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Zofran and Sleepy: What Users Say

Sleepy: mentioned by 5 users (1.8%)

Based on user experiences from 271 Zofran reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

nausea 21.4%
vomiting 15.1%
constipation 12.5%
headaches 7.7%
dizziness 5.5%
drowsiness 3.3%
tiredness 2.2%
diarrhea 1.8%
sleepy 1.8%
tremors 1.5%

Reviews for Zofran

Commonly mentioned side effects
  • hhg...
  • Taken for less than 1 month
  • October 14, 2013

For Gastroenteritis "This is my miracle medicine. Best medicine I have ever taken in my life. Works for me in 1-2 minutes. Have nausea from acid reflux and feel instantly better. A little sleepy but it doesn't put me in a deep slumber. Love Zofran."

10 / 10
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77 Report
  • OLo...
  • Taken for 1 to 2 years
  • May 3, 2014

For Nausea/Vomiting "This medication works wonders for me whenever I feel sick or nauseous. The flavored tablets that disintegrate under the tongue or in the mouth are very convenient and work really quickly to relieve nausea/vomiting. The only real side effect from it that I have noticed is a slight tired feeling. I'd much rather feel a little sleepy than sick to my stomach. I really recommend this medicine if your doctor also feels that it is right for you."

10 / 10
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38 Report
  • asb...
  • Taken for 6 months to 1 year
  • August 22, 2014

For Nausea/Vomiting "I've had recurring nausea for over a year now. The bouts of nausea, dry heaving, and vomiting only bile would last for hours. Phenergan did nothing, but Zofran, within 5 min (usually), I'm cured. It does make you sleepy, but well worth a little tiredness. It is expensive without insurance."

10 / 10
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36 Report

Frequently asked questions

  • Zof...
  • Taken for less than 1 month
  • June 28, 2022

For Nausea/Vomiting "I am having severe digestive issues, and we are trying to figure out what it is. Gastritis? Gallbladder attack? (I do have a gallstone.) IBS? Ulcer? Just don’t know. I have horrible anxiety and stress when something is wrong with me. That probably adds to the nausea. I get nauseous, and it hurts like a gnawing pain. I can’t really eat, it’s miserable. Went to the ER twice, and they administered Zofran, let me tell you! It is a miracle drug! Painful nausea gone! I feel so much more calm, and the gas/bloating is gone. I didn’t experience any effects. Even if I get sleepy, it’s a welcomed side effect after feeling yucky for days! Give it a try!!"

9 / 10
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9 Report
  • Nic...
  • Taken for less than 1 month
  • October 3, 2018

For Nausea/Vomiting "At first, it worked for me when it was given to me at the hospital. It was then prescribed to me by my doctor for nausea and vomiting from gallstones. After a few hours of taking Zofran, I started to experience body tremors, and I still have residual nausea too. It also makes me feel very sleepy from it too. I think it has also caused me to be constipated since I haven't had a bowel movement in a few days. Not sure if I would recommend this to anyone. It does kind of work, but not well for me."

6 / 10
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7 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.