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Spironolactone Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Spironolactone Doxycycline Minocycline
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Spironolactone Doxycycline Minocycline
Prescription only

Spironolactone is a diuretic that may be used to remove excess fluid (edema) from the body, lower blood pressure, or treat hyperaldosteronism. It does not cause potassium loss from the body; however... View more

Prescription only

Doxycycline is an effective antibiotic that treats a wide range of infections. However, it is not usually recommended for children aged less than eight or pregnant women in the last half of their... View more

Prescription only

Prescribed for Bacterial Infection, Acne, Bartonellosis, Bullous Pemphigoid, Rosacea, Actinomycosis, Brucellosis, Campylobacter Gastroenteritis, Cholera, Granuloma Inguinale, Meningitis -... View more

More about Spironolactone More about Doxycycline More about Minocycline
Ratings & Reviews

Spironolactone has an average rating of 6.9 out of 10 from a total of 703 ratings on Drugs.com. 58% of reviewers reported a positive effect, while 24% reported a negative effect.

Doxycycline has an average rating of 6.4 out of 10 from a total of 1635 ratings on Drugs.com. 50% of reviewers reported a positive effect, while 27% reported a negative effect.

Minocycline has an average rating of 5.9 out of 10 from a total of 564 ratings on Drugs.com. 45% of reviewers reported a positive effect, while 33% reported a negative effect.

View all 703 reviews

View all 1635 reviews

View all 564 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Spironolactone side effects

View all Doxycycline side effects

View all Minocycline side effects
Drug Class
Generic Availability

Lower cost generic

Lower cost generic

Lower cost generic
Pricing and Coupons * Prices are without insurance
Quantity 100 each
Strength 25 mg
Per unit* $0.23 - $0.25
Cost* $23.10 - $25.17

View all Spironolactone prices

Quantity 2 tablet
Strength hyclate 100 mg
Per unit* $6.62
Cost* $13.23

View all Doxycycline prices

Quantity 50 each
Strength 100 mg
Per unit* $1.12 - $1.16
Cost* $56.20 - $58.20

View all Minocycline prices

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Dosage Forms
  • Oral suspension
  • Oral tablet
  • Injectable powder for injection
  • Oral capsule
  • Oral delayed release capsule
  • Oral delayed release tablet
  • Oral powder for reconstitution
  • Oral tablet
  • Oral capsule
  • Oral capsule, extended release
  • Oral tablet
  • Oral tablet, extended release
Brand Names
Aldactone, CaroSpir Acticlate, Adoxa, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Doryx MPC, Doxy 100, Doxy 200, Doxy-Caps, Doxy-D, LymePak, Mondoxyne NL, Monodox, Morgidox, Okebo, Oracea, Oraxyl, Targadox, Uracil, Vibramycin View more Dynacin, Emrosi, Minocin, Minocin for Injection, Minolira, Solodyn, Ximino
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

37 hours

23 hours

17.9 hours
CSA Schedule 1 View glossary of CSA terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
D
Category D Positive evidence of risk

See the full pregnancy warnings document.
D
Category D Positive evidence of risk

See the full pregnancy warnings document.
Drug Interactions

A total of 382 drugs are known to interact with Spironolactone:

  • 51 major drug interactions (248 brand and generic names)
  • 311 moderate drug interactions (1487 brand and generic names)
  • 20 minor drug interactions (145 brand and generic names)

A total of 223 drugs are known to interact with Doxycycline:

  • 22 major drug interactions (60 brand and generic names)
  • 196 moderate drug interactions (2214 brand and generic names)
  • 5 minor drug interactions (21 brand and generic names)

A total of 223 drugs are known to interact with Minocycline:

  • 24 major drug interactions (64 brand and generic names)
  • 197 moderate drug interactions (2221 brand and generic names)
  • 2 minor drug interactions (6 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Spironolactone and alcohol may have additive effects in lowering your blood pressure. You may... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Disease Interactions
First Approval Date

January 21, 1960

December 05, 1967

June 30, 1971
WADA Class View classifications

N/A

N/A
More Information
Patient Resources
Professional Resources
Related Treatment Guide

1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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