Pylera Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Pylera (bismuth subcitrate potassium / metronidazole / tetracycline)	Clarithromycin	Omeprazole	Enter another drug to compare

Pylera (bismuth subcitrate potassium / metronidazole / tetracycline)

Clarithromycin

Omeprazole

Prescription only

Prescribed for Helicobacter Pylori Infection. Pylera may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Bronchitis, Bacterial Endocarditis Prevention, Dental Abscess, Follicular Lymphoma, Helicobacter Pylori Infection, Legionella Pneumonia, Middle Ear Infections, Mycobacterium... View more

Prescription and OTC

Omeprazole decreases stomach acid production which promotes the healing of gastric and duodenal ulcers and other inflamed areas of gastrointestinal tissue. The risk of interactions with omeprazole... View more

More about Pylera (bismuth subcitrate potassium / metronidazole / tetracycline)

More about Clarithromycin

More about Omeprazole

Ratings & Reviews

Pylera has an average rating of 5.8 out of 10 from a total of 251 ratings on Drugs.com. 34% of reviewers reported a positive effect, while 25% reported a negative effect.

Clarithromycin has an average rating of 5.4 out of 10 from a total of 850 ratings on Drugs.com. 37% of reviewers reported a positive effect, while 36% reported a negative effect.

Omeprazole has an average rating of 4.7 out of 10 from a total of 498 ratings on Drugs.com. 32% of reviewers reported a positive effect, while 51% reported a negative effect.

View all 251 reviews

View all 850 reviews

View all 498 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Nausea (39.0%)
Headaches (26.3%)
Dark stool (20.3%)
Tiredness (17.5%)
Dizziness (15.9%)
Diarrhea (12.4%)
Loss of appetite (12.4%)

View all Pylera side effects

Bad taste (28.8%)
Metallic taste (20.7%)
Nausea (20.0%)
Diarrhea (13.6%)
Headaches (11.3%)
Upset stomach (10.7%)
Insomnia (10.5%)

View all Clarithromycin side effects

Anxiety (25.3%)
Dizziness (16.1%)
Nausea (11.8%)
Headaches (9.0%)
Brain fog (8.6%)
Depression (8.2%)
Pain (7.6%)

View all Omeprazole side effects

Drug Class

H. pylori eradication agents

Macrolides

Proton pump inhibitors

Generic Availability

Lower cost generic approved

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	120 each
Strength	140 mg-125 mg-125 mg
Per unit^*	$2.72
Cost^*	$326.74

View all Pylera prices

Quantity	30 each
Strength	500 mg
Per unit^*	$1.96
Cost^*	$58.88

View all Clarithromycin prices

Quantity	50 each
Strength	20 mg
Per unit^*	$0.37
Cost^*	$18.67

View all Omeprazole prices

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Dosage Forms

Oral capsule

Oral powder for reconstitution
Oral tablet
Oral tablet, extended release

Oral delayed release capsule
Oral delayed release tablet
Oral tablet, disintegrating, delayed release

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

120 hours

7 hours

1.5 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category D Positive evidence of risk

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 554 drugs are known to interact with Pylera:

29 major drug interactions (81 brand and generic names)
518 moderate drug interactions (3229 brand and generic names)
7 minor drug interactions (28 brand and generic names)

A total of 711 drugs are known to interact with Clarithromycin:

277 major drug interactions (984 brand and generic names)
382 moderate drug interactions (1487 brand and generic names)
50 minor drug interactions (167 brand and generic names)

A total of 240 drugs are known to interact with Omeprazole:

25 major drug interactions (66 brand and generic names)
166 moderate drug interactions (1312 brand and generic names)
48 minor drug interactions (273 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Consumption of alcoholic beverages or products containing alcohol or propylene glycol during... View more
Do not take iron supplements, multivitamins, calcium supplements, antacids, or laxatives within 2... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease Interactions

First Approval Date

September 28, 2006

October 31, 1991

June 20, 2003

WADA Class View classifications

N/A

More Information

Patient Resources

Pylera uses

Clarithromycin uses

Omeprazole uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Pylera Alternatives Compared

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