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Acetaminophen / diphenhydramine and Drowsiness: What Users Say

Brand names: Tylenol PM, Headache Relief PM, Pain Reliever PM, Midol PM, Percogesic Extra Strength, Headache Formula PM, Legatrin PM, Bayer Select Max Strength Night Time Pain, ConRx PM, Acetadryl, Night Time Pain, Percogesic Original Strength, Unisom PM Pain, Genapap PM, Mapap PM, Counteract PM Extra Strength, Wal-Nadol PM Extra Strength, Excedrin PM, Tylenol Sore Throat Nighttime, Pharbetol PM, Non-Aspirin PM Extra Strength Acetaminophen PM Extra Strength Robitussin Honey Severe Cough, Flu + Sore Throat CF Max Nighttime Anacin PM Aspirin Free …show all brand names

Drowsiness: mentioned by 9 users (13.0%)

Based on user experiences from 69 Acetaminophen / diphenhydramine reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

drowsiness 13.0%
anxiety 7.2%
dry mouth 4.3%
headaches 4.3%
insomnia 4.3%
sleepy 4.3%

Reviews for Acetaminophen / diphenhydramine

Commonly mentioned side effects
  • Bri...
  • September 29, 2008

For Insomnia "I've taken other prescription sleep medications in the past, but they do tend to make you drowsy and have all sorts of side effects. I suffer from rheumatoid arthritis, and the pain stops me from sleeping. I now take this at bedtime with a small dose of prescribed codeine. Between the painkillers and the 'sleep' effect of the Tylenol, I truly can't believe how well I am sleeping! Just be aware that this can really make you fall asleep fast, so do be ready for bed. I've spoken to four other people who have various pain problems, and they all love this medication too."

10 / 10
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64 Report
  • Anonymous
  • March 15, 2012

For Insomnia "I really like this pill, besides the fact that I sleep all day. I take the pill every few days at about 12, when I'm not tired, and 15 minutes later I become drowsy. About 30 minutes after that, I'm asleep, but I tend to sleep really late. I don't hear my alarms, and I can't get myself out of bed. If you do take this, I would consider taking it earlier than you normally would. Other than that, this pill is the best I have found and works great, just like it says."

9 / 10
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47 Report
  • Hey...
  • Taken for less than 1 month
  • December 15, 2021

For Insomnia "I just started working third shift and use this when I get home to fall asleep. It works great, and I get 8 hours of uninterrupted sleep. I don’t seem to wake up super groggy either. I am 21 years old, so this may be the reason."

9 / 10
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10 Report
  • taz...
  • Taken for 10 years or more
  • December 19, 2012

For Pain "I was told about this medicine about 10 years ago. At the time, I could only find the original strength and quickly found out that I could not take it during the day because it knocks me out and I would be sleeping. It is the only medicine that will take away the pain I am having. I had knee surgery twice in a year, and the prescription pain medicine I had took away some pain, but with the Percogesic, the rest of the pain went away and I got to sleep. I tried the maximum strength last year for the first time and discovered that it didn't make me sleep... actually hyped me up. I discovered it was different than the original strength by having an antihistamine in which I am sensitive to. So now I can take it during the day. It's the best!"

10 / 10
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20 Report
  • Bab...
  • Taken for less than 1 month
  • January 4, 2022

For Insomnia "Works great for pain and awesome for sleep! I haven’t the slightest idea how anyone can say this doesn’t help as a sleep aid…and I never feel groggy in the am. I take it 15 minutes before I close my eyes."

10 / 10
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6 Report

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  • fle...
  • September 20, 2013

For Insomnia "I love these. When I feel like I will have trouble sleeping, I take 1 pill. That usually works. If it doesn't, I take another one. No side effects except sometimes my dreams are better. No hangover. My sister cannot take them, they make her groggy."

8 / 10
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11 Report
  • Ang...
  • Taken for less than 1 month
  • September 8, 2019

For Pain "I have taken this medication for pain in my foot due to gout. Nothing else I bought over the counter worked. I read the bottle and decided to try it. It eased my pain more than I ever thought an over-the-counter medicine could. The only thing to be aware of is it makes you sleepy and drowsy. But it works!"

10 / 10
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3 Report
  • bba...
  • Taken for 1 to 6 months
  • August 19, 2020

For Insomnia "This stuff keeps me awake and feels pretty groggy in the mornings, especially when I take 2 tablets. All using with good results, take 1 or 2 tablets at bedtime?"

3 / 10
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10 Report
  • Why...
  • Taken for 6 months to 1 year
  • September 8, 2021

For Insomnia "Tylenol PM makes me drowsy. I fall asleep, and then after three hours, I’m wide awake and cannot fall back to sleep."

1 / 10
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4 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.