Clonazepam Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Clonazepam	Caplyta (lumateperone)	Lybalvi (olanzapine / samidorphan)	Enter another drug to compare

Clonazepam

Caplyta (lumateperone)

Lybalvi (olanzapine / samidorphan)

Prescription only

Clonazepam may reduce seizure frequency in specific seizure disorders and can be used short-term for panic disorder, to relieve anxiety, or to sedate. When used long-term it can cause dependence and... View more

Prescription only

Caplyta is an atypical antipsychotic that is used to treat adults with schizophrenia or depression associated with bipolar disorder. Sleepiness is the most common side effect and it should not be... View more

Prescription only

Prescribed for Bipolar Disorder, Schizophrenia. Lybalvi may also be used for purposes not listed in this medication guide.

More about Clonazepam

More about Caplyta (lumateperone)

More about Lybalvi (olanzapine / samidorphan)

Ratings & Reviews

Clonazepam has an average rating of 8.2 out of 10 from a total of 2177 ratings on Drugs.com. 78% of reviewers reported a positive effect, while 12% reported a negative effect.

Caplyta has an average rating of 6.6 out of 10 from a total of 184 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 29% reported a negative effect.

Lybalvi has an average rating of 8.1 out of 10 from a total of 16 ratings on Drugs.com. 75% of reviewers reported a positive effect, while 6% reported a negative effect.

View all 2177 reviews

View all 184 reviews

View all 16 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Anxiety (7.1%)
Drowsiness (6.8%)
Withdrawal (6.5%)
Insomnia (4.7%)
Tiredness (3.2%)
Depression (3.2%)
Panic attacks (3.1%)

View all Clonazepam side effects

Headaches (14.1%)
Dry mouth (10.3%)
Nausea (10.3%)
Dizziness (9.8%)
Drowsiness (9.8%)
Tiredness (9.2%)
Weight gain (6.5%)

View all Caplyta side effects

View all Lybalvi side effects

Drug Class

Atypical antipsychotics

Psychotherapeutic combinations

Generic Availability

Lower cost generic

No lower cost generic approved

Pricing and Coupons * Prices are without insurance

Quantity	10 tablet
Strength	0.5 mg
Per unit^*	$1.04 - $1.22
Cost^*	$10.36 - $12.19

View all Clonazepam prices

Quantity	30 each
Strength	42 mg
Per unit^*	$61.18
Cost^*	$1,835.40

View all Caplyta prices

Quantity	30 tablet
Strength	5 mg-10 mg
Per unit^*	$58.95
Cost^*	$1,768.40

View all Lybalvi prices

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Dosage Forms

Oral tablet
Oral tablet, disintegrating

Oral capsule

Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

40 hours

18 hours

54 hours (empirically)

CSA Schedule ¹ View glossary of CSA terms

Some potential for abuse

Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category D Positive evidence of risk

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Drug Interactions

A total of 531 drugs are known to interact with Clonazepam:

30 major drug interactions (155 brand and generic names)
468 moderate drug interactions (1733 brand and generic names)
33 minor drug interactions (210 brand and generic names)

A total of 604 drugs are known to interact with Caplyta:

167 major drug interactions (620 brand and generic names)
435 moderate drug interactions (1719 brand and generic names)
2 minor drug interactions (5 brand and generic names)

A total of 700 drugs are known to interact with Lybalvi:

66 major drug interactions (350 brand and generic names)
626 moderate drug interactions (2356 brand and generic names)
8 minor drug interactions (24 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Using clonazePAM together with alcohol can increase nervous system side effects such as dizziness... View more

Grapefruit and grapefruit juice may increase the blood levels of lumateperone. In some cases, this... View more
Using lumateperone together with alcohol may increase side effects such as dizziness, drowsiness... View more

Alcohol can increase the nervous system side effects of OLANZapine such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

June 04, 1975

December 20, 2019

May 28, 2021

WADA Class View classifications

N/A

More Information

Patient Resources

Clonazepam uses

Caplyta uses

Lybalvi uses

Professional Resources

Prescribing information

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Clonazepam Alternatives Compared

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