Prilosec User Reviews & Ratings

• Pre...
• Taken for less than 1 month
• September 25, 2019

For GERD "DO NOT TAKE THIS MEDICINE!!!!! This medicine has ripped the life out from inside me. I went from being my totally normal happy self to having serious panic attacks, constant anxiety/depression, and a general feeling of hopelessness. The symptoms started on my 12th day, and I stopped taking the pill on my 13th day. It is a week later, and the panic attacks, anxiety, depression, and hopelessness still remain. This drug is poison to me and many others!!!"

• jus...
• July 24, 2015

For GERD "I have taken Prilosec for over 15 years. It works great for the heartburn/reflux/GERD. But let me tell you what it took away from me! It dropped my iron and my iron stores to the bottom, it also took my B12 to the bottom. It also, after years of taking it, gave me anxiety, cramping of muscles, and led to my potassium being low as well. Then, most recently, I kept having a horrible burning in my stomach, well, guess what Prilosec gave me most of all! A stomach full of gastric polyps!! So now I have weaned myself off this horrible medicine because gastric polyps are a side effect of it and no one tells you! And if you keep taking it, well, guess what, it makes even more in your stomach once it starts!! So I weaned myself off it, took over a month."

• jan...
• Taken for 2 to 5 years
• August 26, 2013

For GERD "A great medicine. I'm on 40 mg daily due to the feeling of my food being stuck in my throat. It was so bad at one time that I purposely made myself vomit for relief. After having my esophagus looked at - and finding out I also have a small hiatal hernia, doctor said my 'flapper' doesn't close, or stay closed. So here I am religiously taking this medicine and mostly loving life. If you miss a day you will again feel miserable. I will say that over the years I have experienced 'breakthrough' reflux at one time or another but never for a second day. Very happy."

• Sta...
• January 31, 2015

For GERD "Doc prescribed this for me, but I didn't think it would help, since my main symptoms of shortness of breath and chest tightness, and rarely heartburn. Left it in the cabinet for months until recurring stomach pains landed me in the ER. All blood tests, urine tests, and ultrasounds came back normal, and once again, my doc suggested the Prilosec. Finally caved. I kid you not, within the first day my stomach pains disappeared. I had the best night's sleep the first few days that I could remember, realizing it was actually heartburn waking me up (I contributed my early wake-ups to anxiety or poor sleep habits). Absolutely no side effects. I can eat whatever I want. I feel like a new person after one week. Hoping this lasts once my 14 days are up!"

• joh...
• Taken for 1 to 6 months
• August 8, 2014

For GERD "This medicine saved my life. I was in pain and miserable. Tried all the OTC stuff Zantac, Pepcid, Prevacid, and many others with no success. Then I tried omeprazole and within days I was better. Great medicine. Would definitely recommend."

• ola...
• August 27, 2007

For GERD "About three months ago, my doctor ordered Prilosec 20 mg for heartburn. I also have diverticulosis that caused me to have a burning itching discharge. By the time I had taken 42 Prilosec, I noticed the burning and itching had completely stopped. I am still taking one Prilosec every other day. I now need to know if I can take one 20 mg Prilosec tablet per day indefinitely without harm to my health."

• ter...
• October 8, 2011

For GERD "I started taking Prilosec over 6 years ago. It was very effective at helping with the acid and GERD symptoms, however, my doctor prescribed two tablets a day (over recommended dosage due to the seriousness of GERD). I seemed to be fine until I started getting horrible spasms in my sides and intestines. I broke my ankle in March, and the spasms were bad, they worsened. I had my calcium checked, and I was dangerously low. We backed down to 1 Prilosec, and the spasms disappeared. So, watch your calcium with higher doses."

• Mar...
• September 6, 2021

For Duodenal Ulcer "DO NOT TAKE HORRIFYING. Took the pills against my better judgment for a nagging ulcer/gastritis per my doc. I usually prefer a holistic route. Mistake. Five days in, an ER trip in an ambulance from sudden dizziness, painful pounding chest, panic like I was dying, extreme sweating, numb hands and feet, and pulse through the roof. Tests showed nothing but ended up back in the ER after night after night of undeniable horrific panic, sweating, extreme anxiety (I have never experienced anxiety or anything panic attack related before in my life), claustrophobic and anxiety-ridden nervous thoughts that are unshakable. No sleep for days. With two toddlers, it was torture. It could not have been anything but these awful pills obviously. I quit the pills, am seeing an acupuncturist and herbs to detox. Better but still a work in progress. Please do NOT risk your mental health over this poison. Not worth it one bit."

• Mis...
• Taken for less than 1 month
• June 30, 2020

For GERD "I've had GERD since 1999 and, in 2016, I was being tested for all sorts of GI conditions because of the symptoms I was experiencing. My GI doc at the time told me to take Prilosec every day to control nausea and acid reflux. I took it for less than a week and had to discontinue because, every time I ate, I felt like I had a brick sitting in my stomach. It felt like the food would just sit there, undigested, and it was very painful. I've done better with other PPIs."

• Anonymous
• Taken for 1 to 6 months
• January 29, 2020

For Helicobacter Pylori Infection "I took Prilosec for a year and a half. I noticed that my whole body ached. My bones hurt, if I bumped up against a door, my arm was so sensitive. I felt like I was 90 years old. My joints ached, and my face lost any glow. My skin was dull, flat, and pale. Once I got off this, all those symptoms went away. I have bad reflux, to where I couldn't swallow or yawn. I now take apple cider vinegar each morning, and I'm fine. I take a couple teaspoons with a splash of water in a small cup when I get up, and it works! Get off Prilosec, it will age you prematurely!"

• Gra...
• Taken for 5 to 10 years
• February 7, 2013

For GERD "Prilosec has worked for me 90 percent of the time for the past eight years. My one and only complaint is: Why does it have to be packaged like it is gold? First, a large box with three smaller boxes in that, and then the pills individually sealed in foil sheets. What a pain to get all this open and just think of the amount of waste to the landfills. I called the company, and they said they do this packaging for safety reasons. Many, many more dangerous other meds are not packaged like this. Please get those pills into a bottle."

• fay...
• Taken for 10 years or more
• September 21, 2017

For Indigestion "I have taken this medication for over two decades, and it works well. Without it, I wouldn't be able to hardly eat anything. If I run out and have to wait to get my refills, it usually takes several days before any horrible symptoms come back. I try to get my meds before that happens. It really does help in making life so much better. You can eat in a normal fashion, but sensible. I try to drink plenty of water, so my meds won't be too much of a strain on my bladder and kidneys and all my organs. I know without this medicine I couldn't even drink water without suffering the consequences. It was that bad."

• ste...
• Taken for 5 to 10 years
• December 30, 2024

For GERD "I had acid reflux so bad I'd wake up choking in the middle of the night. I couldn't catch my breath and almost passed out. I'll take one a day. I can eat anything and never have problems like I used to."

• Bec...
• Taken for 6 months to 1 year
• April 20, 2017

For GERD "I've been having problems for years with my stomach and GERD. I was put on Prilosec and was told that it would possibly cause an upset stomach to begin with, but to try to work through it. I took it for around 5 months, but I could not handle it anymore. I kept having stomach cramps and an upset stomach the whole time. I couldn't keep enough fluids in me to keep myself hydrated. Months later, I was prescribed it again and tried it once again. Same thing, but worse. I had bad blood work come back saying my kidneys weren't working right, and my potassium was so low I was admitted into the hospital. Since then, my kidneys are still not okay. I've been peeing blood on and off. I am pretty sure that this medicine has messed my kidneys up. Bad stuff for me."

• Dan...
• July 27, 2013

For GERD "I have been taking Prilosec for several years, and I take one with water every morning about 30 minutes before I get up. It has totally eliminated any burning in my chest or esophagus. Also, I learned not to eat any Mexican or spicy food within 3-4 hours before going to bed."

• Ady...
• Taken for 10 years or more
• January 16, 2020

For GERD "I started on Zantac and then went to Prilosec and Nexium. I was fine for years, but now I am having side effects I can't live with. After taking one 20 mg pill, I got chills, nausea, and felt very tired. I have a hiatal hernia and not sure what to do."

• neu...
• Taken for 10 years or more
• November 2, 2014

For Zollinger-Ellison Syndrome "I have a hiatal hernia, which can cause bad reflux, etc. I've been taking Prilosec for at least ten years (probably closer to fifteen), and I've never had ANY negative side effects. It has been invaluable for relieving the inflammation and irritation associated with reflux, gastritis, GERD, etc. Awesome medicine, I've never had any interaction issues, and I'm on a number of serious medicines (heart, blood pressure, anti-anxiolytics, and pain meds). I'm 58, and I will probably be taking it as long as I'm around. Great medicine."

• Ell...
• Taken for 6 months to 1 year
• August 28, 2018

For GERD "I took this to help control acid reflux, and it seemed to help that, but it gave me IBS-D (irritable bowel syndrome, diarrhea) that took me years to control, where I couldn't work or leave the house. Still to this day, I deal with it - 6 years later, but improved. I never made the connection until I went back on Prilosec a few months ago, and it flared up like crazy again. I never had problems like this before Prilosec."

• han...
• July 9, 2014

For Erosive Esophagitis "I have taken Prilosec or omeprazole for years, and in increasing doses over time, it has given me perfect control over my reflux and heartburn problem. Nexium made me so sick after 5 days of use that I could not get out of bed. Nothing else has ever worked so extremely well as this medicine."

• Anonymous
• January 22, 2012

"I took this medicine for an acidity problem, especially overnight. After 10 days, acidity feels less, but I had an adverse drug reaction: fever, joint pain in my hips, lower back pain, duodenal discomfort, diarrhea, fatigue, and some side effects: headache and nausea."

• Ric...
• August 12, 2015

For GERD "I love this stuff. Ended my reflux and perpetual sore throat. I was thankful for how quickly it worked. Now to the packaging! These pills are nearly inaccessible in the packaging they come in. I use a scissor to open the pockets where the pills are encased and then store the pills in a small bottle."

• Anonymous
• December 30, 2009

For GERD "I took this drug for several weeks, and my GERD cleared up. Then, out of the blue, I became moody and angry at everyone. I read up on some of the side effects and found that mood issues have been associated. I tend to have this when I take anything that amps up your metabolism, so it must contain something that is somewhat related to that."

• Art...
• August 13, 2015

For Helicobacter Pylori Infection "Yes, Prilosec stopped my heartburn most of the time. I have been hospitalized after I stopped. I now have arthritis so badly in both my hips, I have to have them both replaced. I'm only 44 years old. I've been taking the meds since I was 17. If I had been diagnosed or even tested for H. pylori, this could have been cured years ago, and I wouldn't have to have my hips replaced. There is no arthritis that runs on either side of my family."

• Des...
• Taken for less than 1 month
• December 26, 2024

For GERD "Occasionally my GERD symptoms flare up. So, this time I decided to try Prilosec, and I feel Prilosec has worked better for me than the medication prescribed by my doctor. Within three days, my stomach swelling went down, and I was able to digest my food much better. I will use Prilosec from now on!"

• JCs...
• April 26, 2012

For Indigestion "In 2005, I had many tests. No clear diagnosis, but Prilosec seemed to bring the burning under control for nearly 6 1/2 years. There was breakthrough pain, helped by diet. Though there were mood swings and muscle spasms. Never associated until reading these reviews."