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Clindamycin Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Clindamycin Amoxicillin Doxycycline
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Clindamycin Amoxicillin Doxycycline
Prescription only

Clindamycin is an antibiotic that is usually reserved for treating anaerobic infections or other serious infections caused by gram-positive bacteria in penicillin-allergic people. The risk of C... View more

Prescription only

Amoxicillin is a penicillin-type antibiotic that may be used to treat infections caused by susceptible bacteria. It is usually well tolerated, but a rash is a common side effect. Prescribed for... View more

Prescription only

Doxycycline is an effective antibiotic that treats a wide range of infections. However, it is not usually recommended for children aged less than eight or pregnant women in the last half of their... View more

More about Clindamycin More about Amoxicillin More about Doxycycline
Ratings & Reviews

Clindamycin has an average rating of 5.7 out of 10 from a total of 807 ratings on Drugs.com. 43% of reviewers reported a positive effect, while 35% reported a negative effect.

Amoxicillin has an average rating of 6.4 out of 10 from a total of 366 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 30% reported a negative effect.

Doxycycline has an average rating of 6.4 out of 10 from a total of 1635 ratings on Drugs.com. 50% of reviewers reported a positive effect, while 27% reported a negative effect.

View all 807 reviews

View all 366 reviews

View all 1635 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Clindamycin side effects

View all Amoxicillin side effects

View all Doxycycline side effects
Drug Class
Generic Availability

Lower cost generic

Lower cost generic

Lower cost generic
Pricing and Coupons * Prices are without insurance
Quantity 4 capsule
Strength 150 mg
Per unit* $2.84
Cost* $11.36

View all Clindamycin prices

Quantity 4 capsule
Strength 500 mg
Per unit* $2.61
Cost* $10.42

View all Amoxicillin prices

Quantity 2 tablet
Strength hyclate 100 mg
Per unit* $6.62
Cost* $13.23

View all Doxycycline prices

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Dosage Forms
  • Injectable solution
  • Intravenous solution
  • Oral capsule
  • Oral powder for reconstitution
  • Oral capsule
  • Oral powder for reconstitution
  • Oral tablet
  • Oral tablet, chewable
  • Oral tablet, extended release
  • Injectable powder for injection
  • Oral capsule
  • Oral delayed release capsule
  • Oral delayed release tablet
  • Oral powder for reconstitution
  • Oral tablet
Brand Names
Cleocin, Cleocin HCl, Cleocin Pediatric, Cleocin Phosphate, Cleocin Phosphate ADD-Vantage Amoxil, Apo-Amoxi Acticlate, Adoxa, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Doryx MPC, Doxy 100, Doxy 200, Doxy-Caps, Doxy-D, LymePak, Mondoxyne NL, Monodox, Morgidox, Okebo, Oracea, Oraxyl, Targadox, Uracil, Vibramycin View more
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

3.4 hours

1.7 hours

23 hours
CSA Schedule 1 View glossary of CSA terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
B
Category B No proven risk in humans

See the full pregnancy warnings document.
B
Category B No proven risk in humans

See the full pregnancy warnings document.
D
Category D Positive evidence of risk

See the full pregnancy warnings document.
Drug Interactions

A total of 110 drugs are known to interact with Clindamycin:

  • 6 major drug interactions (15 brand and generic names)
  • 101 moderate drug interactions (384 brand and generic names)
  • 3 minor drug interactions (9 brand and generic names)

A total of 57 drugs are known to interact with Amoxicillin:

  • 7 major drug interactions (25 brand and generic names)
  • 43 moderate drug interactions (257 brand and generic names)
  • 7 minor drug interactions (35 brand and generic names)

A total of 223 drugs are known to interact with Doxycycline:

  • 22 major drug interactions (60 brand and generic names)
  • 196 moderate drug interactions (2214 brand and generic names)
  • 5 minor drug interactions (21 brand and generic names)
Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Disease Interactions
First Approval Date

February 22, 1970

January 18, 1974

December 05, 1967
WADA Class View classifications

N/A

N/A

N/A
More Information
Patient Resources
Professional Resources
Related Treatment Guide

1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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