Trulance and Bloating: What Users Say

• Avi...
• Taken for 1 to 6 months
• February 9, 2019

For Irritable Bowel Syndrome with Constipation "Started this last year, and the first 2 weeks were rough. I'd get gurgling sensations in my stomach each time I took it, along with bloating, gas, and diarrhea for a couple of hours. BUT, my GI warned me that it could happen, and to give my body time to adjust. After 2 weeks, the gurgling stopped. Diarrhea turned into 1-2 times a day, and since then, I am having regular bowel movements. No side effects. The only exception is when I eat certain types of food (normally greasy or high in fat). I notice that I have 1 or 2 loose bowel movements the following day. Having IBS with constipation, this was the only medicine that was able to keep me regular. I used to go 5-6 days without going. I was in pain, backed up, bloated, and had no life because I always felt terrible. Not anymore. I know some people can't handle the diarrhea, but I promise you, it is normal at first, but you have to give it a chance, beyond just a couple of days."

• Ann...
• Taken for less than 1 month
• March 26, 2021

For Irritable Bowel Syndrome with Constipation "So an update from my review yesterday. I took half a pill yesterday after just being given samples. It took like 6 hours to kick in. I had to do an enema to get the ball rolling, but as soon as I did, I passed everything I've eaten in 30 years! Yippee, relief! I took half today and it worked in 2 hours. Zero pain, mild bloating, mild cramping, and full relief. I had three trips to the toilet and pretty much nothing left now. Half a pill is worth a try for anyone who can't handle a whole pill. Seemed to clear out within an hour or two, then I could go about my life. Good luck, guys!"

• Dar...
• June 21, 2017

For Chronic Idiopathic Constipation "I was diagnosed with chronic idiopathic constipation (CIC) at 19 in 2014. After trying both Amitiza and Linzess, this medicine has worked wonders that the other two had not. I could never go while on Amitiza, and I had diarrhea to a point it was just water on Linzess. Went to my gastro after having tender stomach pains and bloating and was switched to this. So far, so good. I poop on a normal consistent basis with no side effects. No more laxatives just to go to the bathroom. Thank goodness for finding something for CIC that works for me. I'd definitely recommend to others who are suffering this nasty 'disease'. Kudos"

• SWa...
• Taken for 1 to 6 months
• July 28, 2019

For Chronic Idiopathic Constipation "I have dealt with chronic idiopathic constipation for years. The only thing that worked was Dulcolax, and that causes crazy diarrhea. I had awful stomach bloating to the point people thought I was pregnant. The instant I ate, I would feel swelling, my bra got tighter, my wedding ring would cut into me, etc. I was given a 4-week supply of Trulance by my doctor. The results are...I no longer bloat and have stomach pain and knots. I'm not scared to eat anymore. The bowel movements are here and there. Before, it was maybe once every 2 weeks. Now it's maybe 2 in one week. I am going to keep taking this just for the comfort of eating."

• Ros...
• Taken for less than 1 month
• January 28, 2019

For Irritable Bowel Syndrome with Constipation "I have been suffering 45 years with severe IBS. I have taken every single prescription and over-the-counter medicine for it. Everything works for a couple of days and then I’m back to normal. I am now taking Trulance and it is like a miracle drug. Within an hour to two after I take it, I feel gurgling in my stomach and then I go diarrhea about 4 times. I feel amazing. No bloatedness anymore. I feel so empty and it feels great. Highly recommend this pill."

• TWa...
• Taken for less than 1 month
• July 23, 2019

For Chronic Idiopathic Constipation "I have tried everything: Phillips pills, Linzess, Almatiza, tea tree root, Milk of Mag for a whole year. Miralax also worked, but bloated me and didn't empty my bowels. I have UC, so fiber is out of the question. Trulance works great, I don't have the diarrhea people talk about, but I do go about 3-4 times a day. But, not bad like having pooping on myself. You feel small cramps, just go to the restroom. The only reason I didn't give a 10 is that it does flare up hemorrhoids, so I have to use cream every day. But I do not care at this point, I'll buy a case from Amazon if needed. I also have gastritis, so not looking bloated/pregnant. I love it."

• Jam...
• August 11, 2017

For Chronic Idiopathic Constipation "I was on Linzess, using it only from time to time as it caused severe bloating and diarrhea. I was skipping doses and was constipated then. It always required a decision: should I take a pill today or not? For the last 2 months, I have been using Trulance, and it is perfect. I take it in the morning and forget about it. It just works! Smooth and nice. I already forgot what diarrhea is! I feel like my life has changed."

• luc...
• Taken for less than 1 month
• January 10, 2020

For Chronic Idiopathic Constipation "I have been constipated my whole life. Several months ago, I started experiencing bowel blockages that ended up causing projectile vomiting, heartburn, and nausea. For years, colonics was on my list of things to do. At my last appointment, my bowels were so blocked, I drank a bottle of magnesium citrate! Wow! Wow! Wow! If your system needs cleaning out, this is exactly what does. As far as the Trulance, for the 2 days I've taken it, my belly looks 8 months pregnant from horrible bloating, gas, and ridiculous diarrhea! For safety purposes, on the 1st night, I wore an overnight adult diaper, only to wake up in a huge feces mess in my bed!!! I feel horrible! Made a call to my gastro's office today."

• LBa...
• Taken for less than 1 month
• July 29, 2020

For Irritable Bowel Syndrome with Constipation "I've been on Linzess for years now for my IBS-C. My insurance decided to deny me and make me try Trulance. I'm on day 2, and I've never felt so sick from a medication in my life. The nausea, bloating, and nasty belly pains are so bad today. It's to the point that I'm running to the bathroom and not knowing which end it's coming out of. Dealing with this while working is not easy. Had explosive diarrhea, and now I have the shakes and feel so weak. By the way, nausea is at an all-time high as well. My stool is now pale in color. I'm all set with this drug! No thank you!"

• Car...
• Taken for less than 1 month
• August 9, 2018

For Chronic Idiopathic Constipation "Those of you saying it caused stomach pain, bloating, and didn't produce a BM should probably make sure that 1. You don't have a blockage and 2. Be tested for pelvic floor dysfunction or possible anal stenosis."

• Wil...
• August 28, 2017

For Chronic Idiopathic Constipation "I was taking Linzess for the better part of three years, it did the job but had major AEs. I experienced bloating, weight gain, and the biggest problem for me was stomach pains. My GI doc switched me over to Trulance about 30 days ago, and as of now, I'm not having any AEs. I hope it continues to work this well."

• BBW...
• Taken for less than 1 month
• November 1, 2019

For Chronic Idiopathic Constipation "I’m a female in my late 30s that has experienced severe constipation since pregnancy 6 years ago. This drug has caused nothing but dehydration, bloating, congestion, and weight gain. I will not continue use of this drug."

• Blu...
• Taken for less than 1 month
• July 25, 2020

For Irritable Bowel Syndrome with Constipation "The doctor gave me samples of this after Linzess made me constantly bloated (I looked pregnant) and gave me nothing but diarrhea. Trulance does the same to me when it comes to diarrhea, and it seems a bit worse at times, like having to stay on the toilet for 2 hours. Sometimes it doesn't work as great, and I feel horribly bloated on my left side until I wake up the next day. One good thing is that I'm not constantly bloated anymore, but the diarrhea is a letdown because I need to be able to leave the house. It's been 3 weeks on this medication, and I'm not sure if I'm really liking it much, I'm not sure what the doctor will suggest next."

• Hay...
• Taken for less than 1 month
• June 24, 2018

For Chronic Idiopathic Constipation "I love Trulance! I’m surprised people are saying it made them gain weight, as it is not a listed side effect, and I actually managed to lose 2 lbs while taking it. I’ve suffered from severe bloating and moderate constipation for almost two years. I was sick of the constant cycle of laxative on Friday night - flat stomach Saturday - constipation building Sunday through Friday - repeat. I was tired of planning my life around my laxative and my bloat. There were and are many times when I take a laxative and it would do nothing but make me bloat up to two sizes bigger than I am. Trulance has been gentle. No cramping, only mild bloat, and no water retention. My only negative comments revolve around the day-long diarrhea and the stomach distension that comes from going off it cold turkey. (I ran out and am waiting for my prescription)"

• Eur...
• Taken for 1 to 6 months
• February 17, 2018

For Chronic Idiopathic Constipation "I take 3 mg at bedtime for my gastroparesis. I wake up each morning with a comfortable, normal BM. At week two, I experienced some bloating, but it subsided within a week. I have never had anything work this well. My choices have always been severe, painful constipation or highly medicated, cramp-inducing diarrhea. Trulance has changed my life after years of too much time spent and thought spent on my bowel management."

• Pun...
• Taken for 1 to 6 months
• September 18, 2018

For Chronic Idiopathic Constipation "I take it twice a week. Usually works within an hour and have relatively normal BM unless I am backed up. Then I get the diarrhea everyone complains about. Have to make sure you have fiber when taking, and that seems to help decrease the bloating."

• Anonymous
• Taken for 1 to 6 months
• June 25, 2018

For Chronic Idiopathic Constipation "Wrote a review previously. Still no side effects after taking for 3 months. The only thing I’ve noticed is weight gain - I was consistently 120 lbs for several years without change, and since starting the medicine, I am up to 126 without any other significant lifestyle changes. This medication somewhat improved the frequency of BM, but it’s hit or miss. Some days I still feel really backed up, others, I have a well-formed movement. When taken with a probiotic, this medication reduced my bloating significantly. I would prefer not to be on long-term medication anyway, so I may consider discontinuing if I can’t drop the weight by increasing exercise. I need to find the root cause of my constipation instead of putting a band-aid on it. Make sure to get your ALS liver panel checked, as this medication can elevate those in some patients. Elevated ALS means your liver is inflamed/irritated."

• Anonymous
• Taken for less than 1 month
• January 13, 2018

For Chronic Idiopathic Constipation "After years of trying everything on the market, including Linzess and Amitiza, I was given samples. It has been working great! I do have days of loose stools, but the alternative to me is worse. I go every day, and my bloating is gone! No cramping, headache, or bloating. I would recommend this medication. I'm not sure the cost, though, I haven't purchased from the pharmacy yet. I hope it is not too expensive! Drug companies need to know that what we go through is awful, and these drugs should be covered by insurance!"

• Sam...
• August 23, 2017

For Chronic Idiopathic Constipation "After suffering for 2 years of bloating, I had been using Miralax, which works slowly every day. Then the doctor said to try this. Within 10 minutes, I was in the bathroom on and off for 2 hours while it was cleaning my system out. I had no bloating and no abdominal pain. I took the second dose today, and it did the same thing. In 10 minutes, rolling thunder started in my stomach and cleaned out everything. I will try in a few more days, then will ask the doctor. So far, no more pain, but I feel like it's an F-18 fighter sound going through my stomach for a few hours after taking this. Thank goodness I tried it after work when I was home. Lol."

• KCa...
• Taken for less than 1 month
• June 14, 2018

For Chronic Idiopathic Constipation "I had to share my experience. Opposite of most. I was afraid to even try this, reading how much diarrhea people get. Took the first one in the evening and prepared to rush to the bathroom. Felt nothing. Next morning, I had a very small hard bowel motion. Throughout the day, I began to feel progressively more sick. Headache, exhausted, foggy, shaky. Almost a migraine-type feeling. Took the second dose that evening. Woke up the next morning feeling like I was run over by a train. Horrible headache, shaking, pain in face behind eyes, totally wiped out. I was completely bloated, felt like I had a round balloon in my stomach. I had a hard time getting through the day and decided I needed to stop. It took a full 24 hours to feel better. Finally, 36 hours later, I have started pooping again and the headache is fading. This medicine was NOT for me. I have never had such serious side effects."

• FOS...
• Taken for less than 1 month
• April 14, 2019

For Chronic Idiopathic Constipation "Five days of taking this medication and not impressed. Had diarrhea twice, for which I'm thankful after reading some of the reviews. All I'm getting from this medication is a stomach so bloated it would appear I'm in my 9th month of pregnancy and cramps that have me constantly running to the bathroom with absolutely no results. Glad this was a sample and I didn't pay any money."

• Mbe...
• October 17, 2017

For Chronic Idiopathic Constipation "I started taking this RX after years of severe constipation. I thought this was just a 'woman' thing. I never knew IBS was also a constipation thing. I started out on Linzess and was moved to this drug as a cheaper alternative that was maybe better. So, 5 days into it, I had nothing.....belly bloat, looked pregnant, and miserable. Day 6 came and let's say it was terrible, poo all over my bed as I slept. Day 7, poo all over the bed again. As I slept, severe diarrhea. So now I sleep with my first pair of diaper underpants. ????? I am 49, this is not a part of my life I wish to have at this point."

• Jak...
• Taken for less than 1 month
• September 2, 2018

For Chronic Idiopathic Constipation "Was on both Lactulose & Relistor for over 2 years. Just started Trulance, and what an amazing drug. Within an hour, had a decent bowel movement without abdominal cramps, bloating, & flatulence. 5 stars out of 5."

• Bri...
• Taken for less than 1 month
• May 31, 2018

For Chronic Idiopathic Constipation "I have struggled with chronic constipation my entire life. I am a 29-year-old female, and my gastro doctor prescribed me Trulance over 2 weeks ago. For the last 11 years, I have tried everything, including Amitiza, Linzess, bag enemas, Miralax, Dulcolax, etc. None worked. I was diagnosed with gastroparesis, celiac disease, and chronic constipation. My entire colon is slow transit. I was really optimistic when I saw other reviews saying within 2 hours they were having diarrhea. I was surprised some people gave up taking this drug due to the diarrhea. I have a 4-year-old son, I don't have time to feel awful anymore. I am so disappointed. Over 2 weeks on Trulance and nothing. Just bloating and gas. I plan on seeing my doctor and asking about removing some of my colon. I am desperate to stop feeling toxic. I am glad this medication works for some people. I would recommend at least giving it a try, you could have better results than what I did. Good luck!"

• mis...
• Taken for less than 1 month
• May 8, 2019

For Chronic Idiopathic Constipation "Took it for a week. I've been so bloated with horrible gas pain the whole time. Diarrhea all day, and then when the diarrhea is done, I strain to pass the same small pellet stool I have when I don't take anything. Tried splitting the pill in half and get the same results. Drinking 3 liters of fluids a day and still feel dehydrated. The only good thing I can say about this medication is that it was a free sample at my doctor's office."