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Acetaminophen / diphenhydramine Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Acetaminophen / diphenhydramine Ubrogepant Fioricet (acetaminophen / butalbital / caffeine)
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Acetaminophen / diphenhydramine Ubrogepant Fioricet (acetaminophen / butalbital / caffeine)
Over-the-counter

Prescribed for Insomnia, Pain, Headache. Acetaminophen / diphenhydramine may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Migraine, Headache. Ubrogepant may also be used for purposes not listed in this medication guide.

Prescription only

Fioricet may be used for the short-term treatment of tension-type headaches; however, it is not a first-choice medicine because it is potentially habit-forming and causes sedation. Simpler and safer... View more

More about Acetaminophen / diphenhydramine More about Ubrogepant More about Fioricet (acetaminophen / butalbital / caffeine)
Ratings & Reviews

Acetaminophen / diphenhydramine has an average rating of 7.0 out of 10 from a total of 69 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 26% reported a negative effect.

Ubrogepant has an average rating of 6.3 out of 10 from a total of 254 ratings on Drugs.com. 57% of reviewers reported a positive effect, while 37% reported a negative effect.

Fioricet has an average rating of 8.8 out of 10 from a total of 167 ratings on Drugs.com. 85% of reviewers reported a positive effect, while 7% reported a negative effect.

View all 69 reviews

View all 254 reviews

View all 167 reviews

Drug Class
Side Effects

Acetaminophen / diphenhydramine side effects

Ubrogepant side effects

Fioricet side effects
Generic Availability

Lower cost generic

N/A

N/A
Pricing and Coupons * Prices are without insurance
Quantity 50 tablet
Strength 500 mg-25 mg
Per Unit* $0.23 - $0.25
Cost* $11.53 - $12.51

View all Acetaminophen / diphenhydramine prices

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Dosage Forms Available
  • Oral tablet

N/A
  • Oral capsule
  • Oral tablet
Brand Names
Acetadryl, Acetaminophen PM Extra Strength, Anacin PM Aspirin Free, Bayer Select Max Strength Night Time Pain, ConRx PM, Counteract PM Extra Strength, Excedrin PM, Genapap PM, Headache Formula PM, Headache Relief PM, Legatrin PM, Mapap PM, Midol PM, Night Time Pain, Non-Aspirin PM Extra Strength, Pain Reliever PM, Percogesic Extra Strength, Percogesic Original Strength, Pharbetol PM, Robitussin Honey Severe Cough, Flu + Sore Throat CF Max Nighttime, Tylenol PM, Tylenol Sore Throat Nighttime, Unisom PM Pain, Wal-Nadol PM Extra Strength View more Ubrelvy Other acetaminophen / butalbital / caffeine brands include: Anolor 300, Capacet, Phrenilin Forte, Vanatol LQ, Vanatol S, Vtol LQ, Zebutal
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

9.3 hours

7 hours

35 hours
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
N
Category N Not classified

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
Drug Interactions

A total of 532 drugs are known to interact with Acetaminophen / diphenhydramine:

  • 22 major drug interactions (112 brand and generic names)
  • 496 moderate drug interactions (1876 brand and generic names)
  • 14 minor drug interactions (54 brand and generic names)

A total of 228 drugs are known to interact with Ubrogepant:

  • 38 major drug interactions (96 brand and generic names)
  • 190 moderate drug interactions (554 brand and generic names)

A total of 682 drugs are known to interact with Fioricet:

  • 47 major drug interactions (196 brand and generic names)
  • 584 moderate drug interactions (2546 brand and generic names)
  • 51 minor drug interactions (269 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Ask your doctor before using acetaminophen together with alcohol. This can cause serious side... View more
  • Grapefruit and grapefruit juice can increase the blood levels of ubrogepant. This may increase... View more
  • Ask your doctor before using acetaminophen together with alcohol. This can cause serious side... View more
Disease Interactions
First Approval Date

N/A

N/A

N/A
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources
Professional Resources

N/A
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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