Sotyktu Side Effects

Generic name: deucravacitinib

Medically reviewed by Drugs.com. Last updated on Jul 22, 2023.

Note: This document provides detailed information about Sotyktu Side Effects associated with deucravacitinib. Some dosage forms listed on this page may not apply specifically to the brand name Sotyktu.

Applies to deucravacitinib: oral tablet.

Serious side effects of Sotyktu

Along with its needed effects, deucravacitinib (the active ingredient contained in Sotyktu) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking deucravacitinib:

More common side effects

• body aches or pain
• chest tightness
• chills
• cough
• dryness or soreness of the throat
• ear congestion
• fever
• headache
• loss of voice
• muscle aches
• pain or tenderness around eyes and cheekbones
• sneezing
• sore throat
• stuffy or runny nose
• swollen glands
• trouble breathing
• trouble in swallowing
• unusual tiredness or weakness
• voice changes

Less common side effects

• burning or stinging of skin
• painful cold sores or blisters on the lips, nose, eyes, or genitals

Incidence not known

• anxiety
• black, tarry stools
• chest pain
• dizziness or lightheadedness
• fainting
• general feeling of illness
• pain, redness, or swelling in the arm or leg
• painful blisters on the trunk of the body
• tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area
• weight loss
• yellow skin and eyes

Other side effects of Sotyktu

Some side effects of deucravacitinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

• blemishes on the skin
• burning, itching, and pain in the hairy areas, pus at the root of the hair
• irritation or soreness of the mouth
• pimples

For healthcare professionals

Applies to deucravacitinib: oral tablet.

General adverse events

The most common adverse reactions occurring in 1% of patients or greater included upper respiratory infections, increased blood creatine phosphokinase, herpes simplex, mouth ulcers, folliculitis, and acne.^[Ref]

Cardiovascular

• Common (1% to 10%): Hypertension^[Ref]

Dermatologic

• Common (1% to 10%): Psoriasis, folliculitis, acne, acneiform rash^[Ref]

"Acne" included acne, acne cystic, and dermatitis acneiform.

"Acneiform rash" included acne, dermatitis acneiform, rash, rosacea, pustule, rash pustular, and papule.^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea, diarrhea, mouth ulcers^[Ref]

"Mouth ulcers" included aphthous ulcer, tongue ulceration, and stomatitis.^[Ref]

Hepatic

• Frequency not reported: Increased liver enzymes (AST, ALT)^[Ref]

Hypersensitivity

• Frequency not reported: Angioedema^[Ref]

Musculoskeletal

• Common (1% to 10%): Arthralgia, back pain, increased creatine phosphokinase
• Frequency not reported: Rhabdomyolysis^[Ref]

Nervous system

• Common (1% to 10%): Headache^[Ref]

Oncologic

• Uncommon (0.1% to 1%): Malignancies (excluding nonmelanoma skin cancer)^[Ref]

Other

• Very common (10% or more): General infections (up to 29%)
• Common (1% to 10%): Herpes simplex infections
• Uncommon (0.1% to 1%): Herpes zoster, serious infections (including coronavirus disease 2019 [COVID-19], pneumonia)
• Frequency not reported: Increased triglycerides, multidermatomal herpes zoster^[Ref]

"Herpes simplex infections" included oral herpes, herpes simplex, genital herpes, and herpes viral infection.^[Ref]

Renal

• Frequency not reported: Decreased glomerular filtration rate, worsening proteinuria^[Ref]

Respiratory

• Very common (10% or more): Upper respiratory infections (up to 19.2%)^[Ref]

"Upper respiratory infections" includes viral upper respiratory tract infection, pharyngitis, sinusitis, acute sinusitis, rhinitis, tonsillitis, peritonsillar abscess, laryngitis, tracheitis, and rhinotracheitis.^[Ref]

Frequently asked questions

• Sotyktu vs Otezla: How do they compare?
• How long does it take for Sotyktu to work?
• How long can I take Sotyktu for?
• How is Sotyktu given / administered?

Further information

Sotyktu side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer