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Comparing Glimepiride vs Trulicity

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Glimepiride Trulicity (dulaglutide)
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Glimepiride Trulicity (dulaglutide)
Prescription only

Glimepiride is used to help maintain blood sugar control in people with type 2 diabetes. It may cause nausea and people who take glimepiride should always be alert for symptoms of hypoglycemia (low... View more

Prescription only

Trulicity mimics the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the liver. It lowers blood glucose levels in people with... View more

More about Glimepiride More about Trulicity (dulaglutide)
Ratings & Reviews

Glimepiride has an average rating of 6.7 out of 10 from a total of 71 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 25% reported a negative effect.

Trulicity has an average rating of 5.3 out of 10 from a total of 971 ratings on Drugs.com. 38% of reviewers reported a positive effect, while 40% reported a negative effect.

View all 71 reviews

View all 971 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Glimepiride side effects

View all Trulicity side effects
Drug Class
Generic Availability

Lower cost generic

N/A
Pricing and Coupons * Prices are without insurance
Quantity 50 each
Strength 4 mg
Per unit* $0.58
Cost* $29.24

View all Glimepiride prices

Quantity 2 mL
Strength 0.75 mg/0.5 mL
Per unit* $531.93
Cost* $1,063.85

View all Trulicity prices

Get free Discount Card

Get free Discount Card

Dosage Forms
  • Oral tablet
  • Subcutaneous solution
Brand Names
Amaryl

N/A
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

3.4 hours

120 hours
CSA Schedule 1 View glossary of CSA terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
Drug Interactions

A total of 493 drugs are known to interact with Glimepiride:

  • 23 major drug interactions (59 brand and generic names)
  • 455 moderate drug interactions (2357 brand and generic names)
  • 15 minor drug interactions (106 brand and generic names)

A total of 271 drugs are known to interact with Trulicity:

  • 15 major drug interactions (34 brand and generic names)
  • 254 moderate drug interactions (1446 brand and generic names)
  • 2 minor drug interactions (14 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood... View more
  • Dulaglutide may affect the absorption of other medications that you take by mouth. In some cases... View more
  • Talk to your doctor before using alcohol together with dulaglutide. Alcohol may affect blood... View more
Disease Interactions
First Approval Date

November 30, 1995

September 18, 2014
WADA Class View classifications

N/A

N/A
More Information
Patient Resources
Professional Resources
Related Treatment Guide

1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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