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Sofosbuvir / velpatasvir User Reviews & Ratings (Page 4)

Brand names: Epclusa

Sofosbuvir / velpatasvir has an average rating of 7.6 out of 10 from a total of 426 reviews on Drugs.com. 62% of reviewers reported a positive experience, while 12% reported a negative experience.

Reviews for Sofosbuvir / velpatasvir

Commonly mentioned side effects
  • Tw ...
  • Taken for 1 to 6 months
  • March 5, 2024

For Hepatitis C "Contracted Hep C in 1991, am a lab technician, took Interferon in 1992 for 6 months. The only side effects I had while taking it was a really bad feeling of the flu for the first month. Didn't work. Have lived a very healthy life, but my doctor and family members talked me into taking Epclusa for fear that later in life the Hep C might start causing me problems. The first week I started having fatigue, brain fog which has never left, anxiety, loss of appetite. I was working a full-time job and had to quit because I didn't have the energy to get up in the morning and get ready, nor the energy to sit at a desk for 8 hours. Now I have started having irregular heartbeats that I never had before and still no energy. My Epclusa cost $91,000 for a 3-month supply. My Hep C is gone but if I had to do it over again, I would NOT take it."

5 / 10
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  • Aus...
  • Taken for 1 to 6 months
  • January 29, 2019

For Hepatitis C "I'm 7 weeks into my 12-week course of Epclusa after having Hep C genotype 3A for about 10 years, and I'm 44. I had not been aware of my Hep C until a month before I started Epclusa and had some aggravating symptoms: lethargy, general malaise, sore eyes, slight memory lapses, and reduced motivation. Since starting my course, I was initially much more energetic, which subsidized to what I consider feeling normal after a week or so. I have been having mild sleeping issues, almost like very light sleeping. My eyes are nearly back to normal again. I have tinnitus, which can be annoying, but is generally bearable. 60% of the time I wake feeling unrested and find it difficult to get out of bed, but a quick strong coffee cures that. I take my medication at 9:30 a.m. sharp, which works for me. In general, I feel much better, I am back at the gym 6 days a week and haven't felt the desire to skip gym days through feeling tired or unwell at all. Highly recommended."

10 / 10
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  • Lig...
  • Taken for 1 to 6 months
  • May 23, 2019

For Hepatitis C "I completed Epclusa treatment in August 2018 and was cleared hep C free in September. During treatment, I didn't have any major physical side effects except for tinnitus, but I was very moody, depressed, short-tempered, and had anxiety. Nine months on, I still have tinnitus, but that's the least of my worries. I have allergies, which I never had before, and I am always sick now. I now have leaky gut syndrome and have some food intolerances. The most challenging thing is having depression and anxiety. Some days, I feel a burst of sadness and depression where I would be affected the entire day, and it has become frequent, but I'm lucky to have a very supportive partner who's there for me. I have absolutely nothing to be depressed about, but I get these feelings. I refuse to fall victim to taking big pharma's antidepressants. Epclusa has maybe saved my life, which I am very grateful for, but I am annoyed that it's priced at 80K for treatment! I no longer have hep C, but it did come at a price. Time to detox."

7 / 10
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Frequently asked questions

  • Chi...
  • Taken for less than 1 month
  • July 12, 2021

For Hepatitis C "Day 5 on generic Epclusa. Haven't experienced any side effects. Sleeping very sound at night, which I haven't done in over a year. My liver feels tender at times, I think it's because it's been working so hard over the last few years and is trying to heal. I've been clean for 3 years and currently taking Suboxone. Extremely grateful there is a cure and will chime in again after my treatment is completed. Idk what stage my liver is in, haven't seen my doctor since I had my liver ultrasound and fibro scan. Will ask these questions at my next appointment."

10 / 10
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  • Sam...
  • Taken for 1 to 6 months
  • June 19, 2019

For Hepatitis C "I was diagnosed with Hep C in February 2019. 56-year-old male. Started Epclusa April 22nd. After 31 days, had blood work. No signs of virus. I will finish the 90 days in July. Only real side effect: tiredness and fatigue about 2–3 pm each day. One pill daily at 7 am. Miracle drug! Very happy. My insurance covers it all!"

10 / 10
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  • Fra...
  • Taken for 1 to 6 months
  • July 26, 2018

For Hepatitis C "I’m 61, and I’ve had Hep C for over 30 years. My viral load was almost 2 million. It went down to 0 within my first month, with no negative side effects, and my enzymes are normal. I’ve got 8 more weeks to go. Hope it stays away forever... God bless!"

10 / 10
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  • Ble...
  • Taken for 1 to 6 months
  • December 27, 2020

For Hepatitis C "I’m on week 6 of Epclusa, and other than the hair loss (I had ever since getting hep C almost a year ago) and ears ringing, it’s not been bad for me at all. My first checkup, my liver enzymes are back to normal, and HCV is undetected. (Genotype 3, which is the hardest to treat), so I was so nervous about this not working. Hope it stays negative! I haven’t experienced any nausea, and I take it in the morning without food. Will update later once I’m further into treatment."

10 / 10
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More FAQ

  • Hop...
  • April 25, 2019

For Hepatitis C "Finished my last dose of Epclusa on March 15, and was weak, but a month later I am so tired and weak it's hard to do anything. I feel like all of my energy has been sucked from my body! I am completely miserable! I'm worried and wondering if anyone else has these symptoms? Literally in bed 24/7!"

1 / 10
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  • Cha...
  • Taken for 6 months to 1 year
  • June 30, 2018

For Hepatitis C "After living with Hep C genotype 3 for 25 years and at the age of 66, I was put on Epclusa for 12 weeks. After 1 month, there was no trace of the virus. I continued to take it until the last dose. I did have side effects, the worst being stomach aches, ringing in my ears, and extreme irritability. It has been one year after my treatment, and the virus is undetected. Epclusa literally saved my life. I was in stage one liver cirrhosis, and I was very ill all of the time. I feel so much better now. One side effect that seems to be permanent is the ringing in the ears."

10 / 10
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  • cor...
  • Taken for 1 to 6 months
  • February 21, 2024

For Hepatitis C "I'm on my last month of Epclusa, and I thought I was the only one to experience these severe side effects! Since I started taking the medication, I itch like crazy and now have a rash on my leg, and the stomach issues, forget about it. The headaches-I've never had such bad headaches in my whole life, and the fatigue and tiredness is unreal. My boss has had to take me home because my body would just not do anything! So, as for having hep C, it's uncanny, let alone having to deal with it. I would not recommend this drug by any means, especially if I have other issues with my liver and/or other organs already."

2 / 10
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  • Hep...
  • Taken for 1 to 6 months
  • January 27, 2019

For Hepatitis C "I took Epclusa for 12 weeks. The first few weeks, I didn't have many side effects. After about a month, I started having a lot of weird dreams and not sleeping well. Began having fatigue and brain fog. I thought I was going to get through the 12 weeks with somewhat mild side effects. About the tenth week, I started having severe fatigue, severe memory issues (brain fog). I could not wait to get through the last three weeks. It almost had me demobilized."

9 / 10
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38 Report
  • Emm...
  • Taken for less than 1 month
  • May 1, 2023

For Hepatitis C "Day 15 of taking Epclusa, and I am stopping treatment. On day 1, I began with a sulfur and metallic taste when the medication was being ingested. Day 2 was a massive headache with nausea. On day 3, I decided to investigate Epclusa ingredients. I discovered a mix of basalt, high levels of a variety of different salts, magnesium stearate, talc, and titanium that are researched on the spleens of laboratory rats."

1 / 10
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22 Report
  • Tre...
  • Taken for 1 to 6 months
  • July 29, 2018

For Hepatitis C "Finished my 12-week treatment 4 days ago on the 25th of July 2018. No side effects the whole treatment, in fact, I have never felt so good. This morning, I woke up feeling really sore, aching, and tired, but not sick, grumpy, and irritable. I didn’t realize there may be some form of withdrawals from the medication, but it makes sense. I have stayed healthy, worked no less than 4 times a week since starting treatment. Today, I feel exhausted, horrible, and depressed. I'm hoping this feeling goes away. I will update in a week or so. I’m still saying 10/10 because I’m so thankful to have been able to use this medication."

10 / 10
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  • ali...
  • May 13, 2017

For Hepatitis C "I take my last pill tomorrow. My arm, around the elbow, is hurting real bad. Real, real bad. I felt it about a week into it. I did my 6-week blood test and no sign of the hep C. I hope it stays that way. I'm not sure of my level? 3-4-5? I forgot. It messed with my memory too. I feel confused and not sure of myself. Nothing worse when 500 craft personnel depend on you. I just turned 58. Had this for 20 years, is my guess. I haven't drank alcohol in 3 months. I hope you folks who are starting the program don't either. Never had headaches or diarrhea like everyone says. My arm is killing me. Can hardly do anything with it. I hope this rids this terrible virus. I wish the best for everyone."

5 / 10
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  • Hop...
  • Taken for 1 to 6 months
  • June 18, 2018

For Hepatitis C "I'm a 34-year-old woman, healthy other than hep C. I got hep C from a blood transfusion when I was a baby. AST and ALT have always fluctuated and have been elevated. Fibro score (estimate of scarring in liver) was F1-F2. Also, I was genotype 3. I never even take Advil, so I was very scared to use this drug. Side effects were ringing in my ears, teeth sensitivity, and not headache, but like a weird head change. Nothing major, and I felt very normal otherwise. I took the pill right before I went to sleep at night. Never missed a pill. After the first month, viral load not detected, after 6 months, still not detected, so I am cured. And all AST and ALT are now normal. My fibro score stayed the same after 3 months, but I was told my liver is still healing, and your liver does heal. So I will give it more time with the help of herbs and vitamins. Ear ringing went away but still happens occasionally. I hope everyone can be cured of this disease. We will win this battle."

10 / 10
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39 Report
  • Joe...
  • Taken for 1 to 6 months
  • March 29, 2022

For Hepatitis C "I took Epclusa from 1-6-18 through 4-6-18 and had no problems the first 2 months, but on the last month, I started feeling jaw pain, arthritis in hands and feet, as well as kidney pain. Within 5-6 months, I had developed kidney stones, lost 8 teeth, and got Bell's palsy. For me, my condition has worsened. The army doctors say no way Epclusa could have done this. My conditions now include chronic kidney disease, autoimmune disease, and arthritis. All of this happened after lab tests were normal other than hep C. Conditions as of 3-29-22 have worsened. Every little cold is life threatening. I would advise against taking this medicine."

3 / 10
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  • Any...
  • Taken for 1 to 6 months
  • April 17, 2025

For Hepatitis C "Just wanted to update my prior post from December. Since completing treatment, my viral load came back at zero. It had been at 20 at my midpoint check-up. I’ve had no side effects or issues since completing treatment in January. Please take this medication if you need it. Not worrying about hep C every day has been wonderful!"

10 / 10
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  • Ano...
  • Taken for less than 1 month
  • June 23, 2025

For Hepatitis C "Well, this is my third day, and everything was going good so far until this morning. I woke up with really sharp pains on my left side underneath my rib cage, and I'm having really bad headaches. Should I be worried about the pain I'm having?"

6 / 10
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  • ale...
  • Taken for 1 to 6 months
  • June 1, 2021

For Hepatitis C "I do not usually Google side effects, etc., for fear of psychosomatic symptoms, but after 6 weeks on the drug, I am losing my mind. It is a relief to read these reviews. Headaches (when I rarely had them prior), absolutely no energy. Weight loss - the nightmare begins when I try to sleep - sleep? LOL - massive insomnia. My feet and hands tingle, resulting in my having to walk around. The tingling disappears when I move. Anxiety, depression, unable to focus - I am on my way to secure a Valium script :("

1 / 10
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25 Report
  • 3aa...
  • January 25, 2017

For Hepatitis C "I have had hep C for about 20 years now, genotype 3a. I already did my 3-month treatment of Epclusa. At the end of 3 months, the virus was undetectable, of course. Waiting to get blood work in March to find out if still undetected. My main side effect of Epclusa was major muscle aches. My muscles were always very stiff and sore. Totally manageable though. I was hoping after I finished treatment, it would go away, but unfortunately it has not. Some days are worse than others, hoping time will make it go away. Praying and hoping I will be undetected and cured still in March. Good luck and God bless to all struggling."

8 / 10
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43 Report
  • Anonymous
  • October 19, 2018

For Hepatitis C "I had hep C, genotype 3 for years with my viral load over 6 million. I took this med for 30 days with very minimal side effects over a year ago. I’m extremely proud to say it worked! I’m cured! I just did a blood test. I can’t say enough good things about this drug! It truly saves lives. Good luck on your journey. I hope it does the same for everyone that needs it."

10 / 10
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  • Kei...
  • April 25, 2024

For Hepatitis C "Had type 1A. Just finished 3 weeks ago. Why they wanted to take Epclusa and not Mavyret, I have no idea. They both cure type 1A. I had no problems and no side effects. It was a piece of cake. This is a miracle since I have cancer too and take a chemo pill for years. Maybe it toughened me up ahead of time. I was with no viral load after the first month. Will take a test in June to make sure it's gone for good."

10 / 10
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  • Ray...
  • March 30, 2017

For Hepatitis C "I took it for 12 weeks. When I did the blood work, it came back neg. No virus. Boy, I was the happiest man on earth, now I have a chance to see my grandbabies grow. Went back for my 3-month checkup and found out it came back! What a heartbreaker. Not sure what to do next. Was told another drug would be available this summer."

1 / 10
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  • Gra...
  • Taken for 1 to 6 months
  • September 15, 2018

For Hepatitis C "I have had genotype 2 for over 50 years without knowing it! My viral load was 12 million/ml. Had several blood transfusions in 1964/1965. I have been on Epclusa since Aug 14th. First blood test Sep 12th, and the virus can no longer be detected! I am so grateful and happy right now!!! Someone here said to drink lots of water, so I drink at least 100 oz/day. Thank you, Gilead, for developing this drug, and thank you, Drugs.com, for creating this review site! I read everyone's review before starting Epclusa, and it helped to know what to look for!"

10 / 10
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36 Report
  • RJa...
  • Taken for 1 to 6 months
  • December 13, 2018

For Hepatitis C "Shared my story a few weeks ago. Received my results this week ahead of appt. with Dr. and feel blessed that HVC was undetectable one month out and liver enzymes were normal after being elevated for 25 plus years. Hope to be virus-free after 90 days, as is the standard. Good luck to everyone and stick with it."

10 / 10
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