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Duloxetine Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Duloxetine Caplyta (lumateperone) Lybalvi (olanzapine / samidorphan)
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Duloxetine Caplyta (lumateperone) Lybalvi (olanzapine / samidorphan)
Prescription only

Duloxetine has antidepressant, anti-anxiety, and pain-relieving properties; however, it may cause a discontinuation syndrome on withdrawal even when tapered. Symptoms may include anxiety, headache... View more

Prescription only

Caplyta is an atypical antipsychotic that is used to treat adults with schizophrenia or depression associated with bipolar disorder. Sleepiness is the most common side effect and it should not be... View more

Prescription only

Prescribed for Bipolar Disorder, Schizophrenia. Lybalvi may also be used for purposes not listed in this medication guide.

More about Duloxetine More about Caplyta (lumateperone) More about Lybalvi (olanzapine / samidorphan)
Ratings & Reviews

Duloxetine has an average rating of 6.2 out of 10 from a total of 2458 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 31% reported a negative effect.

Caplyta has an average rating of 6.6 out of 10 from a total of 184 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 29% reported a negative effect.

Lybalvi has an average rating of 8.1 out of 10 from a total of 16 ratings on Drugs.com. 75% of reviewers reported a positive effect, while 6% reported a negative effect.

View all 2458 reviews

View all 184 reviews

View all 16 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Duloxetine side effects

View all Caplyta side effects

View all Lybalvi side effects
Drug Class
Generic Availability

Lower cost generic

No lower cost generic approved

No lower cost generic approved
Pricing and Coupons * Prices are without insurance
Quantity 100 each
Strength 30 mg
Per unit* $1.31 - $2.34
Cost* $130.61 - $233.77

View all Duloxetine prices

Quantity 30 each
Strength 42 mg
Per unit* $61.18
Cost* $1,835.40

View all Caplyta prices

Quantity 30 tablet
Strength 5 mg-10 mg
Per unit* $58.95
Cost* $1,768.40

View all Lybalvi prices

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Dosage Forms
  • Oral delayed release capsule
  • Oral capsule
  • Oral tablet
Brand Names
Cymbalta, Drizalma Sprinkle, Irenka

N/A

N/A
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

17 hours

18 hours

54 hours (empirically)
CSA Schedule 1 View glossary of CSA terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.
Drug Interactions

A total of 624 drugs are known to interact with Duloxetine:

  • 109 major drug interactions (477 brand and generic names)
  • 492 moderate drug interactions (2134 brand and generic names)
  • 23 minor drug interactions (184 brand and generic names)

A total of 604 drugs are known to interact with Caplyta:

  • 167 major drug interactions (620 brand and generic names)
  • 435 moderate drug interactions (1719 brand and generic names)
  • 2 minor drug interactions (5 brand and generic names)

A total of 700 drugs are known to interact with Lybalvi:

  • 66 major drug interactions (350 brand and generic names)
  • 626 moderate drug interactions (2356 brand and generic names)
  • 8 minor drug interactions (24 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • DULoxetine may cause liver damage, and taking it with alcohol may increase that risk. You should... View more
  • Grapefruit and grapefruit juice may increase the blood levels of lumateperone. In some cases, this... View more
  • Using lumateperone together with alcohol may increase side effects such as dizziness, drowsiness... View more
  • Alcohol can increase the nervous system side effects of OLANZapine such as dizziness, drowsiness... View more
Disease Interactions
First Approval Date

August 03, 2004

December 20, 2019

May 28, 2021
WADA Class View classifications

N/A

N/A

N/A
More Information
Patient Resources
Professional Resources
Related Treatment Guide

1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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