Glimepiride and Weight Gain: What Users Say

• Alm...
• March 16, 2011

Glimepiride for Type 2 Diabetes "Bif's comments are true. This medicine will drop your sugar levels quickly, but it works too well. Thirty minutes after taking 2mg, I can feel my sugar levels getting low. I don't have the shakes (meaning my sugar levels are in the low 60s), but I probably would in a matter of minutes. After eating breakfast, I must eat again about 2 hours later or I'll get the shakes. I must be conscious of my sugar levels for the first 4 hours after taking a dose. Overall, my fasting sugar level has dropped from 140 to 110, simply by taking 2mg each morning. However, I find I am gaining weight and overeating too."

• Fru...
• Taken for 1 to 6 months
• May 4, 2019

For Type 2 Diabetes "Just started this medicine after Januvia made me feel like I had Lyme disease. Have been on glimepiride 1 mg once a day for a month. Works great on lowering sugar levels. My stomach and intestines blow out like a balloon after I eat no matter what it is. Makes me weepy, moody, and have gained 7 lbs in one month. Not going to live like this!"

• Gin...
• Taken for 1 to 6 months
• August 24, 2019

For Type 2 Diabetes "I was taking Januvia and Invokana, but it wasn't quite enough, so my doctor added glimepiride. I started taking it 3 months ago, and it really worked! My A1C dropped to 6.7, and I average 120-130 blood sugar. My blood sugar bottomed out a few times since starting it, but I just have to plan snacks and eat properly. My only complaint is I gained weight since starting it, and I'm hungry more often."

• Mar...
• Taken for 1 to 6 months
• August 19, 2018

For Type 2 Diabetes "I was put on glimepiride because I could no longer afford my other medication. I was on it for four months, gained ten pounds in seven days, and my A1c jumped way up. Before this, I was reaching my next goal weight...only two pounds away...so this sudden gain was devastating. I thought, well, if my A1c improves, I will just deal with the weight issue, but it got much worse."

• gli...
• Taken for 1 to 6 months
• September 4, 2021

For Type 2 Diabetes "I have been on metformin and have tolerated it well. Glimepiride was added since my A1C was at 8.4. After 3 months of taking it, there was no difference. I also gained 10 pounds. This medication does give you an appetite, but I didn't expect this type of weight gain. No good for me. Unfortunately, there are no other options for those without insurance. Investigating which other one I can take without it being $500 per month."

• Tyr...
• Taken for 1 to 6 months
• November 5, 2018

For Type 2 Diabetes "Medication worked great. I took it for 7 months. Just couldn’t deal with the weight gain. I gained about 10 lbs in that time."