Depakote ER Alternatives Compared
| Depakote ER (divalproex sodium) | Caplyta (lumateperone) | Lybalvi (olanzapine / samidorphan) |
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| Depakote ER (divalproex sodium) | Caplyta (lumateperone) | Lybalvi (olanzapine / samidorphan) |
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Prescription only
Prescribed for Bipolar Disorder, Mania, Migraine Prevention, Seizures, Epilepsy. Depakote ER may also be used for purposes not listed in this medication guide. |
Prescription only
Caplyta is an atypical antipsychotic that is used to treat adults with schizophrenia or depression associated with bipolar disorder. Sleepiness is the most common side effect and it should not be... View more |
Prescription only
Prescribed for Bipolar Disorder, Schizophrenia. Lybalvi may also be used for purposes not listed in this medication guide. |
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| More about Depakote ER (divalproex sodium) | More about Caplyta (lumateperone) | More about Lybalvi (olanzapine / samidorphan) | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Depakote ER has an average rating of 7.3 out of 10 from a total of 98 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 12% reported a negative effect. |
Caplyta has an average rating of 6.6 out of 10 from a total of 184 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 29% reported a negative effect. |
Lybalvi has an average rating of 8.1 out of 10 from a total of 16 ratings on Drugs.com. 75% of reviewers reported a positive effect, while 6% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||||||||||
View all Depakote ER side effects |
View all Caplyta side effects |
View all Lybalvi side effects |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Depakote ER prices |
View all Caplyta prices |
View all Lybalvi prices |
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| Dosage Forms | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Other divalproex sodium brands include: Depakote, Depakote Sprinkles |
N/A |
N/A |
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||||||||||
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16 hours |
18 hours |
54 hours (empirically) |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category D
Positive evidence of risk
When Treating Epilepsy And Manic Episodes Associated With Bipolar Disorder
Category X
Not for use in pregnancy
When Treating Migraine See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 424 drugs are known to interact with Depakote ER:
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A total of 604 drugs are known to interact with Caplyta:
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A total of 702 drugs are known to interact with Lybalvi:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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| First Approval Date | ||||||||||||||||||||||||||
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August 04, 2000 |
December 20, 2019 |
May 28, 2021 |
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| WADA Class View classifications | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| Related Treatment Guide | ||||||||||||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.