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Ranitidine Disease Interactions

There are 6 disease interactions with ranitidine.

Major

H2 antagonists (applies to ranitidine) GI bleeding

Major Potential Hazard, Moderate plausibility. Applicable conditions: Gastrointestinal Hemorrhage

Histamine H2 receptor antagonists should not be used in the presence of vomit with blood, or bloody or black stools. These might be serious conditions and the diagnosis needs to be ruled out.

Major

Ranitidine (applies to ranitidine) porphyria

Major Potential Hazard, Moderate plausibility.

Ranitidine may rarely precipitate acute porphyria attacks and should be avoided in patients with a history of acute porphyria.

Moderate

Ranitidine (applies to ranitidine) hemodialysis

Moderate Potential Hazard, High plausibility.

Ranitidine is partially removed by hemodialysis and should be administered after dialysis.

Moderate

Ranitidine (applies to ranitidine) liver disease

Moderate Potential Hazard, Low plausibility.

Ranitidine is partially metabolized by the liver. Although dosage reductions are generally not necessary, therapy with ranitidine should be administered cautiously in patients with liver disease. Elevated ALT (SGPT) has been observed in patients receiving ranitidine intravenously at dosages greater than those normally recommended for 5 days or more.

Moderate

Ranitidine (applies to ranitidine) PKU

Moderate Potential Hazard, High plausibility. Applicable conditions: Phenylketonuria

Zantac (brand of ranitidine) 150 EFFERdose tablets and granules both contain 16.84 mg of phenylalanine per each 150 mg of ranitidine. The phenylalanine content should be considered when these products are used in patients who must restrict their intake of phenylalanine (i.e. phenylketonurics).

Moderate

Ranitidine (applies to ranitidine) renal dysfunction

Moderate Potential Hazard, High plausibility.

Ranitidine is primarily eliminated by the kidney. Although the drug is generally well-tolerated, the daily dosage should initially be reduced in patients with moderate to severe renal impairment (CrCl < 50 mL/min). If necessary, the daily dosage may be increased with caution.

Switch to professional interaction data

Ranitidine drug interactions

There are 149 drug interactions with ranitidine.

Ranitidine alcohol/food interactions

There is 1 alcohol/food interaction with ranitidine.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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