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Acetaminophen / diphenhydramine Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Acetaminophen / diphenhydramine Trazodone Zolpidem
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Acetaminophen / diphenhydramine Trazodone Zolpidem
Over-the-counter

Prescribed for Insomnia, Pain, Headache. Acetaminophen / diphenhydramine may also be used for purposes not listed in this medication guide.

Prescription only

Trazodone is mostly used for its sleep-inducing effects (an off-label indication) rather than as an antidepressant. Only generic forms are available which makes it a lot cheaper than some other... View more

Prescription only

Zolpidem induces sleep; however, longer-acting formulations may impair physical and mental capabilities the next day. May induce complex or dangerous sleep-related behaviors like "sleep-driving"... View more

Related suggestions
More about Acetaminophen / diphenhydramine More about Trazodone More about Zolpidem
Ratings & Reviews

Acetaminophen / diphenhydramine has an average rating of 7.0 out of 10 from a total of 69 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 26% reported a negative effect.

Trazodone has an average rating of 6.3 out of 10 from a total of 1411 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 31% reported a negative effect.

Zolpidem has an average rating of 7.0 out of 10 from a total of 1051 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 22% reported a negative effect.

View all 69 reviews

View all 1411 reviews

View all 1051 reviews

Drug Class
Side Effects

Acetaminophen / diphenhydramine side effects

Trazodone side effects

Zolpidem side effects
Generic Availability

Lower cost generic

Lower cost generic

Lower cost generic
Pricing and Coupons * Prices are without insurance
Quantity 50 tablet
Dosage 500 mg-25 mg
Per Unit* $0.23 - $0.25
Cost* $11.53 - $12.51

View all Acetaminophen / diphenhydramine prices

Quantity 100 each
Dosage 50 mg
Per Unit* $0.22 - $0.23
Cost* $22.09 - $22.76

View all Trazodone prices

Quantity 6 tablet
Dosage 10 mg
Per Unit* $2.34
Cost* $14.05

View all Zolpidem prices

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Get free Discount Card

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Dosage Forms Available
  • Oral tablet
  • Oral tablet
  • Oral capsule
  • Oral tablet
  • Oral tablet, extended release
  • Sublingual tablet
Brand Names
Acetadryl, Acetaminophen PM Extra Strength, Anacin PM Aspirin Free, Bayer Select Max Strength Night Time Pain, ConRx PM, Counteract PM Extra Strength, Excedrin PM, Genapap PM, Headache Formula PM, Headache Relief PM, Legatrin PM, Mapap PM, Midol PM, Night Time Pain, Non-Aspirin PM Extra Strength, Pain Reliever PM, Percogesic Extra Strength, Percogesic Original Strength, Pharbetol PM, Robitussin Honey Severe Cough, Flu + Sore Throat CF Max Nighttime, Tylenol PM, Tylenol Sore Throat Nighttime, Unisom PM Pain, Wal-Nadol PM Extra Strength View more

N/A

 Ambien, Ambien CR, Edluar, Zolpimist
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

9.3 hours

7.5 hours

2.6 hours
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
4
Some potential for abuse

Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
Pregnancy Category
N
Category N Not classified

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
Drug Interactions

A total of 532 drugs are known to interact with Acetaminophen / diphenhydramine:

  • 22 major drug interactions (112 brand and generic names)
  • 496 moderate drug interactions (1875 brand and generic names)
  • 14 minor drug interactions (54 brand and generic names)

A total of 653 drugs are known to interact with Trazodone:

  • 137 major drug interactions (499 brand and generic names)
  • 501 moderate drug interactions (1930 brand and generic names)
  • 15 minor drug interactions (70 brand and generic names)

A total of 474 drugs are known to interact with Zolpidem:

  • 29 major drug interactions (154 brand and generic names)
  • 442 moderate drug interactions (1654 brand and generic names)
  • 3 minor drug interactions (6 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Ask your doctor before using acetaminophen together with alcohol. This can cause serious side... View more
  • Alcohol can increase the nervous system side effects of traZODone such as dizziness, drowsiness... View more
  • You should avoid the use of alcohol while being treated with zolpidem. Alcohol can increase the... View more
Disease Interactions
First Approval Date

N/A

December 24, 1981

December 16, 1992
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources
Professional Resources

N/A
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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