Endep and Weight Gain: What Users Say

• Rho...
• Taken for 10 years or more
• December 3, 2014

For Fibromyalgia "I have been on Endep for 35 years. I have fibromyalgia, chronic fatigue syndrome, and plenty more. In the last six months, I have been getting very odd symptoms such as the ones provided within this article! Sudden weight gain, inability to eat properly, tiredness, rounded face, weakness, sore mouth and tongue, to slight more depression. At the moment, I am on a doctor's treadmill... everyone from my endocrinologist to a neurologist, GP, and many more have put their hands up saying I don't know! The medicines work really well for fibromyalgia, but after some time, they can work against you! Please look at the list of side effects. I have a lot of them. Good luck!"

• Lor...
• December 8, 2007

For Depression "I have only just started using Endep after the sudden onset of a severe depression. I found that it has helped me a great deal. The only side effects that I've had up to this point are a gain in weight (as I wasn't eating properly when depressed) and at night, I'll wake from sleep covered in perspiration - though only from the chest up. I'm hoping with counselling I'll be able to stop taking this medication asap, but it has been a great help. Thanks :)"

• aff...
• Taken for 1 to 6 months
• October 15, 2015

For Depression "I was on 75 mg of Endep and noticed two extreme side effects, which led to me having to stop taking the medication. The first was rapid and excessive weight gain; I gained 6 kgs (13 pounds) within 8 weeks (at 160 cm, this is quite a bit of weight). I had no change in my diet; my exercise stayed the same, so the Endep was the only thing that could have caused the weight gain. The second was extreme night terrors. These occurred every night and were extremely frightening for myself and family, as I would wake up screaming and kicking every night. This occurred almost immediately after starting the Endep. Since stopping the Endep 2 weeks ago, the night terrors have ceased completely, and I have lost 1 kg with no change in diet."

• she...
• July 12, 2011

For Interstitial Cystitis "I had been tested for everything to try and find the cause of constant bladder infections, or so I thought. It wasn't until I saw a urologist that I found the answer to my problem. I never had bladder infections, but chronic cystitis, found after some very intrusive camera shots of my bladder. She first tried stretching my bladder to see if this helped. It didn't. She then suggested Endep, not for depression, but it had been used for cystitis and burning mouth, which I also suffer from. It has helped my burning bladder problem 100% as long as I don't forget to take my tablets. If I forget just one, I have the pain back for about two weeks before I get back on track. My burning mouth is also about 60% better but not gone. Side effect: weight gain."

• Gin...
• Taken for 6 months to 1 year
• December 20, 2021

For Insomnia "Fed up with 10 years of insomnia after menopause commenced, my doctor started me on Amitriptyline earlier this year (2021). I have been taking 50 mg in the evening and sleep soundly. No more 2-3 a.m. awakening or tossing and turning. I wish I had found my current doctor years earlier as this medication has been a lifesaver. I've only gained a small amount of weight, but that's my own fault for sometimes snacking during the evening."

• Me...
• September 13, 2015

For Anxiety and Stress "Dramatic weight gain, heartburn, sleeplessness."