Zofran and Drowsiness: What Users Say

• cam...
• August 7, 2014

For Nausea/Vomiting "I have generalized anxiety disorder and suffer from emetophobia. The anxiety causes stomach upset, and the fear of throwing up increases the anxiety in a vicious cycle. My psychiatrist prescribed Zofran while I was trying out SSRIs to help me get through the first few weeks of side effects. I am now on Celexa with a lot less anxiety and only take Zofran as needed! It works great, it just makes me feel sleepy. Haven't run into any constipation yet."

• pre...
• Taken for less than 1 month
• March 2, 2015

For Nausea/Vomiting "I'm taking this for morning sickness. I feel like it has given me my life back. I lost over 6 lbs in 5 days due to nausea and vomiting and was too sick to do anything for my toddler, myself, or my home. I can tell when it's starting to wear off (at about 6.5-7 hr.) because the nausea comes right back. I'll take being backed up and a little drowsy as a side effect... It allows me to eat and keep things down and be present in my family's life. Never thought I'd be so happy to take a medication, but I'm SO thankful for Zofran."

• pan...
• Taken for less than 1 month
• February 8, 2015

For Nausea/Vomiting "Last night I had severe diarrhea and stomach pain and dizziness, maybe I was dehydrated from the stomach bug, so I went to the ER and they said they were going to give me Zofran, which I have a phobia of trying new pills, but my stomach hurt so bad. I told the nurse I'd break it in half till I seen how small it was, and she said just let it dissolve on your tongue, so I did, and it had a strawberry flavor, which I told her, 'Wow, this tastes good.' Within about 5 minutes, my nausea had gotten so much better, it even relaxed me a bit. I'm telling you folks, if you have the stomach bug or stomach aches, give this a shot. I had no side effects at all, maybe a little sleepiness, but like others, I'll take that over the stomach pain. Thanks, Zofran."

• Ess...
• Taken for 1 to 6 months
• January 7, 2015

For Nausea/Vomiting "I am currently 25 weeks pregnant and have had bad nausea/morning sickness since week 5. This medicine has been wonderful. There are times when I still feel sick, but it's bearable, and I don't throw up. I've been taking it so long now that the sleepiness it causes doesn't affect me anymore. However, the constipation from it has been a downer."

• Mom...
• February 1, 2015

For Nausea/Vomiting "I'm 32 weeks, 5 days pregnant. Was admitted into maternity yesterday after throwing up every few minutes all yesterday morning. They have me fluids and Gravol, but that only made me drowsy and did nothing for the throwing up, so they decided to give me the Zofran. It started working as soon as it was in my body. It was quick and very effective!"

• Kte...
• Taken for less than 1 month
• August 21, 2013

For Nausea/Vomiting "I have had three pregnancies, and with the first two, the morning sickness was bearable enough without medication. This time around, I have had trouble making it to work and have been constantly miserable, nauseous, and dry heaving. I took my first Zofran last night, and the only complaint I have is that I wish it was non-drowsy. I almost fell asleep at my desk today. However, I will take drowsiness over nausea anyway. Thank you, Zofran."

• Nor...
• Taken for 1 to 6 months
• April 3, 2018

For Nausea/Vomiting, Chemotherapy Induced "I'm one of those people that would rather be in pain than nauseous, so when I started chemotherapy, I knew I was in for a ride. I was given a cocktail of meds right before chemo and then Decadron and Zofran for a couple of days after for allergic reaction and nausea. For the times after that 'as needed,' I have Zofran & Compazine for nausea and Ativan for 'anticipatory nausea.' I guess the Ativan would help some commenters in this thread who actually get sick from thinking about getting sick. It made me too drowsy, so I was left with the Compazine and Zofran. I found the Zofran to be by far the most effective; I take one 4 mg tablet as soon as I start feeling queasy, and within 10-15 minutes, I am fine - I'm even able to eat. Thankfully, my insurance covers it as it is a little more expensive than some meds for nausea, but to me, it's worth not vomiting. I recommend this medication highly."

• Joa...
• Taken for 2 to 5 years
• December 6, 2021

For Nausea/Vomiting "I use the sublingual. Every time I take it, I envision the guys designing this: 'We're making an anti-nausea sublingual medication? Great! Let's give it the nastiest fake berry flavor we can possibly come up with. That will help nausea, right?' It really is disgusting. I use it because it doesn't make me sleepy and dangerous to drive like promethazine does, but it's not nearly as effective. It works for queasiness, but on full-blown nausea, it's pretty worthless. But for just queasiness, it's relatively effective."

• Aly...
• Taken for less than 1 month
• June 3, 2021

For Nausea/Vomiting "I took Zofran on May 3, 2021, to help my nauseated stomach. After a little while when it kicked in, I started feeling very drowsy and tired, and my stomach seemed like it was hurting worse. I now know that this medication, Zofran, is not something for me to take. I want to get better, not worse."