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Sofosbuvir / velpatasvir User Reviews & Ratings (Page 3)

Brand names: Epclusa

Sofosbuvir / velpatasvir has an average rating of 7.8 out of 10 from a total of 408 reviews on Drugs.com. 66% of reviewers reported a positive experience, while 12% reported a negative experience.

Reviews for Sofosbuvir / velpatasvir

  • Hpano
  • Taken for 1 to 6 months
  • February 9, 2020

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C "I was tired before with Hep C, but on Epclusa this is exhausting to a whole new level. I've had migraines, nausea, vomiting, diarrhea, and shortness of breath. For a month of taking it, it was causing asthma exacerbation along with thrush. The thrush was horrible. I have five weeks left, and I am looking forward to feeling better. My color came back, and during the second month, I have had good days where I've had energy. I didn't have that before. I also broke out in a rash like shingles and scabies mixed on my neck and arms. I refuse to stop taking it though. The shortness of breath is better than the first month. I have ringing in the ears a lot. My blood pressure is higher than usual. My body is usually aching. The exhaustion from it is the worst because I have never felt so tired in my whole life."

10 / 10
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  • Dee
  • Taken for less than 1 month
  • September 15, 2019

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C "Three months after finishing Epclusa medication, blisters on body, aches and pains worse. Headaches too. I personally am scared out of my mind. I might be cured of hep C, but Epclusa has caused other issues, and getting well from side effects is another thing. I will update after the last blood test in two weeks, if they let me. I hope you all recovered after the cure."

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  • Gerald
  • Taken for 1 to 6 months
  • April 12, 2023

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C "I started taking Epclusa in mid-April 2019 for three months. Within a week of starting the medication, I noticed a major drop in my energy level which continued throughout the duration of the drug course. Prior to starting Epclusa, I had been training for the BMO Marathon since December 2018 and was in incredible shape, as confirmed by my peers. However, I barely managed to complete the marathon and lost almost all my energy. This lack of energy has persisted to this day. Additionally, I was diagnosed with Polymyalgia Rheumatica. My lifestyle has drastically changed since being diagnosed in March 2020. I have been taking Prednisone and using Diclofenac 20 ml for all my aches and pains, just so I can at least walk. I now have high blood pressure, atrial fibrillation, osteoarthritis all over my body, and experience swelling every day, resulting in a low quality of life since taking Epclusa. I have also experienced depression, and aching, and gained 25-30 pounds. At the time of and prior to taking Epclusa, doctors, sports therapists, etc. all told me I was in better shape than most."

1 / 10
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Frequently asked questions

  • Fresh...
  • Taken for 1 to 6 months
  • October 8, 2019

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C "I have been taking Epclusa now for 4 weeks, and the main side effects are as they say: nausea (but haven’t actually thrown up, just a strong feeling) and extreme tiredness (you’ll sleep for a couple of days if you're not on a schedule). Your fluid intake needs to double with this medication!! I’ve been having diarrhea, and it is very easy to get dehydrated, which can cause other problems. Other side effects have been tolerable. I have genotype 1a chronic hepatitis C. And before taking this medicine, I was very weak, and the brain fog was so extreme it had me depressed. Now the cloud is starting to clear, and my strength is coming back too. I too was nervous about taking it, as we all are, but it is worth it to me so I can have a fresh start. Good luck!!!"

6 / 10
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  • Gypsy...
  • Taken for 1 to 6 months
  • March 12, 2019

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C "Week 5 of treatment with Epclusa and blood work results from week 3 of treatment; viral load count down from 1.5 million to 40! Doctor said blood work from week 5 might come back as non-detected! I get those results next month, along with my Fibroscan results. Blood work has my liver damage score between 1-2. Doctor told me that will reverse with the completion of treatment. Side effects have been minimal and tolerable."

10 / 10
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Are you taking this medicine?

  • Rvc
  • Taken for 2 to 5 years
  • March 18, 2022

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C "I am a male 64 years old. I contracted hep c when I was 19. If I had not been as young as I was it would have been fatal. I passed on all the treatments like inteferon etc. In 2005 I had a liver biopsy and it showed mild fibrosis. In 2017 my gastroenterologist ran test and CT scan and determined F4 fibrosis. After further testing he recommended Epclusa it had none of the problems inteferon had. So in May 2017 I started my 90 day $72,000 journey to a place that was not told to me. Yes I am virus free but in 4.5 years of no virus I went from stage 4 fibrosis to stage 4 cirrhosis and liver cancer....it took 40 years to get to stage 4 fibrosis and only 4 years after Epclusa to full blown cirrhosis and cancer, all for a mere $72,000. The thing not told is that once the virus is gone all the long slow moving damage accelerated because the virus was keeping its self in check, when the liver did not have to fend off the virus anymore the damage grew by 10."

5 / 10
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  • Mr Re...
  • May 11, 2021

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C "Took epclusa mid 2018 had no Hep c symptoms went to doctor for stomach ache. Test showed Hep c,no liver damage. Felt sick everyday taking Epclusa, my side effects are nausea headache fatigue body aches. Doctor said keep taking it. Hep c was cleared but now 3 years later I am so ill. I am in so much pain all over it hurts to move, I also have nausea, weight loss sleep the list goes on. I was not sick like this before Epclusa but it's ben like this since I took this medication. Been told I have fibromyalgia. All I know is this medication has ruined my life and I live with extreme pain everyday. If I could go back I would never have taken it."

1 / 10
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More FAQ

  • JAano
  • Taken for less than 1 month
  • August 30, 2019

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C "I've just started my first pill 3 days ago. I was really scared trying this pill because of the side effects that I've been reading. Day 1 was really bad, headache and felt really tired. Day 2 was a bit better, no headache but still tired. But I realized that I just didn't get enough sleep, that's why I felt tired. Because after I took a nap in the afternoon during day 2, I felt really good. Hopefully, it gets better. I will post more if any more side effects kick in. All in all, I just want to live a healthy life for my wife and kids. Good luck, everyone."

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  • DoTho...
  • Taken for 1 to 6 months
  • May 9, 2022

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C "I started taking Epclusa about a year and a half ago and the symptoms have still not gone away. I have this horrible dysphoric restlessness in my legs which causes me to rapidly crossing and uncrossing my legs while crying out “oh God please take it away ”over n over again” Plus my stomach feels funny and I’m nauseous all the time. My hands and feet feel tingly and I’m extremely depressed all the time it feels as though my hormones are unbalanced and the restlessness in my leg feels like I am withdrawing off of opiates or benzos x10. The doctors just say that Epclusa couldn’t have caused this. I feel as though I’m doomed for life."

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  • Angeltn
  • Taken for 1 to 6 months
  • October 6, 2019

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C "I took my last dose of Epclusa on Aug. 13, 2019. I had hep C/geno 3. Last tested to see if I was still carrying the virus was negative. I did very well on this medication. I'm still having an upset stomach, but my energy has returned, my bruising and the overall color of my skin are great. I do feel much better. I was very anxious throughout taking the medication, and I'm still worried about it returning or some side effect attacking my body. I believe I should have been on a nerve pill as I did have trouble sleeping with racing thoughts and being worried. But happy about being negative. Very much recommended."

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  • Reid
  • Taken for 1 to 6 months
  • September 26, 2019

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C "I was really scared to take the treatment at first but got into it. I have tiredness every day and a few headaches, but manageable. I took it every morning at 9 am for the 12 weeks. I was lucky, I had a very good nurse and pharmacist on my team. Hope I get the all clear on my last blood test in Dec 2019, things are looking good so far. I hope you all have a good journey. Good luck to all."

7 / 10
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  • Tw -1...
  • Taken for 1 to 6 months
  • March 5, 2024

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C "Contracted Hep C in 1991, am a lab technician, took Interferon in 1992 for 6 months. The only side effects I had while taking it was a really bad feeling of the flu for the first month. Didn't work. Have lived a very healthy life, but my doctor and family members talked me into taking Epclusa for fear that later in life the Hep C might start causing me problems. The first week I started having fatigue, brain fog which has never left, anxiety, loss of appetite. I was working a full-time job and had to quit because I didn't have the energy to get up in the morning and get ready, nor the energy to sit at a desk for 8 hours. Now I have started having irregular heartbeats that I never had before and still no energy. My Epclusa cost $91,000 for a 3-month supply. My Hep C is gone but if I had to do it over again, I would NOT take it."

5 / 10
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  • amandam
  • February 26, 2023

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C "I'm on my last 27 days of this medicine. I was told no side effects except for maybe headaches. The longer I've been on it the worse it's gotten. I cry every day I have to take it, have migraines daily, can't sleep and when I do I get awful nightmares. I also am having bad abdominal pains, feeling freezing cold, muscle aches, weakness, shortness of breath, dry mouth, and feeling tired all the time and irritable, feel depressed, and emotionally unstable. I wasn't expecting this. I got blood work done today since the side effects have doubled just this last month. Had no issues feeling sick with my Hepatitis C prior but my levels were elevated so I decided to treat it. I think I made a grave mistake."

1 / 10
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  • Brubank
  • Taken for less than 1 month
  • April 29, 2017

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C "I just started my Hep C treatment. I have genotype 2, and I'm going on my second week taking Epclusa. I contracted Hep C using drugs intravenously and have been infected for 48 years. All the time I've had it, I never felt fatigue or had any other symptoms of Hep C. I'm 67 years old, anyway, I haven't had any side effects. I don't want to talk too quickly, but I feel better. I do a little exercise to keep myself strong. So far, I feel much better."

10 / 10
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  • Emma
  • Taken for less than 1 month
  • May 1, 2023

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C "Day 15 of taking Epclusa and I am stopping treatment. On day 1 I began with sulfur and metallic taste when medication was being ingested. Day 2 was a massive headache with nausea. On day 3 I decided to investigate Epclusa ingredients. I discovered a mix of basalt, high levels of a variety of different salts, magnesium stearate, talc, and titanium that are researched on the spleens of laboratory rats."

1 / 10
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  • SexyS...
  • Taken for less than 1 month
  • May 13, 2019

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C "I’m a 37-year-old female. I have been on Epclusa for 5 days, and I have missed almost every day I’ve had to work. I have literally slept the whole time. I really hope this sleepy and nauseous feeling goes away! I’m going to lose my job as I’m so tired I can hardly write this! I’ve been drinking tons of water. I’ll let everyone know how I am later if I’m awake to tell you."

2 / 10
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  • Gypsy...
  • February 13, 2019

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C "I was diagnosed with Hep C on 12/19/18. My healthcare provider was just as shocked as I was, no history of INDU or IVDU, no blood transfusions. Never had any blood work with elevated liver numbers or anything to cause concern. Several tattoos and piercings done in my youth could be a source, and shared grooming tools with an ex-partner. Specialist said I’ve most likely been infected 5-10 years. I have genotype 1A, a viral load of 1.5 million. I’ve been taking Epclusa for 7 days. I read most of the user reviews on this blog and was somewhat skeptical about starting. The success rate of being cured far outweighs any doubt I have. The only side effects thus far have been nausea (waves within an hour), headache (I then followed the increased water intake advice, which seems to help), and unusual tiredness (increases each day), and the strangest effect: I have lost my sense of taste! It’s maddening. All of these symptoms/effects are tolerable."

5 / 10
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  • Thank...
  • Taken for less than 1 month
  • December 3, 2018

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C "I am on day 4, and I feel GREAT! I had to check right back in because I haven't felt like this in years! The medication makes me tired, but not as bad as my Hep C. I am genotype 1 and don't know my viral load. I am so thankful for Gilead's scientists for developing this LIFESAVING medicine. Words cannot express how grateful I am for being able to finally get this medication. Yesterday, I was able to finally take my grandchildren to the store and buy them a present. Before the medication, I could not even leave my house, and yesterday was a gift. THANK YOU! I hope and pray everyone with Hep C is given this opportunity to receive this lifesaving medication. Hopefully, the cost will go down so everyone can have a new lease on life. I will check in after my first blood test. Good luck to everyone, I am truly THANKFUL! And thank everyone for your feedback, especially the drinking water part, it truly helps!"

10 / 10
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  • Chi...
  • Taken for less than 1 month
  • July 12, 2021

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C "Day 5 on generic Epclusa. Haven't experienced any side effects. Sleeping very sound at night which I haven't done in over a year. My liver feels tender at times I think it's because it's been working so hard over the last few years and is trying to heal. I've been clean for 3 years and currently taking Suboxone. Extremely gratefull there is a cure and will chime in again after my treatment is completed. Idk what stage my liver is in haven't seen my doctor since I had my liver ultra sound and fibro scan. Will ask these questions at my next appt."

10 / 10
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  • Amber...
  • Taken for 1 to 6 months
  • December 15, 2016

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C "I am on week 11 of 12. Almost done! I have genotype 3a. I have only had hep C for two years, but it's been a rough two years. I already have stage two liver fibrosis, as well as fatty liver disease, not to mention my liver enzymes had consistently stayed around 90 and 200. I learned that genotype 3 can be very aggressive. Even though my doctor told me this medicine should work great for me, I was still worried it wouldn't work for me. The first couple of weeks taking Epclusa, I was more fatigued than usual, but that side effect subsided. I haven't really had any other side effects at all! Since six weeks in, my viral load is undetectable, and my liver enzymes are back to normal levels for the first time in two years!"

10 / 10
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  • SammyJ
  • Taken for 1 to 6 months
  • June 19, 2019

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C "I was diagnosed with Hep C in February 2019. 56-year-old male. Started Epclusa April 22nd. After 31 days, had blood work. No signs of virus. I will finish the 90 days in July. Only real side effect: tiredness and fatigue about 2–3 PM each day. One pill daily at 7 AM. Miracle drug! Very happy. My insurance covers it all!"

10 / 10
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  • Indig...
  • Taken for 1 to 6 months
  • April 13, 2017

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C "Follow-up to 2/13/17 post. I am 3/4 of the way through my 12-week treatment for Hep C Genotype 3 with Epclusa, and only 2 weeks into the treatment, my blood work was already showing the virus as 'undetectable,' and all my numbers back in normal ranges. I've been back for blood work twice since the first blood work, and the virus is still undetectable, and all #'s excellent! Less than 4 weeks to go, and hoping for the best! Good luck to all!"

9 / 10
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  • Fizbim
  • Taken for 1 to 6 months
  • April 27, 2017

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C "I am into day 36 of 84-day (12 weeks) treatment. An hour after taking my first dose, I could definitely feel the medication coursing through my body. The first 14 days were the worst. Some headache, slight depression. I started feeling much better after 3 weeks. I had blood work done after 30 days, and ALT and AST are way down. I feel much better, and the incredible burning itches I had before treatment started have stopped. It can tire you, but a nap can really help. My appetite has gone through the roof, which is a good thing for me. I am really optimistic about beating this. I have had HCV since the mid-1980s. Here's hoping that the rest of my treatment goes well. Good luck to everyone!"

10 / 10
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  • Keith
  • April 25, 2024

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C "Had type 1A. Just finished 3 weeks ago. Why they wanted to take Epclusa and not Mavyret, I have no idea. They both cure type 1A. I had no problems and no side effects. It was a piece of cake. This is a miracle since I have cancer too and take a chemo pill for years. Maybe it toughened me up ahead of time. I was with no viral load after the first month. Will take a test in June to make sure it's gone for good."

10 / 10
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  • Blessed
  • Taken for 1 to 6 months
  • December 27, 2020

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C "I’m on week 6 of Epclusa and other than the hairloss (I had ever since getting hep c almost a year ago) and ears ringing it’s not been bad for me at all. My first checkup my liver enzymes are back to normal and HCV is undetected. (Genotype 3 which is the hardest to treat) so I was so nervous about this not working. Hope it stays negative! I haven’t experienced no nausea and I take in morning without food. Will update later once I’m further into treatment"

10 / 10
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30 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.