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Pylera User Reviews & Ratings (Page 5)

Pylera has an average rating of 5.8 out of 10 from a total of 251 reviews on Drugs.com. 34% of reviewers reported a positive experience, while 25% reported a negative experience.

Reviews for Pylera

Commonly mentioned side effects
  • Edd...
  • May 22, 2017

For Helicobacter Pylori Infection "I was prescribed Pylera, 3 pills 4 times a day, with omeprazole twice a day. I'm on day 6. The first couple of days were a little tough, but not too bad. Comments made me so scared, but I'm glad I didn't get the bad symptoms. Day 6 was my best day, I even ate a meal and didn't have stomach pain for the first time in years! Hope it works. Good luck to all."

10 / 10
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  • Jan...
  • Taken for less than 1 month
  • August 5, 2014

For Helicobacter Pylori Infection "I've been off of Pylera for 5 days, and just now feeling a little better. The worst has been diarrhea/loose stool for 14 days. Tested negative for C-Diff, thank God. The nausea and fatigue were also just as bad. I went on probiotics 2x daily and a yogurt a day right after treatment. I still have strong urges to use the bathroom as soon as I get up, but things appear to be slowing down. I am on 3 different ointments due to fissure/hemorrhoid, and still feeling fatigued. Worst treatment I have ever experienced, but had little choice after Prepak failure. I give it a '1' only in terms of side effects. If my UBT comes back negative at the end of the month, I give it a '10.' My suffering was then worth it."

4 / 10
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  • Anonymous
  • June 11, 2017

For Helicobacter Pylori Infection "I am on day 5 and all I can say is I hope this Pylera helps. I've been getting a bad taste in my mouth, insomnia, which makes it so hard to function. Also headaches, stomach pain, extreme fatigue, mood swings, dark stools and urine, loss of appetite, etc. But I am hopeful that this works versus all the other antibiotics I've taken. It seems like a never-ending battle, just about a year now, and getting aggravated with this and being so limited on what to and not to eat to upset me. Hoping for the best. Good luck to all."

7 / 10
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  • Cor...
  • January 9, 2018

For Helicobacter Pylori Infection "I am a 58-year-old female who was VERY SCARED after reading the reviews. I was just afraid of taking 140 pills in 10 days. Once I read the package again and it said blister capsules, I became more comfortable, however, I waited until I came back from Christmas vacation to start my pill taking because of the reviews. I didn't have any side effects except my stool was very black. I drank plenty of water. But I am finished. I had a 'FINISHED UP TAKING PYLERA PARTY.' Next follow-up appointment is in February. Hope this helps someone out."

5 / 10
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  • Edm...
  • August 7, 2018

For Helicobacter Pylori Infection "I’ve had stomach pains off and on for a few years. Just recently, I went to a new gastro, which ran some tests that included blood work and a stool sample along with an abdominal ultrasound. Everything came back fine except I tested positive for H. pylori. I was prescribed a 10-day Pylera course along with omeprazole. Besides having dark stool, it was going smoothly for the first couple of days, but on day 6 is when all hell started breaking loose. I began having sharp abdominal pains, dizziness, nausea, and I was very tired. The only thing that helped was eating, as soon as I ate, my pains and symptoms went away temporarily. Two and a half more days to go, and I’m done. Hopefully, I won’t have to go through this again."

6 / 10
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  • Min...
  • April 29, 2014

For Helicobacter Pylori Infection "Today is my 9th day on this medication. The first day, I had no symptoms. As the days went by, it got worse-very nauseous every day after that. I am extremely tired and have a metal taste in my mouth all day that makes me even more sick to my stomach. I recommend chewing gum. Some cramping and black stool. I hope this medicine takes care of the problem. Taking a breathing test in a month-fingers crossed."

4 / 10
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  • Mar...
  • Taken for less than 1 month
  • April 6, 2016

For Helicobacter Pylori Infection "Ok, I'm back to share my experience with Pylera. I completed a 10-day dose of 12 pills/day. Glad that I read reviews before beginning, or else the side effects would've concerned me. From day 1, I experienced daily nausea even though I ate a small meal with each dose, had a slight headache for about 3 days, my feces turned blackish brown by day 3 and lost its stink! No kidding! I also felt a little off, i.e., a feeling not quite right and a little tired. I drank a lot of water with each dose, just as stated. I won't know the results for another 2-3 weeks. In the meantime, I am taking Omeprazole 2x daily and a probiotic."

6 / 10
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  • Mfa...
  • June 10, 2015

For Helicobacter Pylori Infection "I had been experiencing severe stomach pain for about a year and a half that included nausea, stomach pain, always bloated, and pressure under my ribcage. Dr. performed a Urea Breath Test; tested positive for H. Pylori. I completed day 10 yesterday. I was lucky enough not to experience any severe side effects. I did experience multiple migraines while on it, and I always felt very tired. But just after taking the first full day of it, I definitely felt a difference. Today is my first day without having taken them, and I feel a hundred times better. I actually have an appetite! It's harsh and long, and I wanted to give up, but in the end, I thought it was worth it. Now to wait four weeks before I can get retested to ensure it's gone."

8 / 10
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  • Pau...
  • Taken for less than 1 month
  • June 5, 2016

For Helicobacter Pylori Infection "Just finished 10 days of Pylera. This is my second treatment in the past few months for H. pylori after it coming back 2 weeks after finishing triple treatment. Well, this has to be the worst medicine I've ever been prescribed in my life. I was bloated the first few days and looked 6 months pregnant. It got worse... the symptoms that followed were insomnia, itchiness everywhere, especially my nose, anxiety, racing heart, weight gain, mood swings, and just a general feeling of not feeling with it. I'm still bloated 4 days after I've finished and don't feel great."

4 / 10
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  • Jon...
  • Taken for less than 1 month
  • May 9, 2019

For Helicobacter Pylori Infection "I'm on day 9, and apart from a constant metallic taste in my mouth (not so bad), then I have no other side effects. I have cut all dairy and alcohol as recommended for the ten days. If it kills the bacteria and I feel fine taking it, then I'm a happy camper!"

9 / 10
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  • Elm...
  • October 17, 2017

For Helicobacter Pylori Infection "I've tried everything available with or without a prescription. The best medicines for H. pylori are dill and fennel. Three teaspoons of dill and one of fennel boiled in one liter of water, then drink three small cups a day. Within a week, you'll say goodbye to H. pylori and all the stomach problems."

9 / 10
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  • Anonymous
  • October 26, 2011

For Helicobacter Pylori Infection "I have been taking Pylera for 6 days, and besides dry mouth, general feeling of being ill, I noticed my tongue is getting dark (a known side effect). This is a very difficult medication to take for 10 days, however, I will continue in hopes the H. pylori bacteria will be eradicated."

4 / 10
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  • nav...
  • May 14, 2015

For Helicobacter Pylori Infection "I'm on day 4, and I can't wait until this is over. The dark, runny stool, headaches. I'm over it. I don't like yogurt, but if it'll help, I'll try it! Note: If you feel the urge to pass gas, go to the bathroom ASAP."

2 / 10
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  • Val...
  • Taken for less than 1 month
  • January 31, 2019

For Helicobacter Pylori Infection "Well, I had a 120-pill course in Germany from January 7 till January 16. I had black stool and dark urine and went to bed after 10 PM, although usually I do it around midnight. No other side effects, though. And during taking Pylera, my stomach felt pretty comfortable. Now, the feeling is not that comfortable. I do not feel pain, but I experience some discomfort in my stomach. Maybe this is due to the fact that Pylera killed all the flora in my gut. I will have my next gastro in the beginning of February."

6 / 10
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  • Sar...
  • Taken for less than 1 month
  • June 17, 2022

For Helicobacter Pylori Infection "Taking Pylera is a wild ride, and I would suggest everyone to plan time off work for the 10 days of treatment. I'm currently on day seven and had/have many of the side effects. They do come in waves, though, so there are moments in between where I feel really good and even noticed improved H. pylori symptoms, which makes me hopeful that this is actually working. I know many said it here before, but I'm going to say it again: Do not take Pylera on an empty stomach! On day 4, I took my last dose really late because I had slept all day due to side effects. I was not hungry, so I washed down my capsules with half a banana. I woke up 4 hours later with the worst stomach cramps and burning I ever had in my life, and that continued for at least 12 hours! Since then, I made sure to eat a complete meal before taking the capsules, just a little snack didn't work for me. Man, do I hope this works, I wouldn't want to do it again. Yet, thankful this treatment exists. Will report back with results!"

8 / 10
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  • HPy...
  • August 12, 2016

For Helicobacter Pylori Infection "Picked up a nasty H. pylori strain from a casual blind date, I know I should have gotten to know the person better. Took a while before symptoms showed up. Had a severe upset stomach, occasional diarrhea, nausea, and slow but steady weight loss. Took a long time and several doctors to diagnose my steadily worsening condition. Tried PrevPak first, seemed to work at first, but my infection came back. The new GI then prescribed Pylera after my third endoscopy. Pylera has worked, it's been a year, and I am still H. pylori negative. But it's been brutal and a very hard, long road back to recovery. Had severe side effects from tetracycline (in Pylera), my skeletal bones seemed to have absorbed it. Am still not completely detoxed, steadily improving."

5 / 10
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  • Hvh...
  • June 4, 2013

For Helicobacter Pylori Infection "On my 5th day of treatment. The bloating and discomfort in my stomach are pretty intense. I hope I can follow through with my course of medication. My doctor did not mention taking a probiotic while on medicines. I will ask tomorrow and hope I get an answer. I have already called once asking if this feeling is from the medication or the upper endoscopy."

5 / 10
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  • Fra...
  • Taken for less than 1 month
  • November 13, 2018

For Helicobacter Pylori Infection "I'm on day 7. I've been eating a strict diet of no sugar, no wheat, no dairy, no red meat. Basically, everything that takes digestive robustness or helps bad bacteria. I take the Pylera with a half-sized meal and eat the other portion of the meal a couple of hours later with either a probiotic supplement or a healthy scoop of live (not pasteurized) sauerkraut. I've been drinking lots of water by sipping it all day, and I force myself to hit the elliptical for 20 minutes every other day. My poop was dark and like the consistency of wet clay on day two. Day three was a LOT of green loose stool. Now, I'm pooping every other day, and it smells like fresh grass! I get tired just past lunch, and I have a pretty steady headache from about 10 AM on. Still better than dealing with this infection. Excited to rebuild my gut after and see how I feel without H. Pylori."

9 / 10
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  • Ear...
  • Taken for less than 1 month
  • May 31, 2018

For Helicobacter Pylori Infection "Last day on Pylera, and I am happy for this to be over. Overall, not bad at all. Diarrhea the first few days, followed by odd-smelling black bowel movements three times a day, every day. Weird taste in my mouth off and on. Today, I will say I am exhausted. I work a physically demanding job outdoors, and of course, the heat was high all week, but I was able to push through it... not bad at all, honestly."

7 / 10
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  • Glo...
  • Taken for less than 1 month
  • March 30, 2019

For Helicobacter Pylori Infection "The most horrible feeling in the world: tired, nauseated, black stools, depressed, and I just wanted to feel normal again. What helped me was eating big meals, try to eat your first meal as early as possible so that you can take your last pill not so late and get your sleep. I had mints in my purse, it always helps with the bad taste in your mouth, but most of all, sparkling water was by my side constantly. It helped settle my stomach and kept me hydrated. I never again can I go through that! Day 10 was yesterday, today I’m meds-free, and I have a sour stomach and heartburn. I hope this goes away soon."

2 / 10
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  • Sca...
  • February 22, 2022

For Helicobacter Pylori Infection "I'm taking Pylera for HP. It has been over nine days today; I feel like crap. My skin is dry; my anxiety is at its highest, stomach discomfort, anal discomfort, headaches. This treatment is a challenge, honestly. Please stay safe."

2 / 10
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  • wen...
  • Taken for less than 1 month
  • May 25, 2023

For Helicobacter Pylori Infection "Before starting this medication, I was really scared after reading the reviews. I also want to preface this by saying that I have lupus nephritis and was already taking additional medication, so adding Pylera meant I was taking over 20 pills a day. The only side effects I had were dark stool, abdominal cramping (sometimes between doses), and slight joint pain. My diet could’ve played a large role. I ate mainly fruit and vegetables from home, drank a lot of water, and always ate a full meal with doses. Please listen to the instructions and do not lie down after taking this medication for at least 30 minutes. Also, avoid foods with added calcium like cereals, bagels, milk, etc. Read your food labels and try your best to avoid highly processed foods for the course of antibiotics. I still don’t know if my H. pylori is gone, but I do feel better than before I started taking it."

8 / 10
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  • Phi...
  • May 12, 2018

For Helicobacter Pylori Infection "I am 34 and never had vision problems until taking Pylera for about 8 days. Please don't take this medication because it is causing me to go blind in both eyes. Now my vision is very blurry, I can't see anything with clarity. At first, I thought it was a temporary side effect until each and every day my vision got worse, now it's even worse from then. I can't deal being without my vision."

1 / 10
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  • R3b...
  • Taken for less than 1 month
  • November 29, 2019

For Helicobacter Pylori Infection "I have been taking this drug for 2 days now, and the side effects I am dealing with at the moment are (dark stool, weird taste, tiredness, bad mood, and anxiety). Other than that, everything is good. I hope this medicine will be effective, my doctor prescribed it for 20 days :(."

8 / 10
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  • Ang...
  • November 14, 2018

For Helicobacter Pylori Infection "My Pylera experience: 12 antibiotics daily was surprisingly easy, no side effects, just black stools. The only disappointment was that it didn't get rid of the H. pylori, so I'm once again on tetracycline and Flagyl + pantoprazole. The Pylera was like taking nothing compared to this. And by the way, I'm still H. pylori positive."

6 / 10
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