Trintellix User Reviews & Ratings (Page 2)

• Wor...
• Taken for 1 to 2 years
• September 15, 2023

"I am very sensitive to a lot of antidepressants,and I had tried a lot. I would spend countless hours reading reviews of each new antidepressant my doctor prescribed me, hoping something would work. So when I was prescribed this for OCD and GAD, I wasn't expecting much, since I mainly saw reviews for MDD and not my conditions. I initially started at a low dose and worked my way up to 20mg. It took 6 months on 20mg to feel 90% better. I have had GAD for over 20 years and just thought that is how I was. Then I was hit with really bad OCD in 2020 that caused severe distress. After finding Trintellix, I finally know what normal worrying is like and not obsessing over things/thoughts. I can finally sleep better too. I know everyone is different, but I felt hopeless and never believed reviews that said 'game changer.' But Trintellix was a game changer for me, and I hope this review brings hope for someone, especially for GAD and OCD."

• Anonymous
• Taken for less than 1 month
• November 22, 2014

For Depression "Have anxiety and depression and have been on medicines for 20 years. Have taken Paxil, Zoloft, Prozac, Wellbutrin, Lexapro. Just switched 3 weeks ago from Prozac/Wellbutrin to Trintellix with Wellbutrin. Feel fantastic - much better mood, clear head, no anxiety. No side effects at all. Taking 10mg."

• Ski...
• Taken for 2 to 5 years
• March 12, 2025

For Major Depressive Disorder "Male. 28 y/o. 5mg user for 2 years. SSRIs for 5 years. History of concussions + TBI. Father had ALS growing up. Preface this review: I was always a social, outgoing guy. I played varsity sports in HS and led my fraternity's intramural teams. I struggled with health anxiety since HS due to my father’s ALS battle. After a TBI in 2021, where I had to lay in a dark room for 6 weeks, my doctor put me on 10mg of Lexapro. I was on for 2 years, while it helped with anxiety and health paranoia post-TBI, it made me numb to life. In 2023, after 6 months off Lexapro, where I became a shut-in (the opposite of my personality) and severely depressed, a new doctor put me on Trintellix. Trintellix saved my life, from not leaving my apartment for days at a time in 2023 to running 2 marathons in 2024. I was able to leave a toxic relationship, move up in my career, move to a new city, and re-engage lost friendships. It’s gentle enough, it’s still me, but it’s the best version of myself."

• Cla...
• Taken for 6 months to 1 year
• September 28, 2020

For Depression "I have anxiety, OCD, and depression. I took this pill for a year, and it was the most amazing medication I had ever been on for my anxiety. I started low and took it at night to try and sleep away most side effects. But I did have diarrhea for the first 3 days of upping my dose, and I only went up to 10mg. But then it would go away, and I noticed a difference in my anxiety at 7.5mg, but I seriously was able to live my life, and I never knew what genuine happiness was until this medicine. However, after taking it for 6 months, I started to gain weight so fast. I gained 40 pounds in the following 6 months and then stopped taking it because it made me starving, I never felt full, and these kinds of meds are known to affect your metabolism in a bad way. So yes, this pill is amazing, but I got fat on it."

• spo...
• Taken for 1 to 6 months
• April 30, 2014

For Depression "Generally speaking, I don't like antidepressants. I've taken Zoloft, Paxil, Effexor (which was the horrible one for me), Lexapro, Prozac...seems like I'm forgetting one. They've never made me feel 'better' or 'happy,' just 'numb' and 'flat.' With Trintellix, I started off at 10mg for 6 weeks. I go for my checkup tomorrow and will be increasing to 20mg. YES, I DID get nausea in the mornings for a couple of hours after I'd taken it. Taking it with food helped. That is a side effect that, for me anyway, went away within a couple of weeks. I expect the same with increasing to 20mg, but I think it's worth it in the long run. I actually feel HAPPIER! More energetic, want to do things, etc. Has been a miracle so far for me."

• mel...
• Taken for 1 to 6 months
• September 7, 2024

For Major Depressive Disorder "This is the most gentle antidepressant I've ever taken. The first two weeks on this, I was very hungry, but that went away, and now I feel great. Virtually no side effects. I feel calm and happy. When I wake up, I'm not angry anymore, and I'm not down in the dumps. I'm taking 5 mg per day. I'm very happy with Trintellix."

• Ano...
• June 28, 2021

For Major Depressive Disorder "I have been on 20 mg of Trintellix for 6 weeks now, and it has helped me tremendously. Previously, I was on the maximum dose of sertraline for 2.5 years. It worked well, but I experienced a flattening of my emotions, low sex drive, and restless leg syndrome. After a major bout of severe depression about 6 months after getting off sertraline, I tried Lexapro, but it made me sleep all day. My doctor suggested Trintellix, and I've never been happier with an antidepressant. I noticed an increase in motivation after a week. At 4-5 weeks, I felt like myself when I'm well. I am (so far) not experiencing a single side effect. I had mild nausea at the beginning, but that's it. I know everyone's experiences with medication are highly individualized, but as a trauma survivor who does 'everything right' (exercise, therapy, nutrition, etc.) and still experiences severe depression, I am so grateful to have found Trintellix. I will update this review if this changes."

• Joy...
• January 9, 2021

For Depression "I struggle with severe anxiety, worrying, and OCD. I’ve been on Trintellix for 2 months. I started taking it because I was obsessing and catastrophizing over a toxic person. My thoughts would repeat in my mind, and I felt suicidal. It was a legal situation that I thought would ruin me. Wellbutrin 300 XL did absolutely nothing, in fact, it may have made me worse. So I started on 5 mg of Trintellix, and in days, I felt my thoughts more glued, and my fear and anxiety subsided enough to stop my suicide ideation. When this situation ends, I may not need it, but for now, it’s helping me out a lot. I’m on 10 mg now, and I think I’ll stay on 10 mg. One last benefit is my cognition/concentration is sharper, a bonus for work. Hope it works for you!"

• coc...
• Taken for 1 to 2 years
• April 11, 2019

For Major Depressive Disorder "I wanted to wait a good amount of time being on this drug until I gave my review. I have now been on Trintellix for over 1 1/2 years and it works wonders for my depression. Prior to this medication, I was on four different medications including Cymbalta, Prozac, Wellbutrin, and one other, and none of them worked for me after a few months. This medication is for people who have serious depression and are looking for relief. I absolutely love this medication and it is the best I've ever been on."

• Fin...
• Taken for 1 to 6 months
• July 13, 2016

For Depression "I had tried for about 18+ months to find a medicine that would help my depression. I bottomed out and was contemplating suicide. My doc prescribed me Trintellix. I noticed a difference the very first day. I was skeptical at first, but I got better and better as the days went on. I had a few occasions of nausea, and even vomited once, but that all went away after about a month. Trintellix saved my life, literally."

• des...
• February 15, 2014

For Depression "I have been taking 20 mg for about 1 month. I feel awesome. I have taken everything you can imagine and no success. I take this along with 3 other medicines. I have energy and no side effects. I couldn't be happier. I hope it stays this way. I was at a horrible place and now have hope."

• NoS...
• August 8, 2019

For Major Depressive Disorder "I switched from taking Trintellix at night to in the morning and it made a HUGE difference. I started taking this medication 3 months ago. During the first month, I didn't notice any major changes in my mood and was experiencing horrible insomnia (which wasn't out of the norm). I was ready to give up on the medication because there was no real change. So I figured what's the point? Then I read somewhere that someone suggested switching to taking the Trintellix in the morning, so I tried that. I have noticed a MAJOR difference. This medicine really works. My mood is better, I can get through an 8-hour workday without any mood disruptions, and perform regular chores when I get home. It has been years since I was able to perform a 'regular' day with chores. Before, I couldn't get through an 8-hour workday. Now I feel great. Yes, I do still have bad moments, but they are nowhere near what they used to be. I feel good, I am sleeping well, and I have lost some weight."

• MTC...
• May 21, 2017

For Major Depressive Disorder "So, back in the day I started with Wellbutrin, Lexapro, Zoloft, etc...tried it all and nothing was working. Finally, my doctor switched me to Trintellix. There weren't really any side effects when first starting. After about a month and a half, I finally felt something. The darkness went away. The despair, anxiety, and gripping hell that kept me from getting out of my own bed, it's all gone. As if it was lifted before my very eyes. Life is great now. I'm truly happy for the first time in years. Please, give this a try, push through the side effects, and see what you feel like after 1-2 months. It's a small price to pay for a better life."

• Mik...
• Taken for 1 to 2 years
• July 12, 2019

For Major Depressive Disorder "I have suffered from extended major depressive episodes for over 30 of my near 50 years and had very little real success at life. Since my first few months on Trintellix, the clouds began to part for the very first time. I've been on the max dose, 20 mg per day, with 0 side effects and a whole new outlook on life. I've even taken on major projects that have led me to a new career and much happiness. There is a direct correlation between my starting this drug and feeling better."

• Mod...
• Taken for 1 to 6 months
• February 10, 2017

For Depression "December 2016, I started on 5mg of Trintellix. I'd reached a point in life at 65 where my life was more than I could ask for: good job, strong marriage, good friends, healthy, and yet I lived under a dark cloud of fatigue and disconnection, lacking excitement and motivation. I was just maintaining. So I tried Trintellix. I'm now on 10mg. For me, I've had little to no symptoms and a rebirth of joy, motivation, and creativity. I've also added a weekly exercise routine at the local Planet Fitness. Between diet and exercise, I find this modern medicine to be a miracle. Of course, I realize my body will probably adjust to this feeling and I won't be quite 'euphoric' forever, but I now know what feeling good feels like."

• Zer...
• January 13, 2020

For Major Depressive Disorder "I used to believe in exerting strong mental control to handle depression without medication, worrying it will last forever. But this time, after multiple occasions of acting suicidal behaviors, I realized medication is a must. My doctor gave me a few options, including Trintellix, and asked me to research myself and let him know (I’ve been studying this on my own for quite a while, and I actually appreciated this approach). I chose Trintellix. Starting off with 5mg for two weeks and then going onto 10mg, I noticed that suicidal thoughts started to decrease quite immediately. However, I still felt quite depressed periodically. Until after 2 months or so, when I suddenly realized that I started to really be able to enjoy life in a way I hadn't been able to for a long time. I have regained my innermost confidence, and my sense of humor has come back too. I didn’t solely rely on the medication - I also exercised my mental strength during the period and tried to exercise physically. I think combining all these factors really helped. Trintellix works exactly as I had hoped."

• Lfa...
• Taken for less than 1 month
• June 9, 2020

For Depression "I just started two days on this drug. I was told to take it with food in the morning to stop nausea. First day my stomach was upset but no vomiting. Today I took it after I ate and within an hour or so I vomited so badly my throat is completely sore. Is this normal? This is such an expensive drug, even with insurance I paid almost $200. I don’t want to discontinue the use just yet but I am not sure I can handle the nausea and vomiting. Anyone else having these same issues?"

• p24...
• February 4, 2021

For Depression "I've been on most of SSRIs, SNRIs & Bupropion. My depression started to worsen & my Dr. suggested trying Trintellix with a caution that 1/5 people suffered from nausea severe enough to stop taking it. I started on 5mg in the morning and I'm not sure if it was the Trintellix, but my mood and depression worsened to the point of suicidal ideation. Fortunately, I was in a hospital environment. I suffered nausea but it was manageable. Around day 6, I started to feel a little better. By day 8, I actually felt happy for the first time in a long time. Additionally, my thinking became much clearer. Cloudy thinking had been a problem with other SSRIs. I'm now on day 10 and increased to 10mg with no adverse reactions. One lesson I've learned is that SSRIs do different things to different people. Given Psychiatrists don't know exactly how these drugs work/differ from each other, it's a case of trying one, giving it 6-8 weeks to work, and if it's not working go back to your Doctor."

• sto...
• July 20, 2014

For Depression "This medication has been a blessing. I have fibromyalgia, which has caused major depression. I have taken every kind of medication out there that treats both. Side effects from other medications were too much. My doctor prescribed this, although it does not treat fibromyalgia pain like most, it has made my mood much better. I feel much happier and more alive. I have only taken this medication for a month. Unlike most depression medications, I felt a huge difference the first day. Many people talk about the side effects of nausea with this medication... I did not have any. If I did, it was not a big enough deal to make me notice. Overall, I think this was the best antidepressant I have ever taken, and I have so far had no side effects."

• Jus...
• Taken for 1 to 6 months
• November 20, 2014

For Depression "This medication is absolutely amazing. I've tried Prozac, Wellbutrin, Zoloft, Celexa, Lexapro, Viibryd, Paxil, and Cymbalta over the course of ten years. Trintellix was the first medication that didn't give the unpleasant 'disconnected/sedated' side effects of other SSRIs. As a male, the sexual side effects are minute. I began on 5mg for two weeks and achieved a therapeutic dose of 10mg once a day. I have my life back and it also helps with obsessive-compulsive disorder symptoms. I suggest taking it right before bed, as it can make you a little drowsy."

• Flu...
• August 1, 2016

For Depression "I have been on many antidepressant medications for years. The last prescription was mirtazapine. Weight gain was ridiculous. My new doctor has prescribed 5 milligrams for the first two weeks then increase to 10 milligrams. After the first week, I feel amazing. I've had no side effects. I want to get out of bed, get dressed, open the window shade for sunshine. I have not felt this good in a very long time. Two thumbs up kudos to my new doctor for prescribing this amazing antidepressant."

• Ale...
• Taken for 6 months to 1 year
• October 5, 2017

For Depression "I've been on Trintellix for 6 months and this pill has been a miracle for me! I was on Wellbutrin for 5 months prior, but it ended up giving me anxiety so I switched. I've had depression for over a decade and nothing really took it away -- I did therapy, changed my diet, exercised. I still felt grey, lifeless and didn't care much if I died. My depression was never overwhelming sadness, it was quite the opposite: I felt nothing. Nothing gave me pleasure. I was just a robot doing what I had to do. It worked quite quickly, about 3 weeks after I started. I will always have depression, but I'm able to cope now. I no longer feel like life is meaningless. I now do things just for the sake of it. I finally enjoy normal events like everyone else."

• Mic...
• Taken for 1 to 6 months
• October 11, 2018

For Major Depressive Disorder "I've been on Trintellix for about 7 weeks now. I've gone from 5mg to 15mg and about to start 20mg. I've been on many antidepressant meds for over 25 years and nothing has helped like this medication has. I do get the extreme nausea (that's why I didn't give this med a 10 instead of a 9 rating), so I take this at night and sleep through the nausea side effect and no nausea during the day. It has helped me deal with my PTSD, MDD, and anxiety. Now my house is clean, laundry is done, I take time for myself, react in a positive way instead of an emotional negative and defensive way. I have found with therapy and this med my world is changing and I no longer feel broken. My opinion is that it is definitely worth a try if nothing else has worked. This may just be the medication to put you back together again. The benefit of this med outweighs the side effects for me."

• Dan...
• Taken for 1 to 6 months
• November 11, 2019

For Depression "After switching doctors, I also decided to change meds to something that doesn’t make me agitated. My doctor suggested Trintellix due to the lack of negative side effects. To my surprise, he was right, not only do I not have side effects, I can see a noticeable difference in my depression. I no longer suffer from crippling anxiety and depression which prohibited me from accomplishing so much in my life, now I finally have a sense of direction and well, I’m content. I think I’ve finally found something I can take long term!"

• Rip...
• May 9, 2016

For Depression "At first it kept me awake, but that went away in like a week or two. By the 3rd month, I can say this is the best stuff I've been on and can laugh again and not hate the world. I have severe depression, anxiety, with PTSD."