Comparing Rybelsus vs Trulicity
| Rybelsus (semaglutide) | Trulicity (dulaglutide) |
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| Rybelsus (semaglutide) | Trulicity (dulaglutide) |
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Prescription only
Rybelsus (semaglutide) is an oral medicine that can be used as a first-line medication to improve blood sugar control in adults over the age of 18 with type 2 diabetes. It works by mimicking the... View more |
Prescription only
Trulicity mimics the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the liver. It lowers blood glucose levels in people with... View more |
Related suggestions Type 2 Diabetes
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| More about Rybelsus (semaglutide) | More about Trulicity (dulaglutide) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Rybelsus has an average rating of 6.4 out of 10 from a total of 283 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 24% reported a negative effect. |
Trulicity has an average rating of 5.3 out of 10 from a total of 971 ratings on Drugs.com. 38% of reviewers reported a positive effect, while 40% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Rybelsus side effects |
View all Trulicity side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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N/A |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Rybelsus prices |
View all Trulicity prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other semaglutide brands include: Ozempic, Wegovy |
N/A |
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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168 hours |
120 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Summary unavailable. See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 273 drugs are known to interact with Rybelsus:
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A total of 271 drugs are known to interact with Trulicity:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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September 20, 2019 |
September 18, 2014 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
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| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.