Endep Alternatives Compared
| Endep (amitriptyline) | Bupropion | Cymbalta (duloxetine) |
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| Endep (amitriptyline) | Bupropion | Cymbalta (duloxetine) |
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Prescription only
Prescribed for Depression. Endep may also be used for purposes not listed in this medication guide. |
Prescription only
Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black... View more |
Prescription only
Cymbalta has antidepressant, anti-anxiety, and pain-relieving properties; however, it has been associated with a discontinuation syndrome on withdrawal even when tapered. Prescribed for Back Pain... View more |
Related suggestions Depression
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| More about (amitriptyline) | More about Bupropion | More about Cymbalta (duloxetine) | ||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||
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Endep has an average rating of 6.9 out of 10 from a total of 48 ratings on Drugs.com. 58% of reviewers reported a positive effect, while 20% reported a negative effect. |
Bupropion has an average rating of 7.1 out of 10 from a total of 2884 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 20% reported a negative effect. |
Cymbalta has an average rating of 6.3 out of 10 from a total of 1891 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 30% reported a negative effect. |
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| Drug Class | ||||||||||||||||||
| Side Effects | ||||||||||||||||||
| Generic Availability | ||||||||||||||||||
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N/A |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Bupropion prices |
View all Cymbalta prices |
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| Dosage Forms Available | ||||||||||||||||||
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N/A |
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| Brand Names | ||||||||||||||||||
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N/A |
Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR, Wellbutrin XL | Other duloxetine brands include: Drizalma Sprinkle, Irenka | ||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||
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16 hours |
30 hours |
17 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||
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A total of 709 drugs are known to interact with Endep:
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A total of 521 drugs are known to interact with Bupropion:
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A total of 622 drugs are known to interact with Cymbalta:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||
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| Disease Interactions | ||||||||||||||||||
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| First Approval Date | ||||||||||||||||||
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N/A |
December 30, 1985 |
N/A |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||
| Patient resources | ||||||||||||||||||
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N/A |
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| Professional Resources | ||||||||||||||||||
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N/A |
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| Related Treatment Guide | ||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.