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Doxylamine and Irritability: What Users Say

Brand names: Unisom SleepTabs, Sleep Aid, Nighttime Sleepaid

Irritability: mentioned by 6 users (2.5%)

Based on user experiences from 236 Doxylamine reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

drowsiness 24.6%
anxiety 5.5%
dizziness 5.5%
headaches 5.1%
tiredness 4.7%
dry mouth 3.8%
nausea 3.0%
restless leg syndrome 3.0%
insomnia 2.5%
irritability 2.5%

Reviews for Doxylamine

Commonly mentioned side effects
  • Chr...
  • March 5, 2015

For Insomnia "Does it work? You bet, it does. I have suffered from insomnia for 18 years, so I know when I'm asleep or not. This med is wonderful in keeping you asleep for 5 1/2 to 6 hours. This med is also effective in getting you to sleep. The downside... My God, is it drowsy. I'm usually a guy who doesn't complain, but this med makes you super drowsy. In addition to the drowsiness, it will make you irritable because you don't feel good. In conclusion, I would recommend it because the psychological benefit of knowing you slept slightly outweighs its side effects. I hope this info helps. Best of dreams."

8 / 10
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88 Report
  • AbA...
  • July 31, 2015

Doxylamine for Insomnia "Unisom definitely makes good on its word. Within about 15-30 min after taking a pill, drowsiness comes into play, with sleep following soon after. Expect irritability. Especially when someone or something is causing you to come in and out of your sleep. After waking, expect 4-5 hours of drowsiness, and at least 5-8 hours until all side effects clear."

8 / 10
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78 Report
  • Kka...
  • Taken for less than 1 month
  • March 25, 2020

For Insomnia "Doxylamine definitely knocks me out, but I feel odd the next day. My anxiety is through the roof and almost on the verge of panic attacks while feeling very irritable. I believe it stays in your system for quite some time, so this effect lasts all day. Probably not ideal for someone that already has anxiety."

2 / 10
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32 Report

Frequently asked questions

  • Pre...
  • August 11, 2015

Doxylamine for Insomnia "I'm pregnant and my doctor recommended I take Unisom and B6 at night for my morning sickness and nausea. When I took it, I easily fell asleep, but I could not sleep through the night, I would wake up at least 3-4 times. I woke up irritable (more than normal for being pregnant), and it also triggered my migraines. Almost every time I took this, I would get really bad headaches."

2 / 10
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28 Report
  • red...
  • Taken for 1 to 6 months
  • March 1, 2017

For Insomnia "Using 4 weeks or so. Initially half a tab since I'm sensitive. I wasn't experiencing severe grogginess as with another sleep aide years ago. But it didn't always put me to sleep, and I would wake often. Now using the full dose, sleep came sooner and harder, but I still wake at least once a night, and though there's no extreme grogginess in the morning, it makes me sleep about 10 hours and takes me a couple of hours to wake up. I have begun taking a natural-based energizer to wake up and also drinking black tea, and this morning I also took an extra 'energizing' daily vitamin plus a green tea capsule. I never seem to fully wake, I am feeling exhausted, and I notice irritability and a foul mood. I'm not going to keep using it. Worse than before I started."

2 / 10
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8 Report
  • Anonymous
  • Taken for less than 1 month
  • April 18, 2022

Doxylamine for Insomnia "Took it, and it made me feel tingly and irritable. Maybe I need less."

5 / 10
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3 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.