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Bupropion / naltrexone User Reviews & Ratings

Brand names: Contrave

Bupropion / naltrexone has an average rating of 6.6 out of 10 from a total of 2,050 reviews on Drugs.com. 56% of reviewers reported a positive experience, while 25% reported a negative experience.

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Weight Loss (Obesity/Overweight)
6.6
2050 reviews for Weight Loss (Obesity/Overweight) 61 medications

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Reviews for Bupropion / naltrexone

  • mkk...
  • Taken for 6 months to 1 year
  • January 17, 2021

Contrave (bupropion / naltrexone) for Weight Loss (Obesity/Overweight) "I have struggled with my weight for as long as I can remember. I am a 51-year-old female. My doctor has seen me yo-yo with weight and struggle at times with my type 2 diabetes. She seemed excited to offer me this prescription. I read some reviews and had some doubts but I trust her implicitly, so I started the process. Honestly, I wanted to quit within the first couple of months. Horrible nausea, terrible vomiting, and I hate vomiting. I persevered and am ecstatic with my results so far. I have been on this medication for 7 months and I have lost 57 lbs. I don't count calories, I listen to my body. I don't drink coffee anymore, and I used to drink a lot! I don't even like alcohol. Changed my tastes for foods. I don't crave anything. I know it may be rough the first few months, but I recommend sticking it out. I can't even remember the last time I was this weight and size. I'm so emotionally happy. I wish you all the best, what do you have to lose? Hopefully weight. Lol"

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  • Yea...
  • October 3, 2020

Contrave (bupropion / naltrexone) for Weight Loss (Obesity/Overweight) "I wanted to try Contrave not really to lose weight, but because I felt hopelessly addicted to alcohol and opioids, and read that the med. In Contrave also blocks opioids and is an antidepressant. I take one pill each morning for about 3 weeks now. I am overweight also. I had pretty bad leg/foot twitches (at night) for the first week or so also very thirsty. The twitches felt like mild electrical shocks to the bottom of my foot, and kept me from sleeping well. Also, I started walking 3 miles a day and going up and down my stairs 25 times fairly quickly. I limit my food intake to ~ 1200 calories. I never was a big eater, but alcohol was adding 600-900 cals per day. I’ve stopped drinking and opioids, with no problem. I have tried them again, but they are no fun, and just more calories. I've lost 12 pounds in 3.5 weeks and I’m done with alcohol and drugs. I have a better outlook on life now. I hope this helps others."

10 / 10
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  • Dee...
  • Taken for 1 to 6 months
  • November 4, 2019

Contrave (bupropion / naltrexone) for Weight Loss (Obesity/Overweight) "Contrave is costly. To avoid paying unnecessary money, just have your MD prescribe the two medical ingredients separately, i.e., bupropion as one med and the naltrexone as the other. I only pay $20/month. By having them prescribed separately, my insurance covers almost ALL the cost. I've lost 50 pounds over 6 months and saved huge amounts of money by NOT using Contrave."

1 / 10
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Frequently asked questions

  • Car...
  • February 25, 2020

Contrave (bupropion / naltrexone) for Weight Loss (Obesity/Overweight) "I can't believe all of the negative reviews for this drug. I have been on Contrave for 4 weeks now. My appetite and cravings have been drastically reduced over the last two weeks in particular. So far, I have lost 10 lbs and I am absolutely thrilled! I still have 60 lbs to go but this is the first time in 10 years that I am very confident that I will get down to my goal weight. I had absolutely lost all hope and thought I would have to grow old as an obese person. I've tried every diet under the sun including Weight Watchers, Jenny Craig, Keto, Non-Carb. I even had a gastric bubble placed in my stomach to make me feel full but had to have it removed after one week due to severe cramps and nausea. We all know what we need to do to lose weight, but when you are addicted to food and crave snacks all day, I always failed after 2 weeks on any program because I was just so hungry!"

10 / 10
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  • Smi...
  • Taken for 6 months to 1 year
  • April 14, 2021

Contrave (bupropion / naltrexone) for Weight Loss (Obesity/Overweight) "Love love love!!! I started at 223 lb. I am now 150 lb! Thanks to Contrave and the hard work I put in. This is not a magic pill, you do need to help yourself as well. I do recommend that you take a stool softener while taking Contrave, one of the side effects is constipation. I took Contrave for almost a year, and 2 years later, still keeping the weight off!"

10 / 10
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  • Cou...
  • November 4, 2020

Contrave (bupropion / naltrexone) for Weight Loss (Obesity/Overweight) "I started Contrave about 3 months ago. I am 22 years old and am 5ft 11. When I started, I was 275lb and was just not happy with where I was with my body and health. I decided to start taking the medication and got up to taking 2 pills a day. I only really experienced constipation and headaches as bad side effects of this medication. They were not that bad but were worse on some days. As of now (3 months in), I am 45 pounds down, weighing in at 230. It is such a simple medication and works so quickly when paired with a good diet."

10 / 10
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  • Anonymous
  • October 16, 2019

Contrave (bupropion / naltrexone) for Weight Loss (Obesity/Overweight) "So one year ago today I started taking Contrave. I am a 65-year-old male, and when I started, I was 349 lbs. After many diets and weight loss fads with little to no success, I went to see my doctor to discuss bariatric surgery, which I wasn’t looking forward to but felt I didn’t have much choice. At first, I experienced a bit of nausea and lightheadedness, but it was very minor. Right away, I felt my appetite decreasing. I did watch what I ate but didn’t restrict any specific foods, just a whole lot less of it. It began to work immediately, and the weight started coming off pretty quickly. I am very excited to announce that after 1 year, I have dropped 75 lbs (my goal was 60 lbs) and feel wonderful. For me, Contrave was a 'wonder drug' and gave me the boost I needed. I am remaining on the pills for a bit longer, but I really feel I can monitor the quantity of food I consume. The only real side effect has been the money I have spent on new clothes - actually very happily."

10 / 10
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  • Jer...
  • Taken for less than 1 month
  • October 10, 2020

Contrave (bupropion / naltrexone) for Weight Loss (Obesity/Overweight) "I started at 153 lbs. I’m 5’2”. Three weeks later, after starting Contrave, I’m now 144. The side effect symptoms weren’t as severe as others describe, but I do feel a little loopy, occasional headaches. I haven’t upped my dosage to more than 2 a day because I haven’t found it necessary. I used to drink almost every day. It wasn’t only bad, but it was keeping me from losing weight. I felt like I was losing control of the drinking, and Contrave has absolutely almost eliminated all my drinking cravings. I’m so thankful to God, I’ve only drank 3 times in 3 weeks. And I must say, DO NOT DRINK WHILE ON THIS PILL, don’t take it for at least 2 days before drinking. My food cravings are very much diminished, and staying under 1000 calories has been easy. It’s gotten easier as time goes. It does make me sleep through the night, which I love, but it does make me feel slightly loopy during the day. I highly recommend Contrave for weight loss and to stop drinking."

8 / 10
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  • She...
  • Taken for 2 to 5 years
  • January 26, 2021

Contrave (bupropion / naltrexone) for Weight Loss (Obesity/Overweight) "I’ve been on this for over 3 years. I lost about 56 lbs in my first year, and then a few more over time after that. I started at 224, and my lowest weight was 158. I now maintain around 162-165, and I am happy with that. I have kept the weight off by exercising. It's been the best thing for me."

10 / 10
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  • amb...
  • Taken for 1 to 2 years
  • September 6, 2020

Contrave (bupropion / naltrexone) for Weight Loss (Obesity/Overweight) "I lost almost 75 pounds since I started Contrave. My doctor actually prescribed bupropion and naltrexone separately, so my insurance covered most of it. I don't know if this was all because of the pill, but 1.5 years later and the weight is off. I didn't really change my eating habits, I still eat unhealthy, not going to lie to you guys, and never work out, so I feel like it had to be the pill. My doctor just took me off of it, so I am going to start better habits to make sure the weight does not come back."

10 / 10
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  • Ano...
  • Taken for 6 months to 1 year
  • September 28, 2020

Contrave (bupropion / naltrexone) for Weight Loss (Obesity/Overweight) "I have been on Contrave for 8 months and have lost approximately 35 pounds and have another 30 pounds to get to my target weight. If you can get past the first few weeks, it really does work. You can immediately feel the reduction in food cravings and appetite. I used anti-nausea drugs to help me the first week and then I had no issues. You do have to follow a healthy diet, but for people who eat compulsively, it makes a big difference in being able to resist junk food and reduce your food intake. This ultimately allows your body to adjust to healthier food and shrink your stomach."

10 / 10
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  • Cla...
  • July 29, 2019

Contrave (bupropion / naltrexone) for Weight Loss (Obesity/Overweight) "I've had great success on this medication. I experienced mild side effects (headache, constipation, dry mouth, occasional ear ringing) the first 4 weeks while increasing. I have lost a total of 35 pounds so far in 3 months! Binging has stopped, the cravings have significantly subsided, and I get full faster when I eat. This is with minimal diet and exercise. I'm sure when I introduce those 2 things it will take off even more. I have food addiction and no matter what, my brain always told my body to eat even if I was full - I couldn't turn that off no matter how hard I tried. All that has stopped. Contrave has worked great for me and I hope others have the same experience."

10 / 10
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  • Dod...
  • Taken for 1 to 6 months
  • December 5, 2019

Contrave (bupropion / naltrexone) for Weight Loss (Obesity/Overweight) "I have been taking Contrave since late July this year. As of today, I have lost 26kg (56lbs). I had bad side effects for the first 4-6 weeks, but they have since subsided. I haven’t touched alcohol or fast food since early August and currently only eat one meal a day. This drug has worked for me and I’m glad I pushed through the early side effects as it has truly been worth it."

10 / 10
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  • Bea...
  • Taken for less than 1 month
  • October 3, 2020

Contrave (bupropion / naltrexone) for Weight Loss (Obesity/Overweight) "I have just started my second round of Contrave. I used it about 3 years ago in conjunction with my regular weight lift routine and absolutely love the results! Over the course of about 10 months, I went from a size 16 dress to a size 10. I was able to fit in my old college T-shirts again, and ‘that special pair’ of jeans fit again. (You know... those jeans that fit just right in all the right places and make you feel like the hottest thing on earth.) In the beginning, there was some sleepiness and a little nausea, but speaking for myself, it was worth it. I dropped 86 pounds of fat, gained muscle, and started enjoying clothes shopping again. The reason I stopped taking it was because I had to have several surgeries following a car wreck, but now I’m back on my feet and ready to make up the progress I’d made."

10 / 10
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  • JJa...
  • Taken for 1 to 6 months
  • December 26, 2019

Contrave (bupropion / naltrexone) for Weight Loss (Obesity/Overweight) "So, I wanted to wait until I placed a review anywhere about my experience with Contrave. I have been taking it for 3 months and am at full dose (2 tabs 2x a day - 5am and 2pm). The first 6 weeks were tough. Felt nauseous and shaky. And I am someone who relies on Wellbutrin for mental health, but I was 15 lbs overweight. I knocked off the first 20 lbs with diet and exercise, but menopause or age (53) just wouldn’t let me shed the last 15. So, I spoke to my GP and we decided to try this. This medicine worked for me! I now think of food as nutrition, not entertainment or a crutch when I am bored. Anyway, I have 6 more lbs to go and then will taper off and go back to Wellbutrin straight. If you are serious about taking back your health with diet and exercise and can’t drop the last bit, I would say give it a try."

9 / 10
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  • Ali...
  • Taken for less than 1 month
  • September 18, 2020

Contrave (bupropion / naltrexone) for Weight Loss (Obesity/Overweight) "I was on Contrave for about 4 weeks when all of a sudden I had a seizure. Never in my life did I have one before. I am not epileptic, nor is anyone in my family. It was very odd as the doctor who prescribed the Contrave told me there are no side effects! Doctors don’t know everything, I learned the hard way. My driver's license was suspended right away, and now it is taking months to get a neurologist to see me. Be careful if you plan to take this pill!"

1 / 10
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  • Eri...
  • Taken for 1 to 6 months
  • March 13, 2023

Contrave (bupropion / naltrexone) for Weight Loss (Obesity/Overweight) "My experience with Contrave has been amazing! I have lost 24 lbs in 2 and a half months, and I have almost completely stopped binge eating. I think I have had maybe one slight binge since I started taking this medicine. This medicine has changed my life quite literally. I don't even think about food the way I used to, I feel free from the obsession. The only negative is that it does cause constipation, but I just take stool softeners to help with that. I never experienced the nausea or sickness in the beginning, but I have heard that some have and then it goes away. I had to come and leave a review because I want other people to experience this freedom from food."

10 / 10
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  • Mat...
  • November 21, 2019

Contrave (bupropion / naltrexone) for Weight Loss (Obesity/Overweight) "As far as negative effects, I have had absolutely none. Which allowed me to change my diet to 1800 calories or less a day without feeling hungry. I have lost around 32 pounds. Also, if you read this and think that well, if you reduce your calories to 1800 or less, of course you will lose weight, and that's true. However, before taking this drug, I would have never been able to be limiting my food to this amount and feel fine. So I'm hoping that by shrinking my stomach using this, when I am eventually weaned off this drug, my natural appetite will be at a more reasonable level so I can maintain. If you need to lose a lot, I would recommend it. You need to make healthy choices and have some commitment as well."

10 / 10
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  • Rox...
  • Taken for less than 1 month
  • October 9, 2019

Contrave (bupropion / naltrexone) for Weight Loss (Obesity/Overweight) "I have been on Contrave for 3 weeks. My first 2 days I was a little lightheaded but that did not last long. It has certainly curbed my appetite and slowed down my cravings. After 3 weeks on Contrave, I have lost 20 pounds. I did cut out sugar, and I am watching my carbs. I am getting my energy back. It is working great for me. I drink at least 4-5 bottles of water a day. No soda. No junk food. I am very pleased with my results."

9 / 10
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  • Anonymous
  • February 3, 2020

Contrave (bupropion / naltrexone) for Weight Loss (Obesity/Overweight) "Contrave was prescribed specifically for weight loss, but I have also been a moderately heavy drinker for about 10 years (3-6 beers per night, more on weekends). I was already on Bupropion, so the doctor prescribed Naltrexone in addition. One month in, I've lost 5 lbs, stopped snacking at night, and have almost completely lost all interest in drinking. I was sleeping more than usual at first. Mild nausea here and there. Excited to see where I'm at after a few more months of this."

8 / 10
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  • Cas...
  • June 18, 2021

Contrave (bupropion / naltrexone) for Weight Loss (Obesity/Overweight) "I am 5'3 at 167 lbs. I started on June 2, 2021. I kept stepping on the scale. Now on my 2nd week taking 2 pills a day. Just stepped on the scale and I am 2 lbs down. I have been feeling full on just eating smaller portions or snacks. Still want a few cookies though, lol. Now I haven’t changed my diet either, I’ve slowed down on junk but no major changes. I will finish a full 6 weeks, consistency is key, right? Hopefully I can drop another 18 lbs. Update 6/17/21. I am now on 3 pills and my first day was super harsh. I did great in the morning but the evening pill came with side effects. I felt super weak, hot, jittery, and I threw up. I have had chest pains a few times, which didn’t last long. This evening wasn’t as bad, just a little nausea. Anyways, I am now 161 lbs at the beginning of the 3rd week, 6 lbs lost. I started working out and am on my 3rd week as of yesterday. At-home workouts, nothing major. Will update again."

5 / 10
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  • Anonymous
  • April 24, 2021

Contrave (bupropion / naltrexone) for Weight Loss (Obesity/Overweight) "This is my 6th day so far and I lost 4 pesky pounds. I haven't had any side effects so far, but let's see, on Monday I start taking 2 pills in the morning and one at night. I feel much better, my attitude has changed from being messed up to a more pleasant one. I am walking in the park one mile daily and even more sometimes. I no longer have cravings for sitting in front of the TV and munching on chips and dips, and chasing it down with 4 or 5 coronas. What I really like is that my inflated belly is going down, down! From a 44 waist to 40 and I'm aiming for a 36 waist! I looked like I was 6 months pregnant!! I realize that no inanimate thing sitting on the table is making me eat it. I have salmon, cottage cheese, and pineapple for lunch, and for breakfast, I have my protein shake. But most of all, my friends say 'keep moving'. Will check in again next week. Mr. Gil"

10 / 10
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  • Anonymous
  • Taken for 2 to 5 years
  • May 3, 2020

Contrave (bupropion / naltrexone) for Weight Loss (Obesity/Overweight) "Lost 50 pounds over 2 years, was key to the process and got me back to exercising. Did not experience any side effects. Cost of medicine offset by food savings and reduced healthcare costs in the future (I assume)."

10 / 10
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  • Moa...
  • Taken for less than 1 month
  • January 13, 2021

Contrave (bupropion / naltrexone) for Weight Loss (Obesity/Overweight) "This is my very first time taking Contrave. I am 5ft and currently 205lbs. My eating habits prior to Contrave were horrible. I would eat any and everything I could get my hands on even when I wasn't hungry. This is my first day taking it and I can already feel the difference in my appetite. I had no urge to eat today but I did eat a few boiled eggs. I have had this weird taste in my mouth since I've taken it but no serious side effects. Whenever I feel the weird taste, I just drink water. I feel like there's a bit of mental clarity and energy also. I usually nap throughout the day when I'm home but I haven't even sat down. This is my very first prescribed med for weight loss, and I feel like I made the right choice although it is on the pricey side."

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  • Meg...
  • January 14, 2017

Contrave (bupropion / naltrexone) for Weight Loss (Obesity/Overweight) "I cannot say enough positive about this medication. I started the end of March 2016, now 42 weeks in I am at 112 lbs down. I work closely with my physician with monitoring my weight and diet. I followed all the precautions with the medication. Eliminating fat from my diet completely. Working out, etc. I knew it would not be a quick fix and with this med you get what you put into it. No serious side effects in the beginning, some tiredness and nausea. But that is going to happen ANYTIME you start a new medication and your system gets used to it. I also quit smoking after 20 yrs day 1 on this medication. This med it not for people looking for a quick fix, if you do not have the determination and commitment it will not work for you."

10 / 10
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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.