Trintellix User Reviews & Ratings (Page 5)

• Lon...
• December 4, 2015

For Depression "I am a 61-year-old male. I tried all SSRIs and MAOIs for persistent depression over 9 years. Most recently, I was on Prozac. None of these worked beyond moderate improvement. Depression and anxiety plagued me constantly. I used Lorazepam to sleep effectively. I started on Trintellix 10 mg and within 2 weeks felt stable and able to deal with challenging personal setbacks with clarity and resolve. I think that 4 months into it, I have found a drug that truly works."

• asa...
• May 27, 2020

For Depression "I'm in my early 30s, been dealing with depression for almost 15 years. My former doc prescribed me Trintellix. He swore it was a super 'clean' med without side effects. It's been 2+ years taking it (max 20mg) and I had no positive effects. Don't let your doc tell you it won't/rarely cause weight gain. It does, especially if you're a female. It will continue the longer on it/dose increased. Also, awful GI problems - bad nausea or bad constipation. Also, it only makes anxiety worse, especially if you take it in the AM - take it in PM, you can't sleep ^_^ I would stay away from this drug, definitely if you have anxiety, a sensitive stomach, or are prone to weight gain from meds. I'm done off this in 4 days! Can't wait."

• Fig...
• Taken for 1 to 6 months
• March 1, 2019

For Depression "Updating my review as I have now been taking Trintellix 10mg for 5 weeks. Feeling great, no nausea unless I drink a glass of wine. I was taking it in the morning but it was making me very sleepy early in the evenings. Now I take it at about 2:30 pm and that is working great for me. It has regulated my sleep so that in itself has changed my life! It has really helped me with my severe social anxiety, and my low feeling is beginning to lift. I have no feeling of being medicated at all. My insurance is covering it thanks to my doctor and his prior approval letter showing other meds did not work for me. My copay is $60, and there is a savings card with Trintellix on their website that brought my cost down to $10."

• Nik...
• Taken for less than 1 month
• February 13, 2020

For Depression "Was switched to Trintellix from Citalopram as it interfered with an antibiotic I needed. I have been on it for 3 weeks now. Absolutely horrible! I have never felt this crazy. I feel like I am losing my mind. Constant panic attacks, sensitivity to even the slightest sounds, lightheadedness/dizziness, nausea, suicidal ideations, difficulty breathing. I am suffering from severe mood swings. I stopped taking it tonight. Just can't do it anymore. I'd rather have nothing than this."

• Moo...
• Taken for less than 1 month
• February 20, 2014

For Depression "I have been on Trintellix 10 mg and increased to 20 mg on 02/19/2014. I have experienced dry mouth, dizziness, forgetfulness, no desire to eat, weight loss of 11 lbs in 10 days, which is good considering I am overweight. This can't be a bad thing, and wake up often. However, I am in a happier mood and not so stressed out. I have been on Trintellix for a total of 11 days. Hope the yucky side effects go away soon. I have tried almost everything else and nothing has worked mood-wise for me as good as this is."

• Sen...
• Taken for less than 1 month
• February 28, 2014

For Depression "I have been taking 10 mg for 3 weeks. I have taken other antidepressants before with very little to no help. With this one, I feel a lot better. I have more energy, I can focus and concentrate better. My mind is clearer than it has been for a long time, and I am happier. So far, I have no side effects besides I am a little constipated."

• jew...
• April 8, 2014

For Major Depressive Disorder "Great experience so far. Month three, ramping up to 20 mg a day. Constipation side effect eliminated by 2 fiber capsules a day. No sexual side effects and feeling much more like myself! No weight gain!"

• Anonymous
• Taken for 1 to 6 months
• January 15, 2025

For Major Depressive Disorder "Trintellix has been the most effective antidepressant I've ever taken. I've been on numerous SSRIs (and one SNRI... not for me, never again). It took the entire four weeks to start working, but once it did, I immediately saw a difference in my MDD symptoms. I described it to a colleague that my depression has lifted completely. I have motivation to get out of bed and take part in social activities again after work. I'm eating normally again and haven't experienced any side effects from the medication. I'm prescribed 10 mg Trintellix and being treated specifically for MDD. Trintellix isn't helpful for my anxiety at all. My psychiatrist identified some preexisting Bipolar II symptoms (mostly mood swings) and has me on a low-dose mood stabilizer, generic Lamictal, to smooth the ups and downs. So far, so good."

• Bel...
• May 11, 2019

For Major Depressive Disorder "Prescribed 10 mg a day of Trintellix for depression, and the first 10 days I was sick to my stomach and itching, so I take an antihistamine at the same time at bedtime. Day 11 started feeling markedly better, nausea was gone, still itching, but less. Day 14 my overall feeling was 50 percent better than when I started the drug. Today, day 16 saw my doctor again. I had lost weight, my overall anxiety is much better, the depression 70 percent better. All my aches and pains have disappeared. The doctor gave me 2 months of samples and told me to come back in a month if I thought I needed to, otherwise continue as directed. I've been on multiple antidepressants over the years, none worked even half as well as the Trintellix"

• mlo...
• January 6, 2021

For Major Depressive Disorder "I was on every drug in the book for depression: Prozac, Wellbutrin, Pristiq, and Cipralex, nothing took the edge off at all. I lost my mother to depression in July of 2019. Nothing could be worse. I was not on anything but Prozac at the time, and I wasn't doing well. Addicted to benzos, I was struggling. My doctor placed me on Trintellix, 10 mg. He was kind enough to give me samples until I got coverage. I had a bit of a setback and fell into depression six months later. I was boosted to 20 mg, and now I am doing fantastic. Depressive episodes do come back for a few days at a time, but they are easier to handle if you get back into a routine and force yourself. I think this is a great drug, I lost all hope in antidepressants previously."

• Was...
• Taken for 1 to 6 months
• September 24, 2014

For Major Depressive Disorder "I had been diagnosed with Major Depressive Disorder and have been treated with medicines that, at that time, were the best. Venlafaxine being the latest. However, the effects were decreasing over time. After 12 years and having so many side effects, now I am on Trintellix 20mg daily...wow, there is life. My mood is elevated, my outlook, self-esteem, and confidence have returned to normal. My energy level has skyrocketed. My sleep is more restful. Negative thoughts are diminished. Day-to-day living is now controllable. Clear thought process, not a drugged feeling. I am a very content person. Focus on the enabling versus the negativity. Started on 10mg daily, increased to 20mg after 3 weeks, and a slow reduction in my venlafaxine. One side effect is nausea I noted, but a dry snack helps."

• Dav...
• March 15, 2015

For Depression "I have been using this medication for over a month. I find the side effect of nausea to be very minimal and was gone in about 10 days. My mood is positive and stable. However, I find my focus and concentration to be markedly improved. This medication does what it claims to do. Much better than the others and lower side effects."

• Fig...
• January 25, 2019

For Depression "I have suffered for about 10 years with depression and anxiety. Never suicidal, but I have just always felt like the world was passing me by. So my doctor prescribed Wellbutrin XL 300 mg about 2 years ago and the first 6 months worked just ok. I think it really disrupted my sleep patterns and stopped working completely on taking the edge off the depressed feeling a few months ago. I gained 30 lbs in one year on Wellbutrin, which made me more depressed. A week ago, my doctor prescribed Trintellix 10mg. The first day I felt a little nauseous, but it quickly subsided after an hour or so. I didn’t realize what a funk I had been in until the Trintellix. I do not feel medicated at all. The fog is lifting, I feel so clear and normal. From the 2nd day I have felt like I am sleeping like a normal person and am able to get up early and get going with my day, clearly. I am hoping my insurance will cover this, my doctor has assured me he will get me approved and will keep me in samples until then."

• tar...
• Taken for 1 to 6 months
• June 3, 2014

For Major Depressive Disorder "Week four on Trintellix, 10mg to start, upped to 20mg for 3 weeks now, no side effects as of yet. I'm feeling better every day it seems. I feel happy again, less agitation, more energy, and motivation. My personal relationships, which were quickly deteriorating, are seeming to return to normal! My only wish is that I'd found this medication much sooner. Best wishes to anyone else with this medication! (My insurance is needing a pre-authorization to cover this medication, just a note for others.)"

• pre...
• Taken for 6 months to 1 year
• October 26, 2014

For Depression "I love Trintellix. I've been on it for a year. Unfortunately, I take 20 mg. I feel a whole lot better. So much better than Prozac. Only downfall is that my headaches are back. Might lower back to 10 mg. Wish it wasn't so expensive."

• Blo...
• Taken for 1 to 6 months
• February 19, 2020

For Depression "I started Trintellix at 10mg over 4 weeks ago after being on Prestiq for over a year. I have been going into a deeper depression than I have ever experienced. I have sweats, upset stomach (take in the morning with food). My nerves are shot, and I don't want to leave my bedroom. I used to be so active in life, now I just want to hide. I am going to my doctor today to request being taken off this medication and be put on something else. This medicine has just made my life worse than ever before. If you are deciding on what to go on, I would not recommend this product."

• cyp...
• Taken for 6 months to 1 year
• March 6, 2019

For Depression "I have been on Effexor and just about everything else (hated getting off Effexor - they don't warn you about the addiction beforehand), but for the first time ever, I can say I am back to a solid, stable 'normal'. Haven't been this happy and upbeat in well over a decade. All the others seemed to help, but I always had small dips and still struggle a lot with fatigue. It took about 2 months for the total effect to be realized, but I am very happy. As always - your mileage may vary."

• Hop...
• Taken for less than 1 month
• September 1, 2020

For Depression "I went into a mild depression but a major anxiety situation. I started Trintellix 6 days ago. Today I feel the best. I found myself happy and chatting with everyone I saw. I had slight nausea the first 4 days. I took it in the morning with a banana, and it was fine. I kept a little something in my stomach the first 3 days. I did have trouble sleeping but took half a Benadryl, and it helped. I’m feeling good today. I’m hopeful it will work for me. My doctor said I can come off of it in 90 days. It’s just to build up my serotonin levels. He only suggested 5 mg. Try to stay with it if you have no major side effects."

• Anonymous
• Taken for 6 months to 1 year
• July 19, 2015

For Depression "I have had clinical depression since I was a young child. I am now almost 24, and I don't think I've ever been happy for more than a few weeks at a time in my entire life. I have been on Zoloft and Wellbutrin in the past that did not help at all. I have been on Trintellix for a little over 6 months now, and it has changed my life. I'm a better wife, mother, and a significantly better college student. For the first time in my life, I feel alive. There are no longitudinal studies on this new drug, which makes me nervous. Side effects were severe for about 3 weeks, and my insurance doesn't cover this very expensive drug (why I rated 9/10). Ultimately, Trintellix changed my life. I didn't think I would ever be happy."

• Wor...
• Taken for less than 1 month
• April 16, 2016

For Depression "Been on Trintellix for 1 month as an add-on to my longtime SSRI, which had become much less effective in recent months. I felt better in 6 days after starting Trintellix: depression and anger lifted, I began to feel like doing things again. Every day is better and better."

• 29a...
• Taken for 1 to 6 months
• October 8, 2019

For Depression "Tried Zoloft, Wellbutrin, and Lexapro. Trintellix has been GREAT for me. First six weeks on 10 were 'eh,' like not a big difference, but when I increased to 20mg, it was night and day. I’m happy when I am awake. I have energy. Absolutely amazing results. The nausea is HORRIBLE, but if you can get through it, the results are worth it. I took Zofran for the nausea, and it worked. It’s only been 3 weeks since my increase, but it’s been great! Good luck and keep trying!"

• ric...
• Taken for 5 to 10 years
• January 14, 2024

For Major Depressive Disorder "I had major depressive disorder for decades and had been on every antidepressant med., so when I saw a psychiatrist (2014 or 2015) at the insistence of my psychologist, the psychiatrist confirmed that I had been on every antidepressant med. with, at most, brief benefit. She suggested trying a new med., which was originally called Brintellix. My depressive symptoms had included long periods - weeks, months - of extreme depression in reaction to even minor triggering events. I was in one of the long periods of extreme depression when I began taking this medication. The morning after my first dose, I was relieved of the intensity and even of a mildly depressed affect. Since then, I have had brief periods of very disturbing depression, but they have been only periods of hours. I have not had any periods of depressive affect or behavior lasting more than a few hours. I have had mild symptoms from time to time, but none where I could not function. I can still feel hopeless or sometimes."

• Reb...
• Taken for 6 months to 1 year
• November 29, 2018

For Major Depressive Disorder "I used to be on generic escitalopram for 6-7 years. It worked really well at the time, but as I was now becoming an adult (21 now), my major depressive episodes were happening more frequently. I had more adult stress; full-time student, part-time worker, full-time bills. It was becoming too much. I switched psychiatrist and psychologist due to personal reasons and insurance. My new psychiatrist gave me free samples of Trintellix to try for a month. She said it's newer than escitalopram, it's usually faster and has more SSRIs. After 6 days, I began to feel really great. I was able to pay attention in lectures again, I felt so energetic that I started going back to the gym, and I just felt more like myself again. Like a 2.0. It could've been a placebo effect, but after taking it for almost a year now, I can tell you I feel incredible :)"

• Hap...
• Taken for 1 to 6 months
• October 18, 2016

For Depression "This drug was a miracle worker for me. I have battled depression for about 20 years and have been on various medications. I have been on Wellbutrin for 5 years but the last year it wasn't working at all. Crying all the time, suicidal thoughts and constant sadness. My doctor started me on 10 mg of Trintellix in addition to the Wellbutrin. What a great change. I no longer feel suicidal and no longer sobbing all the time. I am laughing again and love life. The first couple of days you do have an upset stomach but it is well worth it!"

• JCa...
• August 23, 2019

For Depression "I have been on Trintellix 10 mg for a week. I noticed something after an hour. My mouth got a strange taste and then vomited. I felt awful after that, so I laid down for a few hours. That night I felt different. My mind was clear, and I was in a mood where I felt like speaking to other people (a rare occasion). After that, I took it on an empty stomach. Still had the strange taste but no vomiting. I have been more upbeat and haven't really wanted to take my Adderall. I also have noticed that I'm not eating as much. I still get hungry but just eat a lot less. We shall see!! :)"