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Acetaminophen / diphenhydramine and Anxiety: What Users Say

Brand names: Tylenol PM, Headache Relief PM, Pain Reliever PM, Midol PM, Percogesic Extra Strength, Headache Formula PM, Legatrin PM, Bayer Select Max Strength Night Time Pain, ConRx PM, Acetadryl, Night Time Pain, Percogesic Original Strength, Unisom PM Pain, Genapap PM, Mapap PM, Counteract PM Extra Strength, Wal-Nadol PM Extra Strength, Excedrin PM, Tylenol Sore Throat Nighttime, Pharbetol PM, Non-Aspirin PM Extra Strength Acetaminophen PM Extra Strength Robitussin Honey Severe Cough, Flu + Sore Throat CF Max Nighttime Anacin PM Aspirin Free …show all brand names

Anxiety: mentioned by 5 users (7.2%)

Based on user experiences from 69 Acetaminophen / diphenhydramine reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

drowsiness 13.0%
anxiety 7.2%
dry mouth 4.3%
headaches 4.3%
insomnia 4.3%
sleepy 4.3%

Reviews for Acetaminophen / diphenhydramine

Showing 5 reviews tagged with "anxiety". Clear filters to view all 69 reviews.
Commonly mentioned side effects
  • Anonymous
  • October 24, 2012

For Insomnia "When I take this medication, I sleep through the night with no pain but wake up restless and feeling anxious and nervous all day. Also, I get heart palpitations and difficulty breathing. You have to be careful with this over-the-counter medication."

1 / 10
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80 Report
  • Anonymous
  • October 24, 2012

For Insomnia "When I take this medication, I sleep through the night with no pain but wake up restless and feeling anxious and nervous all day. Also, I get heart palpitations and difficulty breathing. You have to be careful with this over-the-counter medication."

1 / 10
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80 Report
  • Hel...
  • Taken for 6 months to 1 year
  • August 15, 2021

For Pain "Initially started taking Tylenol PM for ongoing knee and foot pain (I’m a dancer) 6 months ago. Very quickly became a nightly ritual to take one (occasionally 2) and fall asleep within 20 mins and stay asleep for 8+ hrs. The downside - blurred vision (especially in the morning), troubling memory loss (my kids were growing concerned about me not remembering conversations), anxiety and depression (bursting into tears frequently and for no reason). I went ‘cold turkey’ 6 days ago and am already starting to feel better after a couple of sleepless nights. I will NEVER touch this stuff again. It’s easy to see how this drug has been linked to dementia. Please don’t be tempted to use it."

1 / 10
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9 Report
  • Anonymous
  • March 22, 2009

For Headache "I occasionally use Tylenol Rapid Release during the day and recently developed a cold and flu, so I decided to try Tylenol PM at night for better sleep. Make sure to read the drug interactions first, as I spent two restless nights with nervousness. Many of my friends take this product, so I'll pass it on to them, but if you are on other medication, check the list of side effects."

1 / 10
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14 Report
  • Lyg...
  • Taken for 6 months to 1 year
  • September 21, 2013

For Pain "This product is not well known. I had to introduce it to my sister. She was taking Advil PM, and it made her angry, anxious. I took her off Advil PM and got her on Midol PM. A few days later, she called me and shared the same thing I experienced. Calm, well rested, relaxed, and not as angry as before. I love this product. I hate the fact that it took me so long to find it. It needs to be marketed more. Black women like me have issues with our periods. Bad cramps and insomnia plague us. A product that focuses on treating these problems without the side effects is Godsend. I take just two pills at night when I am PMSing and during my period, and I wake up like a new woman."

10 / 10
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8 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.