 162.4. I work out 5-7 days per week and eat a very healthy diet. My metabolism just hasn't been working in my favor, so I reached out to my NP and got started on Saxenda. To date, I have lost 7.8 pounds in ONE WEEK!!! I do get some headaches, fatigue, and I am thirsty all the time. I had 2 days of nausea without vomiting. I find eating a rice cake with peanut butter first thing in the morning coats my stomach, and then small meals throughout the day keep the nausea away. I am very pleased with the results thus far and am looking forward to more weight shedding off. I increased my dose today to 1.2 mg. I am an RN and a huge promoter of exhausting all options first, like eating a healthy diet and exercising. Saxenda is best, in my opinion, for people who work hard to maintain a healthy lifestyle and just need a boost."

10 / 10
Was this helpful?YesNo
64 Report
  • Anonymous
  • Taken for less than 1 month
  • August 19, 2020

For Weight Loss (Obesity/Overweight) "I have just been on this for 5 days and have already lost 5.5 lb. The only side effect is headaches, nothing that paracetamol will not take away. I am only on 0.6 and don't feel hungry at all, sometimes I have to force myself to eat."

10 / 10
Was this helpful?YesNo
52 Report
  • Mom...
  • Taken for less than 1 month
  • February 23, 2019

For Weight Loss (Obesity/Overweight) "I started the pen in late January. I’m a mom of two (19 months and 3-year-old) so I rarely have time to exercise. I started this with low expectations, but it has been amazing. You will have no appetite, but you will have nausea and headaches at first. This is your body’s way of telling you it needs fuel. Try eating small snacks during the day. You basically have to force yourself to eat something. I found that eating about every 3-4 hours (almonds, fruits, yogurt) will stop the nausea and headaches. Drink plenty of water because you will get dehydrated. I had horrible sulfur burps and heartburn for a couple of days. Nothing a little Pepto couldn’t cure. I’m on the 2.4 dosage and have lost 15 lbs in one month. I’m going to try to start walking more once the weather permits. I started at 238 lbs. My goal is to be under 200."

9 / 10
Was this helpful?YesNo
59 Report
  • Hig...
  • Taken for 1 to 6 months
  • March 2, 2020

For Weight Loss (Obesity/Overweight) "Started on Saxenda after a lengthy prior auth process. Right away, I had dizziness and vertigo, plus mild nausea. When I finally titrated to the 3.0 dosage, I had not only dizziness and vertigo but also nausea and vomiting, and headache. Meanwhile, I have lost 15 lbs. It really seems to control the hunger. However, I just couldn't live with the side effects. So I discontinued the drug. I am hoping that the weight loss will 'spur' me on to continue with healthy choices and that I can keep up the weight loss."

8 / 10
Was this helpful?YesNo
52 Report
  • Suc...
  • June 26, 2019

For Weight Loss (Obesity/Overweight) "I started Saxenda on 6/1/2019. I was gastric sleeved in 2012 and have gained back a lot of weight. Was drinking pop, not eating slowly, lots of carbs, etc. I have gone back to eating how I ate after surgery. My doctor told me to eat 1,100 calories and now I have problems getting 700 calories a day. I eat dense protein and drink decaffeinated tea. I am down 18 lbs. I am up to 2.4 ml a day. Only side effects have been headaches this week, not sure if it is the medicine or not, could be the weather. If I eat quickly or eat junk, then I feel nauseated, so I stay away from them. As long as I am eating high protein, I am not hungry. I have not started exercising and am fatigued, but I know it is because I am not eating a lot. Probably need to supplement with 1 or 2 protein shakes a day to get a little more energy. I am very pleased with the help this medication is giving me. It is all about changing your bad habits and when I follow good habits I feel good, and when I don't I pay for it."

10 / 10
Was this helpful?YesNo
56 Report
  • PCa...
  • Taken for less than 1 month
  • May 5, 2020

For Weight Loss (Obesity/Overweight) "For obesity, I use Saxenda for the first time Sunday 05/04/20 @ 7 am. In seconds after the shot, I felt dizzy, headaches, body heat like I had a bad fever. My body felt confused. I took water, water, and more water. My boyfriend and I got so scared. Nothing helped. After an hour of feeling so bad, my dizziness was gone, but my headache was not. Around 8 pm, I started feeling the dizziness again. That really scared me because so many hours had passed. I got so scared I called my doctor. He told me to stop it, not use it again. Side effects were super bad."

1 / 10
Was this helpful?YesNo
69 Report
  • Pal...
  • Taken for less than 1 month
  • June 25, 2019

For Weight Loss (Obesity/Overweight) "I am a 39-year-old 5'6" female and started at 295 pounds on May 30, 2019. Today was my last day of the 2.4 mg dose (starting 3.0 tomorrow) and so far, so good. I am down 9.5 lbs. in 4 weeks, and this is including a 10-day vacation with lots of eating out and drinking. I have noticed that I will suddenly feel full when eating and can just push the rest of the food away. Before, I felt like I was NEVER full. I have experienced some mild sphincter of Oddi spasms and really mild constipation (improved with fluid intake and activity). I have also had a few headaches, which are normally rare for me. The worst side effect has actually been pain at the insertion site and mild bruising. I've tried two types of nano tips and am skilled with injections (hospital RN), so this has surprised me. Overall, I am really pleased and have high hopes for continued progress."

9 / 10
Was this helpful?YesNo
47 Report
  • Amb...
  • Taken for 1 to 6 months
  • January 31, 2017

For Weight Loss (Obesity/Overweight) "I started Saxenda in November 2016, the week before Thanksgiving. It is January 31, 2017. I am 5' 1" and when I started Saxenda I weighed 205 lbs. I now weigh 178 lbs. I have been able to come off of my blood pressure meds and I no longer need my CPAP when I sleep at night. I have less joint pain and I no longer get winded walking up a flight of stairs. The only side effects I've experienced are nausea with each titration up of the medication, mild headache the first few weeks, nasty sulfur burps, and diarrhea. I haven't had any constipation. None of the side effects were severe enough to make me consider stopping the medication."

9 / 10
Was this helpful?YesNo
56 Report
  • Jen...
  • October 22, 2019

For Weight Loss (Obesity/Overweight) "Just started taking Saxenda on Sunday, October 14. My start weight was 112.2 kgs (247 pounds). I weighed myself on Sunday, October 20, and the scales really shocked me, it said I was 108.4 kgs (239 pounds). I have been overweight and dieting all my life. I was recently diagnosed with PCOS. Losing weight has been very hard. I track my steps and calories, I have been reducing the size of my meals. I had half a tuna sandwich and had to stop eating. The drug works on suppressing appetite, but the side effects are also very high for me. I have had diarrhea, constipation, lack of energy, headaches, feeling sick, and vomiting. I have dry mouth and am taking Hydralyte to compensate for the lack of fluids I can keep in my system. I am in two minds about this drug, I don't know if I am going to continue it after I finish the 5 pens in my first box. The drug costs so much, $389 Australian, and can't claim anything back on my private health."

6 / 10
Was this helpful?YesNo
41 Report
  • AND...
  • Taken for 1 to 6 months
  • October 11, 2019

For Weight Loss (Obesity/Overweight) "I started Saxenda 4 weeks ago. I lost 6 pounds in the first two days. To date, I have lost 13 pounds. The side effects are hard. I have large red bumps that get hot and itchy at the injection site, severe fatigue, headaches, and sometimes nausea. I have not been able to increase my dose higher than 1.8 because the side effects are so hard right now. Does anyone else have the red spots on the injection sites?"

8 / 10
Was this helpful?YesNo
40 Report
  • Fay...
  • Taken for less than 1 month
  • October 25, 2016

For Weight Loss (Obesity/Overweight) "I have been on Saxenda since September 26, 2016, today is October 25, 2016, and I just started 3 mg. I have lost 20 lbs. I, too, have experienced nausea and headaches after each time I changed the dosage. It takes about two days to calm down. So far, so good, and hopefully, I continue this progress. I started out at 359.8 and as of today, I am 339.6."

10 / 10
Was this helpful?YesNo
55 Report
  • IRe...
  • Taken for less than 1 month
  • April 8, 2021

For Weight Loss (Obesity/Overweight) "I’ve been on Saxenda for just over a week. Admittedly, I only injected the 0.6 dosage for two days before I increased it to 1.2 because I wasn’t “feeling” anything. I did 1.2 for the rest of that first week and increased to 1.8 today. I have noticed a significant decrease in appetite over the past few days. I haven’t started working out yet. One night I woke up with a really bad taste in my mouth. I did an internet search and found out it’s a common side effect. I’m also experiencing a bit of constipation and a couple of headaches but no nausea. My goal is to lose 100 lbs, and I’d really like to do it with bariatric surgery. Hoping Saxenda will help me out."

8 / 10
Was this helpful?YesNo
31 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.