Spironolactone Interactions
There are 382 drugs known to interact with spironolactone, along with 7 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 51 are major, 311 are moderate, and 20 are minor.
- View all 382 medications that may interact with spironolactone
- View spironolactone alcohol/food interactions (1)
- View spironolactone disease interactions (7)
Most frequently checked interactions
View interaction reports for spironolactone and the medicines listed below.
- Adderall (amphetamine / dextroamphetamine)
- Aspir 81 (aspirin)
- Aspirin Low Strength (aspirin)
- Benadryl (diphenhydramine)
- CoQ10 (ubiquinone)
- Crestor (rosuvastatin)
- Cymbalta (duloxetine)
- Eliquis (apixaban)
- Entresto (sacubitril / valsartan)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Jardiance (empagliflozin)
- Lasix (furosemide)
- Lexapro (escitalopram)
- Lipitor (atorvastatin)
- Lyrica (pregabalin)
- Metoprolol Succinate ER (metoprolol)
- Metoprolol Tartrate (metoprolol)
- Ozempic (semaglutide)
- Plavix (clopidogrel)
- Singulair (montelukast)
- Synthroid (levothyroxine)
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D2 (ergocalciferol)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Xarelto (rivaroxaban)
- Zoloft (sertraline)
- Zyrtec (cetirizine)
Spironolactone alcohol/food interactions
There is 1 alcohol/food interaction with spironolactone.
Spironolactone disease interactions
There are 7 disease interactions with spironolactone which include:
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More about spironolactone
- spironolactone consumer information
- Compare alternatives
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- Reviews (703)
- Drug images
- Latest FDA alerts (2)
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- Support group
- Drug class: aldosterone receptor antagonists
- Breastfeeding
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
