Trazodone Interactions
There are 672 drugs known to interact with trazodone, along with 8 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 138 are major, 519 are moderate, and 15 are minor.
- View all 672 medications that may interact with trazodone
- View trazodone alcohol/food interactions (1)
- View trazodone disease interactions (8)
Most frequently checked interactions
View interaction reports for trazodone and the medicines listed below.
- Abilify (aripiprazole)
- Adderall (amphetamine / dextroamphetamine)
- Ambien (zolpidem)
- Ativan (lorazepam)
- Benadryl (diphenhydramine)
- Cymbalta (duloxetine)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Flexeril (cyclobenzaprine)
- Flonase (fluticasone nasal)
- Klonopin (clonazepam)
- Lamictal (lamotrigine)
- Lexapro (escitalopram)
- Lyrica (pregabalin)
- Metoprolol Succinate ER (metoprolol)
- Norco (acetaminophen / hydrocodone)
- Prozac (fluoxetine)
- Seroquel (quetiapine)
- Singulair (montelukast)
- Synthroid (levothyroxine)
- Topamax (topiramate)
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- Vyvanse (lisdexamfetamine)
- Wellbutrin (bupropion)
- Wellbutrin XL (bupropion)
- Xanax (alprazolam)
- Zoloft (sertraline)
- Zyrtec (cetirizine)
Trazodone alcohol/food interactions
There is 1 alcohol/food interaction with trazodone.
Trazodone disease interactions
There are 8 disease interactions with trazodone which include:
- angle closure glaucoma
- mania
- seizures
- suicidality
- cardiovascular disease
- hyponatremia
- hypotension
- renal/liver disease
Report options
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
