Semaglutide and Tiredness: What Users Say

• Slo...
• Taken for 1 to 6 months
• April 3, 2023

For Weight Loss (Obesity/Overweight) "Starting week 9 with the second injection of 1 mg. I have lost 24 pounds in 8 weeks. The side effects happen about 3 - 4 days a week. The first weekend on 0.25 mg was the worst! I really thought I needed my last rites! I have had headaches, nausea, vomiting, and bowel issues but not like the first-week episode. I try to eat light the day of the shot and take it at night because it makes me tired. You have to stay positive and just buy meds that will help with side effects because the side effects will probably always happen a couple of days a week. Try to drink 1/2 gallon of water a day and stay away from red meat, fried food, fast food, (most) dairy and sugar. If you don't, you will feel sick from eating that stuff. Also only eating one cup of food every couple of hours has made a huge difference in the nausea. Stock up on SF ice pops and SF Gatorade. I am so grateful that I got Wegovy with my insurance and when I want to quit, I just remember how many people would love the opportunity."

• KJF...
• Taken for 1 to 6 months
• September 19, 2021

For Weight Loss (Obesity/Overweight) "I am currently on my 9th injection today, being my 8th full week being on Wegovy. I have lost a total of 40 pounds so far. Appetite is definitely curbed. Sundays when I take the injection, it makes me tired. A lot of gas and the occasional runs, but the weight loss is worth the side effects."

• Bac...
• Taken for 1 to 6 months
• March 9, 2023

For Weight Loss (Obesity/Overweight) "I started Wegovy 6 weeks ago at 0.25 mg for 4 weeks, and for the last 2 weeks at 1 mg. I started at 211 lbs and am now 197 lbs, so have lost 14 lbs and counting in 6 weeks. Not bad! Symptoms I've experienced include being slightly more tired than usual on the day of the injection, and some constipation at first but I use Miralax if there's an issue and it works fine for me. I haven't had any extreme nausea, but the injection definitely makes me less hungry and there are certain foods that I feel slightly queasy even considering eating-like high-fat foods-so I don't eat them. I eat a lot more fruits and vegetables and get full very quickly. I work out 4-5 days a week, my energy has been good and I feel like I'm getting back to my old self. I'd like to be about 135 lbs eventually. Wegovy has been a lifesaver. I'm 55 years old and had considerable cravings, especially at night. I'm happy to be free of them. I hope to make my new habits permanent."

• Chr...
• Taken for 1 to 6 months
• July 11, 2021

For Type 2 Diabetes "I suffered from - Loss of appetite - Exhaustion - Nausea - Vomiting (once a week, usually 2 days after my injection) - Low blood sugar events (probably caused because I just had no appetite). When I spoke to my pharmacist, she encouraged me to try to hang in there, telling me it would get better, and it finally has. I was not expecting it to take over 3 months though. My readings are all good, and I've lost 28 lbs, so there were benefits to sticking it out, but it was hard. I had decided that I would continue to take the medication until my next appointment, and if things were still bad, I would tell the doctor that I no longer wanted to use it. Things are better, and my appointment is next week."

• Shy...
• Taken for 1 to 6 months
• November 1, 2021

For Weight Loss (Obesity/Overweight) "Been on Wegovy for 7 weeks. Lost 14 pounds. 2nd week into 0.50 mg. It’s a little rough on my stomach. Taking prescription for nausea which happens the day of the injection. Feel tired and occasionally get severe abdominal pains. I can’t eat much and have to really watch the types of food. No greasy foods or spicy or heavy. The intestinal pains were very severe after eating wrong foods. I’m happy with the weight loss but the side effects are rough."

• joa...
• Taken for 1 to 6 months
• August 15, 2020

For Type 2 Diabetes "Dr put me on Rybelsus since I had bad luck with Trulicity and feeling sick every time I took the shot. The first month of the dose 3mg, I noticed I never ate. I had a complete lack of appetite. I was exhausted, had weird dreams, and a constant feeling of anxiety, and sometimes insomnia. I put up with it. The second round with the 7 mg, the first day I was sicker than heck. I felt like I was on a cliff dangling, my anxiety turned into panic, rapid heartbeat, and I was unable to sleep. I stopped after day 4. I called the doctor but she never got back to me. I am debating trying to take 7mg every other day or go back to the 3mg and see if there is a difference now that it is almost out of my system. It is brutal to the body. The warnings say nothing about the feelings of anxiety or the insomnia."

• LMH...
• Taken for less than 1 month
• November 8, 2021

For Weight Loss (Obesity/Overweight) "So far so good. I'm only on week 2, but am down 10 pounds with a combination of exercise and a 1200 cal/day diet. The symptoms I've had so far are tiredness, constipation, and some hair falling out (Dr. will be checking my vitamin levels to make sure I don't need supplements with the new diet). It definitely curbs my appetite, which is huge with my diet essentially cut in half. I am looking forward to seeing sustained results."

• Los...
• March 3, 2020

For Type 2 Diabetes "I have taken Ozempic for four days and have not experienced any of the symptoms others are saying they have had with one exception: I am very tired. I am eating a little less but do not feel like some say they can't eat at all. My blood sugar is down to 110, and I have lost three pounds. So far I see only good things. I hope it stays that way as I want to lose about 30 pounds and not take metformin. Hopeful!"

• Pat...
• July 19, 2019

For Type 2 Diabetes "Started taking Ozempic for pre-diabetes and insulin resistance. This is the first medication I've ever taken for diabetes. A1c was 5.7. I increased the dose quickly at the doctor's recommendation if little to no side effects occurred. First dose 0.25 in the office. Second 0.5 a week later. Third dose at 1.0 a week after that. Only side effect I have is mild nausea. Appetite has disappeared, and I eat only when hungry and much smaller portions. Serious bloating when I eat too much, which is a great deterrent. Been on the medication for 4 weeks overall, 2 weeks at 1.0, weight dropped from 305 lbs. to 295 lbs. Still a little lethargic, but I was very lethargic before starting the medication. I feel like this medicine is a game changer for me. I love not thinking about food all of the time, only eating when hungry and not for pleasure, and losing weight. Will retest A1c in 2 months. Hopefully, the weight loss continues, and I caught the A1c level before it turns into full-blown diabetes."

• Mis...
• Taken for 6 months to 1 year
• August 14, 2020

For Type 2 Diabetes "Started Rybelsus when it first came out in October 2019. Took 3 mg at first and my glucose levels started to rise. Changed to 14 mg and was on that for 6 months. Glucose went very low - I was tired and weak. A1C went from 10.1 to 5.2. Changed to 7 mg and feel so much better, glucose levels are still within normal limits. I've had no side effects and great results. I do take this with 5 mg of Glipizide - once a day. Have tried many diabetic drugs and Rybelsus has worked the best. I've had a slight weight loss... under 10 lbs. So glad I tried this drug. It's a winner in my book."

• Bar...
• Taken for 1 to 6 months
• March 24, 2023

For Weight Loss (Obesity/Overweight) "I have been taking Ozempic for six weeks. This will be my second week at 0.50 mg, and I have lost 10 lbs. At 0.25 mg, I had minor nausea and was very tired but felt fine otherwise. After my first 0.50 mg injections, I could not drink, eat, or do anything for the first day. I had a lot of nausea and felt like I was going to be sick constantly. By day 3, I had to go to the bathroom about nine times, which was good because constipation is a real thing with this medication. By day 4 and on, I felt perfectly fine. I do watch what I eat, and the medication has cut my food intake by half. You have to pay attention to what your stomach is telling you."

• Sco...
• Taken for less than 1 month
• May 9, 2023

For Weight Loss (Obesity/Overweight) "Started with the 0.25 mg dose and had very little side effects. A slight tiredness was felt but noticed immediately the reduced level of my appetite and hunger needs. I felt full sooner with smaller portions of food and had no cravings to nibble on stuff at night, which was the norm for me. Make sure to eat well with a basic caloric intake needed for your height and weight, drink plenty of fluids, and get decent sleep daily. This, along with a normal gym schedule, works wonders! I have been on the medication for 5 days now and lost (I assume mostly water weight) 5 lbs in this short time period. I stay active, which also helps with weight loss, but have noticed a complete change in appetite and the lack of needing to snack during the day. I feel this plan will work for me in my goal to lose 20 lbs and will help keep the weight off due to forcing a lifestyle change in my exercise and activity levels being increased. The key is having the desire for change, and Wegovy assists in that."

• Djo...
• Taken for less than 1 month
• July 17, 2021

For Cardiovascular Risk Reduction "I was scared after reading some reviews, but wanted to share my experience so far. I began on .25 one week ago - I injected in my abdomen at night before reading about the thigh being better. The next morning, I woke up with pretty bad nausea, but not vomiting - definitely enough though to prevent me from eating. All day I was lethargic and could not eat much. Each day it improved. It definitely does not allow you to eat heavily - eating very small meals is about all it allows and even then it does give you slight nausea initially. Took my 2nd .25 dose this evening and did inject the thigh. Hoping to update this in a few weeks, but it’s been manageable."

• Mic...
• Taken for 1 to 6 months
• June 7, 2023

For Weight Loss (Obesity/Overweight) "I had a horrible experience. Abdominal pain going to the back. Constant nausea. Depression - very strange feeling, almost like an out-of-body experience. For the first time, I found myself HATING my body. Extreme tiredness. Difficulty focusing. Gained 9 pounds in 3 weeks. Constant headaches."

• Mar...
• Taken for 1 to 6 months
• April 2, 2022

For Weight Loss (Obesity/Overweight) "No weight loss at all in 3 months. I’m at 1.5 dose now. I also have a sluggish thyroid, so not sure. Feel an upset stomach, acid reflux, and nausea. And very tired after the injection. Have lost about 3 lbs and gain it back by the next day. I eat low carb, and usually I’m not hungry. I have no idea why I'm not losing any weight."

• Tre...
• Taken for less than 1 month
• March 25, 2023

For Weight Loss (Obesity/Overweight) "I have been on this medication for one week. On the second day, I was very tired, on days 3-6, I was nauseous the whole time. Every time I ate something other than toast or crackers, I had major cramping, plus a mild headache all week. This was a horrible experience. The pain felt like a gallbladder attack. Never again."

• Bir...
• Taken for 1 to 6 months
• August 12, 2020

For Type 2 Diabetes "Bad news: I started taking the 3 mg Rybelsus for 30 days, did well. Have been taking the 7 mg for the past 3 weeks, and I have had diarrhea, stomach bloating, nausea, and can barely eat anything or drink. Even the smell of food makes me sick. I am extremely exhausted and hate feeling like this. Calling doctor tomorrow. Good news: dropped A1C from 8.4 to 7.3 in 6 weeks and lost 10 pounds, and also cut back on my 24 hr insulin and fast acting due to not eating. — Is it really worth it though???"

• Bon...
• Taken for 1 to 6 months
• July 13, 2021

For Type 2 Diabetes "Started Ozempic about 7 weeks ago. Dosage .25. First week noticed some nausea, a lot of gas, some reflux, and diarrhea. Each week, side effects were getting worse. Nausea very bad, pains in left side, waves of heat, no energy at all. In all, just feeling BAD! Diarrhea is bad and a bit uncontrollable. Have not raised dosage due to being afraid of worse side effects. Have lost 5 pounds. Appetite is definitely less. My sugar numbers have not improved that much, which leads me to believe it is what I am eating. I still crave sweets. I have some jittery feelings at times! I am very discouraged."

• MDl...
• Taken for less than 1 month
• March 16, 2023

For Type 2 Diabetes "Do not use this drug. I took my first and only dose and had terrible diarrhea, so bad I had to cancel several engagements. I also had vomiting after eating, no appetite, a decline in vision, and worst was a mental haziness that took over a month to recover from. My doctor called it an allergic reaction, but I don’t believe that. Even after 8 months, I still have episodes of feeling tired and hazy. I feel like I’ve aged 5 years since taking the one dose. Other than type 2 diabetes, I was in good physical condition and health. Now I have aching muscles, reduced vision, and sporadic haziness. Yes, my A1C went down temporarily, but not worth all the rest of the side effects."

• Arc...
• Taken for less than 1 month
• June 19, 2023

For Weight Loss (Obesity/Overweight) "Began Wegovy three weeks ago, have lost 11 pounds so far. Ready to move up to the 0.5 mg dose. Side effects have been minimal, some tiredness and a bit of constipation, but nothing awful. The key is to listen to your body. If you feel full, then stop eating. That's Wegovy doing its job. Don't ignore it. Good luck to all."

• Sum...
• Taken for less than 1 month
• May 11, 2023

For Weight Loss (Obesity/Overweight) "Never again! I have been taking this for 4 weeks now along with 3 family members, and we all say the same thing. We feel exhausted. I’ve never felt so tired in my life. My son, who’s so fit but has always struggled with his weight, runs several miles a day and is struggling with tiredness too. If I take it on a Sunday, by Wednesday I could sleep standing up. Be warned."

• Mar...
• July 7, 2024

For Weight Loss (Obesity/Overweight) "I was 182 lbs and have been on Wegovy for about 4 months. I am now 168 lbs. I was quite nauseous at the start and found that by eating a mouthful of plain bread helped with the nausea. I have also been quite tired and although not constipated, my poops are firmer."

• Cal...
• Taken for less than 1 month
• May 12, 2023

For Weight Loss (Obesity/Overweight) "My experience with Wegovy has been a rollercoaster. In the first week, the 0.25 mg dose was great. In the second week, I started feeling the side effects of nausea, burping, gas, diarrhea, and bloating. I noticed that I did eat more. Make sure your portions are small and stick to fruit and vegetables. Soups and not greasy processed foods. You may feel sick and will take longer to digest. I am currently reconsidering if I should continue. I am not sure if I want to experience the side effects at a higher dose. I feel terrible all the time and have a headache. I feel exhausted all the time."

• Dut...
• Taken for 1 to 6 months
• September 6, 2024

For Weight Loss (Obesity/Overweight) "I'm almost 2 meters long, and when I started, I was more than 157 kg. Within 11 weeks, I lost 22 kg. Almost every week, I lost 1.5 kg and more after the big water loss. For me, it's an addition to the bigger plan. Yes, I use Wegovy (now on 1 mg), but I also go to the gym 5 times a week and add some hour-long walks to my day. And yes, I also have a strict timeframe where I have my meals. And yes, they are mostly veggies and some yogurt with some granola for some fiber. I had some side effects like heartburn, burping, constipation, and I'm more tired than before. But I think that's a normal thing to process, especially when you make the transition. If you are seriously overweight, please consider this medicine as a small part of the bigger plan!"

• Sus...
• Taken for 1 to 6 months
• April 24, 2021

For Type 2 Diabetes "Well, so far, my experience with Ozempic has not been great. I started out using the 0.25 mg and never had any nausea at all, no lethargy...nothing. My doctor then suggested I increase my dosage to 1 mg, and that, for me, was a HUGE mistake. I have kidney issues, and I began noticing that I was having to urinate less and less frequently, not to mention the constant nausea and extreme lethargy. I felt awful and decided not to do this medication any longer. Since quitting, I feel 100% better, my energy has come back with regular trips to the bathroom now. I would rather have my sugar be a little elevated than wind up on dialysis. For everyone that is on this medication, I wish you the best of luck, and I hope this helps your sugar levels, it just wasn't meant for me."